{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:00:31Z","timestamp":1774846831345,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":343,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES, CAPES-PNPD-23038007200\/11-08"],"award-info":[{"award-number":["CAPES, CAPES-PNPD-23038007200\/11-08"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq-307277\/2013-5"],"award-info":[{"award-number":["CNPq-307277\/2013-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["FAPERGS-1017479"],"award-info":[{"award-number":["FAPERGS-1017479"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.phymed.2014.10.004","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T08:16:26Z","timestamp":1414397786000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Leishmanicidal activity of lipophilic extracts of some Hypericum species"],"prefix":"10.1016","volume":"22","author":[{"given":"Ana Paula","family":"Dagnino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Maikon Corr\u00eaa de","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gari Vidal","family":"Ccana-Ccapatinta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane Somariva","family":"Prophiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilsane Lino von","family":"Poser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-2509","authenticated-orcid":false,"given":"Pedro R.T.","family":"Rom\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2014.10.004_bib0005","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2014.10.004_bib0010","doi-asserted-by":"crossref","first-page":"536","DOI":"10.4269\/ajtmh.1991.44.536","article-title":"Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease","volume":"44","author":"Barral","year":"1991","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.phymed.2014.10.004_bib0015","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.indcrop.2012.11.017","article-title":"Antifungal and antichemotactic activities and quantification of phenolic compounds in lipophilic extracts of Hypericum spp. native to South Brazil","volume":"44","author":"Barros","year":"2013","journal-title":"Industrial Crops and Products"},{"key":"10.1016\/j.phymed.2014.10.004_bib0020","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s00606-013-0842-6","article-title":"Determination of phenolic compounds in flowers of Hypericum species native to South Brazil and Peruvian P\u00e1ramos","volume":"299","author":"Barros","year":"2013","journal-title":"Plant Syst. Evol."},{"key":"10.1016\/j.phymed.2014.10.004_bib0025","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1021\/np040149e","article-title":"Benzophenones from Hypericum carinatum","volume":"68","author":"Bernardi","year":"2005","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2014.10.004_bib0030","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1021\/np040106y","article-title":"The role of natural product chemistry in drug discovery","volume":"67","author":"Butler","year":"2004","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2014.10.004_bib0035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.parint.2012.10.006","article-title":"Anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction and isolated compounds","volume":"62","author":"Cargnin","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.phymed.2014.10.004_bib0040","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0001-706X(94)90103-1","article-title":"Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis","volume":"56","author":"Carvalho","year":"1994","journal-title":"Acta Trop."},{"key":"10.1016\/j.phymed.2014.10.004_bib0045","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/0035-9203(93)90030-T","article-title":"The clinical and immunological spectrum of American cutaneous leishmaniasis","volume":"87","author":"Convit","year":"1993","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.phymed.2014.10.004_bib0050","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: a continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2014.10.004_bib0055","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ptr.1546","article-title":"Bioassay-guided isolation of antimicrobial benzopyrans and phloroglucinol derivatives from Hypericum species","volume":"19","author":"Dall\u2019agnol","year":"2005","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2014.10.004_bib0060","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0031-9422(01)00169-8","article-title":"Benzopyrans from Hypericum polyanthemum","volume":"57","author":"Ferraz","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2014.10.004_bib0065","doi-asserted-by":"crossref","first-page":"e36595","DOI":"10.1371\/journal.pone.0036595","article-title":"Exposure of phosphatidylserine on Leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity","volume":"7","author":"Fran\u00e7a-Costa","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2014.10.004_bib0070","doi-asserted-by":"crossref","first-page":"e1974","DOI":"10.1371\/journal.pntd.0001974","article-title":"Leishmania donovani develops resistance to drug combinations","volume":"6","author":"Garc\u00eda-Hern\u00e1ndez","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.phymed.2014.10.004_bib0075","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/ptr.2490","article-title":"Synergistic effect of three benzopyrans isolated from Hypericum polyanthemum in U-373 MG glioblastoma cell line","volume":"22","author":"Grivicich","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2014.10.004_bib0080","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1021\/jm901677h","article-title":"New benzophenone-derived bisphosphonium salts as leishmanicidal leads targeting mitochondria through inhibition of respiratory complex II","volume":"53","author":"Luque-Ortega","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2014.10.004_bib0085","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1016\/j.bmc.2013.03.045","article-title":"Synthesis and biological evaluation against Leishmania amazonensis of a series of alkyl-substituted benzophenones","volume":"21","author":"Maciel-Rezende","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phymed.2014.10.004_bib0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.0105-2896.2004.00190.x","article-title":"Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?","volume":"201","author":"McMahon-Pratt","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2014.10.004_bib0095","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/ptr.3104","article-title":"Antiplasmodial and cytotoxic activity of phloroglucinol derivatives from Hypericum erectum thunb","volume":"24","author":"Moon","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2014.10.004_bib0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.7555\/JBR.27.20120064","article-title":"Development of Leishmania vaccines: predicting the future from past and present experience","volume":"27","author":"Mutiso","year":"2013","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.phymed.2014.10.004_bib0105","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.bse.2003.10.011","article-title":"Phloroglucinol derivatives from four Hypericum species belonging to the Trigynobrathys section","volume":"32","author":"N\u00f6r","year":"2004","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.phymed.2014.10.004_bib0110","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.foodchem.2012.11.053","article-title":"Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of Hypericum perforatum and their LC \u2013 DAD \u2013 MS analyses","volume":"138","author":"Orhan","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2014.10.004_bib0115","first-page":"97","article-title":"Antileishmanial activity of Polyalthia longifolia leaf extract on the in vitro growth of Leishmania donovani promastigotes","volume":"5","author":"Pal","year":"2011","journal-title":"Glob. J. Pharmacol."},{"key":"10.1016\/j.phymed.2014.10.004_bib0120","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1017\/S0031182099004278","article-title":"Glutathione protects macrophages and Leishmania major against nitric oxide-mediated cytotoxicity","volume":"118","author":"Rom\u00e3o","year":"1999","journal-title":"Parasitology"},{"key":"10.1016\/j.phymed.2014.10.004_bib0125","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1590\/S0100-879X2006000300006","article-title":"Glutathione and the redox control system trypanothione\/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity","volume":"39","author":"Rom\u00e3o","year":"2006","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.phymed.2014.10.004_bib0130","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/AAC.01694-08","article-title":"Low Plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug","volume":"53","author":"S\u00e1nchez-Ca\u00f1ete","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2014.10.004_bib0135","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-3156.2001.00778.x","article-title":"Drug resistance in Indian visceral leishmaniasis","volume":"6","author":"Sundar","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.phymed.2014.10.004_bib0140","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.bmcl.2006.12.100","article-title":"In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure \u2013 activity study","volume":"17","author":"Verotta","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2014.10.004_bib0145","unstructured":"von Poser, G.L., Rech, S.B., Rates, S.M.K., 2006. Chemical and pharmacological aspects of Southern Brazilian Hypericum species. In: Silva, J.T. (Ed.), Floriculture, Ornamental and Plant Biotechnology: Advances and Topical Issues. London, pp. 510 \u2013 516"},{"key":"10.1016\/j.phymed.2014.10.004_bib0150","unstructured":"World Health Organization (WHO), 2010. Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniasis. \u3008http:\/\/whqlibdoc.who.int\/trs\/WHO_TRS_949_eng.pdf\u3009 (accessed 24.03.13)"},{"key":"10.1016\/j.phymed.2014.10.004_bib0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1475-2875-10-167","article-title":"Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark","volume":"10","author":"Zofou","year":"2011","journal-title":"Malaria J."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711314003511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711314003511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T04:35:00Z","timestamp":1598416500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711314003511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0944711314003511"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2014.10.004","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leishmanicidal activity of lipophilic extracts of some Hypericum species","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2014.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}