{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:13:28Z","timestamp":1791598408971,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.phymed.2016.10.012","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T14:30:26Z","timestamp":1477319426000},"page":"1735-1742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"title":["Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial"],"prefix":"10.1016","volume":"23","author":[{"given":"Jun J.","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon X.","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Soeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing S.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay D.","family":"Amsterdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2016.10.012_bib0001","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1017\/S1461145705005973","article-title":"Prevention of relapse in generalized anxiety disorder by escitalopram treatment","volume":"9","author":"Allgulander","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.phymed.2016.10.012_bib0002","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jpsychires.2003.10.005","article-title":"Sustained efficacy of gepirone-IR in major depressive disorder: a double-blind placebo substitution trial","volume":"38","author":"Amsterdam","year":"2004","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phymed.2016.10.012_bib0003","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/JCP.0b013e3181ac935c","article-title":"A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder","volume":"29","author":"Amsterdam","year":"2009","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phymed.2016.10.012_bib0004","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/da.20658","article-title":"Generalized worry disorder: a review of DSM-IV generalized anxiety disorder and options for DSM-V","volume":"27","author":"Andrews","year":"2010","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.phymed.2016.10.012_bib0005","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: psychometric properties","volume":"56","author":"Beck","year":"1988","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.phymed.2016.10.012_bib0006","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.psym.2011.11.009","article-title":"Use of complementary and alternative medicine in a large sample of anxiety patients","volume":"53","author":"Bystritsky","year":"2012","journal-title":"Psychosomatics"},{"key":"10.1016\/j.phymed.2016.10.012_bib0007","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/da.10146","article-title":"Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo controlled, flexible-dose study","volume":"19","author":"Davidson","year":"2004","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.phymed.2016.10.012_bib0008","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.euroneuro.2008.05.002","article-title":"Duloxetine treatment for relapse prevention in adults with generalized anxiety disorder: a double-blind placebo-controlled trial","volume":"18","author":"Davidson","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"61 Suppl","key":"10.1016\/j.phymed.2016.10.012_bib0009","first-page":"37","article-title":"Weight gain and antidepressants","volume":"11","author":"Fava","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0010","series-title":"Biometrics Research","article-title":"Structured clinical interview for DSM-IV-TR axis I disorders (SCID-I\/P W\/PSY screen)","author":"First","year":"2001"},{"key":"10.1016\/j.phymed.2016.10.012_bib0011","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1001\/jama.283.23.3082","article-title":"Efficacy of venlafaxine extended-release capsules in nondepressed outpatients with generalized anxiety disorder: a 6-month randomized controlled trial","volume":"283","author":"Gelenberg","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2016.10.012_bib0012","first-page":"76","author":"Guy","year":"1976","journal-title":"Assessment Manual for Psychopharmacology. DHEW Publication ADM, pp."},{"key":"10.1016\/j.phymed.2016.10.012_bib0013","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol"},{"key":"10.1016\/j.phymed.2016.10.012_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2016.10.013","article-title":"Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder","author":"Keefe","year":"2016","journal-title":"Phytomedicine."},{"issue":"63 Suppl","key":"10.1016\/j.phymed.2016.10.012_bib0014","first-page":"11","article-title":"The long-term clinical course of generalized anxiety disorder","volume":"8","author":"Keller","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0015","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0016","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1176\/ajp.156.12.1915","article-title":"Impairment in pure and comorbid generalized anxiety disorder and major depression at 12 months in two national surveys","volume":"156","author":"Kessler","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0017","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1176\/appi.ajp.158.2.289","article-title":"The use of complementary and alternative therapies to treat anxiety and depression in the United States","volume":"158","author":"Kessler","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0018","first-page":"188","article-title":"Long-term chamomile therapy of generalized anxiety disorder: a study protocol for a randomized, double-blind, placebo-controlled trial","volume":"4","author":"Mao","year":"2014","journal-title":"J. Clin. Trials"},{"key":"10.1016\/j.phymed.2016.10.012_bib0019","doi-asserted-by":"crossref","first-page":"29275","DOI":"10.3402\/qhw.v10.29275","article-title":"Herbal medicine use in adults who experience anxiety: a qualitative exploration","volume":"10","author":"McIntyre","year":"2015","journal-title":"Int. J. Qual. Stud. Health well-being"},{"key":"10.1016\/j.phymed.2016.10.012_bib0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/01.jcp.0000155821.74832.f9","article-title":"A meta-analytic review of the efficacy of drug treatment in generalized anxiety disorder","volume":"25","author":"Mitte","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"issue":"Suppl 3","key":"10.1016\/j.phymed.2016.10.012_bib0021","first-page":"10","article-title":"Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish working group for the study of psychotropic-related sexual dysfunction","volume":"62","author":"Montejo","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0022","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.yic.0000137184.64610.c8","article-title":"Absence of discontinuation symptoms with agomelatine and occurrence of discontinuation symptoms with paroxetine: a randomized, double-blind, placebo-controlled discontinuation study","volume":"19","author":"Montgomery","year":"2004","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.phymed.2016.10.012_bib0023","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0022-3956(02)00005-5","article-title":"Characterization of the longitudinal course of improvement in generalized anxiety disorder during long-term treatment with venlafaxine XR","volume":"36","author":"Montgomery","year":"2002","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phymed.2016.10.012_bib0024","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1248\/bpb.26.474","article-title":"Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test","volume":"26","author":"Nakazawa","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2016.10.012_bib0025","first-page":"1069","article-title":"Treatment emergent symptoms scale","volume":"21","year":"1985","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.phymed.2016.10.012_bib0026","series-title":"Hierarchical Linear Models: Applications and Data Analysis Methods","author":"Raudenbush","year":"2002"},{"key":"10.1016\/j.phymed.2016.10.012_bib0027","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1517\/14656566.2015.1059424","article-title":"Pharmacological treatment for generalized anxiety disorder in adults: an update","volume":"16","author":"Reinhold","year":"2015","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.phymed.2016.10.012_bib0028","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4142\/jvs.2006.7.2.189","article-title":"Matricaria chamomilla CH12 decreases handling stress in Nelore calves","volume":"7","author":"Reis","year":"2006","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.phymed.2016.10.012_bib0029","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1001\/archgenpsychiatry.2010.170","article-title":"Time to relapse after 6 and 12 months' treatment of generalized anxiety disorder with venlafaxine extended release","volume":"67","author":"Rickels","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0030","first-page":"1","article-title":"Chamomile, a medicinal plant","volume":"10","author":"Salamon","year":"1992","journal-title":"Herb Spice Med. Plant Digest"},{"key":"10.1016\/j.phymed.2016.10.012_bib0031","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.phymed.2016.10.012_bib0032","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.4088\/JCP.11m07493","article-title":"Agomelatine prevents relapse in generalized anxiety disorder: a 6-month randomized, double-blind, placebo-controlled discontinuation study","volume":"73","author":"Stein","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0033","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4088\/JCP.v64n0305","article-title":"Efficacy and tolerability of paroxetine for the long-term treatment of generalized anxiety disorder","volume":"64","author":"Stocchi","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phymed.2016.10.012_bib0034","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/00004714-200012000-00009","article-title":"Prevention of relapse in generalized social phobia: results of a 24-week study in responders to 20 weeks of sertraline treatment","volume":"20","author":"Walker","year":"2000","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phymed.2016.10.012_bib0035","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0378-5122(92)90116-L","article-title":"A new methodological approach to the evaluation of quality of life in postmenopausal women","volume":"14","author":"Wiklund","year":"1992","journal-title":"Maturitas"},{"key":"10.1016\/j.phymed.2016.10.012_bib0036","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/da.10106","article-title":"Chronicity, relapse, and illness\u2013course of panic disorder, social phobia, and generalized anxiety disorder: findings in men and women from 8 years of follow-up","volume":"17","author":"Yonkers","year":"2003","journal-title":"Depress. Anxiety"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131630188X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131630188X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T12:00:40Z","timestamp":1692532840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471131630188X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":37,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S094471131630188X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2016.10.012","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2016.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}