{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:46:01Z","timestamp":1774262761184,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["479740\/2011-9"],"award-info":[{"award-number":["479740\/2011-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.phymed.2016.02.020","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T20:37:27Z","timestamp":1457210247000},"page":"498-508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evidences of antihypertensive potential of extract from Solanum capsicoides All. in spontaneously hypertensive rats"],"prefix":"10.1016","volume":"23","author":[{"given":"L.O.","family":"Sim\u00f5es","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Concei\u00e7\u00e3o-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.S.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-4630","authenticated-orcid":false,"given":"J.B.","family":"Fregoneze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.Q.G.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Petreanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cechinel-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Niero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Niero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Tamanaha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2016.02.020_bib0001","series-title":"Solanaceae IV: Advances in Biology and Utilization","first-page":"197","article-title":"Diversity and distribution of Solanum subgenus Leptostemonum in north-east Brazil","author":"Agra","year":"1999"},{"issue":"3","key":"10.1016\/j.phymed.2016.02.020_bib0002","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1590\/S0102-33062009000300024","article-title":"Flora of Paraiba, Brazil: Solanum L.(Solanaceae)","volume":"23","author":"Agra","year":"2009","journal-title":"Acta Bot. Bras."},{"issue":"3","key":"10.1016\/j.phymed.2016.02.020_bib0003","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1590\/S0102-33062008000300015","article-title":"Palynology of species of Solanum L.(Solanaceae A. Juss.) from the restingas of Rio de Janeiro State","volume":"22","author":"Batista-Franklim","year":"2008","journal-title":"Braz. Acta Bot. Bras."},{"issue":"4","key":"10.1016\/j.phymed.2016.02.020_bib0004","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00210-013-0954-0","article-title":"Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models","volume":"387","author":"Bert\u00e9","year":"2014","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.phymed.2016.02.020_bib0005","article-title":"Evaluation of antileishmanial activity of selected Brazilian plants and identification of the active principles","volume":"2013","author":"Cechinel- Filho","year":"2013"},{"issue":"6","key":"10.1016\/j.phymed.2016.02.020_bib0006","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.phymed.2016.02.020_bib0007","first-page":"1","article-title":"Aspectos da flora e da vegeta\u00e7\u00e3o secund\u00e1ria da restinga de Santa Catarina, sul do Brasil","volume":"28","author":"Falkenberg","year":"1999","journal-title":"Insula."},{"issue":"2","key":"10.1016\/j.phymed.2016.02.020_bib0008","first-page":"287","article-title":"Leaf morphoanatomy of Solanum capsicoides All. (Solanaceae) from Restinga Area","volume":"32","author":"Ferreira","year":"2013","journal-title":"Latin Am. J. Pharma."},{"issue":"2","key":"10.1016\/j.phymed.2016.02.020_bib0009","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1590\/S0100-40422007000200026","article-title":"Plantas medicinais: fatores de influ\u00eancia no conte\u00fado de metab\u00f3litos secund\u00e1rios","volume":"30","author":"Gobbo-Neto","year":"2007","journal-title":"Qu\u00edmica Nova."},{"key":"10.1016\/j.phymed.2016.02.020_bib0010","series-title":"Catalogo de Plantas Medcinales (y Alimenticias y Utiles) Usadas em el Paraguay","first-page":"371","author":"Gonzales -Torrez","year":"1992"},{"issue":"1","key":"10.1016\/j.phymed.2016.02.020_bib0011","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0378-8741(96)01442-0","article-title":"Hypotensive effect of crude root extract of Solanum sisymbriifolium (Solanaceae) in normo-and hypertensive rats","volume":"54","author":"Ibarrola","year":"1996","journal-title":"J. Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.phymed.2016.02.020_bib0012","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0378-8741(00)00191-4","article-title":"Isolation of hypotensive compounds from Solanum sisymbriifolium Lam","volume":"70","author":"Ibarrola","year":"2000","journal-title":"J. Ethnopharmacol"},{"issue":"5","key":"10.1016\/j.phymed.2016.02.020_bib0013","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/13880200600748937","article-title":"Cardiovascular action of nuatigenosido from Solanum sisymbriifolium","volume":"44","author":"Ibarrola","year":"2006","journal-title":"Pharma. Biol."},{"key":"10.1016\/j.phymed.2016.02.020_bib0014","unstructured":"ICH, 2005. Validation of Analytical Procedures: Text and Methodology \u2013 ICH Harmonized Tripartite Guideline."},{"issue":"5","key":"10.1016\/j.phymed.2016.02.020_bib0015","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.phymed.2016.02.020_bib0016","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.phymed.2010.01.003","article-title":"Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca 2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery","volume":"17","author":"Lin","year":"2010","journal-title":"Phytomedicine."},{"key":"10.1016\/j.phymed.2016.02.020_bib0017","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.steroids.2013.10.017","article-title":"Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling","volume":"81","author":"Lindsey","year":"2014","journal-title":"Steroids"},{"issue":"3","key":"10.1016\/j.phymed.2016.02.020_bib0018","doi-asserted-by":"crossref","first-page":"C399","DOI":"10.1152\/ajpcell.1990.258.3.C399","article-title":"cGMP-dependent protein kinase mediates the reduction of Ca2+ by cAMP in vascular smooth muscle cells","volume":"258","author":"Lincoln","year":"1990","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1016\/j.phymed.2016.02.020_bib0019","series-title":"Plantas Daninhas do Brasil: Terrestres, Aqu\u00e1ticas, Parasitas E T\u00f3xicas","first-page":"608","author":"Lorenzi","year":"2000"},{"issue":"4","key":"10.1016\/j.phymed.2016.02.020_bib0020","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1161\/01.HYP.8.4.344","article-title":"Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensiverat","volume":"8","author":"L\u00fcscher","year":"1986","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.phymed.2016.02.020_bib0021","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.phrs.2010.09.003","article-title":"Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats","volume":"63","author":"Monroy-ruiz","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2016.02.020_bib0022","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.HYP.2.5.664","article-title":"Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats","volume":"2","author":"Mulvany","year":"1980","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.phymed.2016.02.020_bib0023","first-page":"505","article-title":"Vascular remodeling","volume":"28","author":"Mulvany","year":"1996","journal-title":"Hypertension."},{"issue":"3","key":"10.1016\/j.phymed.2016.02.020_bib0024","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jep.2009.04.057","article-title":"Hypertensive effects of oral administration of the aqueous extract of Solanum torvum fruits in l-NAME treated rats: Evidence from in vivo and in vitro studies","volume":"124","author":"Nguelefack","year":"2009","journal-title":"J. Ethnopharmacol"},{"issue":"13","key":"10.1016\/j.phymed.2016.02.020_bib0025","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1080\/14786410600888459","article-title":"Cilistepoxide and cilistadiol, two new withanolides from Solanum sisymbiifolium","volume":"20","author":"Niero","year":"2006","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2016.02.020_bib0026","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/10942910801992942","article-title":"Total antioxidant activity and total phenolic contents in different Turkish eggplant (Solanum melongena L.) cultivars","volume":"12","author":"Okmen","year":"2009","journal-title":"Int. J. Food Prop."},{"issue":"7","key":"10.1016\/j.phymed.2016.02.020_bib0027","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.jhh.1002196","article-title":"Validity of four indirect methods to measure adherence in primary care hypertensives","volume":"21","author":"Prado","year":"2007","journal-title":"J. Human Hypertens"},{"issue":"2","key":"10.1016\/j.phymed.2016.02.020_bib0028","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3797\/scipharm.aut-02-16","article-title":"Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice","volume":"70","author":"Raza","year":"2002","journal-title":"Sci. Pharma."},{"key":"10.1016\/j.phymed.2016.02.020_bib0029","series-title":"Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine, v","first-page":"2013","article-title":"Involvement of potassium channels in vasorelaxant effect induced by valeriana prionophylla Standl","author":"Reis","year":"2013"},{"key":"10.1016\/j.phymed.2016.02.020_bib0030","doi-asserted-by":"crossref","first-page":"C299","DOI":"10.1152\/ajpcell.1993.265.1.C299","article-title":"cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells","volume":"265","author":"Robertson","year":"1993","journal-title":"Am. J. Physiol. Cell Physiol"},{"issue":"4","key":"10.1016\/j.phymed.2016.02.020_bib0031","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1179\/136485905X36208","article-title":"Molluscicidal activity of some Brazilian Solanum spp. (Solanaceae) against Biomphalaria glabrata","volume":"99","author":"Silva","year":"2005","journal-title":"Ann. Trop. Med. Parasitol."},{"issue":"1","key":"10.1016\/j.phymed.2016.02.020_bib0032","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1590\/S0102-695X2007000100008","article-title":"Brine shrimp bioassay of some species of Solanum from Northestern Brazil","volume":"17","author":"Silva","year":"2007","journal-title":"Rev. Bras. de Farmacogn"},{"issue":"6","key":"10.1016\/j.phymed.2016.02.020_bib0033","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1742-7843.2011.00749.x","article-title":"Rotundifolone\u2010induced relaxation is mediated by BKCa channel activation and Cav channel inactivation","volume":"109","author":"Silva","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol"},{"issue":"3","key":"10.1016\/j.phymed.2016.02.020_bib0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0300-483X(02)00338-4","article-title":"A 90-day oral gavage toxicity study of d-methylphenidate and d, l-methylphenidate in Sprague\u2013Dawley rats","volume":"179","author":"Teo","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2016.02.020_bib0036","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI118394","article-title":"Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin dependent diabetes mellitus","volume":"97","author":"Ting","year":"1996","journal-title":"J. Clin. Investig"},{"key":"10.1016\/j.phymed.2016.02.020_bib0037","series-title":"Experimental and Genetic Models of Hypertension","first-page":"224","article-title":"Development of the spontaneously hypertensive rat (SHR) and of various spontaneous rat models, and their implications","author":"Yamori","year":"1984"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711316000738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711316000738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T04:05:58Z","timestamp":1567656358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711316000738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0944711316000738"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2016.02.020","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidences of antihypertensive potential of extract from Solanum capsicoides All. in spontaneously hypertensive rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2016.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}