{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:11:43Z","timestamp":1778778703329,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC101-2320-B-324-001"],"award-info":[{"award-number":["NSC101-2320-B-324-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["102-2320-B-324-001"],"award-info":[{"award-number":["102-2320-B-324-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC102-2320-B-030-012-MY2"],"award-info":[{"award-number":["NSC102-2320-B-030-012-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC101-2320-B-030-013"],"award-info":[{"award-number":["NSC101-2320-B-030-013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2632-B-324-001"],"award-info":[{"award-number":["105-2632-B-324-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.phymed.2017.09.015","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T23:00:50Z","timestamp":1506639650000},"page":"137-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A comparative proteomic study of secretomes in kaempferitrin-treated CTX TNA2 astrocytic cells"],"prefix":"10.1016","volume":"36","author":[{"given":"Wei-chi","family":"Ku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-ling","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-fa","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-nung","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yew-min","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-ru","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-ming","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh Chandra","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-lan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-an","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siendong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-jen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2017.09.015_bib0001","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/(SICI)1097-4547(19991215)58:6<815::AID-JNR8>3.0.CO;2-R","article-title":"Neuroprotective effects of estradiol in the adult rat hippocampus: interaction with insulin-like growth factor-I signalling","volume":"58","author":"Azcoitia","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phymed.2017.09.015_bib0002","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nprot.2009.21","article-title":"Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics","volume":"4","author":"Boersema","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2017.09.015_bib0003","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.phymed.2009.06.007","article-title":"Hypoglycemic activity of dried extracts of Bauhinia forficata link","volume":"17","author":"da Cunha","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2017.09.015_bib0005","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1515\/znc-2000-5-627","article-title":"Phytochemical and pharmacognostic investigation of Bauhinia forficata link (Leguminosae)","volume":"55","author":"da Silva","year":"2000","journal-title":"Z. Naturforsc. C"},{"key":"10.1016\/j.phymed.2017.09.015_bib0006","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/np030513u","article-title":"Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves","volume":"67","author":"de Sousa","year":"2004","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2017.09.015_bib0007","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jep.2013.03.072","article-title":"Kaempferitrin induces immunostimulatory effects in vitro","volume":"148","author":"Del Carmen Juarez-Vazquez","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0008","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.bmc.2005.01.050","article-title":"Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS\/IFN-gamma-activated murine macrophages","volume":"13","author":"Fang","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phymed.2017.09.015_bib0009","doi-asserted-by":"crossref","first-page":"R668","DOI":"10.1152\/ajpregu.00058.2011","article-title":"Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate","volume":"301","author":"Fanne","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.expneurol.2013.11.020","article-title":"Extracellular matrix regulation of inflammation in the healthy and injured spinal cord","volume":"258","author":"Gaudet","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0011","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.imbio.2008.11.004","article-title":"Influence of the mannose receptor in host immune responses","volume":"214","author":"Gazi","year":"2009","journal-title":"Immunobiology"},{"key":"10.1016\/j.phymed.2017.09.015_bib0012","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2017.09.015_bib0013","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1742-2094-11-68","article-title":"Exosomes as mediators of neuroinflammation","volume":"11","author":"Gupta","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2017.09.015_bib0014","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fendo.2014.00043","article-title":"Control of IGFBP-2 expression by steroids and peptide hormones in vertebrates","volume":"5","author":"Hoeflich","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12929-014-0092-0","article-title":"Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite","volume":"21","author":"Hung","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.phymed.2017.09.015_bib0016","first-page":"177","article-title":"Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling","volume":"50","author":"Imparl-Radosevich","year":"1998","journal-title":"Horm. Res."},{"issue":"Suppl 2","key":"10.1016\/j.phymed.2017.09.015_bib0017","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.2337\/dc11-s225","article-title":"Insulin: potential negative consequences of early routine use in patients with type 2 diabetes","volume":"34","author":"Lebovitz","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2017.09.015_bib0018","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jep.2009.08.006","article-title":"Effect of flavonol glycosides from Cinnamomum osmophloeum leaves on adiponectin secretion and phosphorylation of insulin receptor-beta in 3T3-L1 adipocytes","volume":"126","author":"Lee","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0019","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1021\/jf401039z","article-title":"Chemical composition and hypoglycemic and pancreas-protective effect of leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kanehira)","volume":"61","author":"Lee","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2017.09.015_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-5728(99)00084-3","article-title":"Adhesion molecule expression and regulation on cells of the central nervous system","volume":"98","author":"Lee","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0021","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.fct.2012.10.024","article-title":"Protective effect of cinnamon polyphenols against STZ-diabetic mice fed high-sugar, high-fat diet and its underlying mechanism","volume":"51","author":"Li","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0022","series-title":"Studies and ethanol extract of Cinnamomum osmophloeum Kaneh against diabetic rat","author":"Lin","year":"2013"},{"key":"10.1016\/j.phymed.2017.09.015_bib0023","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/ptr.3408","article-title":"Antidyslipidemic activity of hot-water extracts from leaves of Cinnamomum osmophloeum Kaneh","volume":"25","author":"Lin","year":"2011","journal-title":"Phytother. Res. PTR"},{"key":"10.1016\/j.phymed.2017.09.015_bib0024","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1248\/bpb.27.125","article-title":"Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats","volume":"27","author":"Lino Cde","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2017.09.015_bib0025","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1073\/pnas.0508139103","article-title":"Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation","volume":"103","author":"Majdalawieh","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.phymed.2017.09.015_bib0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1471-4159.2004.02841.x","article-title":"Insulin exerts neuroprotection by counteracting the decrease in cell-surface GABA receptors following oxygen-glucose deprivation in cultured cortical neurons","volume":"92","author":"Mielke","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2017.09.015_bib0027","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/sj.ijo.0800412","article-title":"Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone","volume":"21","author":"Nam","year":"1997","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.phymed.2017.09.015_bib0028","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2174\/156720508785908919","article-title":"Insulin resistance and Alzheimer's disease: molecular links & clinical implications","volume":"5","author":"Neumann","year":"2008","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.phymed.2017.09.015_bib0029","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1074\/mcp.T500030-MCP200","article-title":"Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap","volume":"4","author":"Olsen","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.phymed.2017.09.015_bib0030","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1021\/jf103997s","article-title":"Lotus corniculatus regulates the inflammation induced by bradykinin in a murine model of pleurisy","volume":"59","author":"Pereira","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2017.09.015_bib0031","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/cne.21149","article-title":"Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved","volume":"500","author":"Pineau","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0032","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"Rappsilber","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2017.09.015_bib0033","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.3390\/molecules16043338","article-title":"Kaempferol and kaempferol rhamnosides with depigmenting and anti-inflammatory properties","volume":"16","author":"Rho","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2017.09.015_bib0034","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cytogfr.2014.12.001","article-title":"IGFBP-2: the dark horse in metabolism and cancer","volume":"26","author":"Russo","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.phymed.2017.09.015_bib0035","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-8993(89)90078-4","article-title":"Production of tumor necrosis factor-alpha by microglia and astrocytes in culture","volume":"491","author":"Sawada","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.phymed.2017.09.015_bib0036","doi-asserted-by":"crossref","first-page":"26279","DOI":"10.1074\/jbc.M110.134775","article-title":"Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease","volume":"285","author":"Strauss","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2017.09.015_bib0037","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/386506a0","article-title":"A second serine protease associated with mannan-binding lectin that activates complement","volume":"386","author":"Thiel","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2017.09.015_bib0038","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejphar.2009.01.023","article-title":"Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes","volume":"607","author":"Tzeng","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0039","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/978-1-4614-0653-2_19","article-title":"Neurodegeneration in diabetes mellitus","volume":"724","author":"Umegaki","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2017.09.015_bib0040","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1074\/mcp.M112.021618","article-title":"Unconventional secretion is a major contributor of cancer cell line secretomes","volume":"12","author":"Villarreal","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.phymed.2017.09.015_bib0041","doi-asserted-by":"crossref","first-page":"21384","DOI":"10.1074\/jbc.M112.340513","article-title":"Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD)","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.phymed.2017.09.015_bib0042","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.euroneuro.2014.01.020","article-title":"Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects","volume":"24","author":"Werner","year":"2014","journal-title":"Eur. Neuropsychopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:30:06Z","timestamp":1778776206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711317301320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":42,"alternative-id":["S0944711317301320"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2017.09.015","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparative proteomic study of secretomes in kaempferitrin-treated CTX TNA2 astrocytic cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2017.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}