{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:26:29Z","timestamp":1787502389753,"version":"build-2736575974"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"EuroPharma USA. Sponsor of the of the research: Terry Lemerond, EuroPharma USA Inc.","award":["2017-01"],"award-info":[{"award-number":["2017-01"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.phymed.2018.09.202","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T06:35:15Z","timestamp":1537425315000},"page":"285-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells"],"prefix":"10.1016","volume":"50","author":[{"given":"Ean-Jeong","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Panossian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2018.09.202_bib0001","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1471-2105-10-275","article-title":"Comparative study of gene set enrichment methods","volume":"10","author":"Abatangelo","year":"2009","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.phymed.2018.09.202_bib0002","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/bph.12131","article-title":"Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers","volume":"169","author":"Aggarwal","year":"2013","journal-title":"Br. J. Pharmacol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0003","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/ALN.0b013e318238bba6","article-title":"Molecular mechanisms of opioid receptor-dependent signaling and behavior","volume":"115","author":"Al-Hasani","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.phymed.2018.09.202_bib0004","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/bja\/aet153","article-title":"Opioids and immune modulation: more questions than answers","volume":"111","author":"Al-Hashimi","year":"2013","journal-title":"Br. J. Anaesth"},{"key":"10.1016\/j.phymed.2018.09.202_bib0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pnpbp.2015.02.007","article-title":"Nociceptin and the nociceptin receptor in learning and memory","volume":"62","author":"Andero","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2018.09.202_bib0078","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1755-5922.2010.00241.x","article-title":"Nociceptin\/orphanin phenylalanine glutamine (FQ) receptor and cardiovascular disease","volume":"29","author":"Armstead","year":"2011","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.phymed.2018.09.202_bib0006","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejphar.2013.11.033","article-title":"Effect of curcumin on diabetic peripheral neuropathic pain: possible involvement of opioid system","volume":"723","author":"Banafshe","year":"2014","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2018.03.001","article-title":"Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis","author":"Bannuru","year":"2018","journal-title":"Semin. Arthritis Rheum"},{"key":"10.1016\/j.phymed.2018.09.202_bib0008","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jneuroim.2018.04.004","article-title":"The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia","volume":"320","author":"Belkhelfa","year":"2018","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0009","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/jir.2013.0085","article-title":"IFN-\u03b3 and TNF-\u03b1 are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients","volume":"34","author":"Belkhelfa","year":"2014","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.phymed.2018.09.202_bib0010","first-page":"139","article-title":"The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review","volume":"26","author":"Bondeson","year":"2008","journal-title":"Clin. Exp. Rheumatol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0011","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1469-7580.2005.00428.x","article-title":"From nociception to pain perception: imaging the spinal and supraspinal pathways","volume":"207","author":"Brooks","year":"2005","journal-title":"J. Anat"},{"key":"10.1016\/j.phymed.2018.09.202_bib0012","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00213-016-4513-5","article-title":"Neuropeptide systems and new treatments for nicotine addiction","volume":"234","author":"Bruijnzeel","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.phymed.2018.09.202_bib0013","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1038\/srep10278","article-title":"Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2018.09.202_bib0014","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4103\/1673-5374.230303","article-title":"Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease","volume":"13","author":"Chen","year":"2018","journal-title":"Neural. Regen. Res"},{"key":"10.1016\/j.phymed.2018.09.202_bib0015","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/bioinformatics\/bts090","article-title":"Causal reasoning on biological networks: interpreting transcriptional changes","volume":"28","author":"Chindelevitch","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phymed.2018.09.202_bib0016","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ptr.2142","article-title":"Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain","volume":"21","author":"Chrubasik","year":"2007","journal-title":"Phytother. Res"},{"key":"10.1016\/j.phymed.2018.09.202_bib0017","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/bph.12612","article-title":"Challenges for opioid receptor nomenclature: IUPHAR Review 9","volume":"172","author":"Cox","year":"2015","journal-title":"Br. J. Pharmacol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0018","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3344\/kjp.2012.25.4.221","article-title":"Evidence for the participation of ATP-sensitive potassium channels in the antinociceptive effect of curcumin","volume":"25","author":"De Paz-Campos","year":"2012","journal-title":"Korean J. Pain"},{"key":"10.1016\/j.phymed.2018.09.202_bib0021","doi-asserted-by":"crossref","DOI":"10.1111\/jcpt.12703","article-title":"Curcumin in turmeric: basic and clinical evidence for a potential role in analgesia","author":"Eke-Okoro","year":"2018","journal-title":"J. Clin. Pharm. Ther"},{"issue":"1","key":"10.1016\/j.phymed.2018.09.202_bib0022","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12859-016-1181-8","article-title":"Interpreting transcriptional changes using causal graphs: new methods and their practical utility on public networks","volume":"17","author":"Fakhry","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.phymed.2018.09.202_bib0023","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1101\/gr.152132.112","article-title":"Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia","volume":"24","author":"Ferreira","year":"2014","journal-title":"Genome Res"},{"key":"10.1016\/j.phymed.2018.09.202_bib0024","first-page":"4156","article-title":"A novel lecithin based delivery form of Boswellic acids (Casperome\u00ae) for the management of osteo-muscular pain: a registry study in young rugby players","volume":"20","author":"Franceschi","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci"},{"key":"10.1016\/j.phymed.2018.09.202_bib0079","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/836569","article-title":"NOP receptor ligands as potential agents for inflammatory and autoimmune diseases","author":"Gavioli","year":"2011","journal-title":"J Amino Acids"},{"key":"10.1016\/j.phymed.2018.09.202_bib0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1681.2011.05648.x","article-title":"Discovery of curcumin, a component of golden spice, and its miraculous biological activities","volume":"39","author":"Gupta","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0026","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1002\/jcp.26620","article-title":"The versatile role of curcumin in cancer prevention and treatment: a focus on PI3K\/AKT pathway","volume":"233","author":"Hamzehzadeh","year":"2018","journal-title":"J. Cell Physiol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3344\/kjp.2012.25.1.1","article-title":"Analgesic effects of intrathecal curcumin in the rat formalin test","volume":"25","author":"Han","year":"2012","journal-title":"Korean J. Pain"},{"issue":"1","key":"10.1016\/j.phymed.2018.09.202_bib0028","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12906-017-2062-z","article-title":"Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study","volume":"18","author":"Haroyan","year":"2018","journal-title":"BMC Complement Altern. Med"},{"key":"10.1016\/j.phymed.2018.09.202_bib0029","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1124\/jpet.114.219303","article-title":"Curcumin attenuates opioid tolerance and dependence by inhibiting Ca2+\/calmodulin-dependent protein kinase II \u03b1 activity","volume":"352","author":"Hu","year":"2015","journal-title":"J. Pharmacol Exp. Ther"},{"issue":"1","key":"10.1016\/j.phymed.2018.09.202_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0191154","article-title":"A critical comparison of topology-based pathway analysis methods","volume":"13","author":"Ihnatova","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.09.202_bib0031","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3760\/cma.j.issn.0366-6999.20122095","article-title":"Curcumin exerts antinociceptive effects by inhibiting the activation of astrocytes in spinal dorsal horn and the intracellular extracellular signal-regulated kinase signaling pathway in rat model of chronic constriction injury","volume":"126","author":"Ji","year":"2013","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.phymed.2018.09.202_bib0032","doi-asserted-by":"crossref","first-page":"36754","DOI":"10.1038\/srep36754","article-title":"Genomic and transcriptomic profiling of resistant CEM\/ADR-5000 and sensitive CCRF-CEM leukaemia cells for unravelling the full complexity of multi-factorial multidrug resistance","volume":"6","author":"Kadioglu","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.phymed.2018.09.202_bib0033","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41398-017-0080-8","article-title":"A systematic review of the role of the nociceptin receptor system in stress, cognition, and reward: relevance to schizophrenia","volume":"8","author":"Khan","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phymed.2018.09.202_bib0034","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/bs.apha.2015.10.001","article-title":"Central N\/OFQ-NOP receptor system in pain modulation","volume":"75","author":"Kiguchi","year":"2016","journal-title":"Adv. Pharmacol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0036","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phymed.2018.09.202_bib0037","doi-asserted-by":"crossref","first-page":"32799","DOI":"10.1038\/srep32799","article-title":"Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain","volume":"6","author":"Labuz","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2018.09.202_bib0080","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nrd2572","article-title":"The nociceptin\/orphanin FQ receptor: a target with broad therapeutic potential","volume":"7","author":"Lambert","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.phymed.2018.09.202_bib0038","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-3565(24)38179-0","article-title":"Regulation of opioid receptor activities","volume":"289","author":"Law","year":"1999","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.phymed.2018.09.202_bib0039","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/bja\/aet176","article-title":"Antinociceptive curcuminoid, KMS4034, effects on inflammatory and neuropathic pain likely via modulating TRPV1 in mice","volume":"111","author":"Lee","year":"2013","journal-title":"Br. J. Anaesth"},{"key":"10.1016\/j.phymed.2018.09.202_bib0039a","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/j.1365-2826.2009.01912.x","article-title":"Endogenous nociceptin\/ orphanin FQ system involvement in hypothalamic\u2013pituitary\u2013adrenal axis responses: relevance to models of inflammation","volume":"21","author":"Leggett","year":"2009","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1742-2094-10-133","article-title":"ADAMTS proteoglycanases in the physiological and pathological central nervous system","volume":"10","author":"Lemarchant","year":"2013","journal-title":"J Neuroinflammation"},{"issue":"F1000 Faculty Rev","key":"10.1016\/j.phymed.2018.09.202_bib0041","doi-asserted-by":"crossref","first-page":"642","DOI":"10.12688\/f1000research.6514.1","article-title":"Advances in understanding cartilage remodeling","volume":"4","author":"Li","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.phymed.2018.09.202_bib0042","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpain.2012.10.005","article-title":"Epigenetic regulation of opioid-induced hyperalgesia, dependence, and tolerance in mice","volume":"14","author":"Liang","year":"2013","journal-title":"J. Pain"},{"key":"10.1016\/j.phymed.2018.09.202_bib0043","series-title":"Molucular Targets and Therapeutic Uses of spices. Modern use For Ancient Medicine","first-page":"403","article-title":"Turmeric (Curcumin)","author":"Lin","year":"2009"},{"key":"10.1016\/j.phymed.2018.09.202_bib0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.pmbts.2015.10.003","article-title":"The nociceptin receptor as an emerging molecular target for cocaine addiction","volume":"137","author":"Lutfy","year":"2016","journal-title":"Prog. Mol. Biol. Transl. Sci"},{"key":"10.1016\/j.phymed.2018.09.202_bib0081","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2009.12.027","article-title":"Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: focus on corticotropin-releasing factor, nociceptin\/orphanin FQ, and orexin\/hypocretin","volume":"1314","author":"Martin-Fardon","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.phymed.2018.09.202_bib0046","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/WNR.0b013e328314decb","article-title":"Curcumin blocks chronic morphine analgesic tolerance and brain-derived neurotrophic factor upregulation","volume":"20","author":"Matsushita","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.phymed.2018.09.202_bib0077","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/377532a0","article-title":"Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor","volume":"377","author":"Meunier","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2018.09.202_bib0047","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6374907","article-title":"Antinociceptive activities of the methanolic extract of the stem bark of Boswellia dalzielii Hutch. (Burseraceae) in rats are NO\/cGMP\/ATP-sensitive-K(+) channel activation dependent","volume":"2017","author":"Mbiantcha","year":"2017","journal-title":"Evid. Based Complement. Alternat. Med"},{"issue":"Suppl 1","key":"10.1016\/j.phymed.2018.09.202_bib0048","doi-asserted-by":"crossref","first-page":"eS43","DOI":"10.1007\/s12306-015-0364-1","article-title":"Co-analgesic therapy for arthroscopic supraspinatus tendon repair pain using a dietary supplement containing Boswellia serrata and Curcuma longa: a prospective randomized placebo-controlled study","volume":"99","author":"Merolla","year":"2015","journal-title":"Musculoskelet. Surg."},{"key":"10.1016\/j.phymed.2018.09.202_bib0049","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2018.09.202_bib0050","first-page":"125","article-title":"Attenuation of morphine withdrawal syndrome by various dosages of curcumin in comparison with clonidine in mouse: possible mechanism","volume":"40","author":"Motaghinejad","year":"2015","journal-title":"Iran J. Med. Sci"},{"key":"10.1016\/j.phymed.2018.09.202_bib0082","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0006-8993(99)01906-X","article-title":"The role of nociceptin in cognition","volume":"848","author":"Nabeshima","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.phymed.2018.09.202_bib0051","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000065432","article-title":"The ORL1 receptor: molecular pharmacology and signaling mechanisms","volume":"11","author":"New","year":"2002","journal-title":"Neurosignals"},{"key":"10.1016\/j.phymed.2018.09.202_bib0054","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4103\/0253-7613.140570","article-title":"A randomized, double blind, placebo controlled, cross over study to evaluate the analgesic activity of Boswellia serrata in healthy volunteers using mechanical pain model","volume":"46","author":"Prabhavathi","year":"2014","journal-title":"Indian J. Pharmacol"},{"issue":"Suppl 12","key":"10.1016\/j.phymed.2018.09.202_bib0055","doi-asserted-by":"crossref","first-page":"C188","DOI":"10.12968\/hmed.2013.74.Sup12.C188","article-title":"An introduction to pain pathways and mechanisms","volume":"74","author":"Reddi","year":"2013","journal-title":"Br. J. Hosp. Med. (Lond)"},{"key":"10.1016\/j.phymed.2018.09.202_bib0056","first-page":"5258","article-title":"A novel boswellic acids delivery form (Casperome\u00ae) in the management of musculoskeletal disorders: a review","volume":"21","author":"Riva","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci"},{"key":"10.1016\/j.phymed.2018.09.202_bib0057","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11357-018-0017-z","article-title":"Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies","volume":"40","author":"Sarker","year":"2018","journal-title":"Geroscience"},{"key":"10.1016\/j.phymed.2018.09.202_bib0083","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/bja\/aeq337","article-title":"Nociceptin\/orphanin FQ in inflammation and sepsis","volume":"106","author":"Serrano-Gomez","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.phymed.2018.09.202_bib0059","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.3390\/molecules20022728","article-title":"The multifaceted role of curcumin in cancer prevention and treatment","volume":"20","author":"Shanmugam","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2018.09.202_bib0060","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1021\/mp400358z","article-title":"Orally administered nanocurcumin to attenuate morphine tolerance: comparison between negatively charged PLGA and partially and fully PEGylated nanoparticles","volume":"10","author":"Shen","year":"2013","journal-title":"Mol. Pharm"},{"key":"10.1016\/j.phymed.2018.09.202_bib0061","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00535-013-0753-x","article-title":"Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives","volume":"49","author":"Sobczak","year":"2014","journal-title":"J. Gastroenterol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.04.045","article-title":"Role of curcumin in the management of pathological pain","author":"Sun","year":"2018","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.phymed.2018.09.202_bib0063","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23040835","article-title":"Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases","volume":"23","author":"Sundar Dhilip Kumar","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2018.09.202_bib0064","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.3923\/pjbs.2007.2583.2586","article-title":"Interaction between curcumin and opioid system in the formalin test of rats","volume":"10","author":"Tajik","year":"2007","journal-title":"Pak. J. Biol. Sci"},{"key":"10.1016\/j.phymed.2018.09.202_bib0065","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3923\/pjbs.2008.312.314","article-title":"The effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats","volume":"11","author":"Tajik","year":"2008","journal-title":"Pak. J. Biol. Sci"},{"key":"10.1016\/j.phymed.2018.09.202_bib0066","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.npep.2015.03.006","article-title":"Migraine and neuropeptides","volume":"52","author":"Tajti","year":"2015","journal-title":"Neuropeptides"},{"key":"10.1016\/j.phymed.2018.09.202_bib0067","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/pr.114.009209","article-title":"Nociceptin\/orphanin FQ receptor structure, signaling, ligands, functions, and interactions with opioid systems","volume":"68","author":"Toll","year":"2016","journal-title":"Pharmacol. Rev"},{"key":"10.1016\/j.phymed.2018.09.202_bib0069","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/jcb.23298","article-title":"ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis","volume":"112","author":"Verma","year":"2011","journal-title":"J. Cell Biochem"},{"issue":"1","key":"10.1016\/j.phymed.2018.09.202_bib0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12931-018-0785-0","article-title":"Pollution and respiratory disease: can diet or supplements help? A review","volume":"19","author":"Whyand","year":"2018","journal-title":"Respir Res"},{"key":"10.1016\/j.phymed.2018.09.202_bib0071","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pharmthera.2013.10.011","article-title":"The biology of Nociceptin\/Orphanin FQ (N\/OFQ) related to obesity, stress, anxiety, mood, and drug dependence","volume":"141","author":"Witkin","year":"2014","journal-title":"Pharmacol. Ther"},{"key":"10.1016\/j.phymed.2018.09.202_bib0072","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.bjp.0704478","article-title":"Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801","volume":"135","author":"Yamada","year":"2002","journal-title":"Br. J. Pharmacol"},{"key":"10.1016\/j.phymed.2018.09.202_bib0073","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1021\/acs.jmedchem.5b01499","article-title":"Nociceptin opioid receptor (NOP) as a therapeutic target: progress in translation from preclinical research to clinical utility","volume":"59","author":"Zaveri","year":"2016","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.phymed.2018.09.202_bib0074","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neuropharm.2011.08.050","article-title":"Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: descending monoamine system and opioid receptors are differentially involved","volume":"62","author":"Zhao","year":"2012","journal-title":"Neuropharmacology"},{"issue":"4932","key":"10.1016\/j.phymed.2018.09.202_bib0076","first-page":"1","article-title":"Antinociceptive effects of curcumin in a rat model of postoperative pain","volume":"4","author":"Zhu","year":"2014","journal-title":"Sci. Rep."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318304781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318304781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T22:10:06Z","timestamp":1751926206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711318304781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":75,"alternative-id":["S0944711318304781"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.09.202","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.09.202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}