{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:10:39Z","timestamp":1787242239352,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","issue":"4","content-domain":{"domain":["phytomedicinejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.phymed.2013.10.004","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T03:46:55Z","timestamp":1385524015000},"page":"529-533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D3 and deapi-platycodin on production and secretion of airway mucin in vitro"],"prefix":"10.1016","volume":"21","author":[{"given":"Jiho","family":"Ryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwoong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Kook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Shik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ho","family":"Seok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choong Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2013.10.004_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.03.012","article-title":"Platycodin D-induced apoptosis through nuclear factor-kappaB activation in immortalized keratinocytes","volume":"537","author":"Ahn","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.phymed.2013.10.004_bib0010","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1021\/np100496p","article-title":"Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells","volume":"73","author":"Choi","year":"2010","journal-title":"J. Nat. Prod."},{"issue":"11","key":"10.1016\/j.phymed.2013.10.004_bib0015","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1248\/bpb.31.2114","article-title":"Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition","volume":"31","author":"Chung","year":"2008","journal-title":"Biol. Pharm. Bull."},{"issue":"5","key":"10.1016\/j.phymed.2013.10.004_bib0020","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/ptr.2102","article-title":"Carbenoxolone and triterpenoids inhibited mucin secretion from airway epithelial cells","volume":"21","author":"Heo","year":"2007","journal-title":"Phytother. Res."},{"issue":"10","key":"10.1016\/j.phymed.2013.10.004_bib0025","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/ptr.2801","article-title":"Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells","volume":"23","author":"Heo","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2013.10.004_bib0030","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jmb.2004.09.059","article-title":"PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells via PKC, EGF\/TGF-alpha, Ras\/Raf, MEK, REK and Sp1-dependent mechanisms","volume":"344","author":"Hewson","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.phymed.2013.10.004_bib0035","first-page":"G1041","article-title":"Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-epsilon","volume":"277","author":"Hong","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.phymed.2013.10.004_bib0040","series-title":"Treatise on asian herbal medicines","first-page":"1421","author":"Jang","year":"2003"},{"issue":"9","key":"10.1016\/j.phymed.2013.10.004_bib0045","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/ptr.3727","article-title":"Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells","volume":"26","author":"Kim","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2013.10.004_bib0050","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.canlet.2007.11.010","article-title":"Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells","volume":"261","author":"Kim","year":"2008","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.phymed.2013.10.004_bib0055","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1055\/s-2001-14317","article-title":"Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum","volume":"67","author":"Kim","year":"2001","journal-title":"Planta Med."},{"issue":"10","key":"10.1016\/j.phymed.2013.10.004_bib0060","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/PL00012417","article-title":"Effects of polycationic peptides on mucin release from airway goblet cells: relationship between polymer size and activity","volume":"51","author":"Lee","year":"2002","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.phymed.2013.10.004_bib0065","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1073\/pnas.94.3.967","article-title":"Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease","volume":"94","author":"Li","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.phymed.2013.10.004_bib0070","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1081\/IPH-120003751","article-title":"Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60cells","volume":"24","author":"Park","year":"2002","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.phymed.2013.10.004_bib0075","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/07853890600585795","article-title":"Treatment of airway mucus hypersecretion","volume":"38","author":"Rogers","year":"2006","journal-title":"Ann. Med."},{"key":"10.1016\/j.phymed.2013.10.004_bib0080","doi-asserted-by":"crossref","first-page":"11618","DOI":"10.1073\/pnas.1534804100","article-title":"Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells","volume":"100","author":"Shao","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.phymed.2013.10.004_bib0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-2002-23130","article-title":"Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters","volume":"68","author":"Shin","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2013.10.004_bib0095","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1073\/pnas.96.6.3081","article-title":"Epidermal growth factor system regulates mucin production in airways","volume":"96","author":"Takeyama","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.phymed.2013.10.004_bib0100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.08-0412","article-title":"Mucins, mucus, and sputum","volume":"135","author":"Voynow","year":"2009","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.phymed.2013.10.004_bib0105","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.intimp.2004.04.005","article-title":"Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells","volume":"4","author":"Wang","year":"2004","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2013.10.004_bib0110","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1089\/jmf.2009.1226","article-title":"Platycodin D induces apoptosis in MCF-7 human breast cancer cells","volume":"13","author":"Yu","year":"2010","journal-title":"J. Med. Food"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711313004133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711313004133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T13:56:19Z","timestamp":1539006979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711313004133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0944711313004133"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2013.10.004","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D3 and deapi-platycodin on production and secretion of airway mucin in vitro","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2013.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}