{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:17:55Z","timestamp":1790144275507,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.phymed.2018.12.017","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T21:50:17Z","timestamp":1544478617000},"page":"95-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Piceatannol-3-O-\u03b2-D-glucopyranoside (PG) exhibits in vitro anti-metastatic and anti-angiogenic activities in HT1080 malignant fibrosarcoma cells"],"prefix":"10.1016","volume":"57","author":[{"given":"Aeyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Yeul","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2018.12.017_bib0001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s13318-016-0381-y","article-title":"Pharmacokinetics and pharmacodynamics of promising arginase inhibitors","volume":"42","author":"Abdelkawy","year":"2017","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.phymed.2018.12.017_bib0002","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1007\/s13277-014-2421-z","article-title":"Metastasis review: From bench to bedside","volume":"35","author":"Alizadeh","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0003","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.semcancer.2015.02.005","article-title":"Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds","volume":"35","author":"Amin","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0004","first-page":"1557","article-title":"Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1","volume":"15","author":"Bae","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.phymed.2018.12.017_bib0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/0148607108314371","article-title":"Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro","volume":"32","author":"Cai","year":"2008","journal-title":"J. Parenter Enteral Nutr."},{"key":"10.1016\/j.phymed.2018.12.017_bib0006","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1158\/1541-7786.MCR-06-0002","article-title":"Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment","volume":"4","author":"Cairns","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.phymed.2018.12.017_bib0007","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1055\/s-0029-1185304","article-title":"Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK\/Ay diabetic mice","volume":"75","author":"Chen","year":"2009","journal-title":"Planta. Med."},{"key":"10.1016\/j.phymed.2018.12.017_bib0008","first-page":"120","article-title":"Hypoxia-induced angiogenesis during carcinogenesis","volume":"36","author":"Choi","year":"2003","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0009","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.matbio.2015.04.004","article-title":"Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature","author":"Deryugina","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0010","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc2403","article-title":"VEGF-targeted therapy: Mechanisms of anti-tumour activity","volume":"8","author":"Ellis","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2018.12.017_bib0011","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1158\/0008-5472.CAN-13-0661","article-title":"Targeting the tumor microenvironment: From understanding pathways to effective clinical trials","volume":"73","author":"Fang","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2018.12.017_bib0012","article-title":"A systemic review of Rhubarb (a traditional chinese medicine) used for the treatment of experimental sepsis","volume":"2015","author":"Fang","year":"2015","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.phymed.2018.12.017_bib0013","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10555-010-9224-5","article-title":"Hypoxia, inflammation, and the tumor microenvironment in metastatic disease","volume":"29","author":"Finger","year":"2010","journal-title":"Cancer Metast. Rev"},{"key":"10.1016\/j.phymed.2018.12.017_bib0014","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/cancers3011351","article-title":"Cisplatin as an anti-tumor drug: Cellular mechanisms of activity, drug resistance and induced side effects","volume":"3","author":"Florea","year":"2011","journal-title":"Cancers"},{"key":"10.1016\/j.phymed.2018.12.017_bib0015","first-page":"25","article-title":"The effect of raw Chinese rhubarb on the activities of four digestive enzymes and the discussion on its medicine property","volume":"6","author":"Gao","year":"1981","journal-title":"Zhong Yao Tong Bao"},{"key":"10.1016\/j.phymed.2018.12.017_bib0016","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3748\/wjg.v9.i6.1144","article-title":"Mechanism and its regulation of tumor-induced angiogenesis","volume":"9","author":"Gupta","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0017","first-page":"347","article-title":"Induction of apoptosis by rhapontin having stilbene moiety, a component of rhubarb (Rheum officinale Baillon) in human stomach cancer KATO III cells","volume":"18","author":"Hibasami","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.phymed.2018.12.017_bib0018","doi-asserted-by":"crossref","first-page":"273","DOI":"10.15430\/JCP.2014.19.4.273","article-title":"Induction of cell cycle arrest and apoptosis by physcion, an anthraquinone isolated from rhubarb (Rhizomes of Rheum tanguticum), in MDA-MB-231 human breast cancer cells","volume":"19","author":"Hong","year":"2014","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.phymed.2018.12.017_bib0019","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/med.20094","article-title":"Anti-cancer properties of anthraquinones from rhubarb","volume":"27","author":"Huang","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.phymed.2018.12.017_bib0020","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.3892\/ijo.2016.3742","article-title":"Ethanol extract of baked Gardeniae Fructus exhibits in vitro and in vivo anti-metastatic and anti-angiogenic activities in malignant cancer cells: Role of suppression of the NF-kappaB and HIF-1alpha pathways","volume":"49","author":"Im","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0021","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00280-013-2362-z","article-title":"Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1alpha), in patients with refractory solid tumors","volume":"73","author":"Jeong","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0022","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccr.2005.05.024","article-title":"Therapeutic targeting of the tumor microenvironment","volume":"7","author":"Joyce","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2018.12.017_bib0023","first-page":"572","article-title":"Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis","volume":"6","author":"Kaya","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2018.12.017_bib0024","doi-asserted-by":"crossref","first-page":"36277","DOI":"10.1038\/srep36277","article-title":"Ethanol extract of Lophatheri Herba exhibits anti-cancer activity in human cancer cells by suppression of metastatic and angiogenic potential","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2018.12.017_bib0025","first-page":"1160","article-title":"Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF1alpha pathway","volume":"53","author":"Kim","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0026","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/jbmr.2183","article-title":"Emodin regulates bone remodeling by inhibiting osteoclastogenesis and stimulating osteoblast formation","volume":"29","author":"Kim","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2018.12.017_bib0027","first-page":"881","article-title":"Molecular principles of cancer invasion and metastasis (review)","volume":"34","author":"Leber","year":"2009","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0028","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/jcb.21159","article-title":"Tumor microenvironment: The role of the tumor stroma in cancer","volume":"101","author":"Li","year":"2007","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2018.12.017_bib0029","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0021-9673(99)00771-2","article-title":"Computer-aided development of a high-performance liquid chromatographic method for the determination of hydroxyanthraquinone derivatives in Chinese herb medicine rhubarb","volume":"857","author":"Liu","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phymed.2018.12.017_bib0030","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1074\/jbc.M109.074930","article-title":"Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: A novel therapeutic strategy for angiogenesis","volume":"285","author":"Nowak","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2018.12.017_bib0031","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"Ouyang","year":"2012","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2018.12.017_bib0032","first-page":"20896","article-title":"Inhibition of growth and metastasis of colon cancer by delivering 5-Fluorouracil-loaded pluronic P85 copolymer micelles","volume":"11","author":"Pengxi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2018.12.017_bib0033","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm0603-677","article-title":"Regulation of angiogenesis by hypoxia: Role of the HIF system","volume":"9","author":"Pugh","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2018.12.017_bib0034","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jep.2012.03.048","article-title":"Rheum australe D. Don: A review of its botany, ethnobotany, phytochemistry and pharmacology","volume":"14","author":"Rokaya","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0035","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jep.2010.10.020","article-title":"Suppression on metastasis by rhubarb through modulation on MMP-2 and uPA in human A549 lung adenocarcinoma: An ex vivo approach","volume":"133","author":"Shia","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0036","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/1947601911423031","article-title":"Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: A crucial target for anti- and pro-angiogenic therapies","volume":"2","author":"Shibuya","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.phymed.2018.12.017_bib0037","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0169-5002(03)00308-8","article-title":"Targeting angiogenesis: A review of angiogenesis inhibitors in the treatment of lung cancer","volume":"42","author":"Sridhar","year":"2003","journal-title":"Lung Cancer"},{"key":"10.1016\/j.phymed.2018.12.017_bib0038","first-page":"178","article-title":"Correlation between Chinese traditional drug Rhubarb and Western medicine","volume":"12","author":"Sun","year":"1992","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.phymed.2018.12.017_bib0039","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.foodchem.2012.10.038","article-title":"Rhubarb inhibits hepatocellular carcinoma cell metastasis via GSK-3-beta activation to enhance protein degradation and attenuate nuclear translocation of beta-catenin","volume":"138","author":"Tsai","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2018.12.017_bib0040","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2011.09.024","article-title":"Tumor metastasis: Molecular insights and evolving paradigms","volume":"147","author":"Valastyan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2018.12.017_bib0041","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/pca.1365","article-title":"Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis","volume":"23","author":"VanMen","year":"2012","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.phymed.2018.12.017_bib0042","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3858\/emm.2010.42.7.053","article-title":"Piceatannol-3\u2032-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity","volume":"42","author":"Woo","year":"2010","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2018.12.017_bib0043","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3892\/ijmm.2013.1261","article-title":"Arginase inhibition by piceatannol-3\u2032-O-beta-d-glucopyranoside improves endothelial dysfunction via activation of endothelial nitric oxide synthase in ApoE-null mice fed a high-cholesterol diet","volume":"31","author":"Woo","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2018.12.017_bib0044","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/bjc.1995.181","article-title":"Induction of apoptosis by anti-cancer drugs with disparate modes of action: Kinetics of cell death and changes in c-myc expression","volume":"71","author":"Wood","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.phymed.2018.12.017_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1010428317700411","article-title":"MMP-2 together with MMP-9 overexpression correlated with lymph node metastasis and poor prognosis in early gastric carcinoma","volume":"39","author":"Yao","year":"2017","journal-title":"Tumor Biol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0046","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1016\/j.semcancer.2015.03.007","article-title":"Therapeutic targeting of relicative immortality","volume":"35","author":"Yaswen","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2018.12.017_bib0047","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/1472-6882-14-353","article-title":"Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo","volume":"14","author":"Yi","year":"2014","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.phymed.2018.12.017_bib0048","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ptr.2042","article-title":"Vasorelaxant effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aorta","volume":"21","author":"Yoo","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2018.12.017_bib0049","first-page":"516","article-title":"Association of microvessel density and blood vessel invasion with the prognosis in rectal carcinoma at stages I to II","volume":"13","author":"Zhou","year":"2010","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318306081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711318306081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:16:18Z","timestamp":1760552178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711318306081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":49,"alternative-id":["S0944711318306081"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2018.12.017","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piceatannol-3-O-\u03b2-D-glucopyranoside (PG) exhibits in vitro anti-metastatic and anti-angiogenic activities in HT1080 malignant fibrosarcoma cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2018.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}