{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:02:38Z","timestamp":1773975758198,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202944"],"award-info":[{"award-number":["81202944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["szy10005"],"award-info":[{"award-number":["szy10005"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.phymed.2015.05.002","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T16:22:48Z","timestamp":1432225368000},"page":"705-712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effect of angoroside C on pressure overload-induced ventricular remodeling in rats"],"prefix":"10.1016","volume":"22","author":[{"given":"Wei Liang","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Xun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian Ping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2015.05.002_bib0001","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejcts.2006.07.006","article-title":"The relationship between myocardial extracellular matrix remodeling and ventricular function","volume":"30","author":"Brower","year":"2006","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.phymed.2015.05.002_bib0002","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-beta signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phymed.2015.05.002_bib0003","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00059-002-2354-y","article-title":"Cardiac fibrosis as a cause of diastolic dysfunction","volume":"27","author":"Burlew","year":"2002","journal-title":"Herz"},{"key":"10.1016\/j.phymed.2015.05.002_bib0004","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.lfs.2003.10.008","article-title":"Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity","volume":"74","author":"D\u00edaz","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2015.05.002_bib0005","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1113\/expphysiol.2010.055277","article-title":"Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases","volume":"96","author":"Ferreira","year":"2011","journal-title":"Exp Physiol."},{"key":"10.1016\/j.phymed.2015.05.002_bib0006","first-page":"770","article-title":"Effects of Chinese herb medicine Radix Scrophulariae on ventricular remodeling","volume":"65","author":"Gu","year":"2010","journal-title":"Pharmazie"},{"key":"10.1016\/j.phymed.2015.05.002_bib0007","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.phymed.2012.10.012","article-title":"Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats","volume":"20","author":"Huang","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2015.05.002_bib0008","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.phymed.2011.09.079","article-title":"Effects of ethanolic extract from Radix Scrophulariae on ventricular remodeling in rats","volume":"19","author":"Huang","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2015.05.002_bib0009","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1161\/01.CIR.98.19.2065","article-title":"Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats","volume":"98","author":"Iwanaga","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2015.05.002_bib0010","first-page":"210","article-title":"Increased superoxide radical with a decrease in vascular endothelial growth factor and inducible nitric oxide synthase level leads to the progression of left ventricular hypertrophy in a pressure-overload rat heart model","volume":"14","author":"Ji","year":"2008","journal-title":"Ann. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.phymed.2015.05.002_bib0011","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/01.HYP.0000062465.60601.CC","article-title":"Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure","volume":"41","author":"Kacimi","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2015.05.002_bib0012","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/01926230500419421","article-title":"Cardiac hypertrophy: a risk factor for QT-prolongation and cardiac sudden death","volume":"34","author":"Kang","year":"2006","journal-title":"Toxicol Pathol."},{"key":"10.1016\/j.phymed.2015.05.002_bib0013","series-title":"Heart Failure, Pathophysiology, Molecular Biology and Clinical Management","first-page":"173","author":"Katz","year":"2000"},{"key":"10.1016\/j.phymed.2015.05.002_bib0014","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2567.2006.02336.x","article-title":"Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia","volume":"118","author":"Khan","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.phymed.2015.05.002_bib0015","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1161\/01.CIR.83.5.1808","article-title":"Endothelin has biological actions at pathophysiological concentrations","volume":"83","author":"Lerman","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2015.05.002_bib0016","first-page":"1125","article-title":"Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl","volume":"21","author":"Li","year":"2000","journal-title":"Acta Pharmacol Sin."},{"key":"10.1016\/j.phymed.2015.05.002_bib0017","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1073\/pnas.97.2.931","article-title":"Overexpression of angiotensin \u2161 type \u2160 receptor in cardiomyocytes induces cardiac hypertrophy and remodeling","volume":"97","author":"Paradis","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.phymed.2015.05.002_bib0018","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/B:HREV.0000011395.11179.af","article-title":"Matrix metalloproteinase inhibitor development and the remodeling of drug discovery","volume":"9","author":"Peterson","year":"2004","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.phymed.2015.05.002_bib0019","series-title":"Pharmacology of Traditional Chinese Medicine [M]","author":"Shen","year":"2000"},{"key":"10.1016\/j.phymed.2015.05.002_bib0020","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1291\/hypres.30.863","article-title":"Beneficial effects of pioglitazone on left ventricular hypertrophy in genetically hypertensive rats","volume":"30","author":"Shinzato","year":"2007","journal-title":"Hypertens Res."},{"key":"10.1016\/j.phymed.2015.05.002_bib0021","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1152\/physrev.00012.2007","article-title":"Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function","volume":"87","author":"Spinale","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.phymed.2015.05.002_bib0022","series-title":"Pharmacopoeia of the People's Republic of China, Part I [M]","author":"The State Pharmacopoeia Committee of China","year":"2010"},{"key":"10.1016\/j.phymed.2015.05.002_bib0023","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.cardiores.2005.10.002","article-title":"Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window","volume":"69","author":"Vanhoutte","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phymed.2015.05.002_bib0024","series-title":"Chromato-graphic Fingerprint Analysis of Herbal Medicines (TLC and HPLC of Chinese Drugs), vol. \u2161","first-page":"427","author":"Wagner","year":"2011"},{"key":"10.1016\/j.phymed.2015.05.002_bib0025","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm1101-1236","article-title":"Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gaq\/Ga11 in cardiomyocytes","volume":"7","author":"Wettschureck","year":"2001","journal-title":"Nature Med"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315001130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315001130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T08:25:40Z","timestamp":1537604740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711315001130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":25,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0944711315001130"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2015.05.002","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of angoroside C on pressure overload-induced ventricular remodeling in rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2015.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier GmbH","name":"copyright","label":"Copyright"}]}}