{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:42:07Z","timestamp":1787888527504,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Liaoning Province Department of Education","doi-asserted-by":"publisher","award":["LZ2014043"],"award-info":[{"award-number":["LZ2014043"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.phymed.2018.03.014","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T07:17:54Z","timestamp":1520493474000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Protective role and mechanism of snakegourd peel against myocardial infarction in rats"],"prefix":"10.1016","volume":"42","author":[{"given":"Guanlin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyu","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2018.03.014_bib0001","first-page":"151","article-title":"Coronary stenting in elderly patients with acute myocardial infarction (review)","volume":"26","author":"Bogomolov","year":"2013","journal-title":"Adv. Gerontol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0002","doi-asserted-by":"crossref","first-page":"22932","DOI":"10.1074\/jbc.274.33.22932","article-title":"Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells","volume":"274","author":"Boulares","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2018.03.014_bib0003","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s00395-011-0199-3","article-title":"Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K\/Akt, p38 MAPK and ERK pathways","volume":"106","author":"Cao","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0004","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1182\/blood-2007-08-106336","article-title":"Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway","volume":"111","author":"Chen","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2018.03.014_bib0005","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1159\/000324005","article-title":"L-type calcium current (ICa,L) and inward rectifier potassium current (IK1) are involved in QT prolongation induced by arsenic trioxide in rat","volume":"26","author":"Chen","year":"2010","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.phymed.2018.03.014_bib0006","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.RES.0000189270.72915.D1","article-title":"Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes","volume":"97","author":"Chen","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2018.03.014_bib0007","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1742-7843.2006.pto_313.x","article-title":"Increasing intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway","volume":"98","author":"Chu","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0008","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2013from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2018.03.014_bib0009","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1096\/fj.01-0629com","article-title":"Losing heart: the role of apoptosis in heart disease\u2013a novel therapeutic target","volume":"16","author":"Gill","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2018.03.014_bib0010","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1254\/jjp.79.369","article-title":"An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons","volume":"79","author":"Harada","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0011","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1038\/mtna.2016.12","article-title":"Combination of microRNA-21 and microRNA-146a Attenuates Cardiac Dysfunction and Apoptosis During Acute Myocardial Infarction in Mice","volume":"5","author":"Huang","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.phymed.2018.03.014_bib0012","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/toxsci\/kfh221","article-title":"Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages","volume":"81","author":"Kim","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phymed.2018.03.014_bib0013","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.taap.2003.11.020","article-title":"Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling","volume":"196","author":"Kim","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0014","first-page":"789","article-title":"Effects of preconditioning of wufu jingfang on ischemia\/reperfusion injury induced apoptosis in rats","volume":"33","author":"Li","year":"2013","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.phymed.2018.03.014_bib0015","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.phymed.2012.04.007","article-title":"Allicin protects against myocardial apoptosis and fibrosis in streptozotocin-induced diabetic rats","volume":"19","author":"Liu","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2018.03.014_bib0016","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/CS20070430","article-title":"MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets","volume":"115","author":"Muslin","year":"2008","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.phymed.2018.03.014_bib0017","doi-asserted-by":"crossref","first-page":"H2726","DOI":"10.1152\/ajpheart.2001.280.6.H2726","article-title":"Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats","volume":"280","author":"Palojoki","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0018","doi-asserted-by":"crossref","first-page":"827","DOI":"10.5858\/2000-124-0827-IAADMO","article-title":"Is apoptosis a diagnostic marker of acute myocardial infarction","volume":"124","author":"Piro","year":"2000","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.phymed.2018.03.014_bib0019","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.95.2.320","article-title":"Apoptosis in human acute myocardial infarction","volume":"95","author":"Saraste","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2018.03.014_bib0020","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1046\/j.1523-1747.1999.00582.x","article-title":"Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells","volume":"112","author":"Shimizu","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0021","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s10495-006-9037-8","article-title":"Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways","volume":"11","author":"Sun","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.phymed.2018.03.014_bib0022","doi-asserted-by":"crossref","first-page":"E329","DOI":"10.1152\/ajpendo.00489.2002","article-title":"Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1\/2 in H-500 cells","volume":"285","author":"Tfelt-Hansen","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2018.03.014_bib0023","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MCC.0b013e32835075c5","article-title":"Malignant middle cerebral artery infarction","volume":"18","author":"Wartenberg","year":"2012","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.phymed.2018.03.014_bib0024","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1172\/JCI17664","article-title":"A mechanistic role for cardiac myocyte apoptosis in heart failure","volume":"111","author":"Wencker","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2018.03.014_bib0025","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.phymed.2018.03.014_bib0026","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1074\/jbc.M806487200","article-title":"Atrogin-1\/MAFbx enhances simulated ischemia\/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation","volume":"284","author":"Xie","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2018.03.014_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/726723","article-title":"Traditional chinese medicines in treatment of patients with type 2 diabetes mellitus","volume":"2011","author":"Xie","year":"2011","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.phymed.2018.03.014_bib0028","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nm1569","article-title":"The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2","volume":"13","author":"Yang","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2018.03.014_bib0029","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1742-7843.2007.00150.x","article-title":"Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity","volume":"102","author":"Zhao","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2018.03.014_bib0030","doi-asserted-by":"crossref","first-page":"25939","DOI":"10.1074\/jbc.M001185200","article-title":"p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide","volume":"275","author":"Zhuang","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318300503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318300503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T16:46:51Z","timestamp":1660582011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711318300503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":30,"alternative-id":["S0944711318300503"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.03.014","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective role and mechanism of snakegourd peel against myocardial infarction in rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}