{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:15:54Z","timestamp":1784657754512,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173504"],"award-info":[{"award-number":["81173504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Province of China","award":["2008PY001"],"award-info":[{"award-number":["2008PY001"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.phymed.2017.12.023","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T13:30:08Z","timestamp":1513863008000},"page":"93-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates"],"prefix":"10.1016","volume":"39","author":[{"given":"Guo-Ying","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Xian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2017.12.023_bib0001","first-page":"17","article-title":"Phytochemistry, pharmacology, and clinical trials of Morus alba","volume":"14","author":"Chan","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2017.12.023_bib0002","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1128\/JCM.43.7.3574-3575.2005","article-title":"Inhibition of growth of Streptococcus mutans, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococci by kurarinone, a bioactive flavonoid isolated from Sophora flavescens","volume":"43","author":"Chen","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.phymed.2017.12.023_bib0003","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jac\/dkm457","article-title":"Potential synergy activity of the novel ceragenin, CAS-13, against clinical isolates of Pseudomonas aeruginosa, including multidrug-resistant P. aeruginosa","volume":"61","author":"Chin","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.12.023_bib0004","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2017.12.023_bib0005","series-title":"Twenty Second Informational Supplement. Approved Standard (M100\u2013S22)","article-title":"Table 2C. Zone diameter and MIC interpretive standards for Staphylococcus spp. Performance standards for antimicrobial susceptibility testing","year":"2012"},{"key":"10.1016\/j.phymed.2017.12.023_bib0006","first-page":"1560","article-title":"New isoprenylated flavonoid from Morus alba","volume":"35","author":"Geng","year":"2010","journal-title":"Chin. J. Chin. Mat. Med."},{"key":"10.1016\/j.phymed.2017.12.023_bib0007","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/jac\/dkv298","article-title":"Molecular epidemiology of MRSA in 13 ICUs from eight European countries","volume":"71","author":"Hetem","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.12.023_bib0008","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1055\/s-0029-1185541","article-title":"Additive antimicrobial [corrected] effects of the active components of the essential oil of Thymus vulgaris\u2014chemotype carvacrol","volume":"75","author":"Iten","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2017.12.023_bib0009","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1021\/jf200423g","article-title":"Isolation of cholinesterase-inhibiting flavonoids from Morus ihou","volume":"59","author":"Kim","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2017.12.023_bib0010","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1128\/AAC.41.6.1392","article-title":"Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans","volume":"41","author":"Klepser","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2017.12.023_bib0011","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jac\/41.3.397","article-title":"Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B against Cryptococcus neoformans","volume":"41","author":"Klepser","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.12.023_bib0012","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1055\/s-0028-1097569","article-title":"Morusinol, isoprenoid flavone from Morus root barks","volume":"32","author":"Konno","year":"1977","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2017.12.023_bib0013","unstructured":"Ku, Y.L., Liang, S.T., Lin, Y.H., Chen, L.H., Kuo, Y.Y., 2010. Anti-bacterial use of extract from Morus australis poir and compound kuwanon H. US2010\/166898A1, 2010, 1."},{"key":"10.1016\/j.phymed.2017.12.023_bib0014","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nm.2692","article-title":"MRSA epidemic linked to a quickly spreading colonization and virulence determinant","volume":"18","author":"Li","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2017.12.023_bib0015","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1016\/0031-9422(92)83669-P","article-title":"Pyranoflavonoids from Artocarpus communis","volume":"31","author":"Lin","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2017.12.023_bib0016","doi-asserted-by":"crossref","first-page":"751","DOI":"10.5897\/AJPP11.260","article-title":"Antioxidant and antibacterial constituents from Morus nigra","volume":"5","author":"Mazimba","year":"2011","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2017.12.023_bib0017","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/fpd.2013.1627","article-title":"The mechanism of antimicrobial activity of sophoraflavanone B against methicillin-resistant Staphylococcus aureus","volume":"11","author":"Mun","year":"2014","journal-title":"Foodborne Pathog. Dis."},{"key":"10.1016\/j.phymed.2017.12.023_bib0018","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/823794","article-title":"Combination therapy of sophoraflavanone B against MRSA: in vitro synergy testing","volume":"2013","author":"Mun","year":"2013","journal-title":"Evid. Based Compl. Alt."},{"key":"10.1016\/j.phymed.2017.12.023_bib0019","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1016\/j.bmc.2009.06.009","article-title":"Antimicrobial and immunomodulatory properties of prenylated xanthones from twigs of Garcinia staudtii","volume":"17","author":"Ngoupayo","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phymed.2017.12.023_bib0020","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3987\/R-1978-09-1295","article-title":"Kuwanon E, a new flavanone derivatives from the root bark of the cultivated Mulberry tree (Morus alba L.)","volume":"9","author":"Nomura","year":"1978","journal-title":"Heterocycles"},{"key":"10.1016\/j.phymed.2017.12.023_bib0021","series-title":"Dictionary of Chinese Crude Drugs","first-page":"2786","article-title":"Nanjing University of Traditional Chinese Medicine (NUTCM) (Ed.), 2005","author":"NUTCM","year":"2005"},{"key":"10.1016\/j.phymed.2017.12.023_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.12.023_bib0023","first-page":"221","article-title":"Antibacterial activity of 10 phenolic compounds from mulberry","volume":"45","author":"Pang","year":"2014","journal-title":"J. Chin. Pharm. Univ."},{"key":"10.1016\/j.phymed.2017.12.023_bib0024","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1046\/j.1472-765X.1998.00386.x","article-title":"Anti-MRSA activity of sophoraflavanone G and synergism with other antibacterial agents","volume":"27","author":"Sakagami","year":"1998","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.phymed.2017.12.023_bib0025","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.phymed.2003.09.005","article-title":"Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent. Sophora flavescens Ait and Echinosophora koreensis Nakai","volume":"11","author":"Sohn","year":"2004","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2017.12.023_bib0026","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phymed.2008.12.018","article-title":"Synergy research: approaching a new generation of phytopharmaceuticals","volume":"16","author":"Wagner","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2017.12.023_bib0027","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/jac\/dks522","article-title":"Cell wall thickening is associated with adaptive resistance to amikacin in methicillin-resistant Staphylococcus aureus clinical isolates","volume":"68","author":"Yuan","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phymed.2017.12.023_bib0028","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1017\/S0950268812001343","article-title":"Virulence and antimicrobial resistance genes in human MRSA ST398 isolates in Austria","volume":"141","author":"Zarfel","year":"2013","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.phymed.2017.12.023_bib0029","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1128\/JCM.43.10.5026-5033.2005","article-title":"Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus","volume":"43","author":"Zhang","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.phymed.2017.12.023_bib0030","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.3390\/ijms13078210","article-title":"Isojacareubin from the Chinese Herb Hypericum japonicum: potent antibacterial and synergistic effects on clinical methicillin-resistant Staphylococcus aureus (MRSA)","volume":"13","author":"Zuo","year":"2012","journal-title":"Int. J. Mol. Sci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711317301976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T07:57:44Z","timestamp":1570521464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711317301976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":30,"alternative-id":["S0944711317301976"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2017.12.023","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2017.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}