{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:13:20Z","timestamp":1788884000940,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":331,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["APQ 0171\/11"],"award-info":[{"award-number":["APQ 0171\/11"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["BPD 00284-14"],"award-info":[{"award-number":["BPD 00284-14"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["APQ 02015\/14"],"award-info":[{"award-number":["APQ 02015\/14"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["487221\/2012-5"],"award-info":[{"award-number":["487221\/2012-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["307729\/2012-5"],"award-info":[{"award-number":["307729\/2012-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["00\/11624-5"],"award-info":[{"award-number":["00\/11624-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.phymed.2015.06.009","type":"journal-article","created":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T21:41:50Z","timestamp":1436132510000},"page":"921-928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Cardamonin, a schistosomicidal chalcone from Piper aduncum L. (Piperaceae) that inhibits Schistosoma mansoni ATP diphosphohydrolase"],"prefix":"10.1016","volume":"22","author":[{"given":"Clarissa C.B.","family":"de Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poliana S.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele T.","family":"Laktin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo H.D.","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo B.","family":"Geraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.S.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara R.C.","family":"Couri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila de F.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar A.","family":"Da Silva Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2015.06.009_bib0001","first-page":"25","article-title":"Antifungal flavonoids isolated from Piper septuplinervium (Miq.) C. DC (Piperaceae)","volume":"40","author":"Avila","year":"2011","journal-title":"Rev. Colomb. Quim."},{"key":"10.1016\/j.phymed.2015.06.009_bib0002","series-title":"Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components","first-page":"109","article-title":"Natural products with activity against Schistosoma species","author":"Barbosa de Castro","year":"2013"},{"key":"10.1016\/j.phymed.2015.06.009_bib0003","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1590\/S0036-46651996000600006","article-title":"Oviposition by Schistosoma mansoni during in vitro cultivation","volume":"38","author":"Barth","year":"1996","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"10.1016\/j.phymed.2015.06.009_bib0004","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/bioinformatics\/btq662","article-title":"Toward the estimation of the absolute quality of individual protein structure models","volume":"27","author":"Benkert","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phymed.2015.06.009_bib0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-0028-1097682","article-title":"Cardamonin and alpinetin from the seeds of Amomum subulatum","volume":"29","author":"Bheemasankara Rao","year":"1976","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2015.06.009_bib0006","first-page":"1","article-title":"In vitro schistosomicidal effects of aqueous and dichloromethane fractions from leaves and stems of Piper species and the isolation of an active amide from P. amalago L. (Piperaceae)","author":"Carrara","year":"2013","journal-title":"J. Helminthol."},{"key":"10.1016\/j.phymed.2015.06.009_bib0007","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11302-014-9416-5","article-title":"Schistosome apyrase SmATPDase1, but not SmATPDase2, hydrolyses exogenous ATP and ADP","volume":"10","author":"Da'dara","year":"2014","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.phymed.2015.06.009_bib0008","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0006-291X(03)01268-3","article-title":"Molecular characterization and immunolocalization of Schistosoma mansoni ATP-diphosphohydrolase","volume":"307","author":"DeMarco","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2015.06.009_bib0009","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.exppara.2012.07.004","article-title":"Schistosoma mansoni: In vitro schistosomicidal activity and tegumental alterations induced by piplartine on schistosomula","volume":"132","author":"de Moraes","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.phymed.2015.06.009_bib0010","series-title":"Advances in Bioinformatics and Computational Biology","first-page":"91","article-title":"Structural comparative analysis of secreted NTPDase models of Schistosoma mansoni and Homo sapiens","author":"de Souza","year":"2014"},{"key":"10.1016\/j.phymed.2015.06.009_bib0011","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1017\/S0031182004005244","article-title":"ATP diphosphohydrolase from Schistosoma mansoni egg: characterization and immunocytochemical localization of a new antigen","volume":"129","author":"Faria-Pinto","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.phymed.2015.06.009_bib0012","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1155\/2014\/957107","article-title":"Cheminformatics models for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase","volume":"2014","author":"Gaba","year":"2014","journal-title":"Scientific World J."},{"key":"10.1016\/j.phymed.2015.06.009_bib0013","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1155\/2014\/460342","article-title":"Anthelmintic activity of crude extract and essential oil of Tanacetum vulgare (Asteraceae) against adult worms of Schistosoma mansoni","volume":"2014","author":"Godinho","year":"2014","journal-title":"Scientific World J."},{"key":"10.1016\/j.phymed.2015.06.009_bib0014","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/jmf.2013.0061","article-title":"An overview on cardamonin","volume":"17","author":"Gon\u00e7alves","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2015.06.009_bib0015","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2015.06.009_bib0016","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1016\/S0968-0896(03)00406-1","article-title":"Antileishmanial activities of dihydrochalcones from Piper elongatum and synthetic related compounds. Structural requirements for activity","volume":"11","author":"Hermoso","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phymed.2015.06.009_bib0017","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0031-9422(00)84672-5","article-title":"Cardamonin and alpinetin from the seeds of Alpinia speciosa","volume":"12","author":"Krishna","year":"1973","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2015.06.009_bib0018","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.phymed.2015.06.009_bib0019","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.dci.2011.03.026","article-title":"Occurrence of a conserved domain in ATP diphosphohydrolases from pathogenic organisms associated to antigenicity in human parasitic diseases","volume":"35","author":"Maia","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.phymed.2015.06.009_bib0020","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1023\/A:1010330017583","article-title":"Inhibition of the ecto-ATPdiphosphohydrolase of Schistosoma mansoni by thapsigargin","volume":"20","author":"Martins","year":"2000","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phymed.2015.06.009_bib0021","first-page":"2157","article-title":"Intraspecific variability of dihydrochalcone, chromenes and benzoic acid derivatives in leaves of Piper aduncum L. (Piperaceae)","volume":"8","author":"Morandim","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.phymed.2015.06.009_bib0022","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2015.06.009_bib0023","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2007.05.028","article-title":"A new series of schistosomicide drugs, the alkylaminoalkanethiosulfuric acids, partially inhibit the activity of Schistosoma mansoni ATP diphosphohydrolase","volume":"570","author":"Penido","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2015.06.009_bib0024","first-page":"53","article-title":"Chemical study of Piper steerni","volume":"23","author":"Posso","year":"1994","journal-title":"Rev. Colomb. Quim."},{"key":"10.1016\/j.phymed.2015.06.009_bib0025","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1055\/s-0032-1327832","article-title":"In vitro schistosomicidal activity of balsaminol F and karavilagenin C","volume":"78","author":"Ramalhete","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2015.06.009_bib0026","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.phytol.2011.08.001","article-title":"Activity-guided isolation of antileishmanial compounds from Piper hispidum","volume":"4","author":"Ruiz","year":"2011","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phymed.2015.06.009_bib0027","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ijpara.2006.01.007","article-title":"Functions of the tegument of schistosomes: clues from the proteome and lipidome","volume":"36","author":"Van Hellemond","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.phymed.2015.06.009_bib0028","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0166-6851(93)90042-V","article-title":"Characterization and localization of an ATP-diphosphohydrolase on the external surface of the tegument of Schistosoma mansoni","volume":"58","author":"Vasconcelos","year":"1993","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.phymed.2015.06.009_bib0029","doi-asserted-by":"crossref","first-page":"22139","DOI":"10.1074\/jbc.271.36.22139","article-title":"Partial purification and immunohistochemical localization of ATP diphosphohydrolase from Schistosoma mansoni. Immunological cross-reactivities with potato apyrase and Toxoplasma gondii nucleoside triphosphate hydrolase","volume":"271","author":"Vasconcelos","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2015.06.009_bib0030","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.2174\/092986712800167347","article-title":"Activity of epiisopiloturine against Schistosoma mansoni","volume":"19","author":"Veras","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2015.06.009_bib0031","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.abb.2008.11.023","article-title":"Integrin inhibitors from snake venom: exploring the relationship between the structure and activity of RGD-peptides","volume":"482","author":"Wermelinger","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2015.06.009_bib0032","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1476-5381.2011.01603.x","article-title":"Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins","volume":"165","author":"Yadav","year":"2012","journal-title":"Br. J. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315002081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315002081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T03:54:09Z","timestamp":1537502049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711315002081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0944711315002081"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2015.06.009","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardamonin, a schistosomicidal chalcone from Piper aduncum L. (Piperaceae) that inhibits Schistosoma mansoni ATP diphosphohydrolase","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2015.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier GmbH","name":"copyright","label":"Copyright"}]}}