{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:15:00Z","timestamp":1778087700683,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["NSC 102-2628-B-037-001-MY3"],"award-info":[{"award-number":["NSC 102-2628-B-037-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2320-B-037- 013-MY3"],"award-info":[{"award-number":["MOST 105-2320-B-037- 013-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.phymed.2017.08.018","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T13:15:50Z","timestamp":1503062150000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein"],"prefix":"10.1016","volume":"34","author":[{"given":"Yu-Ting","family":"Tseng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh-Jyh","family":"Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Fang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Rong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ching","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2017.08.018_bib0001","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s12035-013-8399-5","article-title":"Spinal muscular atrophy and the antiapoptotic role of survival of motor neuron (SMN) protein","volume":"47","author":"Anderton","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2017.08.018_bib0002","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/hmg\/ddq021","article-title":"Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model","volume":"19","author":"Bowerman","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phymed.2017.08.018_bib0003","first-page":"597","article-title":"Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? Nature reviews","volume":"10","author":"Burghes","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2017.08.018_bib0004","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/cns.12242","article-title":"Gem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover","volume":"20","author":"Cauchi","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2017.08.018_bib0005","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2174\/1389450117666160401123825","article-title":"ROCK in CNS: different roles of isoforms, and therapeutic target for neurodegenerative disorders","volume":"18","author":"Chong","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.phymed.2017.08.018_bib0006","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/wrna.76","article-title":"SMN in spinal muscular atrophy and snRNP biogenesis","volume":"2","author":"Coady","year":"2011","journal-title":"Wiley Interdiscipl. Rev."},{"key":"10.1016\/j.phymed.2017.08.018_bib0007","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fnins.2014.00271","article-title":"ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets","volume":"8","author":"Coque","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phymed.2017.08.018_bib0008","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/neu.10282","article-title":"Regulation of growth cone actin filaments by guidance cues","volume":"58","author":"Gallo","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.phymed.2017.08.018_bib0009","first-page":"2564","article-title":"Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism","volume":"25","author":"Gallotta","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phymed.2017.08.018_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1256405","article-title":"The role of the rho GTPases in neuronal development","volume":"19","author":"Govek","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2017.08.018_bib0011","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.taap.2013.08.008","article-title":"Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth","volume":"272","author":"Hsu","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2017.08.018_bib0012","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/hmg\/ddi078","article-title":"SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN","volume":"14","author":"Le","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phymed.2017.08.018_bib0013","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2017.08.018_bib0014","article-title":"Selective neuromuscular denervation in taiwanese severe SMA mouse can be reversed by morpholino antisense oligonucleotides","volume":"11","author":"Lin","year":"2016","journal-title":"PloS one"},{"key":"10.1016\/j.phymed.2017.08.018_bib0015","doi-asserted-by":"crossref","first-page":"e15457","DOI":"10.1371\/journal.pone.0015457","article-title":"Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy","volume":"5","author":"Ling","year":"2010","journal-title":"PloS one"},{"key":"10.1016\/j.phymed.2017.08.018_bib0016","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1471-4159.2007.04756.x","article-title":"Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo","volume":"103","author":"Lingor","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2017.08.018_bib0017","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddw262","article-title":"Motor neuron mitochondrial dysfunction in spinal muscular atrophy","author":"Miller","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phymed.2017.08.018_bib0018","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF03033366","article-title":"Survival motor neuron protein regulates apoptosis in an in vitro model of spinal muscular atrophy","volume":"13","author":"Parker","year":"2008","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.phymed.2017.08.018_bib0019","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddw247","article-title":"Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice","author":"Perera","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.phymed.2017.08.018_bib0020","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00418-012-0989-1","article-title":"Laminin induced local axonal translation of beta-actin mRNA is impaired in SMN-deficient motoneurons","volume":"138","author":"Rathod","year":"2012","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.phymed.2017.08.018_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/908724","article-title":"Altered gene expression, mitochondrial damage and oxidative stress: converging routes in motor neuron degeneration","volume":"2012","author":"Rossi","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.phymed.2017.08.018_bib0022","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.200304128","article-title":"Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons","volume":"163","author":"Rossoll","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2017.08.018_bib0023","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2011.06.031","article-title":"Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration","volume":"71","author":"Saxena","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2017.08.018_bib0024","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/bph.12277","article-title":"Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis","volume":"170","author":"Takata","year":"2013","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.phymed.2017.08.018_bib0025","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.cell.2008.05.002","article-title":"Is good housekeeping the key to motor neuron survival?","volume":"133","author":"Talbot","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2017.08.018_bib0026","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.phymed.2013.11.001","article-title":"The Chinese herbal formula Liuwei dihuang protects dopaminergic neurons against Parkinson's toxin through enhancing antioxidative defense and preventing apoptotic death","volume":"21","author":"Tseng","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2017.08.018_bib0027","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.phrs.2016.05.023","article-title":"Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt\/mTOR in experimental models of spinal muscular atrophy","volume":"111","author":"Tseng","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2017.08.018_bib0028","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/SHK.0b013e31823fe939","article-title":"Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons","volume":"37","author":"Tseng","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2017.08.018_bib0029","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/hmg\/ddq058","article-title":"Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy","volume":"19","author":"Wen","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phymed.2017.08.018_bib0030","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1089\/ars.2012.4905","article-title":"Regulation of the intrinsic apoptosis pathway by reactive oxygen species","volume":"19","author":"Wu","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2017.08.018_bib0031","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pharmthera.2016.02.004","article-title":"Effect of Liuwei Dihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network","volume":"162","author":"Zhou","year":"2016","journal-title":"Pharmacol. Therapeut."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:40:14Z","timestamp":1719398414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711317301071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":31,"alternative-id":["S0944711317301071"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2017.08.018","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2017.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}