{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:48:10Z","timestamp":1792007290238,"version":"4.4.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 524"],"award-info":[{"award-number":["PIP 524"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT2014-1170"],"award-info":[{"award-number":["PICT2014-1170"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT2016-1833"],"award-info":[{"award-number":["PICT2016-1833"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.phymed.2017.10.021","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T07:19:10Z","timestamp":1511507950000},"page":"14-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Hybrid combinations containing natural products and antimicrobial drugs that interfere with bacterial and fungal biofilms"],"prefix":"10.1016","volume":"37","author":[{"given":"Susana A.","family":"Zacchino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Butassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Cordisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Svetaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2017.10.021_bib0001","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/jac\/dkr512","article-title":"Antibiofilm activity of certain phytocompounds and their synergy with fluconazole against Candida albicans biofilms","volume":"67","author":"Ahmad Khan","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0002","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jac\/44.1.43","article-title":"Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in vitro","volume":"44","author":"Amorena","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0003","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/1874437001105010029","article-title":"Antibiofilm strategies: how to eradicate Candida biofilms","volume":"5","author":"Bink","year":"2011","journal-title":"Open Mycol. J."},{"key":"10.1016\/j.phymed.2017.10.021_bib0004","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1128\/AAC.49.10.4339-4343.2005","article-title":"Epigallocatechin gallate inhibits biofilm formation by ocular staphylococcal isolates","volume":"49","author":"Blanco","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0167-7012(99)00048-2","article-title":"LIVE\/DEAD\u00ae Baclight\u2122: application of a new rapid staining method for direct enumeration of viable and total bacteria in drinking water","volume":"37","author":"Boulos","year":"1999","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.phymed.2017.10.021_bib0006","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2017.10.021_bib0007","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Using the Chou-Talalay method drug combination studies and their synergy quantification","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.phymed.2017.10.021_bib0008","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enz. Regul."},{"key":"10.1016\/j.phymed.2017.10.021_bib0009","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1128\/jcm.22.6.996-1006.1985","article-title":"Adherence of coagulase negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices","volume":"22","author":"Christensen","year":"1985","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mimet.2010.08.018","article-title":"In vitro and in vivo model systems to study microbial biofilm formation","volume":"83","author":"Coenye","year":"2010","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.phymed.2017.10.021_bib0011","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/scientificamerican0178-86","article-title":"How bacteria stick","volume":"238","author":"Costerton","year":"1978","journal-title":"Sci. Am."},{"key":"10.1016\/j.phymed.2017.10.021_bib0012","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.phymed.2017.10.021_bib0013","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/417243a","article-title":"Caenorhabditis elegans: plague bacteria biofilm blocks food intake","volume":"417","author":"Darby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2017.10.021_bib0014","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1128\/AAC.04229-14","article-title":"Artemisinins, new miconazole potentiators resulting in increased activity against Candida albicans biofilms","volume":"59","author":"De Cremer","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0015","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/jac\/dkt449","article-title":"Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms","volume":"69","author":"Delattin","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0016","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2323\/jgam.60.163","article-title":"Sensitization of Candida albicans biofilms to fluconazole by terpenoids of plant origin","volume":"60","author":"Doke","year":"2014","journal-title":"J. Gen. Appl. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0017","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1128\/jcm.32.10.2564-2568.1994","article-title":"Testing antimicrobial susceptibilities of adherent bacteria by a method that incorporates guidelines of the National Committee for Clinical Laboratory Standards","volume":"32","author":"Domingue","year":"1994","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0018","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3201\/eid0809.020063","article-title":"Biofilms: microbial life on surfaces","volume":"8","author":"Donlan","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.phymed.2017.10.021_bib0019","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0167-7012(02)00011-8","article-title":"Evaluation of redox indicators and the use of digital scanners and spectrophotometer for quantification of microbial growth in microplates","volume":"50","author":"Gabrielson","year":"2002","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.phymed.2017.10.021_bib0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/jac\/40.3.329","article-title":"The development of a small-scale biofilm model suitable for studying the effects of antibiotics on biofilms of gram-negative bacteria","volume":"40","author":"Gander","year":"1997","journal-title":"J. Antimicrob. Chemother"},{"key":"10.1016\/j.phymed.2017.10.021_bib0021","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1128\/AAC.01037-06","article-title":"Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin","volume":"51","author":"Garo","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0022","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.pnsc.2008.04.001","article-title":"Bacterial adhesion and biofilm in surfaces","volume":"18","author":"Garrett","year":"2008","journal-title":"Prog. Nat. Sci"},{"issue":"98S","key":"10.1016\/j.phymed.2017.10.021_bib0023","first-page":"110S","article-title":"Biofilms in vitro and in vivo: do singular mechanisms imply cross-resistance?","volume":"92","author":"Gilbert","year":"2002","journal-title":"J. Appl. Microbiol"},{"key":"10.1016\/j.phymed.2017.10.021_bib0024","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1522-7243(199901\/02)14:1<23::AID-BIO513>3.0.CO;2-M","article-title":"In vitro development of Staphylococcus aureus biofilms using slime-producing variants and ATP-bioluminescence for automated bacterial quantification","volume":"14","author":"Gracia","year":"1999","journal-title":"Luminescence"},{"key":"10.1016\/j.phymed.2017.10.021_bib0025","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0031-6997(25)06847-4","article-title":"The search for synergy: a critical review from a response surface perspective","volume":"47","author":"Greco","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2017.10.021_bib0026","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0021-9258(18)72830-5","article-title":"The isolation of bactericidal substances from cultures of Bacillus brevis","volume":"141","author":"Hotchkiss","year":"1941","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2017.10.021_bib0027","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1515\/znc-2003-11-1224","article-title":"Influence of polyphenols on bacterial biofilm formation and quorum-sensing","volume":"58c","author":"Huber","year":"2003","journal-title":"Z. Naturforsch"},{"key":"10.1016\/j.phymed.2017.10.021_bib0028","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1055\/s-0029-1185541","article-title":"Additive antimicrobial effects of the active components of the essential oil of Thymus vulgaris\u2013chemotype carvacrol","volume":"75","author":"Iten","year":"2009","journal-title":"Planta Med"},{"key":"10.1016\/j.phymed.2017.10.021_bib0029","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1128\/AAC.50.4.1463-1469.2006","article-title":"Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility","volume":"50","author":"Jabra-Rizk","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0030","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/jac\/dku374","article-title":"In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms","volume":"70","author":"Katragkou","year":"2015","journal-title":"J. Antimicrob. Chemother"},{"key":"10.1016\/j.phymed.2017.10.021_bib0031","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1128\/AEM.71.2.797-803.2005","article-title":"Antimicrobial action of carvacrol at different stages of dual-species biofilm development by Staphylococcus aureus and Salmonella enterica serovar Typhimurium","volume":"71","author":"Knowles","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0032","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1034\/j.1399-302X.2002.170602.x","article-title":"Effects of apigenin and tt-farnesol on glucosyltransferase activity","volume":"17","author":"Koo","year":"2002","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0033","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ijantimicag.2016.01.007","article-title":"Effect of caspofungin and micafungin in combination with farnesol against Candida parapsilosis biofilms","volume":"47","author":"Kov\u00e1cs","year":"2016","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.phymed.2017.10.021_bib0034","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.phymed.2005.10.008","article-title":"Antimicrobial activity of diterpenoids from hairy roots of Salvia sclarea L.: salvipisone as a potential antibiofilm agent active against antibiotic resistant staphylococci","volume":"14","author":"Kuzma","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2017.10.021_bib0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/jac\/49.2.345","article-title":"Comparison of Etest, chequerboard dilution and time-kill studies for the detection of synergy or antagonism between antifungal agents tested against Candida species","volume":"49","author":"Lewis","year":"2002","journal-title":"J Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0108","doi-asserted-by":"crossref","first-page":"6558","DOI":"10.1128\/jb.173.20.6558-6567.1991","article-title":"Optical sectioning of microbial biofilms","volume":"173","author":"Lawrence","year":"1991","journal-title":"J. Bacteriol"},{"key":"10.1016\/j.phymed.2017.10.021_bib0036","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrmicro1557","article-title":"Persister cells, dormancy and infectious disease","volume":"5","author":"Lewis","year":"2007","journal-title":"Nature Rev.\/Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0037","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1081\/MC-120020161","article-title":"Review of chitosan and its derivatives as antimicrobial agents and their use as textile chemicals","volume":"43","author":"Lim","year":"2003","journal-title":"J. Macromol. Sci. Part C"},{"key":"10.1016\/j.phymed.2017.10.021_bib0038","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/lam.12401","article-title":"Synergy among thymol, eugenol, berberine, cinnamaldehyde and streptomycin against planktonic and biofilm-associated food-borne pathogens","volume":"60","author":"Liu","year":"2015","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0039","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1128\/AAC.01557-09","article-title":"Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France","volume":"54","author":"Morvan","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"e307","key":"10.1016\/j.phymed.2017.10.021_bib0040","first-page":"2458","article-title":"Looking for chinks in the armor of bacterial biofilms","volume":"5","author":"Monroe","year":"2007","journal-title":"PLoSBiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0041","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.foodcont.2013.10.032","article-title":"Inhibitory effects of chitosan in combination with antibiotics on Listeria monocytogenes biofilm","volume":"38","author":"Mu","year":"2014","journal-title":"Food Control"},{"key":"10.1016\/j.phymed.2017.10.021_bib0042","doi-asserted-by":"crossref","first-page":"22296","DOI":"10.3390\/ijms151222296","article-title":"Chitosan improves antibiofilm efficacy of gentamicin through facilitating antibiotic penetration","volume":"15","author":"Mu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2017.10.021_bib0043","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/AAC.27.4.619","article-title":"Tobramycin resistance of Pseudomonas aeruginosa cells growing as a biofilm on urinary catheter material","volume":"27","author":"Nickel","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0044","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1128\/AEM.70.12.6951-6956.2004","article-title":"Colorimetric method for identifying plant essential oils components that affect biofilm formation and structure","volume":"70","author":"Niu","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0045","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1046\/j.1432-1327.2000.01606.x","article-title":"Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity","volume":"267","author":"O'Brien","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.phymed.2017.10.021_bib0046","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3390\/molecules15031705","article-title":"The molecular mechanism of action of artemisinin-the debate continues","volume":"15","author":"O'Neill","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2017.10.021_bib0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0048","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1203\/PDR.0b013e318232a984","article-title":"Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin","volume":"70","author":"Pammi","year":"2011","journal-title":"Ped. Res."},{"key":"10.1016\/j.phymed.2017.10.021_bib0049","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mimet.2007.11.010","article-title":"Comparison of multiple methods for quantification of microbial biofilms grown in microtiter plates","volume":"72","author":"Peeters","year":"2008","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.phymed.2017.10.021_bib0050","first-page":"1032","article-title":"Candida albicans biofilm inhibition by synergistic action of terpenes and fluconazole","volume":"51","author":"Pemmaraju","year":"2013","journal-title":"Ind. J. Exp. Biol"},{"key":"10.1016\/j.phymed.2017.10.021_bib0051","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/nprot.2008.141","article-title":"A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing","volume":"3","author":"Pierce","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2017.10.021_bib0052","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/528521","article-title":"Fungal biofilm resistance","author":"Ramage","year":"2012","journal-title":"Int. J. Microbiol. 528-521."},{"key":"10.1016\/j.phymed.2017.10.021_bib0053","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/AAC.37.3.613","article-title":"Reproducibility of the microdilution checkerboard method for antibiotic synergy","volume":"37","author":"Rand","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0054","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0022-1759(91)90114-U","article-title":"An improved colorimetric assay for cell proliferation and viability utilising the tetrazolium salt XTT","volume":"142","author":"Roehm","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.phymed.2017.10.021_bib0055","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jobm.200510088","article-title":"Effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol on the biofilm formation of Streptococcus mutans","volume":"46","author":"Rukayadi","year":"2006","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0056","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1128\/IAI.67.5.2627-2632.1999","article-title":"Characterization of the importance of polysaccharide intercellular adhesin\/hemagglutinin of Staphylococcus epidermidis in the pathogenesis of biomaterial-based infection in a mouse foreign body infection model","volume":"67","author":"Rupp","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.phymed.2017.10.021_bib0057","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1601-0825.2007.01424.x","article-title":"Biofilm lifestyle of Candida: a mini review","volume":"14","author":"Seneviratne","year":"2008","journal-title":"Oral Dis"},{"key":"10.1016\/j.phymed.2017.10.021_bib0058","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.archoralbio.2009.08.002","article-title":"Architectural analysis, viability assessment and growth kinetics of Candida albicans and Candida glabrata biofilms","volume":"54","author":"Seneviratne","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0059","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1039\/b821648g","article-title":"Understanding antimicrobial activities of phytochemicals against multidrug resistant bacteria and biofilms","volume":"26","author":"Sim\u00f5es","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phymed.2017.10.021_bib0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0167-7012(00)00122-6","article-title":"A modified microtiter-plate test for quantification of staphylococcal biofilm formation","volume":"40","author":"Stepanovic","year":"2000","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.phymed.2017.10.021_bib0061","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1078\/1438-4221-00196","article-title":"Mechanisms of antibiotic resistance in bacterial biofilms","volume":"292","author":"Stewart","year":"2002","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0062","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0140-6736(01)05321-1","article-title":"Antibiotic resistance of bacteria in biofilms","volume":"358","author":"Stewart","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2017.10.021_bib0063","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev.micro.56.012302.160705","article-title":"Biofilms as complex differentiated communities","volume":"56","author":"Stoodley","year":"2002","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0064","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10327-007-0005-0","article-title":"Epigallocatechin gallate, a major tea catechin, induces biofilm formation of Pseudomonas syringae pv. theae","volume":"73","author":"Tomihama","year":"2007","journal-title":"J. Gen. Plant Pathol."},{"key":"10.1016\/j.phymed.2017.10.021_bib0065","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1128\/AAC.02381-14","article-title":"Synergistic activity of the tyrocidines, antimicrobial cyclodecapeptides from Bacillus aneurinolyticus, with amphotericin B and caspofungin against Candida albicans biofilms","volume":"58","author":"Troskie","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.10.021_bib0066","first-page":"283","article-title":"Model of Staphylococcus aureus central venous catheter-associated infection in rats","volume":"49","author":"Ulphani","year":"1999","journal-title":"Lab. Anim. Sci."},{"key":"10.1016\/j.phymed.2017.10.021_bib0067","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1086\/424487","article-title":"Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo","volume":"190","author":"Vuong","year":"2004","journal-title":"J. Inf. Dis."},{"key":"10.1016\/j.phymed.2017.10.021_bib0068","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1055\/s-2007-967179","article-title":"Salvipisone and aethiopinone from Salvia sclarea hairy roots modulate Staphylococcus antibiotic resistance and express antibiofilm activity","volume":"73","author":"Walencka","year":"2007","journal-title":"Planta Med"},{"key":"10.1016\/j.phymed.2017.10.021_bib0069","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.micpath.2015.07.006","article-title":"In vitro antifungal activity of baicalin against Candida albicans biofilms via apoptotic induction","volume":"87","author":"Wang","year":"2015","journal-title":"Microb. Pathogen"},{"key":"10.1016\/j.phymed.2017.10.021_bib0070","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.archoralbio.2010.11.021","article-title":"In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures","volume":"56","author":"Wei","year":"2011","journal-title":"Archiv. Oral Biol"},{"key":"10.1016\/j.phymed.2017.10.021_bib0071","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4103\/0971-5916.156631","article-title":"Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli","volume":"141","author":"Wojnicz","year":"2015","journal-title":"Indian J. Med Res."},{"key":"10.1016\/j.phymed.2017.10.021_bib0072","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1021\/pr9005074","article-title":"Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: endogenous ROS augmentation","volume":"8","author":"Xu","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.phymed.2017.10.021_bib0073","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1158\/1078-0432.CCR-04-1087","article-title":"Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses","volume":"10","author":"Zhao","year":"2004","journal-title":"Clin. Cancer Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:15:18Z","timestamp":1751030118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711317301599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":74,"alternative-id":["S0944711317301599"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2017.10.021","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hybrid combinations containing natural products and antimicrobial drugs that interfere with bacterial and fungal biofilms","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2017.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}