{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:56:23Z","timestamp":1790319383208,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"crossref","award":["09ZZ124"],"award-info":[{"award-number":["09ZZ124"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["12401900300"],"award-info":[{"award-number":["12401900300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.phymed.2014.11.006","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T15:47:46Z","timestamp":1416671266000},"page":"128-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii"],"prefix":"10.1016","volume":"22","author":[{"given":"Zhaohui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2014.11.006_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/15733998113099990069","article-title":"Goto-Kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus","volume":"9","author":"Akash","year":"2013","journal-title":"Curr. Diab. Rev."},{"key":"10.1016\/j.phymed.2014.11.006_bib0002","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc11-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"34","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2014.11.006_bib0003","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbrc.2006.09.039","article-title":"Insulin and nateglinide reduce monocyte adhesion to endothelial cells in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation","volume":"350","author":"Atsuko","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2014.11.006_bib0004","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/00008480-200008000-00004","article-title":"Type 2 diabetes mellitus in adolescents","volume":"12","author":"Callahan","year":"2000","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.phymed.2014.11.006_bib0005","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.numecd.2008.01.012","article-title":"Guideline for management of postmeal glucose","volume":"18","author":"Ceriello","year":"2008","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.phymed.2014.11.006_bib0006","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.numecd.2006.05.006","article-title":"Postprandial hyperglycemia and cardiovascular complications of diabetes: an update","volume":"16","author":"Ceriello","year":"2006","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.phymed.2014.11.006_bib0007","first-page":"17","article-title":"Fructus Arctii is hypoglycemic and good for back and joints","volume":"30","author":"Chen","year":"1999","journal-title":"Fujian J. TCM"},{"key":"10.1016\/j.phymed.2014.11.006_bib0008","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/00007611-200108000-00010","article-title":"Importance of postprandial glucose control","volume":"94","author":"David","year":"2001","journal-title":"South Med. J."},{"key":"10.1016\/j.phymed.2014.11.006_bib0009","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1055\/s-0032-1328332","article-title":"Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC\/MS\/MS after oral administration in rats","volume":"79","author":"Gao","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2014.11.006_bib0010","first-page":"2097","article-title":"Quo vadis nateglinide? Ten-year perspective","volume":"12","author":"George","year":"2011","journal-title":"Drug Eval."},{"key":"10.1016\/j.phymed.2014.11.006_bib0011","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1021\/jm00119a007","article-title":"N-acylphenylalanines and related compounds: a new class of oral hypoglycemic agents","volume":"31","author":"Hisashi","year":"1988","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2014.11.006_bib0012","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0378-8741(89)90001-9","article-title":"A review of natural products and plants as potential antidiabetic drugs","volume":"27","author":"Ivorra","year":"1989","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2014.11.006_bib0013","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1210\/jcem.85.3.6446","article-title":"Synergistic effects of nateglinide and meal administration on insulin secretion in patients with type 2 diabetes mellitus","volume":"85","author":"Keilson","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2014.11.006_bib0014","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.3987\/COM-05-10361","article-title":"Isolation and identification of potent stimulatory allelopathic substances exuded from germinating Burdoch (Arctium Lappa) seeds","volume":"65","author":"Keiko","year":"2005","journal-title":"Heterocycles"},{"key":"10.1016\/j.phymed.2014.11.006_bib0015","first-page":"536","article-title":"The protection effect of arctiin on filtration barrier injury of kidney glomerulus in diabetic nephropathy rats","volume":"26","author":"Liu","year":"2011","journal-title":"West China J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2014.11.006_bib0016","series-title":"Manual of Histological Screening Methods of Armed Forces Institute of Pathology","author":"Luna","year":"1990"},{"key":"10.1016\/j.phymed.2014.11.006_bib0017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/0253-7613.40483","article-title":"Evaluation of hypoglycemic effect of Morus alba in animal model","volume":"40","author":"Mohammadi","year":"2008","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.phymed.2014.11.006_bib0018","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0378-8741(83)90037-5","article-title":"Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala","volume":"9","author":"Twaij","year":"1983","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2014.11.006_bib0019","first-page":"589","article-title":"Clinical observation on treatment of diabetic nephropathy with compound Fructus Arctii mixture","volume":"24","author":"Wang","year":"2004","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2014.11.006_bib0020","first-page":"444","article-title":"Chemical constituents of antihyperglycemic active fraction from Arctium lappa.","volume":"4","author":"Xu","year":"2006","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2014.11.006_bib0021","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ptr.2273","article-title":"The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats.","volume":"22","author":"Xu","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2014.11.006_bib0022","first-page":"75","article-title":"Effects of extract from Fructus Arctii on blood glucose and immune function in mice","volume":"8","author":"Yan","year":"1993","journal-title":"Northwest Pharm. J."},{"key":"10.1016\/j.phymed.2014.11.006_bib0023","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1053\/meta.2002.35195","article-title":"Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes","volume":"51","author":"Yoshiro","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2014.11.006_bib0024","first-page":"1708","article-title":"Study on quality standard of Tangshenkang Soft Capsules","volume":"31","author":"Zhai","year":"2009","journal-title":"Chin. Tradit. Patent Med."},{"key":"10.1016\/j.phymed.2014.11.006_bib0025","first-page":"2222","article-title":"Study on effect of Arctium Lappa on experimental diabetic mice","volume":"18","author":"Zhang","year":"2007","journal-title":"Lishizhen Med. Mater. Medica Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711314003870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711314003870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T13:57:18Z","timestamp":1538056638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711314003870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0944711314003870"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2014.11.006","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2014.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}