{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:54:08Z","timestamp":1773294848136,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Universidad Arturo Prat","award":["VRIIP0006-17 and VRIIP0209-17"],"award-info":[{"award-number":["VRIIP0006-17 and VRIIP0209-17"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.phymed.2018.09.226","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T21:48:54Z","timestamp":1537998534000},"page":"99-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats"],"prefix":"10.1016","volume":"50","author":[{"given":"Fredi","family":"Cifuentes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-9295","authenticated-orcid":false,"given":"Javier","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovan","family":"Kuzmicic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Carvajal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Quispe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-9382","authenticated-orcid":false,"given":"Chukwuemeka R.","family":"Nwokocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glauco","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Norambuena-Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Chiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.phymed.2018.09.226_bib0001","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2174\/138920008786049285","article-title":"Classical inhibitors of NOX NAD(P)H oxidases are not specific","volume":"9","author":"Aldieri","year":"2008","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.phymed.2018.09.226_bib0002","series-title":"Manual de Plantas y Canciones Aymar\u00e1s","author":"Araya","year":"2003"},{"issue":"1","key":"10.1016\/j.phymed.2018.09.226_bib0003","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.foodchem.2011.01.009","article-title":"Use of HPLC-DAD-ESI\/MS to profile phenolic compounds in edible wild greens from Portugal","volume":"127","author":"Barros","year":"2011","journal-title":"Food Chem."},{"issue":"6","key":"10.1016\/j.phymed.2018.09.226_bib0004","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1007\/s10600-011-9806-7","article-title":"Chemical composition of the essential oil of Xenophyllum poposum","volume":"46","author":"Benites","year":"2011","journal-title":"Chem. Nat. Compd."},{"issue":"11","key":"10.1016\/j.phymed.2018.09.226_bib0005","doi-asserted-by":"crossref","first-page":"17400","DOI":"10.3390\/molecules191117400","article-title":"HPLC-UV-MS profiles of phenolic compounds and antioxidant activity of fruits from three citrus species consumed in Northern Chile","volume":"19","author":"Brito","year":"2014","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.phymed.2018.09.226_bib0006","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1007\/s00044-013-0542-3","article-title":"Design, synthesis, and biological evaluation of benzofuran derivatives as ET receptor antagonists","volume":"22","author":"Cai","year":"2013","journal-title":"Med. Chem. Res."},{"issue":"6","key":"10.1016\/j.phymed.2018.09.226_bib0007","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/1091581809345924","article-title":"Chronic exposure to arsenic in tap water reduces acetylcholine-induced relaxation in the aorta and increases oxidative stress in female rats","volume":"28","author":"Cifuentes","year":"2009","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.phymed.2018.09.226_bib0008","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jep.2015.12.048","article-title":"Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch. Bip. (Compositae) in mice: Chronotropic and negative inotropic effect, a nifedipine-like action","volume":"179","author":"Cifuentes","year":"2016","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.phymed.2018.09.226_bib0009","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bse.2006.10.006","article-title":"Incisol, an alcohol with a novel sesquiterpene skeleton from Xenophyllum incisum","volume":"35","author":"de Marchese","year":"2007","journal-title":"Biochem. Syst. Ecol."},{"issue":"2","key":"10.1016\/j.phymed.2018.09.226_bib0010","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jep.2006.11.018","article-title":"Ethnobotanical study of medicinal plants used by the Andean people of Canta, Lima, Peru","volume":"111","author":"De-la-Cruz","year":"2007","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2018.09.226_bib0011","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1139\/v97-039","article-title":"Comparison of crystal and solution structures and H-1 and C-13 chemical shifts for grandiflorenic acid, kaurenoic acid, and monoginoic acid","volume":"75","author":"Enriquez","year":"1997","journal-title":"Can. J. Chem.-Rev. Can. Chim."},{"key":"10.1016\/j.phymed.2018.09.226_bib0012","first-page":"165","article-title":"Actividades biol\u00f3gicas de Xenophyllum poposum Phil. (Asteraceae), planta del Altiplano Chileno","volume":"6","author":"Erazo","year":"2006","journal-title":"Rev. Fitoterapia"},{"issue":"6","key":"10.1016\/j.phymed.2018.09.226_bib0013","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1044-0305(01)00226-4","article-title":"Determination of flavone, flavonol, and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry","volume":"12","author":"Fabre","year":"2001","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"3","key":"10.1016\/j.phymed.2018.09.226_bib0014","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2307\/3391934","article-title":"Xenophyllum, a new Andean genus extracted from Werneria s.l. (Compositae: Senecioneae)","volume":"7","author":"Funk","year":"1997","journal-title":"Novon"},{"issue":"12","key":"10.1016\/j.phymed.2018.09.226_bib0015","first-page":"1663","article-title":"Chemical composition, antimicrobial and antioxidant properties of the volatile oil and methanol extract of Xenophyllum poposum","volume":"7","author":"Gonz\u00e1lez","year":"2012","journal-title":"Nat. Prod. Commun."},{"issue":"2","key":"10.1016\/j.phymed.2018.09.226_bib0016","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.foodchem.2011.04.078","article-title":"Characterisation of phenolic acid derivatives and flavonoids from different morphological parts of Helichrysum obconicum by a RP-HPLC-DAD-(-)-ESI-MSn method","volume":"129","author":"Gouveia","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2018.09.226_bib0017","series-title":"Textbook of Medical Physiology","author":"Hall","year":"2010"},{"issue":"2","key":"10.1016\/j.phymed.2018.09.226_bib0018","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bjp.2015.02.008","article-title":"HPLC-DAD-MS\/MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic activities","volume":"25","author":"Ibrahim","year":"2015","journal-title":"Rev. Bras. Farmacogn.-Braz. J. Pharmacogn."},{"issue":"15","key":"10.1016\/j.phymed.2018.09.226_bib0019","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1021\/jf1014457","article-title":"Profile and characterization of the chlorogenic acids in green Robusta coffee beans by LC-MS(n): identification of seven new classes of compounds","volume":"58","author":"Jaiswal","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.phymed.2018.09.226_bib0020","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jep.2010.05.013","article-title":"Antihypertensive activity of Salvia elegans Vahl. (Lamiaceae): ACE inhibition and angiotensin II antagonism","volume":"130","author":"Jim\u00e9nez-Ferrer","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2018.09.226_bib0021","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0960-894X(01)80188-8","article-title":"Benzofuran based nonpeptide antagonist of angiotensin-II related to GR117289.4. imidazopyridinylbenzofurans","volume":"4","author":"Judd","year":"1994","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2018.09.226_bib0022","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ejmech.2014.11.039","article-title":"Bioactive Benzofuran derivatives: a review","volume":"97","author":"Khanam","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.phymed.2018.09.226_bib0023","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0031-9422(00)81074-2","article-title":"Para-hydroxyacetophenone derivatives from Senecio-Graveolens","volume":"24","author":"Loyola","year":"1985","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.phymed.2018.09.226_bib0024","first-page":"50","article-title":"Medicinal plants used in Chile for the treatment of hypertension and mountain sickness","volume":"3","author":"Mart\u00ednez","year":"2006","journal-title":"Afr. J. Trad. Complement Altern. Med."},{"issue":"4","key":"10.1016\/j.phymed.2018.09.226_bib0025","first-page":"407","article-title":"Quercetin and its derivatives: chemical structure and bioactivity- a review","volume":"58","author":"Materska","year":"2008","journal-title":"Polish J. Food Nutr. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2018.09.226_bib0026","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jpha.2011.09.009","article-title":"Characterization of flavonoids in Millettia nitida var. hirsutissima by HPLC\/DAD\/ESI-MSn","volume":"2","author":"Min","year":"2012","journal-title":"J. Pharma. Anal."},{"issue":"2","key":"10.1016\/j.phymed.2018.09.226_bib0027","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.phymed.2018.09.226_bib0028","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12012-013-9216-0","article-title":"Apocynin ameliorates cadmium-induced hypertension through elevation of endothelium nitric oxide synthase","volume":"13","author":"Nwokocha","year":"2013","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.phymed.2018.09.226_bib0029","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2016.07.008","article-title":"Hydroalcoholic extract and pure compounds from Senecio nutans Sch. Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms","volume":"192","author":"Paredes","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2018.09.226_bib0030","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0031-9422(97)00341-5","article-title":"Benzopyran derivatives from Werneria nubigena","volume":"46","author":"Piacente","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2018.09.226_bib0031","unstructured":"Ponce, M.A., Gros, E.G. A flavonoid and coumarins from Werneria-Poposa. An. Asoc. Qu\u00edm. Arg. 83 (1-2), 1995, 93-95."},{"issue":"4","key":"10.1016\/j.phymed.2018.09.226_bib0032","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ccl.2007.09.003","article-title":"Anti-angiotensin therapy: new perspectives","volume":"25","author":"Ramasubbu","year":"2007","journal-title":"Cardiol. Clin."},{"key":"10.1016\/j.phymed.2018.09.226_bib0033","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.lfs.2015.12.043","article-title":"Rat aorta as a pharmacological tool for in vitro and in vivo studies","volume":"145","author":"Rameshrad","year":"2016","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.phymed.2018.09.226_bib0034","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/14786410701589899","article-title":"Characterization and crystal structure of 2R-(-)-6-hydroxytremetone from Xenophyllum poposum (Phil.) V.A. Funk","volume":"22","author":"Romano","year":"2008","journal-title":"Nat. Prod. Res."},{"issue":"47","key":"10.1016\/j.phymed.2018.09.226_bib0035","doi-asserted-by":"crossref","first-page":"11723","DOI":"10.1021\/jf303204s","article-title":"Quantification of flavonoids in black rice by liquid chromatography-negative electrospray ionization tandem mass spectrometry","volume":"60","author":"Sriseadka","year":"2012","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.phymed.2018.09.226_bib0036","first-page":"81","article-title":"La tradici\u00f3n Altipl\u00e1nica: estudio etnobot\u00e1nico en los Andes de Iquique, Primera Regi\u00f3n, Chile","volume":"31","author":"Villagr\u00e1n","year":"2000","journal-title":"Chungara"},{"key":"10.1016\/j.phymed.2018.09.226_bib0037","series-title":"Etnobot\u00e1nica del sur de los Andes de la Primera Regi\u00f3n de Chile: Un Enlace Entre Las Culturas Altipl\u00e1nicas y las De Quebradas Altas del loa Superior, Elibro Catedra","first-page":"73","author":"Villagr\u00e1n","year":"2003"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318305099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318305099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T16:22:13Z","timestamp":1755706933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711318305099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":37,"alternative-id":["S0944711318305099"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.09.226","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.09.226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}