{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:52:53Z","timestamp":1781013173016,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2017R1D1A3B03027847"],"award-info":[{"award-number":["2017R1D1A3B03027847"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2019R1A2C1003200"],"award-info":[{"award-number":["2019R1A2C1003200"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["KSN1812102"],"award-info":[{"award-number":["KSN1812102"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.phymed.2018.12.003","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T13:53:59Z","timestamp":1544450039000},"page":"152780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Liquiritigenin inhibits hepatic fibrogenesis and TGF-\u03b21\/Smad with Hippo\/YAP signal"],"prefix":"10.1016","volume":"62","author":[{"given":"Eun Hye","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-8090","authenticated-orcid":false,"given":"Kwang-Il","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2471-2611","authenticated-orcid":false,"given":"Kwang-Youn","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4147-9794","authenticated-orcid":false,"given":"Ju-Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jeong","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae Kwang","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Chan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Young","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Youn","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-7106","authenticated-orcid":false,"given":"Young Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7430","key":"10.1016\/j.phymed.2018.12.003_bib0001","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature11693","article-title":"Restriction of intestinal stem cell expansion and the regenerative response by YAP","volume":"493","author":"Barry","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phymed.2018.12.003_bib0002","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"15","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.phymed.2018.12.003_bib0003","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1002\/hep.23931","article-title":"E-cadherin antagonizes transforming growth factor \u03b21 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation","volume":"52","author":"Cho","year":"2010","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.phymed.2018.12.003_bib0004","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1074\/jbc.M112.436311","article-title":"Yes-associated protein isoform 1 (YAP1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury","volume":"288","author":"Del Re","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phymed.2018.12.003_bib0005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1309\/J8CD-E9C8-X4NG-GTVG","article-title":"Expression of decorin, transforming growth factor-beta 1, tissue inhibitor metalloproteinase 1 and 2, and type IV collagenases in chronic hepatitis","volume":"115","author":"Dud\u00e1s","year":"2001","journal-title":"Am. J. Clin. Pathol."},{"issue":"12","key":"10.1016\/j.phymed.2018.12.003_bib0006","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/febs.13665","article-title":"TGF-\u03b2 signalling and liver disease","volume":"283","author":"Fabregat","year":"2016","journal-title":"FEBS J"},{"issue":"6","key":"10.1016\/j.phymed.2018.12.003_bib0007","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.phymed.2018.12.003_bib0008","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.phymed.2013.10.015","article-title":"In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin","volume":"21","author":"Gaur","year":"2014","journal-title":"Phytomedicine"},{"issue":"21","key":"10.1016\/j.phymed.2018.12.003_bib0009","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.jmb.2015.04.015","article-title":"Crosstalk between Hippo and TGF\u03b2: Subcellular Localization of YAP\/TAZ\/Smad Complexes","volume":"427","author":"Grannas","year":"2015","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.phymed.2018.12.003_bib0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.phymed.2018.12.003_bib0011","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.phymed.2018.12.003_bib0012","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tox.2004.01.010","article-title":"Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage)","volume":"197","author":"Kim","year":"2004","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.phymed.2018.12.003_bib0013","doi-asserted-by":"crossref","first-page":"G372","DOI":"10.1152\/ajpgi.90524.2008","article-title":"Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes","volume":"296","author":"Kim","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.phymed.2018.12.003_bib0014","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2006.03.008","article-title":"Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine","volume":"161","author":"Kim","year":"2006","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.phymed.2018.12.003_bib0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/bjp.2008.79","article-title":"Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production","volume":"154","author":"Kim","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2018.12.003_bib0016","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/jmf.2006.0114","article-title":"Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride","volume":"10","author":"Lee","year":"2007","journal-title":"J. Med. Food."},{"key":"10.1016\/j.phymed.2018.12.003_bib0017","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cbi.2014.10.005","article-title":"Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-\u03b2\/Smad signaling pathway","volume":"224","author":"Lee","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.phymed.2018.12.003_bib0018","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"2","key":"10.1016\/j.phymed.2018.12.003_bib0019","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2273.1981.tb01800.x","article-title":"Pathological factors influencing excision of tumours in the head and neck. Part I","volume":"6","author":"Levene","year":"1981","journal-title":"Clin. Otolaryngol. Allied Sci."},{"issue":"4","key":"10.1016\/j.phymed.2018.12.003_bib0020","doi-asserted-by":"crossref","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","article-title":"Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis","volume":"308","author":"Liu","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"3","key":"10.1016\/j.phymed.2018.12.003_bib0021","first-page":"185","article-title":"Postulated carbon tetrachloride mode of action: a review","volume":"25","author":"Manibusan","year":"2007","journal-title":"J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev."},{"issue":"3","key":"10.1016\/j.phymed.2018.12.003_bib0022","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","article-title":"The Hippo pathway effector YAP controls mouse hepatic stellate cell activation","volume":"63","author":"Mannaerts","year":"2015","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.phymed.2018.12.003_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.274027.115","article-title":"Mechanisms of Hippo pathway regulation","volume":"30","author":"Meng","year":"2016","journal-title":"Genes Dev"},{"issue":"22","key":"10.1016\/j.phymed.2018.12.003_bib0024","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1242\/dev.030338","article-title":"The regulation of TGFbeta signal transduction","volume":"136","author":"Moustakas","year":"2009","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.phymed.2018.12.003_bib0025","doi-asserted-by":"crossref","first-page":"E71","DOI":"10.1073\/pnas.1517188113","article-title":"Dysregulated YAP1\/TAZ and TGF-\u03b2 signaling mediate hepatocarcinogenesis in Mob1a\/1b-deficient mice","volume":"113","author":"Nishio","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.phymed.2018.12.003_bib0026","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1248\/bpb.b14-00430","article-title":"Tacrine, an oral acetylcholinesterase inhibitor, induced hepatic oxidative damage, which was blocked by liquiritigenin through GSK3-beta inhibition","volume":"38","author":"Park","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2018.12.003_bib0027","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biochi.2017.05.017","article-title":"Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo\/YAP and TGF-\u03b21\/Smad signaling","volume":"140","author":"Perumal","year":"2017","journal-title":"Biochimie"},{"issue":"4","key":"10.1016\/j.phymed.2018.12.003_bib0028","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/j.2040-4603.2013.tb00529.x","article-title":"Hepatic stellate cells and liver fibrosis","volume":"3","author":"Puche","year":"2013","journal-title":"Compr. Physiol."},{"issue":"9","key":"10.1016\/j.phymed.2018.12.003_bib0029","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/qjmed\/hcs069","article-title":"Liver fibrosis: a bidirectional model of fibrogenesis and resolution","volume":"105","author":"Ramachandran","year":"2012","journal-title":"Q. J. M."},{"issue":"3-4","key":"10.1016\/j.phymed.2018.12.003_bib0030","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000343851","article-title":"Molecular link between liver fibrosis and hepatocellular carcinoma","volume":"2","author":"Sakurai","year":"2013","journal-title":"Liver Cancer"},{"issue":"28","key":"10.1016\/j.phymed.2018.12.003_bib0031","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"3","key":"10.1016\/j.phymed.2018.12.003_bib0032","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.phymed.2018.12.003_bib0033","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2010.11.012","article-title":"The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-\u03b2-SMAD pathway","volume":"19","author":"Varelas","year":"2010","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.phymed.2018.12.003_bib0034","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/jphp.12170","article-title":"Liquiritigenin exhibits antitumour action in pituitary adenoma cells via Ras\/ERKs and ROS-dependent mitochondrial signalling pathways","volume":"66","author":"Wang","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"issue":"34","key":"10.1016\/j.phymed.2018.12.003_bib0035","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector YAP promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phymed.2018.12.003_bib0036","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.addr.2017.07.010","article-title":"Drug targeting to myofibroblasts: implications for fibrosis and cancer","volume":"121","author":"Yazdani","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2018.12.003_bib0037","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/649568","article-title":"Liquiritigenin protects rats from carbon tetrachloride induced hepatic injury through PGC-1\u03b1 pathway","volume":"2015","author":"Zhang","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"14","key":"10.1016\/j.phymed.2018.12.003_bib0038","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev"},{"key":"10.1016\/j.phymed.2018.12.003_bib0039","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3389\/fphar.2016.00462","article-title":"Targeting mechanotransduction at the transcriptional Level: YAP and BRD4 are novel therapeutic targets for the reversal of liver fibrosis","volume":"7","author":"Zhubanchaliyev","year":"2016","journal-title":"Front. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131830597X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471131830597X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:19:07Z","timestamp":1760552347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471131830597X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":39,"alternative-id":["S094471131830597X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.12.003","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquiritigenin inhibits hepatic fibrogenesis and TGF-\u03b21\/Smad with Hippo\/YAP signal","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152780"}}