{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:17:45Z","timestamp":1790770665408,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["MLP0039"],"award-info":[{"award-number":["MLP0039"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["MLP0066"],"award-info":[{"award-number":["MLP0066"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.phymed.2017.09.018","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T08:46:10Z","timestamp":1506674770000},"page":"108-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Iridoid glycosides fraction from Picrorhiza kurroa attenuates cyclophosphamide-induced renal toxicity and peripheral neuropathy via PPAR-\u03b3 mediated inhibition of inflammation and apoptosis"],"prefix":"10.1016","volume":"36","author":[{"given":"Supriya","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Kulurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damanpreet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Patial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2017.09.018_bib0001","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cbi.2014.11.001","article-title":"Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats","volume":"224","author":"Abd","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2017.09.018_bib0002","doi-asserted-by":"crossref","first-page":"8861","DOI":"10.1158\/0008-5472.CAN-08-1902","article-title":"Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis","volume":"68","author":"Anand","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2017.09.018_bib0003","first-page":"1373","article-title":"Effects of acrolein on rat liver antioxidant defense system","volume":"35","author":"Arumugam","year":"1997","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0004","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejon.2008.10.003","article-title":"Docetaxel related side effects and their management","volume":"13","author":"Baker","year":"2009","journal-title":"Eur. J. Oncol. Nurs."},{"key":"10.1016\/j.phymed.2017.09.018_bib0005","first-page":"323","article-title":"Online hplc-dpph method for antioxidant activity of Picrorhiza kurroa royle ex Benth. and characterization of kutkoside by ultra-performance LC-electrospray ionization quadrupole time-of-flight mass spectrometry","volume":"48","author":"Bhandari","year":"2010","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0006","doi-asserted-by":"crossref","first-page":"47","DOI":"10.15806\/j.issn.2311-8571.2015.0019","article-title":"Herbal medicines for acute kidney injury: evidence, gaps and frontiers","volume":"1","author":"Bunel","year":"2015","journal-title":"World J. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2017.09.018_bib0007","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12031-011-9662-8","article-title":"Changes of peroxisome proliferator-activated receptor-\u03b3 on crushed rat sciatic nerves and differentiated primary Schwann cells","volume":"47","author":"Cao","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.phymed.2017.09.018_bib0008","first-page":"6","article-title":"Chemotherapy induced peripheral neuropathy","volume":"7","author":"del Pino","year":"2010","journal-title":"NCI Cancer Bull."},{"key":"10.1016\/j.phymed.2017.09.018_bib0009","series-title":"Therapeutic Drugs","first-page":"349","article-title":"Cyclophosphamide","author":"Dollery","year":"1999"},{"key":"10.1016\/j.phymed.2017.09.018_bib0010","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pain.2004.01.029","article-title":"Ethosuximide reverses paclitaxel- and vincritine-induced painful peripheral neuropathy","volume":"109","author":"Flatters","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.phymed.2017.09.018_bib0011","first-page":"238","article-title":"Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines? Front","volume":"8","author":"Freitag","year":"2014","journal-title":"Cell Neurosci."},{"key":"10.1016\/j.phymed.2017.09.018_bib0012","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.niox.2015.09.002","article-title":"Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxide-mediated Nrf2\/ARE signaling pathway and apoptosis inhibition","volume":"50","author":"Gupta","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.phymed.2017.09.018_bib0013","first-page":"3016","article-title":"Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein","volume":"42","author":"Hales","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2017.09.018_bib0014","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5455\/jice.20140916011549","article-title":"Protective effect of cornel iridoid glycoside in D-galactosamine\/tumor necrosis factor-\u03b1-injured L02 hepatocytes and its mechanism","volume":"3","author":"Jiang","year":"2014","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0378-8741(00)00168-9","article-title":"Effect of Picrorhiza kurroa extract on transplanted tumours and chemical carcinogenesis in mice","volume":"71","author":"Joy","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0016","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.2353\/ajpath.2010.090370","article-title":"Peroxisome proliferator-activated receptor (PPAR)\u03b3 can inhibit chronic renal allograft damage","volume":"176","author":"Kiss","year":"2010","journal-title":"Am J Pathol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0017","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1007\/s10973-013-3179-z","article-title":"Examination of the cyclophosphamide-induced polyneuropathy on guinea pig sciatic nerve and gastrocnemius muscle with differential scanning calorimetry","volume":"115","author":"K\u00f6ncz\u00f6l","year":"2014","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.phymed.2017.09.018_bib0018","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/1386207319666160114092538","article-title":"Comprehensive metabolomic profiling of an endangered medicinal plant Picrorhiza kurroa Royle ex Benth cultivated in Indian Himalayas","volume":"19","author":"Kumar","year":"2016","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.phymed.2017.09.018_bib0019","first-page":"337","article-title":"Nephrotoxicity of anticancer drugs\u2014an underestimated problem?","volume":"66","author":"Lameire","year":"2011","journal-title":"Acta Clin. Belg."},{"key":"10.1016\/j.phymed.2017.09.018_bib0020","first-page":"F243","article-title":"PPAR-alpha ligand ameliorates acute renal failure by reducing cisplatin-induced increased expression of renal endonuclease G","volume":"288","author":"Li","year":"2004","journal-title":"Am J Physiol Renal Physiol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0021","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pbb.2012.06.007","article-title":"Analgesic effect of iridoid glycosides from Paederia Scandens (Lour.) Merrill (Rubiaceae) on spared nerve injury rat model of neuropathic pain","volume":"102","author":"Liu","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2017.09.018_bib0022","doi-asserted-by":"crossref","first-page":"e24740","DOI":"10.1371\/journal.pone.0024740","article-title":"Iridoid glycosides fraction of Folium syringae leaves modulates NF-kB signal pathway and intestinal epithelial cells apoptosis in experimental colitis","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2017.09.018_bib0023","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1139\/cjpp-2014-0204","article-title":"Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPAR\u03b3 and abrogation of oxidative stress and inflammation","volume":"92","author":"Mahmoud","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0024","doi-asserted-by":"crossref","first-page":"14747","DOI":"10.1074\/jbc.M210819200","article-title":"15d-PGJ2 and rosiglitazone suppress JAK-STAT inflammatory signaling through induction of SOCS1 and SOCS3 in glia","volume":"278","author":"Park","year":"2003","journal-title":"J Biol Chem."},{"key":"10.1016\/j.phymed.2017.09.018_bib0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11010-012-1250-x","article-title":"Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid","volume":"365","author":"Rehman","year":"2012","journal-title":"Mol. Cell Biochem."},{"issue":"403","key":"10.1016\/j.phymed.2017.09.018_bib0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/47520","article-title":"Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase","volume":"6","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2017.09.018_bib0027","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.etap.2015.04.012","article-title":"Phytotrapy of cyclophosphamide-induced immunosuppression","volume":"39","author":"Shirani","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1392","key":"10.1016\/j.phymed.2017.09.018_bib0028","first-page":"e1","article-title":"The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats","volume":"80","author":"Sinanoglu","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.phymed.2017.09.018_bib0029","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/713857191","article-title":"Protection against cyclophosphamide-induced renal oxidative stress by amifostine: the role of antioxidative mechanisms","volume":"13","author":"Stankiewicz","year":"2003","journal-title":"Toxicol. Mech. Meth."},{"key":"10.1016\/j.phymed.2017.09.018_bib0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-8069-5-9","article-title":"Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli","volume":"5","author":"Ta","year":"2009","journal-title":"Mol. Pain"},{"key":"10.1016\/j.phymed.2017.09.018_bib0031","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.fct.2009.01.021","article-title":"Therapeutic efficacy of Picroliv in chronic cadmium toxicity","volume":"47","author":"Yadav","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2017.09.018_bib0032","doi-asserted-by":"crossref","first-page":"27252","DOI":"10.3390\/ijms161126021","article-title":"Chemical profiles and protective effect of Hedyotis diffusa Willd in lipopolysaccharide-induced renal inflammation mice","volume":"16","author":"Ye","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2017.09.018_bib0033","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1046\/j.1471-4159.2002.00899.x","article-title":"Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPAR\u00c1","volume":"81","author":"Zander","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2017.09.018_bib0034","doi-asserted-by":"crossref","DOI":"10.1007\/s00005-008-0037-y","article-title":"Structure and physiological functions of the human peroxisome proliferator-activated receptor gamma","author":"Zieleniak","year":"2008","journal-title":"Arch. Immunol. Ther. Exp."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T02:35:09Z","timestamp":1535337309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711317301344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":34,"alternative-id":["S0944711317301344"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2017.09.018","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iridoid glycosides fraction from Picrorhiza kurroa attenuates cyclophosphamide-induced renal toxicity and peripheral neuropathy via PPAR-\u03b3 mediated inhibition of inflammation and apoptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2017.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}