{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:32:57Z","timestamp":1791333177190,"version":"4.3.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["CUHK463613"],"award-info":[{"award-number":["CUHK463613"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012479","name":"General Research Fund of Shanghai Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["ITS\/212\/12"],"award-info":[{"award-number":["ITS\/212\/12"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.phymed.2015.03.010","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T08:36:44Z","timestamp":1428309404000},"page":"536-544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity"],"prefix":"10.1016","volume":"22","author":[{"given":"Tao","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby L.Y.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.K.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth K.W.","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Hin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2015.03.010_bib0001","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1158\/1535-7163.MCT-13-0058","article-title":"BH3 mimetics: status of the field and new developments","volume":"12","author":"Billard","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phymed.2015.03.010_bib0002","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"Bjorkoy","year":"2009","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.phymed.2015.03.010_bib0003","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1158\/0008-5472.CAN-08-2023","article-title":"Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition","volume":"69","author":"Dallas","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2015.03.010_bib0004","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.tcb.2013.07.006","article-title":"Evading apoptosis in cancer","volume":"23","author":"Fernald","year":"2013","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.phymed.2015.03.010_bib0005","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ijc.24064","article-title":"Tumor resistance to apoptosis","volume":"124","author":"Fulda","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phymed.2015.03.010_bib0006","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1046\/j.1365-2036.2003.01735.x","article-title":"Review article: colorectal cancer chemotherapy","volume":"18","author":"Gill","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2015.03.010_bib0007","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13238-011-1127-x","article-title":"The crosstalk between autophagy and apoptosis: where does this lead?","volume":"3","author":"Gordy","year":"2012","journal-title":"Protein Cell"},{"key":"10.1016\/j.phymed.2015.03.010_bib0008","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrc706","article-title":"Multidrug resistance in cancer: role of ATP-dependent transporters","volume":"2","author":"Gottesman","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2015.03.010_bib0009","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2015.03.010_bib0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jcp.10256","article-title":"Overcoming resistance of cancer cells to apoptosis","volume":"196","author":"Hersey","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phymed.2015.03.010_bib0011","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.phymed.2014.06.013","article-title":"Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza","volume":"21","author":"Hu","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2015.03.010_bib0012","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc776","article-title":"Death and anti-death: tumour resistance to apoptosis","volume":"2","author":"Igney","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2015.03.010_bib0013","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc1692","article-title":"The role of autophagy in cancer development and response to therapy","volume":"5","author":"Kondo","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2015.03.010_bib0014","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/ijc.2910490512","article-title":"P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines","volume":"49","author":"Lai","year":"1991","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phymed.2015.03.010_bib0015","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0092-8674(93)90719-7","article-title":"p53-dependent apoptosis modulates the cytotoxicity of anticancer agents","volume":"74","author":"Lowe","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2015.03.010_bib0016","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCRESAHA.108.188318","article-title":"Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential","volume":"104","author":"Martinet","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2015.03.010_bib0017","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","article-title":"p62 at the crossroads of autophagy, apoptosis, and cancer","volume":"137","author":"Moscat","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2015.03.010_bib0018","first-page":"4285","article-title":"Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents","volume":"57","author":"O'Connor","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2015.03.010_bib0019","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"Ogata","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2015.03.010_bib0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10495-013-0929-0","article-title":"Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma","volume":"19","author":"Park","year":"2014","journal-title":"Apoptosis"},{"key":"10.1016\/j.phymed.2015.03.010_bib0021","first-page":"2984","article-title":"Correlation of p53 mutations with resistance to platinum-based chemotherapy and shortened survival in ovarian cancer","volume":"7","author":"Reles","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2015.03.010_bib0022","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.bcp.2007.08.009","article-title":"Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis","volume":"74","author":"Tsai","year":"2007","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.phymed.2015.03.010_bib0023","doi-asserted-by":"crossref","first-page":"629","DOI":"10.4161\/auto.5941","article-title":"Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells","volume":"4","author":"Yokoyama","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2015.03.010_bib0024","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ptr.5015","article-title":"Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM-5 leukemia cells","volume":"28","author":"Yun","year":"2014","journal-title":"Phytother. Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315000768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315000768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:12:52Z","timestamp":1760551972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711315000768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0944711315000768"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2015.03.010","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2015.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}