{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:31:04Z","timestamp":1784914264123,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["K18030"],"award-info":[{"award-number":["K18030"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science & Technology","doi-asserted-by":"publisher","award":["D17450"],"award-info":[{"award-number":["D17450"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.phymed.2019.152835","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T03:07:26Z","timestamp":1547608046000},"page":"152835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Siraitia grosvenorii residual extract attenuates ovalbumin-induced lung inflammation by down-regulating IL-4, IL-5, IL-13, IL-17, and MUC5AC expression in mice"],"prefix":"10.1016","volume":"61","author":[{"given":"Yoon-Young","family":"Sung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-1733","authenticated-orcid":false,"given":"Seung-Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung Joo","family":"Yuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Kyung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Mi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Seon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2019.152835_bib0001","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1358\/dnp.2002.15.1.660501","article-title":"The role of TARC in the pathogenesis of allergic asthma","volume":"15","author":"Berin","year":"2002","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.phymed.2019.152835_bib0002","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1081-1206(10)60528-5","article-title":"Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma","volume":"103","author":"Busse","year":"2009","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.phymed.2019.152835_bib0003","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molimm.2014.11.001","article-title":"Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-\u03baB in a murine model of asthma","volume":"64","author":"Chen","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phymed.2019.152835_bib0004","series-title":"Pharmacopoeia of P.R. China","year":"2010"},{"key":"10.1016\/j.phymed.2019.152835_bib0005","doi-asserted-by":"crossref","first-page":"7474","DOI":"10.1021\/jf201207m","article-title":"Anti-inflammatory activities of mogrosides from Momordica grosvenori in murine macrophages and a murine ear edema model","volume":"59","author":"Di","year":"2011","journal-title":"J. Agric. Food Chem"},{"key":"10.1016\/j.phymed.2019.152835_bib0006","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.4049\/jimmunol.151.5.2399","article-title":"Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family","volume":"151","author":"Fleming","year":"1993","journal-title":"J. Immunol"},{"key":"10.1016\/j.phymed.2019.152835_bib0007","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.intimp.2014.05.034","article-title":"Key mediators in the immunopathogenesis of allergic asthma","volume":"23","author":"Hall","year":"2014","journal-title":"Immunopharmacol"},{"key":"10.1016\/j.phymed.2019.152835_bib0008","article-title":"Antiasthmatic effects of herbal complex MA and its fermented product MA128","volume":"2012","author":"Kim","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2019.152835_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/485402","article-title":"Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma","volume":"2011","author":"Kim","year":"2011","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2019.152835_bib0010","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.intimp.2013.12.009","article-title":"Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, ROR\u03b3t and Foxp3 in asthmatic mice","volume":"18","author":"Kim","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2019.152835_bib0011","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.bbrc.2011.12.084","article-title":"Anti-inflammatory effects of Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma","volume":"417","author":"Lee","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2019.152835_bib0012","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.foodchem.2017.02.018","article-title":"Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro","volume":"228","author":"Li","year":"2017","journal-title":"Food. Chem."},{"key":"10.1016\/j.phymed.2019.152835_bib0013","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1271\/bbb.90832","article-title":"Digestion and absorption of Siraitia grosvenori triterpenoids in the rat","volume":"74","author":"Murata","year":"2010","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"10.1016\/j.phymed.2019.152835_bib0014","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.all.0000162309.97480.45","article-title":"Cytokines, allergy, and asthma","volume":"5","author":"Ngoc","year":"2005","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2019.152835_bib0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.nutres.2008.02.008","article-title":"Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice","volume":"28","author":"Qi","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.phymed.2019.152835_bib0016","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12931-016-0359-y","article-title":"CD4+ and CD8+ T cells play a central role in a HDM driven model of allergic asthma","volume":"17","author":"Raemdonck","year":"2016","journal-title":"Respir. Res."},{"key":"10.1016\/j.phymed.2019.152835_bib0017","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/eji.200425715","article-title":"CD8+ T cell contributions to allergen induced pulmonary inflammation and airway hyperreactivity","volume":"35","author":"Schaller","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phymed.2019.152835_bib0018","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.coph.2013.03.013","article-title":"Cytokine targets in airway inflammation","volume":"13","author":"Schuijs","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.phymed.2019.152835_bib0019","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jaci.2016.03.042","article-title":"CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells","volume":"139","author":"Selb","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2019.152835_bib0020","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3109\/13880209.2013.867451","article-title":"Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice","volume":"52","author":"Shi","year":"2014","journal-title":"Pharm Biol"},{"key":"10.1016\/j.phymed.2019.152835_bib0021","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1124\/jpet.116.239137","article-title":"Mogroside IIIE, a novel anti-fibrotic compound, reduces pulmonary fibrosis through toll-like receptor 4 pathways","volume":"36","author":"Tao","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2019.152835_bib0022","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1084\/jem.20101376","article-title":"A novel subset of CD4+ Th2 memory\/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma","volume":"207","author":"Wang","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2019.152835_bib0023","first-page":"593","article-title":"Expression of surface CD11b antigen and eosinophil activation","volume":"51","author":"Yachie","year":"1993","journal-title":"Nippon Rinsho"},{"key":"10.1016\/j.phymed.2019.152835_bib0024","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/j.ajpath.2013.02.042","article-title":"CD19 expression in B cells regulated atopic dermatitis in a mouse model","volume":"182","author":"Yanaba","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2019.152835_bib0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2131\/jts.33.197","article-title":"Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats","volume":"33","author":"Yasuno","year":"2008","journal-title":"J. Toxicol. Sci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T23:13:22Z","timestamp":1694560402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711319300133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":25,"alternative-id":["S0944711319300133"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152835","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Siraitia grosvenorii residual extract attenuates ovalbumin-induced lung inflammation by down-regulating IL-4, IL-5, IL-13, IL-17, and MUC5AC expression in mice","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152835"}}