{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:52:25Z","timestamp":1790668345586,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173644"],"award-info":[{"award-number":["81173644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81222054"],"award-info":[{"award-number":["81222054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.phymed.2017.08.005","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T20:01:17Z","timestamp":1502136077000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury"],"prefix":"10.1016","volume":"34","author":[{"given":"Yi","family":"Kuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2017.08.005_bib0001","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ptr.2362","article-title":"Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds","volume":"22","author":"Asl","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2017.08.005_bib0002","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1007\/s10620-006-9472-y","article-title":"Drug-induced liver injury: review article","volume":"52","author":"Bleibel","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.phymed.2017.08.005_bib0003","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1271\/bbb.120675","article-title":"Biochanin A protects against acute carbon tetrachloride-induced hepatotoxicity in rats","volume":"77","author":"Breikaa","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.phymed.2017.08.005_bib0004","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1021\/jf405352g","article-title":"Glycyrrhetinic acid suppressed NF-\u03baB activation in TNF-\u03b1-induced hepatocytes","volume":"62","author":"Chen","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2017.08.005_bib0005","volume":"vol. 1","year":"2005"},{"key":"10.1016\/j.phymed.2017.08.005_bib0006","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3892\/ijmm_00000177","article-title":"Hepatoprotective effects of daidzein against 7,12-dimetylbenz[\u03b1]anthracene-induced oxidative stress in mice","volume":"23","author":"Choi","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2017.08.005_bib0007","first-page":"12","article-title":"Protective effect of liquiritin on the hepatoxicity induced by CCl4","volume":"18","author":"Ding","year":"2002","journal-title":"Pharmacol. Clin. Chin. Mater. Med."},{"key":"10.1016\/j.phymed.2017.08.005_bib0008","doi-asserted-by":"crossref","first-page":"28705","DOI":"10.3390\/ijms161226126","article-title":"Current status of herbal medicines in chronic liver disease therapy: the biological effects, molecular targets and future prospects","volume":"16","author":"Hong","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2017.08.005_bib0009","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/ptr.5487","article-title":"Pharmacological effects of Glycyrrhiza spp. and its bioactive constituents: update and review","volume":"29","author":"Hosseinzadeh","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2017.08.005_bib0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/acs.jnatprod.5b00877","article-title":"Bioactive constituents of Glycyrrhiza uralensis (licorice): discovery of the effective components of a traditional herbal medicine","volume":"79","author":"Ji","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2017.08.005_bib0011","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/ptr.2710","article-title":"Protective effect of daidzin against d-galactosamine and lipopolysaccharide-induced hepatic failure in mice","volume":"23","author":"Kim","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2017.08.005_bib0012","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2006.03.008","article-title":"Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine","volume":"161","author":"Kim","year":"2006","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.phymed.2017.08.005_bib0013","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/0960327112459530","article-title":"Antioxidative and cytoprotective effects of andrographolide against CCl4-induced hepatotoxicity in HepG2 cells","volume":"32","author":"Krithika","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.phymed.2017.08.005_bib0014","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1021\/acs.jnatprod.6b00783","article-title":"Glycybridins A-K, bioactive phenolic compounds from Glycyrrhiza glabra","volume":"80","author":"Li","year":"2017","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2017.08.005_bib0015","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1016\/j.bmc.2017.05.009","article-title":"Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata","volume":"25","author":"Lin","year":"2017","journal-title":"Bioorgan. Med. Chem"},{"key":"10.1016\/j.phymed.2017.08.005_bib0016","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1099-1573(199602)10:1<13::AID-PTR764>3.0.CO;2-1","article-title":"Evaluation of the liver protective principles from the root of Cudrania cochinchinensis var. gerontogea","volume":"10","author":"Lin","year":"1996","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2017.08.005_bib0017","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1055\/s-2007-1007249","article-title":"Mechanisms of liver damage","volume":"16","author":"Losser","year":"1996","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.phymed.2017.08.005_bib0018","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cbi.2014.07.001","article-title":"Effect of glycyrrhizic acid on titanium dioxide nanoparticles-induced hepatotoxicity in rats","volume":"220","author":"Orazizadeh","year":"2014","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.phymed.2017.08.005_bib0019","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/019262338701500407","article-title":"Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: a time and dose study","volume":"15","author":"Placke","year":"1987","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.phymed.2017.08.005_bib0020","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.fitote.2013.03.005","article-title":"Licochalcone A regulates hepatic lipid metabolism through activation of AMP-activated protein kinase","volume":"86","author":"Quan","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2017.08.005_bib0021","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1139\/cjpp-2014-0192","article-title":"Thioacetamide-induced liver injury: protective role of genistein","volume":"92","author":"Saleh","year":"2014","journal-title":"Can. J. Physiol. Pharma."},{"key":"10.1016\/j.phymed.2017.08.005_bib0022","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10068-014-0075-7","article-title":"Protective effects of dehydroglyasperin C against carbon tetrachloride-induced liver damage in mice","volume":"23","author":"Seo","year":"2014","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.phymed.2017.08.005_bib0023","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.freeradbiomed.2015.07.006","article-title":"Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy","volume":"89","author":"Song","year":"2015","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phymed.2017.08.005_bib0024","first-page":"910","article-title":"Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice","volume":"19","author":"Teng","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.phymed.2017.08.005_bib0025","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/molecules21050559","article-title":"The traditional medicine and modern medicine from natural products","volume":"21","author":"Yuan","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2017.08.005_bib0026","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.chroma.2008.07.072","article-title":"Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)","volume":"1216","author":"Zhang","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phymed.2017.08.005_bib0027","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cbi.2014.10.030","article-title":"Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine","volume":"225","author":"Zhao","year":"2015","journal-title":"Chem.-Biol. Interact."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317300946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317300946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T10:37:50Z","timestamp":1538044670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711317300946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":27,"alternative-id":["S0944711317300946"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2017.08.005","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2017.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}