{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:40:38Z","timestamp":1786995638749,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Wan-Fang Hospital","award":["105swf04"],"award-info":[{"award-number":["105swf04"]}]},{"name":"Health and Welfare Surcharge of Tobacco Products","award":["MOHW104-TDU-B-212-124001"],"award-info":[{"award-number":["MOHW104-TDU-B-212-124001"]}]},{"name":"Health and Welfare Surcharge of Tobacco Products","award":["MOHW105-TDU-B-212134001"],"award-info":[{"award-number":["MOHW105-TDU-B-212134001"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.phymed.2016.02.021","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T23:01:50Z","timestamp":1457478110000},"page":"517-527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis"],"prefix":"10.1016","volume":"23","author":[{"given":"Chien-Ju","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-An","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing Hwa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Kuei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5728-0571","authenticated-orcid":false,"given":"Ruei-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2016.02.021_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2003.12.005","article-title":"Cell cycle regulation of neuronal apoptosis in development and disease","volume":"72","author":"Becker","year":"2004","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2016.02.021_bib0002","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.surg.2013.02.003","article-title":"Propofol protects against nitrosative stress-induced breakage of the blood-brain barrier through reducing apoptotic insults to cerebrovascular endothelial cells","volume":"154","author":"Chen","year":"2013","journal-title":"Surgery"},{"key":"10.1016\/j.phymed.2016.02.021_bib0003","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1158\/1535-7163.MCT-11-0606","article-title":"MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis","volume":"11","author":"Cheng","year":"2012","journal-title":"Mol. Cancer. Ther."},{"key":"10.1016\/j.phymed.2016.02.021_bib0004","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-230X-9-39","article-title":"Induction of G1 and G2\/M cell cycle arrests by the dietary compound 3,3\u2032-diindolylmethane in HT-29 human colon cancer cells","volume":"9","author":"Choi","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.phymed.2016.02.021_bib0005","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1371\/journal.pmed.1000010","article-title":"HMGB1 mediates endogenous TLR2 activation and brain tumor regression","volume":"6","author":"Curtin","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.phymed.2016.02.021_bib0006","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10637-014-0120-7","article-title":"Preclinical characterization of the CDK4\/6 inhibitor LY2835219: in-vivo cell cycle-dependent\/independent anti-tumor activities alone\/in combination with gemcitabine","volume":"32","author":"Gelbert","year":"2014","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.phymed.2016.02.021_bib0007","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/MCB.20.5.1797-1815.2000","article-title":"Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription","volume":"20","author":"Guardavaccaro","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2016.02.021_bib0008","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.bjc.6600711","article-title":"Temozolomide induced apoptosis and senescence in glioma cells cultured as multicellular apheroids","volume":"88","author":"Gunther","year":"2003","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.phymed.2016.02.021_bib0009","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1158\/1078-0432.CCR-07-1926","article-title":"Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction","volume":"14","author":"Hahm","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2016.02.021_bib0010","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1158\/1535-7163.MCT-07-0217","article-title":"Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level\/phosphorylation and inhibition of E2F1 transcriptional activity","volume":"6","author":"Hahm","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phymed.2016.02.021_bib0011","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1101\/gad.813200","article-title":"The Rb\/E2F pathway: expanding roles and emerging paradigms","volume":"14","author":"Harbour","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2016.02.021_bib0012","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.bbagen.2012.03.009","article-title":"Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia","volume":"1820","author":"Ishikawa","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2016.02.021_bib0013","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.cellsig.2010.01.013","article-title":"Examination of the expanding pathways for the regulation of p21 expression and activity","volume":"22","author":"Jung","year":"2010","journal-title":"Cell Signal"},{"key":"10.1016\/j.phymed.2016.02.021_bib0014","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1128\/MCB.20.20.7751-7763.2000","article-title":"RB-dependent S-phase response to DNA damage","volume":"20","author":"Knudsen","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2016.02.021_bib0015","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.285.5434.1733","article-title":"A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy","volume":"285","author":"Komarov","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.phymed.2016.02.021_bib0016","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/cdd.2011.155","article-title":"Regulation of CD95\/Fas signaling at the DISC","volume":"19","author":"Lavrik","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2016.02.021_bib0017","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1016\/j.febslet.2006.08.064","article-title":"Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells","volume":"580","author":"Lee","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2016.02.021_bib0018","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/neuonc\/nor217","article-title":"Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway","volume":"14","author":"Lin","year":"2012","journal-title":"Neuro-Oncol."},{"key":"10.1016\/j.phymed.2016.02.021_bib0019","article-title":"Use of Chinese herb medicine in cancer patients: a survey in southwestern china","author":"Liu","year":"2012","journal-title":"Evid. Based Complement Alternat. Med. 2012, 769042"},{"key":"10.1016\/j.phymed.2016.02.021_bib0020","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/bjc.2013.325","article-title":"Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78","volume":"109","author":"Martin","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.phymed.2016.02.021_bib0021","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/bcr3128","article-title":"Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis","volume":"14","author":"Nagalingam","year":"2012","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.phymed.2016.02.021_bib0022","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1038\/emboj.2012.124","article-title":"Mitotic and mitogenic Wnt signalling","volume":"31","author":"Niehrs","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.phymed.2016.02.021_bib0023","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.canlet.2008.11.029","article-title":"Down-regulation of c-Src\/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells","volume":"277","author":"Park","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2016.02.021_bib0024","first-page":"8218","article-title":"Phases of apoptosis of melanoma cells, but not of normal melanocytes, differently affect maturation of myeloid dendritic cells","volume":"61","author":"Pietra","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2016.02.021_bib0026","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jss.2007.03.038","article-title":"RB activity alters checkpoint response and chemosensitivity in lung cancer lines","volume":"142","author":"Reed","year":"2007","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.phymed.2016.02.021_bib0027","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1128\/MCB.23.13.4713-4727.2003","article-title":"p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1","volume":"23","author":"Rocha","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2016.02.021_bib0028","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1471-2407-7-215","article-title":"Deficiency of G1 regulators P53, P21Cip1 and\/or pRb decreases hepatocyte sensitivity to TGF-\u03b2 cell cycle arrest","volume":"7","author":"Sheahan","year":"2007","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phymed.2016.02.021_bib0029","doi-asserted-by":"crossref","first-page":"e88164","DOI":"10.1371\/journal.pone.0088164","article-title":"HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells","volume":"9","author":"Staudacher","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2016.02.021_bib0030","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2016.02.021_bib0031","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1749-8546-6-27","article-title":"Anti-cancer natural products isolated from Chinese medicinal herbs","volume":"6","author":"Tan","year":"2011","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2016.02.021_bib0032","doi-asserted-by":"crossref","first-page":"e18490","DOI":"10.1371\/journal.pone.0018490","article-title":"Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2016.02.021_bib0033","doi-asserted-by":"crossref","first-page":"202","DOI":"10.5582\/ddt.2011.v5.5.202","article-title":"Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis","volume":"5","author":"Xu","year":"2011","journal-title":"Drug Discov. Ther."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131600074X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131600074X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T09:26:09Z","timestamp":1536917169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471131600074X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S094471131600074X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2016.02.021","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2016.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}