{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:40:38Z","timestamp":1786995638696,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Agriculture","award":["201303040"],"award-info":[{"award-number":["201303040"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.phymed.2017.09.001","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T04:45:25Z","timestamp":1508906725000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats"],"prefix":"10.1016","volume":"38","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xurong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Passantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2017.09.001_bib0001","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijcard.2013.10.064","article-title":"Prognostic significance of cardiovascular biomarkers and renal dysfunction in outpatients with systolic heart failure: a long term follow-up study","volume":"170","author":"Bosselmann","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0002","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005052.pub2","article-title":"Shengmai (a traditional Chinese herbal medicine) for heart failure","volume":"17","author":"Chen","year":"2007","journal-title":"Cochrane Database Systematic Rev."},{"key":"10.1016\/j.phymed.2017.09.001_bib0003","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1161\/01.HYP.0000144400.49062.6b","article-title":"Angiotensin II regulation of collagen Type I expression in cardiac fibroblasts: modulation by PPAR-[gamma] ligand pioglitazone","volume":"44","author":"Chen","year":"2004","journal-title":"Hypertensino"},{"key":"10.1016\/j.phymed.2017.09.001_bib0004","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1248\/bpb.33.825","article-title":"Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts","volume":"33","author":"Chen","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2017.09.001_bib0005","doi-asserted-by":"crossref","first-page":"e79418","DOI":"10.1371\/journal.pone.0079418","article-title":"Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2017.09.001_bib0006","series-title":"The Experiment For Shengmaiyin on Treating Chronic Heart Failure Rats [Dissertation]","author":"Cheng","year":"2011"},{"key":"10.1016\/j.phymed.2017.09.001_bib0007","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.lfs.2008.03.006","article-title":"Schisandrin B stereoisomers protect against hypoxia\/reoxygenation-induced apo- ptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes","volume":"82","author":"Chiu","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2017.09.001_bib0008","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jep.2014.01.024","article-title":"Schisandrin B suppresses TGFbeta1-induced stress fiber formation by inhibiting myosin light chain phosphorylation","volume":"152","author":"Chun","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0009","series-title":"Chinese Pharmacopoeia. Part I","year":"2005"},{"key":"10.1016\/j.phymed.2017.09.001_bib0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cardiores.2004.05.011","article-title":"IL-6 plays an obligatoryrole in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2","volume":"64","author":"Dawn","year":"2004","journal-title":"Cardiovasc"},{"key":"10.1016\/j.phymed.2017.09.001_bib0012","first-page":"1199","article-title":"Extracellular matrix turnover biomarkers predict long-term left ventricular remodeling after myocardial infarction insights from the REVE-2 study","volume":"6","author":"Eschalier","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2017.09.001_bib0013","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.phymed.2006.03.004","article-title":"Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract","volume":"14","author":"Fong","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2017.09.001_bib0014","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1039\/C4NP00134F","article-title":"Dereplication: racing to speed up the natural products discovery process","volume":"32","author":"Gaud\u00eancio","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phymed.2017.09.001_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-2952(97)00193-7","article-title":"Panax ginseng pharmacology: a nitric oxide link?","volume":"54","author":"Gillis","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0016","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/eurjhf\/hfp025","article-title":"Incidence and predictors of hospitalization or death in patients managed in multidisciplinary heart failure clinics","volume":"11","author":"Gustafsson","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.phymed.2017.09.001_bib0017","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijcard.2006.01.031","article-title":"Parallel gene expressions of IL-6 and BNP during cardiac hypertrophy complicated with diastolic dysfunction in spontaneously hypertensive rats","volume":"15","author":"Haugen","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0018","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jcma.2014.01.001","article-title":"Neuroprotective effects of ginsenoside Rg1 against oxygen-glucose deprivation in cultured hippocampal neurons","volume":"77","author":"He","year":"2014","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.phymed.2017.09.001_bib0019","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.CIR.102.2.203","article-title":"Renal function, neurohormonal activation, and survival in patients with chronic heart failure","volume":"102","author":"Hillege","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2017.09.001_bib0020","series-title":"A Study On the Relationship Between MMPs\/TIMPs and the Diabetic Myocardium Damage in Type 2 Diabetes Rats [Dissertation]","author":"Huang","year":"2006"},{"key":"10.1016\/j.phymed.2017.09.001_bib0021","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1093\/ndt\/gfh872","article-title":"Role of atrophic changes in proximal tubular cells in the peritubular deposition of type IV collagen in a rat renal ablation model","volume":"20","author":"Kimura","year":"2005","journal-title":"Nephrol. Dial. Transplant"},{"key":"10.1016\/j.phymed.2017.09.001_bib0022","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11010-005-4539-1","article-title":"Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells","volume":"276","author":"Ko","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phymed.2017.09.001_bib0023","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phymed.2017.09.001_bib0024","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1039\/c0cc04927a","article-title":"A natural product-like inhibitor of NEDD8-activating enzyme","volume":"47","author":"Leung","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.phymed.2017.09.001_bib0025","first-page":"124","article-title":"Preparation and observation of scanning electron microscopy (SEM) biological sample","volume":"3","author":"Li","year":"2008","journal-title":"Mod. Sci. Instrum."},{"key":"10.1016\/j.phymed.2017.09.001_bib0026","first-page":"415","article-title":"A modified rat model of dilated cardiomyopathy induced by adriamycin","volume":"16","author":"Li","year":"2006","journal-title":"Chinese Journal of Comparative Medicine"},{"key":"10.1016\/j.phymed.2017.09.001_bib0027","doi-asserted-by":"crossref","first-page":"e1293","DOI":"10.1038\/cddis.2014.250","article-title":"Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2017.09.001_bib0028","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00041552-200403000-00008","article-title":"Role of matrix metalloproteinases in hypertension-associated cardiac fibrosis","volume":"13","author":"L\u00f3pez","year":"2004","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.phymed.2017.09.001_bib0029","doi-asserted-by":"crossref","first-page":"13885","DOI":"10.1039\/C4CC04498C","article-title":"Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library","volume":"50","author":"Ma","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.phymed.2017.09.001_bib0030","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejmech.2017.03.033","article-title":"Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive e based, natural product lead optimization approach","volume":"133","author":"Manivannan","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2017.09.001_bib0031","first-page":"743","article-title":"Sheng-Mai-San attenuates contractile dysfunction and structural damage induced by chronic intermittent hypoxia in mice","volume":"13","author":"Mo","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2017.09.001_bib0032","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2017.09.001_bib0033","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2013.10.018","article-title":"Cardiac fibrosis and arrhythmogenesis: the road to repair is paved with perils","volume":"70","author":"Nguyen","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0034","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0254-6272(11)60044-7","article-title":"Study on the protective effect of shengmai san (see text) on the myocardium in the type 2 diabetic cardiomyopathy model rat","volume":"31","author":"Ni","year":"2011","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2017.09.001_bib0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1620\/tjem.197.159","article-title":"Upregulated expression of transforming growth factor- beta, type IV collagen, and plasminogen activator inhibitor- 1 mRNA are decreased after release of unilateral ureteral obstruction","volume":"197","author":"Ogata","year":"2002","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.phymed.2017.09.001_bib0036","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bcp.2011.11.002","article-title":"Schisandrin B suppresses TGFbeta1 signaling by inhibiting Smad2\/3 and MAPK pathways","volume":"83","author":"Park","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0037","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cell.2015.11.031","article-title":"A new golden age of natural products drug discovery","volume":"163","author":"Shen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2017.09.001_bib0038","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cardiores.2005.08.017","article-title":"IL-6 induces PI 3-kinase and nitricoxide-dependentprotection and preservesmitochondrialfunction in cardiomyocytes","volume":"69","author":"Smart","year":"2006","journal-title":"Cardiovasc"},{"key":"10.1016\/j.phymed.2017.09.001_bib0039","first-page":"1176","article-title":"Traditional herbs: a remedy for cardiovascular disorders","volume":"18","author":"Rastogi","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2017.09.001_bib0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2172-12-69","article-title":"Impact of acute stress on antimicrobial polypeptides mRNA copy number in several tissues of marine sea bass (Dicentrarchus labrax)","volume":"12","author":"Terova","year":"2011","journal-title":"BMC Immunol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0041","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/01.shk.0000226341.32786.b9","article-title":"Jak\/STAT\/SOCS signaling circuits and associated cytokine-mediated inflammation and hypertrophy in the heart","volume":"26","author":"Terrell","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2017.09.001_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119214","article-title":"Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK\/p53 signaling","volume":"10","author":"Thandavarayan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2017.09.001_bib0043","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/01.PRS.0000129079.19089.6C","article-title":"Matrix Metalloproteinases, tissue Inhibitors of Metalloproteinases, aminoterminal propeptide of procollagen type III, and hyaluronan in sera and tissue of patients with capsular contracture after augmentation with trilucent breast implants","volume":"114","author":"Ulrich","year":"2004","journal-title":"Plast. Reconstruct. Surg."},{"key":"10.1016\/j.phymed.2017.09.001_bib0044","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2017.09.001_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1254\/jphs.FP0050018","article-title":"Shengmai San, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation","volume":"98","author":"Wang","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2017.09.001_bib0046","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1253\/circj.66.763","article-title":"Sheng-Mai-San is protective against post-ischemic myocardial dysfunction in rats through its opening of the mitochondrial KATP channels","volume":"66","author":"Wang","year":"2002","journal-title":"Circ J"},{"key":"10.1016\/j.phymed.2017.09.001_bib0047","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.foodchem.2009.07.061","article-title":"Structural and enhanced memory activity studies of extracts from Panax ginseng root","volume":"119","author":"Wang","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2017.09.001_bib0048","first-page":"95","article-title":"The role of interleukin-6 in the failingheart","volume":"6","author":"Wollert","year":"2001","journal-title":"HeartFail Rev."},{"key":"10.1016\/j.phymed.2017.09.001_bib0049","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1681\/ASN.2008091007","article-title":"C\/EBP- beta modulates transcription of tubulointerstitial nephritis antigen in obstructiveuropathy","volume":"20","author":"Xie","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0050","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jep.2013.04.019","article-title":"Cardioprotective effects of the YiQiFuMai injection and isolated compounds on attenuating chronic heart failure via NF-\u0138B inactivation and cytokine suppression","volume":"148","author":"Xing","year":"2013","journal-title":"J. Ethopharmacol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0051","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1152\/ajpheart.00624.2003","article-title":"Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroidson IL-6 regulation and cardiac function","volume":"287","author":"Yang","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phymed.2017.09.001_bib0052","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1089\/rej.2008.0771","article-title":"Long-term treatment with a Chinese herbal formula, Sheng-Mai-San, improves cardiac contractile function in aged rats: the role of Ca(2+) homeostasis","volume":"11","author":"Zhang","year":"2008","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.phymed.2017.09.001_bib0053","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1756-5391.2010.01089.x","article-title":"Adverse drug reactions of SHENMAI injection: a systematic review","volume":"3","author":"Zhang","year":"2010","journal-title":"J. Evid. Based Med."},{"key":"10.1016\/j.phymed.2017.09.001_bib0054","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1124\/jpet.114.219261","article-title":"Ophiopogonin D attenuates doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo","volume":"352","author":"Zhang","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2017.09.001_bib0055","first-page":"170","article-title":"Expression of CNP\/NPR-B axis and NPR-C\/NEP elimination pathway in rats with unilateral ureteral obstruction","volume":"32","author":"Zhao","year":"2014","journal-title":"J Clin Pediatr"},{"key":"10.1016\/j.phymed.2017.09.001_bib0056","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1039\/C5CC02728D","article-title":"Structure-based discovery of an immunomodulatory inhibitor of TLR1\u2013TLR2 heterodimerization from a natural product-like database","volume":"51","author":"Zhong","year":"2015","journal-title":"Chem. Commun."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T10:06:31Z","timestamp":1535277991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711317301174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":55,"alternative-id":["S0944711317301174"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2017.09.001","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2017.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}