{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:31:50Z","timestamp":1778866310836,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1047025"],"award-info":[{"award-number":["1047025"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1058786"],"award-info":[{"award-number":["1058786"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.phymed.2018.06.004","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T12:46:35Z","timestamp":1528375595000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium"],"prefix":"10.1016","volume":"49","author":[{"given":"Yasaswi Kaumadha","family":"Wijesuriya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-6929","authenticated-orcid":false,"given":"Martha","family":"Lappas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2018.06.004_bib0001","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1158\/1541-7786.MCR-06-0076","article-title":"Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway","volume":"4","author":"Ahn","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.phymed.2018.06.004_bib0002","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/jamapediatrics.2014.3040","article-title":"The distribution of clinical phenotypes of preterm birth syndrome: implications for prevention","volume":"169","author":"Barros","year":"2015","journal-title":"JAMA Pediatr."},{"issue":"2","key":"10.1016\/j.phymed.2018.06.004_bib0003","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1469-7793.1999.00399.x","article-title":"Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta: involvement of p38 mitogen-activated protein kinase","volume":"520Pt","author":"Bartlett","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0004","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/jnr.22368","article-title":"Inflammation-induced preterm birth alters neuronal morphology in the mouse fetal brain","volume":"88","author":"Burd","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phymed.2018.06.004_bib0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/j.1879-3479.1977.tb00648.x","article-title":"Interruption of first trimester pregnancy by prostaglandins","volume":"15","author":"Bygdeman","year":"1977","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.phymed.2018.06.004_bib0006","first-page":"3468","article-title":"Expression of cyclooxygenase-2 and prostanoid receptors by human myometrium","volume":"85","author":"Erkinheimo","year":"2000","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0007","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.bmcl.2004.02.067","article-title":"Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan","volume":"14","author":"Esumi","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2018.06.004_bib0008","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.siny.2015.12.011","article-title":"The epidemiology, etiology, and costs of preterm birth","volume":"21","author":"Frey","year":"2016","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.phymed.2018.06.004_bib0009","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2018.06.004_bib0010","first-page":"345","article-title":"Tocolytic therapy for preterm delivery: systematic review and network meta-analysis","author":"Haas","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.phymed.2018.06.004_bib0011","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0090-6980(72)80017-0","article-title":"Inhibition of abortion and fetal death produced by endotoxin or prostaglandin F2alpha","volume":"2","author":"Harper","year":"1972","journal-title":"Prostaglandins"},{"key":"10.1016\/j.phymed.2018.06.004_bib0012","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1745-7254.2005.00164.x","article-title":"Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin","volume":"26","author":"Hu","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2018.06.004_bib0013","first-page":"173","article-title":"Use of prostaglandins for induction of labor","volume":"15","author":"Husslein","year":"1991","journal-title":"Semin. Perinatol."},{"issue":"Suppl A","key":"10.1016\/j.phymed.2018.06.004_bib0014","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1053\/plac.2002.0948","article-title":"Cytokines, prostaglandins and parturition\u2013a review","volume":"24","author":"Keelan","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.phymed.2018.06.004_bib0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1745-7254.2008.00725.x","article-title":"Anti-inflammatory effect of honokiol is mediated by PI3K\/Akt pathway suppression","volume":"29","author":"Kim","year":"2008","journal-title":"Acta. Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2018.06.004_bib0016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1095\/biolreprod.105.045328","article-title":"Proinflammatory cytokines found in amniotic fluid induce collagen remodeling, apoptosis, and biophysical weakening of cultured human fetal membranes","volume":"74","author":"Kumar","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phymed.2018.06.004_bib0017","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.placenta.2016.03.015","article-title":"The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited","volume":"42","author":"Kumar","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.phymed.2018.06.004_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2018.01.003","article-title":"Runt-related transcription factor 1 (RUNX1) deficiency attenuates inflammation-induced pro-inflammatory and pro-labour mediators in myometrium","author":"Lappas","year":"2018","journal-title":"Mol. Cell Endocrinol"},{"key":"10.1016\/j.phymed.2018.06.004_bib0019","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1095\/biolreprod67.2.668","article-title":"Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro","volume":"67","author":"Lappas","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phymed.2018.06.004_bib0020","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.placenta.2006.05.011","article-title":"The role and regulation of the nuclear factor kappa B signalling pathway in human labour","volume":"28","author":"Lappas","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.phymed.2018.06.004_bib0021","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yrtph.2007.06.005","article-title":"Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract","volume":"49","author":"Li","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0022","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1095\/biolreprod.113.108126","article-title":"A novel role for FOXO3 in human labor: increased expression in laboring myometrium, and regulation of proinflammatory and prolabor mediators in pregnant human myometrial cells","volume":"88","author":"Lim","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phymed.2018.06.004_bib0023","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1095\/biolreprod.112.105163","article-title":"SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes","volume":"88","author":"Lim","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phymed.2018.06.004_bib0024","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/aji.12229","article-title":"The TLR2 ligand FSL-1 and the TLR5 ligand Flagellin mediate pro-inflammatory and pro-labour response via MyD88\/TRAF6\/NF-kappaB-dependent signalling","volume":"71","author":"Lim","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/molehr\/gat015","article-title":"Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium","volume":"19","author":"Lim","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.phymed.2018.06.004_bib0026","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1095\/biolreprod.115.134726","article-title":"The transcription factor interferon regulatory factor-1 (IRF1) plays a key role in the terminal effector pathways of human preterm labor","volume":"94","author":"Lim","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phymed.2018.06.004_bib0027","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(03)02121-6","article-title":"The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production","volume":"475","author":"Liou","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0028","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2018.06.004_bib0029","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yrtph.2007.06.006","article-title":"Evaluation of short-term and subchronic toxicity of magnolia bark extract in rats","volume":"49","author":"Liu","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108390","article-title":"The citrus flavone nobiletin reduces pro-inflammatory and pro-labour mediators in fetal membranes and myometrium: implications for preterm birth","volume":"9","author":"Morwood","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.06.004_bib0031","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4049\/jimmunol.179.2.753","article-title":"Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis","volume":"179","author":"Munroe","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0032","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1521-6934(03)00069-5","article-title":"The role of prostaglandins in the initiation of parturition","volume":"17","author":"Olson","year":"2003","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0033","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/s41598-017-01774-5","article-title":"Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet-induced inflammation and DNA hypermethylation in mouse skin","volume":"7","author":"Prasad","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2018.06.004_bib0034","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1476-5381.2012.02010.x","article-title":"Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice","volume":"167","author":"Qu","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.phymed.2018.06.004_bib0035","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.8755-8920.2000.430304.x","article-title":"Interleukin-1 stimulates human uterine prostaglandin production through induction of cyclooxygenase-2 expression","volume":"43","author":"Rauk","year":"2000","journal-title":"Am. J. Reproduct. Immunol. (New York, N.Y.: 1989)"},{"key":"10.1016\/j.phymed.2018.06.004_bib0036","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.siny.2006.05.001","article-title":"Inflammation in preterm and term labour and delivery","volume":"11","author":"Romero","year":"2006","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.phymed.2018.06.004_bib0037","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0140-6736(08)60136-1","article-title":"An overview of mortality and sequelae of preterm birth from infancy to adulthood","volume":"371","author":"Saigal","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2018.06.004_bib0038","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1476-5381.1993.tb12832.x","article-title":"In vitro characterization of prostanoid receptors on human myometrium at term pregnancy","volume":"108","author":"Senior","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0039","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pbb.2015.02.015","article-title":"Beneficial effect of honokiol on lipopolysaccharide induced anxiety-like behavior and liver damage in mice","volume":"132","author":"Sulakhiya","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2018.06.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173373","article-title":"Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle","volume":"12","author":"Tran","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.06.004_bib0041","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/485201","article-title":"Dietary flavonoids as therapeutics for preterm birth: luteolin and kaempferol suppress inflammation in human gestational tissues in vitro","author":"Wall","year":"2013","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2018.06.004_bib0042","doi-asserted-by":"crossref","first-page":"e18490","DOI":"10.1371\/journal.pone.0018490","article-title":"Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9 L intracerebral gliosarcoma model and human U251 xenograft glioma model","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.06.004_bib0043","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00134-010-2104-1","article-title":"Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation","volume":"37","author":"Weng","year":"2011","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.phymed.2018.06.004_bib0044","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12860-017-0145-9","article-title":"Honokiol improved chondrogenesis and suppressed inflammation in human umbilical cord derived mesenchymal stem cells via blocking nuclear factor-\u03baB pathway","volume":"18","author":"Wu","year":"2017","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.phymed.2018.06.004_bib0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/molehr\/gav018","article-title":"PGF2alpha modulates the output of chemokines and pro-inflammatory cytokines in myometrial cells from term pregnant women through divergent signaling pathways","volume":"21","author":"Xu","year":"2015","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.phymed.2018.06.004_bib0046","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2012.11.052","article-title":"Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-kappaB activation and cytokine production of glial cells","volume":"534","author":"Zhang","year":"2013","journal-title":"Neurosci. Lett."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318301879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318301879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T18:44:11Z","timestamp":1565289851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711318301879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":46,"alternative-id":["S0944711318301879"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.06.004","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}