{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T20:51:41Z","timestamp":1783803101487,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.phymed.2015.06.014","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T15:14:07Z","timestamp":1437059647000},"page":"952-960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide\/streptozotocin induced type 2 diabetic rats"],"prefix":"10.1016","volume":"22","author":[{"given":"R.K.","family":"Lekshmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2015.06.014_bib0001","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ymben.2006.09.003","article-title":"Novel transgenic rice over expressing anthocyanidin synthase accumulates a mixture of flavonoids leading to an increased antioxidant potential","volume":"9","author":"Ambavaram","year":"2007","journal-title":"Metab. Eng."},{"key":"10.1016\/j.phymed.2015.06.014_bib0002","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0076-6879(81)71055-3","article-title":"Lipoxygenases from soybeans","volume":"71","author":"Axelrod","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.phymed.2015.06.014_bib0003","series-title":"Theory and Practice of Technique","author":"Bancroft","year":"1996"},{"key":"10.1016\/j.phymed.2015.06.014_bib0004","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/03009730902891784","article-title":"Evidence-based assessment of antiosteoporotic activity of petroleum-ether extract of Cissus quadrangularis Linn. on ovariectomy-induced osteoporosis","volume":"114","author":"Bhagath","year":"2009","journal-title":"Ups. J. Med. Sci"},{"key":"10.1016\/j.phymed.2015.06.014_bib0005","first-page":"156","article-title":"Single-step method of RNA isolation by acid guanidiniumthiocyanate-phenolchloroform extraction","volume":"162","author":"Chomcynski","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.phymed.2015.06.014_bib0006","series-title":"Methods of Enzymatic Analysis","first-page":"258","article-title":"Glutathione reductase","author":"David","year":"1983"},{"key":"10.1016\/j.phymed.2015.06.014_bib0007","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/dom.12172","article-title":"Targeting inflammation in the treatment of type 2 diabetes","volume":"15","author":"Donath","year":"2013","journal-title":"Diabetes, Obes. Metab."},{"key":"10.1016\/j.phymed.2015.06.014_bib0008","first-page":"871","article-title":"Enzyme-linked immunosorbent assay (ELISA)","volume":"8","author":"Engval","year":"1971","journal-title":"Quantitative assay of immunoglobulin G. Immunochemistry."},{"key":"10.1016\/j.phymed.2015.06.014_bib0009","first-page":"3080","article-title":"Medicinal properties of plants from the genus Cissus: a review","volume":"6","author":"Fernandes","year":"2012","journal-title":"J. Med. Plant Res."},{"key":"10.1016\/j.phymed.2015.06.014_bib0010","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycation end products: sparking the development of diabetic vascular injury","volume":"114","author":"Goldin","year":"2006","journal-title":"Circulation."},{"key":"10.1016\/j.phymed.2015.06.014_bib0011","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/10715762.2013.847528","article-title":"Physical inactivity, insulin resistance, and the oxidative inflammatory loop","volume":"48","author":"Gratas-Delamarche","year":"2014","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.phymed.2015.06.014_bib0012","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1182\/blood.V87.5.2020.2020","article-title":"Regulated expression of CD36 in foam cell formation","volume":"87","author":"Huch","year":"1996","journal-title":"Blood."},{"key":"10.1016\/j.phymed.2015.06.014_bib0032","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.2337\/diacare.26.7.2139","article-title":"Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes","volume":"26","author":"Jain","year":"2003","journal-title":"Diabetes Care."},{"key":"10.1016\/j.phymed.2015.06.014_bib0013","first-page":"130","article-title":"A modified spectrophotometric assay of superoxide dismutase","volume":"21","author":"Kakkar","year":"1984","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2015.06.014_bib0014","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1179\/1351000214Y.0000000096","article-title":"Cissus quadrangularis extract attenuates hyperglycaemia-mediated oxidative stress in streptozotocin-induced diabetic rats","volume":"19","author":"Lekshmi","year":"2014","journal-title":"Redox Report"},{"key":"10.1016\/j.phymed.2015.06.014_bib0015","first-page":"1259","article-title":"Evaluation of antioxidant and antiglycation activities of various solvent fractions of Cissus quadrangularis stem","volume":"4","author":"Lekshmi","year":"2013","journal-title":"Int. J. Pharm. Biosci."},{"issue":"4","key":"10.1016\/j.phymed.2015.06.014_bib0016","first-page":"1","article-title":"The regulatory effects of Cissus quadrangularis on some enzymes involved in carbohydrate metabolism in Streptozotocin induced diabetic rats","volume":"53","author":"Lekshmi","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2015.06.014_bib0017","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2015.06.014_bib0018","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000081952","article-title":"Inducible nitric oxide synthase activity and expression in liver and hepatocytes of diabetic rats","volume":"73","author":"Madar","year":"2004","journal-title":"Pharmacology."},{"key":"10.1016\/j.phymed.2015.06.014_bib0019","first-page":"357","article-title":"The assay of catalases and peroxidises","volume":"1","author":"Maehly","year":"1954"},{"key":"10.1016\/j.phymed.2015.06.014_bib0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2337\/diab.47.2.224","article-title":"Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide","volume":"47","author":"Masiello","year":"1998","journal-title":"Diabetes."},{"key":"10.1016\/j.phymed.2015.06.014_bib0021","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1055\/s-2006-959688","article-title":"Free radicals scavenger and antihepatotoxic activity of Rosmarinus","volume":"59","author":"Navarro","year":"1993","journal-title":"Planta Med"},{"key":"10.1016\/j.phymed.2015.06.014_bib0022","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1681\/ASN.2007091048","article-title":"The role of inflammatory cytokines in diabetic nephropathy","volume":"19","author":"Navarro-Gonzalez","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2015.06.014_bib0023","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1476-511X-7-12","article-title":"The use of a Cissus quadrangularis\/Irvingia gabonensis combination in the management of weight loss: a double blind placebo-controlled study","volume":"7","author":"Oben","year":"2008","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phymed.2015.06.014_bib0024","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric reaction","volume":"95","author":"Okhawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.phymed.2015.06.014_bib0025","series-title":"Methods of Biochemical Analysis","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/9780470110188.ch9","article-title":"Determination of glutathione","author":"Patterson","year":"1955"},{"key":"10.1016\/j.phymed.2015.06.014_bib0026","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical roles as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science."},{"key":"10.1016\/j.phymed.2015.06.014_bib0027","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00125-005-0065-7","article-title":"Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice","volume":"49","author":"Shanmugam","year":"2006","journal-title":"Diabetologia."},{"key":"10.1016\/j.phymed.2015.06.014_bib0028","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1016\/j.fct.2011.09.029","article-title":"Safety assessment of Cissus quadrangularis extracts (CQR-300): subchronic toxicity and mutagenicity studies","volume":"49","author":"Shil","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2015.06.014_bib0030","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-9861(81)90091-6","article-title":"Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction","volume":"206","author":"Shimazu","year":"1981","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2015.06.014_bib0031","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1016\/j.fct.2012.08.046","article-title":"Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats","volume":"50","author":"Sunil","year":"2012","journal-title":"Food Chem. Toxicol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315002147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711315002147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T05:53:47Z","timestamp":1652853227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711315002147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0944711315002147"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2015.06.014","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide\/streptozotocin induced type 2 diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2015.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}