{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T18:47:42Z","timestamp":1768675662320,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.phymed.2016.08.006","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T21:01:04Z","timestamp":1472158864000},"page":"1484-1493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Eremophila maculata\u2014Isolation of a rare naturally-occurring lignan glycoside and the hepatoprotective activity of the leaf extract"],"prefix":"10.1016","volume":"23","author":[{"given":"Fadia S.","family":"Youssef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9270-6267","authenticated-orcid":false,"given":"Mohamed L.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Sobeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham A.","family":"El-Beshbishy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel Nasser","family":"Singab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2016.08.006_bib0001","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.phymed.2010.03.008","article-title":"Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2 insulin-like signaling pathway","volume":"17","author":"Abbas","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2016.08.006_bib0002","first-page":"1318","article-title":"A review of natural products with hepatoprotective activity","volume":"4","author":"Adewusi","year":"2010","journal-title":"J. Med. Plants Res"},{"key":"10.1016\/j.phymed.2016.08.006_bib0003","series-title":"Lignans: Chemical, Biological and Clinical Properties","author":"Ayres","year":"1990"},{"key":"10.1016\/j.phymed.2016.08.006_bib0004","first-page":"358","article-title":"Oxidative stress and hypertension: possibility of hypertension therapy with antioxidants","volume":"19","author":"Baradaran","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.phymed.2016.08.006_bib0005","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.phytochem.2010.12.011","article-title":"Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth","volume":"72","author":"Beattie","year":"2011","journal-title":"(Myoporaceae). Phytochemistry"},{"key":"10.1016\/j.phymed.2016.08.006_bib0006","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0748-5514(85)90026-1","article-title":"Pathological mechanisms in carbon tetrachloride hepatotoxicity","volume":"1","author":"Brattin","year":"1985","journal-title":"J. Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2016.08.006_bib0007","first-page":"306","article-title":"The thiobarbituric acid assay","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.phymed.2016.08.006_bib0008","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q","article-title":"Antioxidant activity of Nigella sativa essential oil","volume":"14","author":"Burits","year":"2000","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2016.08.006_bib0009","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jep.2003.08.006","article-title":"Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II","volume":"89","author":"Chattopadhyay","year":"2003","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2016.08.006_bib0010","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1021\/jf801792n","article-title":"Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities","volume":"56","author":"Chin","year":"2008","journal-title":"J. Agric. Food Chem"},{"key":"10.1016\/j.phymed.2016.08.006_bib0011","first-page":"16","article-title":"Neurosedative and antioxidant activities of phenylpropanoids from Ballota nigra","volume":"50","author":"Daels-Rakotoarison","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.phymed.2016.08.006_bib0012","series-title":"Medicinal Natural Products : A Biosynthetic Approach","author":"Dewick","year":"2009"},{"key":"10.1016\/j.phymed.2016.08.006_bib0013","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/10412905.2013.796498","article-title":"Chemical composition and anti-inflammatory activity of the essential oils of Psidium guajava fruits and leaves","volume":"25","author":"El-Ahmady","year":"2013","journal-title":"J. Essent. Oil Res."},{"key":"10.1016\/j.phymed.2016.08.006_bib0014","first-page":"214","article-title":"A spectrophotometric method for determination of reduced glutathione in tissues","volume":"74","author":"Ellman","year":"1959","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.phymed.2016.08.006_bib0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.mam.2008.09.001","article-title":"GSH and analogs in antiviral therapy","volume":"30","author":"Fraternale","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.phymed.2016.08.006_bib0016","series-title":"Hepatology: A Textbook of Liver Disease","first-page":"791","article-title":"Liver function tests and the objective evaluation of the patient with liver disease","author":"Friedman","year":"1996"},{"key":"10.1016\/j.phymed.2016.08.006_bib0017","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.3748\/wjg.v16.i48.6035","article-title":"Oxidative stress and antioxidants in hepatic pathogenesis","volume":"16","author":"Ha","year":"2010","journal-title":"World J. Gastroenterol"},{"key":"10.1016\/j.phymed.2016.08.006_bib0018","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1126\/science.1116304","article-title":"Small-molecule inhibition of TNF-\u03b1","volume":"310","author":"He","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.phymed.2016.08.006_bib0019","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.3109\/13880209.2013.777931","article-title":"Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat","volume":"51","author":"Heidarian","year":"2013","journal-title":"Pharm Biol."},{"key":"10.1016\/j.phymed.2016.08.006_bib0020","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1124\/jpet.108.144451","article-title":"Therapeutic effect of lecithinized superoxide dismutase against colitis","volume":"328","author":"Ishihara","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2016.08.006_bib0021","first-page":"765","article-title":"Ameliorative role of oleuropein extracted from olive leaf on tamoxifen-induced hepatic 8-hydroxydeoxyguanosine in DNA of Balb\/C Mice","volume":"30","author":"Jamshed","year":"2014","journal-title":"World Appl. Sci. J."},{"key":"10.1016\/j.phymed.2016.08.006_bib0022","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"J. Clin. Path."},{"key":"10.1016\/j.phymed.2016.08.006_bib0023","first-page":"15","article-title":"Phenylpropanoids as naturally occurring antioxidants: from plant defense to human health","volume":"53","author":"Korkina","year":"2007","journal-title":"Cell Mol. Biol."},{"key":"10.1016\/j.phymed.2016.08.006_bib0024","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jms.3218","article-title":"Sodium adduct formation efficiency in ESI source","volume":"48","author":"Kruve","year":"2013","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.phymed.2016.08.006_bib0025","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.phytochem.2006.04.014","article-title":"Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii","volume":"67","author":"Liu","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2016.08.006_bib0026","first-page":"255","article-title":"Medicinal plants and antioxidants: why they are not always beneficial?","volume":"43","author":"Nasri","year":"2014","journal-title":"Iran. J. Public Health"},{"key":"10.1016\/j.phymed.2016.08.006_bib0027","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"Measurement of superoxide dismutase","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.phymed.2016.08.006_bib0028","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jep.2004.08.015","article-title":"Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense","volume":"95","author":"Oh","year":"2004","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2016.08.006_bib0029","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1021\/jf0709808","article-title":"Inhibitory activity against tobacco mosaic virus (TMV) replication of pinoresinol and syringaresinol lignans and their glycosides from the root of Rhus javanica var. roxburghiana","volume":"55","author":"Ouyang","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2016.08.006_bib0030","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/0024-3205(78)90378-8","article-title":"Reactions of the carbon tetrachloride-related peroxy free radical (CCl3 O2) with amino acids: pulse radiolysis evidence","volume":"23","author":"Packer","year":"1978","journal-title":"Life Sci"},{"key":"10.1016\/j.phymed.2016.08.006_bib0031","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5812\/nephropathol.12116","article-title":"Plants antioxidants: from laboratory to clinic","volume":"2","author":"Rafieian-Kopaie","year":"2013","journal-title":"J. Nephropathol."},{"key":"10.1016\/j.phymed.2016.08.006_bib0032","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A calorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.phymed.2016.08.006_bib0033","first-page":"2711","article-title":"Botanical and genetic characteristics of Eremophila maculata and Eremophila purpurascens (Scrophulariaceae)","volume":"2","author":"Labib","year":"2013","journal-title":"World J. Pharm. Res."},{"key":"10.1016\/j.phymed.2016.08.006_bib0034","series-title":"Schiff's Diseases of the Liver","author":"Schiff","year":"2007"},{"key":"10.1016\/j.phymed.2016.08.006_bib0035","first-page":"1","article-title":"The history and ups and downs of herbal medicine usage","volume":"3","author":"Sewell","year":"2014","journal-title":"J. Herbmed. Pharmacol"},{"key":"10.1016\/j.phymed.2016.08.006_bib0036","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/jphp.12092","article-title":"The genus Eremophila (Scrophulariaceae): an ethnobotanical, biological and phytochemical review","volume":"65","author":"Singab","year":"2013","journal-title":"J. Pharm. Pharmacol"},{"key":"10.1016\/j.phymed.2016.08.006_bib0037","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.phymed.2016.08.006_bib0038","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/jobm.200410534","article-title":"Characterisation of antibacterial Australian medicinal plant extracts by investigation of the mechanism of action and the effect of interfering substances","volume":"45","author":"Tomlinson","year":"2005","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.phymed.2016.08.006_bib0039","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.phymed.2009.02.004","article-title":"Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats","volume":"16","author":"Yan","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2016.08.006_bib0040","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/cbdv.201300366","article-title":"Volatile oils from the aerial parts of Eremophila maculata and their antimicrobial activity","volume":"11","author":"Youssef","year":"2014","journal-title":"Chem. Biodivers"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711316301507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711316301507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T20:56:12Z","timestamp":1536440172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711316301507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0944711316301507"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2016.08.006","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eremophila maculata\u2014Isolation of a rare naturally-occurring lignan glycoside and the hepatoprotective activity of the leaf extract","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2016.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}