{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:41:03Z","timestamp":1791484863203,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","content-domain":{"domain":["phytomedicinejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.phymed.2013.08.019","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T13:48:12Z","timestamp":1380030492000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Hautriwaic acid as one of the hepatoprotective constituent of Dodonaea viscosa"],"prefix":"10.1016","volume":"21","author":[{"given":"Hamid","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul","family":"Kabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhtar","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Raza","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Ghulam","family":"Musharraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2013.08.019_bib0005","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jep.2013.02.005","article-title":"Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: in vitro and in vivo studies","volume":"146","author":"Ai","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0010","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.jhep.2005.11.004","article-title":"Epidemiology of viral hepatitis and HIV co-infection","volume":"44","author":"Alter","year":"2006","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0015","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/S0264-410X(99)00456-9","article-title":"Hepatitis B epidemiology in Asia, the middle East and Africa","volume":"18","author":"Andr\u00e9","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.phymed.2013.08.019_bib0020","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0006-2952(03)00443-X","article-title":"Depletion of kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity: expression of metallothionein and HSP70","volume":"66","author":"Andr\u00e9s","year":"2003","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0025","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jep.2008.05.026","article-title":"Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models","volume":"118","author":"Arun","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0300-483X(03)00157-4","article-title":"Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients","volume":"189","author":"Basu","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0035","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/0192623311418680","article-title":"Role of quercetin in preventing thioacetamide-induced liver injury in rats","volume":"39","author":"deDavid","year":"2011","journal-title":"Toxicologic Pathology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0040","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s10620-005-2942-9","article-title":"Herbal medicines for liver diseases","volume":"50","author":"Dhiman","year":"2005","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.phymed.2013.08.019_bib0045","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/taap.1993.1069","article-title":"The involvement of kupffer cells in carbon tetrachloride toxicity","volume":"119","author":"Edwards","year":"1993","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0050","first-page":"1632","article-title":"Cytokine-induced upregulation of hepatic intercellular adhession molecule-1 messanger RNA expression and its role in the pathophysiology of meurin endotoxin shock and acute liver failure","volume":"21","author":"Essani","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0055","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/MOG.0b013e3283383c7c","article-title":"Drug-induced liver injury: a clinical update","volume":"26","author":"Ghabril","year":"2010","journal-title":"Current Opinion in Gastroenterology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0060","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jlb.61.6.647","article-title":"Mechanisms of neutrophil-induced parenchymal cell injury","volume":"61","author":"Jaeschke","year":"1997","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0065","first-page":"36","article-title":"Molecular docking of viscosine as a new lipoxygenase inhibitor isolated from Dodonaea viscosa","volume":"8","author":"Khan","year":"2013","journal-title":"Bangladesh Journal of Pharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0070","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/molecules14031332","article-title":"Antibacterial activities of Dodonaea viscosa using contact bioautography technique","volume":"14","author":"Khurram","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2013.08.019_bib0075","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1248\/bpb.35.980","article-title":"The role of kupffer cells in carbon tetrachloride intoxication in mice","volume":"35","author":"Kiso","year":"2012","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.phymed.2013.08.019_bib0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1423-0127-16-35","article-title":"Green tea extract supplement reduces d-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling","volume":"16","author":"Lin","year":"2009","journal-title":"Journal of Biomedical Science"},{"issue":"2","key":"10.1016\/j.phymed.2013.08.019_bib0085","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jep.2012.05.040","article-title":"Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats","volume":"142","author":"Lin","year":"2012","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0090","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10590500701569398","article-title":"Postulated carbon tetrachloride mode of action: a review","volume":"25","author":"Manibusan","year":"2007","journal-title":"Journal of Environmental Science and Health Part C"},{"key":"10.1016\/j.phymed.2013.08.019_bib0095","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s12272-012-0305-6","article-title":"Biologically active C-alkylated flavonoids from Dodonaea viscosa","volume":"35","author":"Muhammad","year":"2012","journal-title":"Archives of Pharmacal Research"},{"key":"10.1016\/j.phymed.2013.08.019_bib0100","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bmcl.2011.10.072","article-title":"Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase","volume":"22","author":"Muhammad","year":"2012","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.phymed.2013.08.019_bib0105","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1016\/j.fct.2010.05.047","article-title":"Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats","volume":"48","author":"Olaleye","year":"2010","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0110","first-page":"337","article-title":"Antifungal activity of Dodonaea Viscosa Jacq extract on pathogenic fungi isolated from super ficial skin infection","volume":"23","author":"Pirzada","year":"2010","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.phymed.2013.08.019_bib0120","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jep.2009.10.019","article-title":"Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats","volume":"127","author":"Ranawat","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0125","first-page":"97","article-title":"Dodonaea viscosa Linn. An overview","volume":"1","author":"Rani","year":"2009","journal-title":"Journal of Pharmaceutical Research and Health Care"},{"key":"10.1016\/j.phymed.2013.08.019_bib0130","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.phymed.2007.11.010","article-title":"Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine","volume":"15","author":"Rathi","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2013.08.019_bib0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10408447309082019","article-title":"Carbon tetrachloride hepatotoxicity: an example of lethal cleavage","volume":"2","author":"Recknagel","year":"1973","journal-title":"CRC Critical Reviews in Toxicology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0145","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/10575630290034258","article-title":"Alysinol\u2014a new triterpene from Alysicarpus monolifer","volume":"16","author":"Riaz","year":"2002","journal-title":"Natural Product Letters"},{"key":"10.1016\/j.phymed.2013.08.019_bib0150","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.3390\/molecules17044292","article-title":"Anti-inflammatory activity of hautriwaic acid isolated from Dodonaea viscosa leaves","volume":"17","author":"Salinas-S\u00e1nchez","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2013.08.019_bib0155","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jep.2011.07.040","article-title":"Investigation of the extraction process and phytochemical composition of preparations of Dodonaea viscosa (L.) Jacq","volume":"137","author":"Shanmugavasan","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0160","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9440(10)65594-0","article-title":"Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride","volume":"153","author":"Shi","year":"1998","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0165","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.fct.2008.12.022","article-title":"Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats","volume":"47","author":"Sreelatha","year":"2009","journal-title":"Food and Chemical Toxicology"},{"issue":"2","key":"10.1016\/j.phymed.2013.08.019_bib0170","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0925-4439(00)00098-3","article-title":"Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver","volume":"1535","author":"Sun","year":"2001","journal-title":"Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease"},{"key":"10.1016\/j.phymed.2013.08.019_bib0175","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1046\/j.1440-1746.2003.03064.x","article-title":"Clinical usefulness of edaravone for acute liver injury","volume":"18","author":"Tada","year":"2003","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.phymed.2013.08.019_bib0180","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0031-9422(00)84767-6","article-title":"Biologically active saponins from Dodonaea viscosa","volume":"26","author":"Wagner","year":"1987","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2013.08.019_bib0185","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"CRC Critical Reviews in Toxicology"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131300322X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131300322X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T04:26:46Z","timestamp":1564028806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471131300322X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S094471131300322X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2013.08.019","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hautriwaic acid as one of the hepatoprotective constituent of Dodonaea viscosa","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2013.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}