{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:17:18Z","timestamp":1775585838350,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2014R1A5A2009936"],"award-info":[{"award-number":["2014R1A5A2009936"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2014R1A5A2009936"],"award-info":[{"award-number":["2014R1A5A2009936"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.phymed.2018.09.230","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T11:17:32Z","timestamp":1538479052000},"page":"151-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Positive effects of \u03b1-asarone on transplanted neural progenitor cells in a murine model of ischemic stroke"],"prefix":"10.1016","volume":"51","author":[{"given":"Hong Ju","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Min","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malk Eun","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Hee","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo-Yeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa Kyoung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-4346","authenticated-orcid":false,"given":"Byung Tae","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2018.09.230_bib0001","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrn1665","article-title":"WNTs in the vertebrate nervous system: from patterning to neuronal connectivity","volume":"6","author":"Ciani","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0002","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.288.5471.1660","article-title":"Generalized potential of adult neural stem cells","volume":"288","author":"Clarke","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.phymed.2018.09.230_bib0003","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3727\/096368912X655091","article-title":"Neural stem cells and stroke","volume":"22","author":"Ding","year":"2013","journal-title":"Cell Transplant"},{"key":"10.1016\/j.phymed.2018.09.230_bib0004","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.expneurol.2015.07.023","article-title":"Post-stroke transplantation of adult subventricular zone derived neural progenitor cells \u2013 a comprehensive analysis of cell delivery routes and their underlying mechanisms","volume":"273","author":"Doeppner","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0005","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.brainres.2015.03.007","article-title":"Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy","volume":"1623","author":"Duncan","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2018.09.230_bib0006","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","article-title":"PI3K\/Akt signalling pathway and cancer","volume":"30","author":"Fresno Vara","year":"2004","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.phymed.2018.09.230_bib0007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112698","article-title":"Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK\/ERK signaling pathway in vitro","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.09.230_bib0008","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nn.2226","article-title":"Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon","volume":"11","author":"Gulacsi","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0009","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/13880209.2012.751616","article-title":"Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii","volume":"51","author":"Han","year":"2013","journal-title":"Pharm Biol"},{"key":"10.1016\/j.phymed.2018.09.230_bib0010","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1046\/j.1471-4159.2003.02219.x","article-title":"Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells","volume":"88","author":"Harada","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2018.09.230_bib0011","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.stemcr.2016.12.007","article-title":"Polysaccharides from ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of alzheimer's disease","volume":"8","author":"Huang","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.phymed.2018.09.230_bib0012","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nn.2953","article-title":"Stroke research at a crossroad: asking the brain for directions","volume":"14","author":"Iadecola","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0013","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00004647-200204000-00005","article-title":"Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia","volume":"22","author":"Iwai","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2018.09.230_bib0014","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jep.2012.09.026","article-title":"Acorus gramineus inhibits microglia mediated neuroinflammation and prevents neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease","volume":"144","author":"Jiang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fncel.2017.00200","article-title":"Cell\u2013cell connection enhances proliferation and neuronal differentiation of rat embryonic neural stem\/progenitor cells","volume":"11","author":"Jiao","year":"2017","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0016","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2121-9-66","article-title":"Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip\/WAF1 pathway","volume":"9","author":"Jung","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0017","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1460-9568.2007.05336.x","article-title":"Mechanism of insulin-like growth factor I-mediated proliferation of adult neural progenitor cells: role of Akt","volume":"25","author":"Kalluri","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0018","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuropharm.2015.04.037","article-title":"alpha-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease","volume":"97","author":"Kim","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2018.09.230_bib0019","doi-asserted-by":"crossref","first-page":"14497","DOI":"10.1074\/jbc.M708373200","article-title":"Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus","volume":"283","author":"Kim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2018.09.230_bib0020","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/nn.2408","article-title":"GSK-3 is a master regulator of neural progenitor homeostasis","volume":"12","author":"Kim","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0021","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1242\/dev.050146","article-title":"The role of FGF\/Erk signaling in pluripotent cells","volume":"137","author":"Lanner","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.phymed.2018.09.230_bib0022","doi-asserted-by":"crossref","first-page":"e33374","DOI":"10.1371\/journal.pone.0033374","article-title":"Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis","volume":"7","author":"Lau","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.09.230_bib0023","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","article-title":"Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner","volume":"8","author":"Le Belle","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2018.09.230_bib0024","doi-asserted-by":"crossref","first-page":"41","DOI":"10.11637\/kjpa.2018.31.2.41","article-title":"Effects of \u03b1-asarone on proliferation and differentiation of neural progenitor cells","volume":"31","author":"Lee","year":"2018","journal-title":"Korean J. Phys. Anthropol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stemcr.2014.05.012","article-title":"Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rats","volume":"3","author":"Li","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.phymed.2018.09.230_bib0026","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/stem.768","article-title":"Concise review: A chemical approach to control cell fate and function","volume":"30","author":"Li","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.phymed.2018.09.230_bib0027","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3727\/096368910X557236","article-title":"Neural differentiation of brain-derived neurotrophic factor-expressing human umbilical cord blood-derived mesenchymal stem cells in culture via TrkB-mediated ERK and beta-catenin phosphorylation and following transplantation into the developing brain","volume":"20","author":"Lim","year":"2011","journal-title":"Cell Transplant"},{"key":"10.1016\/j.phymed.2018.09.230_bib0028","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neulet.2009.02.011","article-title":"Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-beta((25-35))","volume":"453","author":"Limon","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2018.09.230_bib0029","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1161\/STROKEAHA.110.599654","article-title":"Stem cell research in stroke: how far from the clinic?","volume":"42","author":"Lindvall","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2018.09.230_bib0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejps.2014.06.006","article-title":"Distribution of alpha-asarone in brain following three different routes of administration in rats","volume":"63","author":"Lu","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0031","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/1871527314666150225124348","article-title":"The effect of acori graminei rhizoma and extract fractions on spatial memory and hippocampal neurogenesis in amyloid beta 1-42 injected mice","volume":"14","author":"Ma","year":"2015","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.phymed.2018.09.230_bib0032","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/acel.12356","article-title":"A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation","volume":"14","author":"Mao","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.phymed.2018.09.230_bib0033","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1242\/jcs.03012","article-title":"Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem\/precursor cells","volume":"119","author":"Otaegi","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0034","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jep.2016.01.006","article-title":"Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects","volume":"179","author":"Pak","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0035","doi-asserted-by":"crossref","first-page":"e37742","DOI":"10.1371\/journal.pone.0037742","article-title":"Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons","volume":"7","author":"Park","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.09.230_bib0036","doi-asserted-by":"crossref","first-page":"12","DOI":"10.14715\/cmb\/2017.63.7.2","article-title":"Hypoxia stimulates neural stem cell proliferation by increasing HIF1alpha expression and activating Wnt\/beta-catenin signaling","volume":"63","author":"Qi","year":"2017","journal-title":"Cell Mol. Biol. (Noisy-le-grand)"},{"key":"10.1016\/j.phymed.2018.09.230_bib0037","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.phymed.2013.09.020","article-title":"An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species","volume":"21","author":"Rajput","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2018.09.230_bib0038","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"Reya","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2018.09.230_bib0039","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.phymed.2018.09.230_bib0040","doi-asserted-by":"crossref","first-page":"26547","DOI":"10.1038\/srep26547","article-title":"Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells","volume":"6","author":"Rhim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2018.09.230_bib0041","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1478-3231.2005.01069.x","article-title":"Coordinated expression of cyclin D1 and LEF-1\/TCF transcription factor is restricted to a subset of hepatocellular carcinoma","volume":"25","author":"Schmitt-Graeff","year":"2005","journal-title":"Liver Int."},{"key":"10.1016\/j.phymed.2018.09.230_bib0042","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.expneurol.2006.11.005","article-title":"Anatomical integration of newly generated dentate granule neurons following traumatic brain injury in adult rats and its association to cognitive recovery","volume":"204","author":"Sun","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0043","doi-asserted-by":"crossref","first-page":"e74857","DOI":"10.1371\/journal.pone.0074857","article-title":"Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site","volume":"8","author":"Tajiri","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2018.09.230_bib0044","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/35081577","article-title":"Stem cell plasticity\u2013building the brain of our dreams","volume":"2","author":"Temple","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.phymed.2018.09.230_bib0045","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1634\/stemcells.2005-0281","article-title":"Persistent production of neurons from adult brain stem cells during recovery after stroke","volume":"24","author":"Thored","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.phymed.2018.09.230_bib0046","first-page":"692","article-title":"Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli","volume":"140","author":"Tornero","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.phymed.2018.09.230_bib0047","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/dbio.1998.9192","article-title":"Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon","volume":"208","author":"Tropepe","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0048","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3797\/scipharm.1204-21","article-title":"Comparative study of the cytotoxicity and genotoxicity of alpha- and Beta-asarone","volume":"80","author":"Unger","year":"2012","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.phymed.2018.09.230_bib0049","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/01.LAB.0000075556.74231.A5","article-title":"High efficacy of clonal growth and expansion of adult neural stem cells","volume":"83","author":"Wachs","year":"2003","journal-title":"Lab. Invest."},{"key":"10.1016\/j.phymed.2018.09.230_bib0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","article-title":"Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human","volume":"79","author":"Widmann","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2018.09.230_bib0051","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1211\/jpp.59.2.0016","article-title":"Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice","volume":"59","author":"Zhang","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2018.09.230_bib0052","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131830521X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131830521X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:15:07Z","timestamp":1760552107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471131830521X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":52,"alternative-id":["S094471131830521X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.09.230","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive effects of \u03b1-asarone on transplanted neural progenitor cells in a murine model of ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.09.230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}