{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:12:39Z","timestamp":1790172759327,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.phymed.2018.06.040","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T13:16:56Z","timestamp":1534166216000},"page":"249-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae)"],"prefix":"10.1016","volume":"55","author":[{"given":"\u00c9rica","family":"Benassi-Zanqueta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Fernandes","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Machado","family":"Valone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Lu\u00edza","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelize","family":"Bauermeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel Cristina Piloto","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto Peporine","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Vataru","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-397X","authenticated-orcid":false,"given":"Benedito Prado","family":"Dias Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Raquel Mar\u00e7al","family":"Natali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Ueda-Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2018.06.040_bib0001","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/jms.3982","article-title":"Fragmentation pathway and structural characterization of new glycosylated phenolic derivatives from Eremanthus glomerulatus Less (Asteraceae) by electrospray ionization tandem mass spectrometry","volume":"52","author":"Amaral","year":"2017","journal-title":"J. Mass Spectrom. JMS"},{"key":"10.1016\/j.phymed.2018.06.040_bib0002","series-title":"Guia para a condu\u00e7\u00e3o de estudos n\u00e3o cl\u00ednicos de toxicologia e seguran\u00e7a farmacol\u00f3gica necess\u00e1ria ao desenvolvimento de medicamentos","year":"2013"},{"key":"10.1016\/j.phymed.2018.06.040_bib0003","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1468-1331.2008.02527.x","article-title":"Valacyclovir neurotoxicity: clinical experience and review of the literature","volume":"16","author":"Asahi","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.phymed.2018.06.040_bib0004","doi-asserted-by":"crossref","DOI":"10.1159\/000490055","article-title":"Parthenolide influences HSV-1 replication in vitro","author":"Benassi-Zanqueta","year":"2018","journal-title":"Intervirology"},{"key":"10.1016\/j.phymed.2018.06.040_bib0005","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1128\/AAC.02250-12","article-title":"In vivo anti-herpes simplex virus activity of a sulfated derivate of Agaricus brasiliensis mycelial polysaccharide","volume":"57","author":"Cardozo","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2018.06.040_bib0006","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.nbt.2009.03.007","article-title":"Recent advancements for the evaluation of anti-viral activities of natural products","volume":"25","author":"Chattopadhyay","year":"2009","journal-title":"New Biotechnol."},{"key":"10.1016\/j.phymed.2018.06.040_bib0007","series-title":"Opportunities, Challanges and Scope of Natural Products in Medicinal Chemistry","first-page":"313","article-title":"Sesquiterpene lactones: structural diversity and their biological activities","author":"Chaturvedi","year":"2011"},{"key":"10.1016\/j.phymed.2018.06.040_bib0008","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-3542(02)00007-4","article-title":"Antiviral activity of Plantago major extracts and related compounds in vitro","volume":"55","author":"Chiang","year":"2002","journal-title":"Antivir. Res."},{"key":"10.1016\/j.phymed.2018.06.040_bib0009","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1021\/jf026187q","article-title":"Hierarchical scheme for LC-MS in identification of chlorogenic acids","volume":"51","author":"Clifford","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2018.06.040_bib0011","first-page":"1","article-title":"Anti-inflammatory and anti-tumor activities of parthenolide: an update","volume":"2","author":"Dey","year":"2016","journal-title":"J. Chem. Biol. Ther."},{"key":"10.1016\/j.phymed.2018.06.040_bib0013","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1345\/aph.17135","article-title":"Acyclovir- and ganciclovir-induced neurotoxicity","volume":"32","author":"Ernst","year":"1998","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.phymed.2018.06.040_bib0014","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00011-013-0674-4","article-title":"Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells","volume":"63","author":"Hwang","year":"2014","journal-title":"Inflam. Res."},{"key":"10.1016\/j.phymed.2018.06.040_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2005.06.004","article-title":"Antiviral activity and mode of action of caffeoylquinic acids from Scheffera heptaphylla (L.) Frodin","volume":"68","author":"Li","year":"2005","journal-title":"Antivir. Res."},{"key":"10.1016\/j.phymed.2018.06.040_bib0017","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2018.06.040_bib0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/095632029200300404","article-title":"Poly(hydroxy)carboxylates as selective inhibitors of cytomegalovirus and herpes simplex virus replication","volume":"3","author":"Neyts","year":"1992","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.phymed.2018.06.040_bib0021","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/ptr.2638","article-title":"Tanacetum vulgare: antiherpes v\u00edrus activity of crude extract and the purified compound parthenolide","volume":"23","author":"Onozato","year":"2009","journal-title":"Phytoter. Res."},{"key":"10.1016\/j.phymed.2018.06.040_bib0022","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/0973-7847.79105","article-title":"Feverfew (Tanacetum parthenium L.): a systematic review","volume":"5","author":"Pareek","year":"2011","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.phymed.2018.06.040_bib0023","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1128\/AAC.00615-10","article-title":"Resistance of herpes simplex virus to nucleoside analogues: mechanism, prevalence and management","volume":"55","author":"Piret","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2018.06.040_bib0024","first-page":"1824","article-title":"Development and validation of a method for simultaneous determination of bioactive compounds of Tanacetum parthenium (L.) Schultz-Bip","volume":"25","author":"Rabito","year":"2014","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.phymed.2018.06.040_bib0025","series-title":"Fields Virol","first-page":"2399","article-title":"The Family Herpesviridae: A Brief Introduction","author":"Roizman","year":"2001"},{"key":"10.1016\/j.phymed.2018.06.040_bib0026","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1248\/bpb.29.2236","article-title":"Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acids","volume":"29","author":"Santos","year":"2006","journal-title":"Biol. Pharmac. Bull."},{"key":"10.1016\/j.phymed.2018.06.040_bib0029","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jchromb.2007.09.016","article-title":"Purification and identification of antiviral components from Laggera pterodonta by high-speed counter-current chromatography","volume":"859","author":"Shi","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.phymed.2018.06.040_bib0030","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/AAC.49.11.176-182.2005","article-title":"Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium","volume":"49","author":"Tiuman","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2018.06.040_bib0032","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jnutbio.2011.06.018","article-title":"Protective effects of chlorogenic acids against ischemia\/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties","volume":"23","author":"Yun","year":"2012","journal-title":"J. Nutrit. Biochem."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318302289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318302289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T11:43:36Z","timestamp":1553859816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711318302289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":24,"alternative-id":["S0944711318302289"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.06.040","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae)","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.06.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}