{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:45:28Z","timestamp":1790181928146,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Sciences Foundation of ChinaNational Sciences Foundation of China","award":["81273402"],"award-info":[{"award-number":["81273402"]}]},{"name":"National Sciences Foundation of ChinaNational Sciences Foundation of China","award":["81573548"],"award-info":[{"award-number":["81573548"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.phymed.2018.10.035","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:50:00Z","timestamp":1540947000000},"page":"136-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin"],"prefix":"10.1016","volume":"56","author":[{"given":"Luan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naixin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaner","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxia","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2018.10.035_bib0001","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/bcpt.12291","article-title":"Renoprotective effects of gamma-aminobutyric acid on cisplatin-induced acute renal injury in rats","volume":"1","author":"Ali","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0002","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0270-9295(03)00089-5","article-title":"Cisplatin nephrotoxicity","volume":"5","author":"Arany","year":"2003","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/biof.5520270101","article-title":"Free radicals in biology and medicine: from inflammation to biotechnology","volume":"27","author":"Aruoma","year":"2006","journal-title":"Biofactors"},{"key":"10.1016\/j.phymed.2018.10.035_bib0004","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tox.2005.04.016","article-title":"Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats","volume":"2\u20133","author":"Atessahin","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2018.10.035_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5829.2007.00142.x","article-title":"Cisplatin: a review of toxicities and therapeutic applications","volume":"1","author":"Barabas","year":"2008","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0006","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1089\/jmf.2010.0286","article-title":"Pomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in rats","volume":"14","author":"Cayir","year":"2011","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2018.10.035_bib0007","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.3390\/toxins5122353","article-title":"An extract of Rhodobacter sphaeroides reduces cisplatin-induced nephrotoxicity in mice","volume":"5","author":"Chang","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.phymed.2018.10.035_bib0008","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1002\/rcm.3801","article-title":"Silver complexation and tandem mass spectrometry for differentiation of triterpenoid saponins from the roots of Pulsatilla chinensis (Bunge) Regel","volume":"22","author":"Cheng","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.phymed.2018.10.035_bib0009","first-page":"104","volume":"1","author":"Chinese Pharmacopoeia Commission","year":"2015"},{"key":"10.1016\/j.phymed.2018.10.035_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15327914NC3701_1","article-title":"Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects","volume":"37","author":"Conklin","year":"2000","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.phymed.2018.10.035_bib0011","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejphar.2011.06.051","article-title":"Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes","volume":"668","author":"El-Beshbishy","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0012","first-page":"479","article-title":"Ameliorative effect of fish oil on the cisplatin induced hepatotoxicity and nephrotoxicity in rats","volume":"4","author":"El-Gerbed","year":"2013","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"10.1016\/j.phymed.2018.10.035_bib0013","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1089\/jmf.2009.0175","article-title":"Nephroprotective activity of Prosthechea michuacana against cisplatin-induced acute renal failure in rats","volume":"13","author":"Gutierrez","year":"2010","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2018.10.035_bib0014","first-page":"99","article-title":"Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat","volume":"6","author":"Hadjzadeh","year":"2012","journal-title":"Iran. J. Kidney Dis."},{"key":"10.1016\/j.phymed.2018.10.035_bib0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/0975-7406.120083","article-title":"Effect of aqueous extract of Rheum ribes on cisplatin-induced nephrotoxicity in rat","volume":"5","author":"Hadjzadeh","year":"2013","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.phymed.2018.10.035_bib0016","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/1547691X.2015.1017624","article-title":"Role of Chinese herbal medicinal ingredients in secretion of cytokines by PCV2-induced endothelial cells","volume":"13","author":"Hu","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0017","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3109\/08923970902814129","article-title":"Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells","volume":"31","author":"Hu","year":"2009","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0018","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/1547691X.2015.1017624","article-title":"Role of Chinese herbal medicinal ingredients in secretion of cytokines by PCV2-induced endothelial cells","volume":"13","author":"Hu","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0024-3205(02)02176-8","article-title":"23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells","volume":"72","author":"Ji","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2018.10.035_bib0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bbamcr.2014.12.033","article-title":"Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury","volume":"1854","author":"Kruger","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2018.10.035_bib0021","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/0886022X.2017.1282871","article-title":"Ameliorative effects of pine bark extract on cisplatin-induced acute kidney injury in rats","volume":"39","author":"Lee","year":"2017","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2018.10.035_bib0022","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ki.2013.559","article-title":"Rictor\/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury","volume":"86","author":"Li","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2018.10.035_bib0023","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/aps.2015.114","article-title":"Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy","volume":"37","author":"Liu","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2018.10.035_bib0024","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jss.2014.01.026","article-title":"Pulsatilla saponin A, an active molecule from Pulsatilla chinensis, induces cancer cell death and inhibits tumor growth in mouse xenograft models","volume":"188","author":"Liu","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.phymed.2018.10.035_bib0025","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/nu8090566","article-title":"Ginsenoside Rg5 ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2018.10.035_bib0026","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/ndt\/gfn090","article-title":"The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats","volume":"23","author":"Luo","year":"2008","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.phymed.2018.10.035_bib0027","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/carcin\/21.3.361","article-title":"Oxyradicals and DNA damage","volume":"21","author":"Marnett","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.phymed.2018.10.035_bib0028","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.intimp.2015.06.020","article-title":"Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-\u03baB signalling pathways","volume":"28","author":"Ma","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0029","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3390\/ijms18071407","article-title":"Nephroprotective effects of saponins from leaves of panax quinquefolius against cisplatin-induced acute kidney injury Int","volume":"18","author":"Ma","year":"2017","journal-title":"J. Mol. Sci."},{"key":"10.1016\/j.phymed.2018.10.035_bib0030","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1043-6618(03)00040-9","article-title":"The effects of oral glutamine on cisplatin-induced nephrotoxicity in rats","volume":"47","author":"Mora Lde","year":"2003","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2018.10.035_bib0031","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.freeradbiomed.2011.08.006","article-title":"Poly (ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury","volume":"51","author":"Mukhopadhyay","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2018.10.035_bib0032","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2018.10.035_bib0033","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1172\/JCI200215606","article-title":"TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity","volume":"110","author":"Ramesh","year":"2002","journal-title":"Clin. Investig."},{"key":"10.1016\/j.phymed.2018.10.035_bib0034","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0773.1995.tb00167.x","article-title":"Mechanism of cisplatin ototoxicity: antioxidant system","volume":"6","author":"Ravi","year":"1995","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0035","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3109\/10408444.2011.602662","article-title":"An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity","volume":"41","author":"Sanchez-Gonzalez","year":"2011","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0036","first-page":"39","article-title":"Renoprotective effects of antioxidants against cisplatin nephrotoxicity","volume":"3","author":"Shabnam","year":"2014","journal-title":"J. Nephropharmacol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0037","doi-asserted-by":"crossref","first-page":"F726","DOI":"10.1152\/ajprenal.2000.278.5.F726","article-title":"Heme oxygenase-1 gene ablation or expression modulates cisplatin induced renal tubular apoptosis","volume":"278","author":"Shiraishi","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0038","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1254\/jjp.40.353","article-title":"Modification of cisplatin toxicity by antioxidants","volume":"40","author":"Sugihara","year":"1986","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0039","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jchromb.2018.03.013","article-title":"Simultaneous determination of eight bioactive compounds by LC-MS\/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng-Baitouweng (GB) in rats","volume":"1084","author":"Tian","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.phymed.2018.10.035_bib0040","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrc3748","article-title":"New PARP targets for cancer therapy","volume":"14","author":"Vyas","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2018.10.035_bib0041","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.freeradbiomed.2011.04.038","article-title":"Salubrinal, an eIF2a dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model","volume":"51","author":"Wu","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2018.10.035_bib0042","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1080\/10286020.2013.790901","article-title":"Cytotoxic activity of Pulsatilla chinensis saponins and their structure-activity relationship","volume":"15","author":"Xu","year":"2013","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2018.10.035_bib0043","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.phymed.2011.08.066","article-title":"Antitumor activity of Pulsatilla chinensis (Bunge) Regel saponins in human liver tumor 7402 cells in vitro and in vivo","volume":"19","author":"Xu","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2018.10.035_bib0044","first-page":"506","article-title":"Lupane-type triterpenoidal saponins from Pulsatilla chinensis and their anticomplement activities through the classical pathway","volume":"79","author":"Xu","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2018.10.035_bib0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1367-5931(03)00081-4","article-title":"New metal complexes as potential therapeutics","volume":"7","author":"Zhang","year":"2003","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.phymed.2018.10.035_bib0046","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1039\/C4MT00035H","article-title":"A comprehensive biological insight of trinuclear copper (II)-tin(IV) chemotherapeutic anticancer drug entity: in vitro cytotoxicity and in vivo systemic toxicity studies","volume":"8","author":"Zaidi","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.phymed.2018.10.035_bib0047","first-page":"756","article-title":"Triterpene saponins from Pulsatilla cernua","volume":"35","author":"Zhang","year":"2000","journal-title":"Acta Pharm. Sin."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318305567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318305567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T20:56:41Z","timestamp":1554411401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711318305567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":47,"alternative-id":["S0944711318305567"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.10.035","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.10.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}