{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T20:28:51Z","timestamp":1772656131106,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81001379"],"award-info":[{"award-number":["81001379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503316"],"award-info":[{"award-number":["81503316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.phymed.2016.08.003","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T07:35:10Z","timestamp":1472542510000},"page":"1475-1483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats"],"prefix":"10.1016","volume":"23","author":[{"given":"Zi","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui-Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Tao","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Qi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2016.08.003_bib0001","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/pgmj.2005.042200","article-title":"Treatment of non-alcoholic fatty liver disease","volume":"82","author":"Adams","year":"2006","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.phymed.2016.08.003_bib0002","first-page":"43","article-title":"Initial study of quantitative analysis of fatty liver by 1H-MR spectroscopy imaging","volume":"41","author":"Liang","year":"2007","journal-title":"Chin. J. Radiol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0003","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MOL.0b013e3282ff5e55","article-title":"Hepatic triglyceride synthesis and nonalcoholic fatty liver disease","volume":"19","author":"Choi","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0004","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1142\/S0192415X13500353","article-title":"Triterpenoid-rich fraction from Ilex hainanensis Merr. Attenuates non-alcoholic fatty liver disease induced by high fat diet in rats","volume":"41","author":"Cui","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2016.08.003_bib0005","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u2018\u2018hits\u2019\u2019?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2016.08.003_bib0006","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1463-1326.2011.01403.x","article-title":"Current therapeutic strategies in non-alcoholic fatty liver disease","volume":"13","author":"Dowman","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phymed.2016.08.003_bib0007","first-page":"614","article-title":"TNF-\u03b1 induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)","volume":"232","author":"Endo","year":"2007","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.phymed.2016.08.003_bib0008","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.20283","article-title":"Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway","volume":"40","author":"Feldstein","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2016.08.003_bib0009","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ejrnm.2014.05.015","article-title":"MRI evaluation of fatty liver in day to day practice: Quantitative and qualitative methods","volume":"45","author":"Gangadhar","year":"2014","journal-title":"Egypt. J. Radiol. Nucl. Med."},{"key":"10.1016\/j.phymed.2016.08.003_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-5793(03)00560-X","article-title":"Management of cellular energy by the AMP-activated protein kinase system","volume":"546","author":"Hardie","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2016.08.003_bib0011","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/j.1872-034X.2008.00382.x","article-title":"Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease","volume":"38","author":"Higuchi","year":"2008","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.phymed.2016.08.003_bib0012","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1463-1326.2003.00268.x","article-title":"Rapid reversal of hepatic steatosis, and reduction of muscle triglyceride, by rosiglitazone: MRI\/S studies in Zucker fatty rats","volume":"5","author":"Hockings","year":"2003","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.phymed.2016.08.003_bib0013","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1211\/jpp.57.10.0013","article-title":"Protective effects of the Alisma orientalis extract on the experimental nonalcoholic fatty liver disease","volume":"58","author":"Hong","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0014","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jep.2015.10.006","article-title":"Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leave in hyperlipidemic mice","volume":"176","author":"Jiang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0015","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/j.1440-1746.2012.07165.x","article-title":"Exercise and diet modification in non-obese non-alcoholic fatty liver disease: analysis of biopsies of living liver donors","volume":"27","author":"Jin","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0016","first-page":"507","article-title":"SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease","volume":"21","author":"Kohjima","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2016.08.003_bib0017","doi-asserted-by":"crossref","first-page":"e465","DOI":"10.1111\/j.1440-1746.2007.05052.x","article-title":"Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet","volume":"23","author":"Kuzu","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0018","doi-asserted-by":"crossref","first-page":"e86724","DOI":"10.1371\/journal.pone.0086724","article-title":"Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2016.08.003_bib0019","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/ajcn\/79.3.502","article-title":"Model of nonalcoholic steatohepatitis","volume":"79","author":"Lieber","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2016.08.003_bib0020","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jep.2013.10.020","article-title":"Modulation of hepatic sterol regulatory element-binding protein-1c-mediated gene expression contributes to Salacia oblonga root-elicited improvement of fructose-induced fatty liver in rats","volume":"150","author":"Liu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0021","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.11569\/wcjd.v16.i15.1612","article-title":"Evaluation of nonalcoholic fatty liver model in rats using 1H magnetic resonance spectroscopy","volume":"16","author":"Liu","year":"2008","journal-title":"World Chin. J. Digestol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0022","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.phymed.2016.08.003_bib0023","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jep.2015.03.030","article-title":"Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice","volume":"166","author":"Ma","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0024","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/MEG.0b013e3282f9b203","article-title":"Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease","volume":"20","author":"Morgan","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0025","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3892\/mmr.2014.2398","article-title":"Inhibitory effects of Rubi Fructus extracts on hepatic steatosis development in high-fat diet-induced obese mice","volume":"10","author":"Nam","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2016.08.003_bib0026","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1439-0396.2007.00752.x","article-title":"Liver lipid metabolism","volume":"92","author":"Nguyen","year":"2008","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"10.1016\/j.phymed.2016.08.003_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/145754","article-title":"Diagnosis and evaluation of nonalcoholic fatty liver disease","author":"Obika","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.phymed.2016.08.003_bib0028","doi-asserted-by":"crossref","first-page":"32379","DOI":"10.1074\/jbc.R000017200","article-title":"Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action","volume":"275","author":"Osborne","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2016.08.003_bib0029","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1172\/JCI32752","article-title":"Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents","volume":"118","author":"Ota","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2016.08.003_bib0030","first-page":"257","article-title":"Effect of soy isoflavones on malondialdehyde and superoxide dismutase of blood and liver in hypercholesterolemia rats","volume":"21","author":"Pang","year":"2002","journal-title":"Chin. J. New Drugs. Clin. Rem."},{"key":"10.1016\/j.phymed.2016.08.003_bib0031","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mpdhp.2014.01.008","article-title":"Fatty liver disease","volume":"20","author":"Petts","year":"2014","journal-title":"Diagn. Histopathol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0032","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/dom.12112","article-title":"Effects of pioglitazone versus glimepiride exposure on hepatocellular fat content in type 2 diabetes","volume":"15","author":"Phielix","year":"2013","journal-title":"Diabetes, Obesity Metab."},{"key":"10.1016\/j.phymed.2016.08.003_bib0033","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1262-3636(08)74599-3","article-title":"The role of the lipogenic pathway in the development of hepatic steatosis","volume":"34","author":"Postic","year":"2009","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.phymed.2016.08.003_bib0034","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"Postic","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2016.08.003_bib0035","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2016.08.003_bib0036","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2004.04.010","article-title":"Targets for TNF-alpha-induced lipolysis in human adipocytes","volume":"318","author":"Ryden","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2016.08.003_bib0037","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jhep.2009.05.023","article-title":"Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance","volume":"51","author":"Schwenzer","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0038","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.3390\/nu6062179","article-title":"Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats","volume":"6","author":"Song","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2016.08.003_bib0039","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-0030-1267538","article-title":"The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis","volume":"30","author":"Sozio","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.phymed.2016.08.003_bib0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1011927812753","article-title":"Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status","volume":"224","author":"Sumitra","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phymed.2016.08.003_bib0041","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2016.08.003_bib0042","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0168-8278(97)80287-5","article-title":"Therapeutic effects of restricted diet and exercise in obese patients with fatty liver","volume":"27","author":"Ueno","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0043","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1042\/bst0310216","article-title":"Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models","volume":"31","author":"Viollet","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.phymed.2016.08.003_bib0044","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11596-008-0315-2","article-title":"Application of proton magnetic resonance spectroscopy and computerized tomography in the diagnosis and treatment of nonalcoholic fatty liver disease","volume":"28","author":"Wang","year":"2008","journal-title":"J. Huazhong Univ. Sci. Technol. (Med. Sci.)"},{"key":"10.1016\/j.phymed.2016.08.003_bib0045","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jep.2013.10.040","article-title":"Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats","volume":"150","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0046","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/jgh.12011","article-title":"Nonalcoholic fatty liver disease in Asia: a story of growth","volume":"28","author":"Wong","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0047","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1139\/cjpp-2014-0477","article-title":"Cyclocarya paliurus prevents high fat diet induced hyperlipidemia and obesity in Sprague-Dawley rats","volume":"93","author":"Yao","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.phymed.2016.08.003_bib0048","doi-asserted-by":"crossref","first-page":"12052","DOI":"10.1021\/jf8026217","article-title":"Effect of dietary wine pomace extract and oleanolic acid on plasma lipids in rats fed high-fat diet and its DNA microarray analysis","volume":"56","author":"Yunoki","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2016.08.003_bib0049","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.phymed.2015.05.058","article-title":"Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation","volume":"22","author":"Zhu","year":"2015","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711316301465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711316301465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T01:58:40Z","timestamp":1568339920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711316301465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0944711316301465"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2016.08.003","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2016.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}