{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:17:41Z","timestamp":1783340261153,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Science and Technology","award":["103-2320-B-040 -003 -MY3"],"award-info":[{"award-number":["103-2320-B-040 -003 -MY3"]}]},{"name":"Ministry of Science and Technology","award":["104-2811-B-040 -004"],"award-info":[{"award-number":["104-2811-B-040 -004"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.phymed.2016.09.003","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T04:26:57Z","timestamp":1474000017000},"page":"1566-1573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells"],"prefix":"10.1016","volume":"23","author":[{"given":"I-Lun","family":"Hsin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ri","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai-Chun","family":"Ciou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsien","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Liang","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2016.09.003_bib0001","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1038\/emboj.2010.43","article-title":"AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX","volume":"29","author":"Artus","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.phymed.2016.09.003_bib0002","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1200\/JCO.2011.38.6979","article-title":"Randomized phase III study comparing paclitaxel\/cisplatin\/gemcitabine and gemcitabine\/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC Intergroup Study 30987","volume":"30","author":"Bellmunt","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0003","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12016-010-8243-x","article-title":"Hydroxychloroquine: from malaria to autoimmunity","volume":"42","author":"Ben-Zvi","year":"2012","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0004","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI39987","article-title":"Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance","volume":"120","author":"Bonapace","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2016.09.003_bib0005","doi-asserted-by":"crossref","first-page":"14147","DOI":"10.1073\/pnas.1404171111","article-title":"Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy","volume":"111","author":"Changou","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.phymed.2016.09.003_bib0006","article-title":"Clinical significance of survivin expression in patients with urothelial carcinoma","author":"Chen","year":"2014","journal-title":"Dis Markers 2014"},{"key":"10.1016\/j.phymed.2016.09.003_bib0007","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/bjc.2014.591","article-title":"Phase II study of pemetrexed in combination with cisplatin in patients with advanced urothelial cancer: the PECULIAR study (KCSG 10-17)","volume":"112","author":"Choi","year":"2015","journal-title":"British J. Cancer"},{"key":"10.1016\/j.phymed.2016.09.003_bib0008","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0009","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1586\/era.11.201","article-title":"Molecular mechanisms of cisplatin resistance in bladder cancer","volume":"12","author":"Drayton","year":"2012","journal-title":"Exp. Rev. Anticancer Therapy"},{"key":"10.1016\/j.phymed.2016.09.003_bib0010","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tibtech.2013.09.003","article-title":"Mushroom immunomodulators: unique molecules with unlimited applications","volume":"31","author":"El Enshasy","year":"2013","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.canlet.2005.02.027","article-title":"Chemosensitization of bladder cancer cells by survivin-directed antisense oligodeoxynucleotides and siRNA","volume":"232","author":"Fuessel","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2016.09.003_bib0012","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2016.09.003_bib0013","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bcp.2010.04.007","article-title":"Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells","volume":"80","author":"Hour","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2016.09.003_bib0014","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/mp500840z","article-title":"GMI, an Immunomodulatory protein from ganoderma microsporum, potentiates cisplatin-induced apoptosis via autophagy in lung cancer cells","volume":"12","author":"Hsin","year":"2015","journal-title":"Molecul. Pharm"},{"key":"10.1016\/j.phymed.2016.09.003_bib0015","doi-asserted-by":"crossref","first-page":"873","DOI":"10.4161\/auto.7.8.15698","article-title":"GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells","volume":"7","author":"Hsin","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2016.09.003_bib0016","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1476-5381.2012.02073.x","article-title":"Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum","volume":"167","author":"Hsin","year":"2012","journal-title":"British J. Pharmacol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0017","doi-asserted-by":"crossref","first-page":"e76719","DOI":"10.1371\/journal.pone.0076719","article-title":"Prognostic role of survivin in bladder cancer: a systematic review and meta-analysis","volume":"8","author":"Jeon","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.phymed.2016.09.003_bib0018","doi-asserted-by":"crossref","first-page":"8960","DOI":"10.1158\/0008-5472.CAN-04-1830","article-title":"Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria","volume":"64","author":"Kang","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2016.09.003_bib0019","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016394","article-title":"DNA degradation and its defects","volume":"6","author":"Kawane","year":"2014","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0020","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.cdd.4400526","article-title":"Caspase-independent programmed cell death with necrotic morphology","volume":"6","author":"Kitanaka","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2016.09.003_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2016.09.003_bib0022","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrc3817","article-title":"Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity","volume":"15","author":"Knowles","year":"2015","journal-title":"Nature reviews. Cancer"},{"key":"10.1016\/j.phymed.2016.09.003_bib0023","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2008.150","article-title":"Classification of cell death: recommendations of the nomenclature committee on cell death 2009","volume":"16","author":"Kroemer","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2016.09.003_bib0024","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","article-title":"Caspase-independent cell death","volume":"11","author":"Kroemer","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2016.09.003_bib0025","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/15548627.2015.1009789","article-title":"Chromatophagy: autophagy goes nuclear and captures broken chromatin during arginine-starvation","volume":"11","author":"Kung","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2016.09.003_bib0026","first-page":"2973","article-title":"FIP-gts potentiate autophagic cell death against cisplatin-resistant urothelial cancer cells","volume":"34","author":"Li","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.phymed.2016.09.003_bib0027","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/mc.20161","article-title":"Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line","volume":"45","author":"Liao","year":"2006","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.phymed.2016.09.003_bib0028","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.fct.2008.01.044","article-title":"Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae","volume":"46","author":"Liao","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0029","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bcp.2007.07.025","article-title":"Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae","volume":"74","author":"Liao","year":"2007","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.phymed.2016.09.003_bib0030","doi-asserted-by":"crossref","first-page":"12014","DOI":"10.1021\/jf103068w","article-title":"GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor alpha-induced expression of matrix metalloproteinase 9 via NF-kappaB pathway in human alveolar epithelial A549 cells","volume":"58","author":"Lin","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2016.09.003_bib0031","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.procbio.2010.06.006","article-title":"A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells","volume":"45","author":"Lin","year":"2010","journal-title":"Proc. Biochem."},{"key":"10.1016\/j.phymed.2016.09.003_bib0032","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: the interplay of autophagy and apoptosis","volume":"15","author":"Marino","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0033","doi-asserted-by":"crossref","first-page":"e81162","DOI":"10.1371\/journal.pone.0081162","article-title":"Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions","volume":"8","author":"Marullo","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.phymed.2016.09.003_bib0034","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1038\/sj.onc.1207532","article-title":"DNA damage-induced apoptosis","volume":"23","author":"Norbury","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2016.09.003_bib0035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4161\/auto.7.5.14226","article-title":"Autophagic cell death: Loch Ness monster or endangered species?","volume":"7","author":"Shen","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2016.09.003_bib0036","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1038\/onc.2008.311","article-title":"Caspase-independent cell death: leaving the set without the final cut","volume":"27","author":"Tait","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2016.09.003_bib0037","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1093\/hmg\/ddq253","article-title":"Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease","volume":"19","author":"Underwood","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phymed.2016.09.003_bib0038","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"Regulated necrosis: the expanding network of non-apoptotic cell death pathways","volume":"15","author":"Vanden Berghe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0039","doi-asserted-by":"crossref","first-page":"25292","DOI":"10.1074\/jbc.M111.291195","article-title":"Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation","volume":"287","author":"Wu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2016.09.003_bib0040","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/carcin\/bgr221","article-title":"Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway","volume":"32","author":"Wu","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.phymed.2016.09.003_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114495","article-title":"Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2016.09.003_bib0042","doi-asserted-by":"crossref","first-page":"19179","DOI":"10.1074\/jbc.M513377200","article-title":"Autophagy contributes to caspase-independent macrophage cell death","volume":"281","author":"Xu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2016.09.003_bib0043","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1101\/gad.2016111","article-title":"Pancreatic cancers require autophagy for tumor growth","volume":"25","author":"Yang","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.phymed.2016.09.003_bib0044","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.fct.2012.01.040","article-title":"Mechanism of cisplatin resistance in human urothelial carcinoma cells","volume":"50","author":"Yu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2016.09.003_bib0045","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4161\/auto.7.6.15103","article-title":"PARP and RIP 1 are required for autophagy induced by 11\u2032-deoxyverticillin A, which precedes caspase-dependent apoptosis","volume":"7","author":"Zhang","year":"2011","journal-title":"Autophagy"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131630157X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131630157X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T07:26:56Z","timestamp":1536391616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471131630157X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":45,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S094471131630157X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2016.09.003","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2016.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}