{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:29:48Z","timestamp":1768462188806,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["14104349"],"award-info":[{"award-number":["14104349"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018530","name":"Major Science and Technology Projects in Anhui Province","doi-asserted-by":"publisher","award":["171100310500"],"award-info":[{"award-number":["171100310500"]}],"id":[{"id":"10.13039\/501100018530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.phymed.2019.152857","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T12:02:59Z","timestamp":1549281779000},"page":"152857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Chinese yam extract and adenosine attenuated LPS-induced cardiac dysfunction by inhibiting RAS and apoptosis via the ER-mediated activation of SHC\/Ras\/Raf1 pathway"],"prefix":"10.1016","volume":"61","author":[{"given":"Mengnan","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benke","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Kan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weisheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoke","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2019.152857_bib0001","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/star.201500302","article-title":"Physico\u2010chemical, functional and pasting properties of native and chemically modified water yam (Dioscorea alata) starch and production of water yam starch\u2010based yoghurt","volume":"68","author":"Awolu","year":"2016","journal-title":"Starch"},{"key":"10.1016\/j.phymed.2019.152857_bib0002","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/emmm.201000080","article-title":"Angiotensin \u2161 revisited: new roles ininflammation,immunology and aging","volume":"2","author":"Benigni","year":"2010","journal-title":"Embo. Mol. Med."},{"key":"10.1016\/j.phymed.2019.152857_bib0003","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.8755-8920.2000.440511.x","article-title":"Femalesex hormones modulate the function of LPS-treated macrophages","volume":"44","author":"Chao","year":"2000","journal-title":"AM J. Reprod. Immunol."},{"key":"10.1016\/j.phymed.2019.152857_bib0004","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.yjmcc.2009.11.003","article-title":"Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis","volume":"48","author":"Ceylan-Isik","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phymed.2019.152857_bib0005","first-page":"241","volume":"06","author":"Chai","year":"2017","journal-title":"Chapter 10-Estrogen-Metabolizing Enzymes in Systemic and Local Liver Injuries: A Case Study of Disease-Drug Interaction"},{"key":"10.1016\/j.phymed.2019.152857_bib0006","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/eji.201747150","article-title":"The vaccine adjuvant alum promotes IL\u201010 production that suppresses Th1 responses","volume":"48","author":"Ewa","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phymed.2019.152857_bib0007","first-page":"38","article-title":"A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: dysregulated glandular homeostasis, survival and metastasis","volume":"10","author":"Edward","year":"2018","journal-title":"J. Steroid. Biochem."},{"key":"10.1016\/j.phymed.2019.152857_bib0008","first-page":"896","article-title":"Myocardial dysfunction in sepsis: a large,unsolved puzzle","volume":"2012","author":"Fernandes","year":"2012","journal-title":"Crit. Care Res. Pract."},{"key":"10.1016\/j.phymed.2019.152857_bib0009","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1471-4159.2010.07044.x","article-title":"Phosphorylation of APP\u2010CTF\u2010AICD domains and interaction with adaptor proteins: signal transduction and\/or transcriptional role-relevance for Alzheimer pathology","volume":"115","author":"Gennaro","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phymed.2019.152857_bib0010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molimm.2018.03.005","article-title":"Smurf1 regulates macrophage proliferation, apoptosis and migration via JNK and p38 MAPK signaling pathways","volume":"97","author":"Guo","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phymed.2019.152857_bib0011","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s12098-014-1618-x","article-title":"Clinical epidemiology of SIRS and sepsis in newly admitted children","volume":"82","author":"Ganjoo","year":"2014","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.phymed.2019.152857_bib0012","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jcrc.2017.11.038","article-title":"Coronary artery calcification predicts cardiovascular complications after sepsis","volume":"44","author":"Gupta","year":"2018","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.phymed.2019.152857_bib0013","doi-asserted-by":"crossref","unstructured":"Gullestad, L., Ueland, T., Vinge, L.E., Inflammatory cytokines in heart failure: mediators and markers.2012 Cardiology. 122, 23\u201335.","DOI":"10.1159\/000338166"},{"key":"10.1016\/j.phymed.2019.152857_bib0014","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jsbmb.2018.02.005","article-title":"Estrogen serum concentration affects blood immune cell composition and polarization in human females under controlled ovarian stimulation","volume":"178","author":"Habib","year":"2018","journal-title":"J. Steroid. Biochem."},{"key":"10.1016\/j.phymed.2019.152857_bib0017","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1152\/ajpheart.2000.279.5.H2053","article-title":"Endotoxin infusion in rats induces apoptotic and survival pathways in hearts","volume":"279","author":"McDonald","year":"2000","journal-title":"Am. J. Physiol. Heart Circ.Physiol."},{"key":"10.1016\/j.phymed.2019.152857_bib0018","first-page":"40","article-title":"Epidemiology of sepsis inColombian intensive care units","volume":"34","author":"Ortiz","year":"2014","journal-title":"Biom edica."},{"key":"10.1016\/j.phymed.2019.152857_bib0019","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12943-017-0727-3","article-title":"Linc-RoR promotes MAPK\/ERK signaling and confers estrogen-independent growth of breast cancer","volume":"16","author":"Peng","year":"2017","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.phymed.2019.152857_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":". Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"N. Engl.J. Med."},{"key":"10.1016\/j.phymed.2019.152857_bib0021","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.foodhyd.2015.11.003","article-title":"Effect of oxidation, cross-linking and dual modification on physicochemical, crystallinity, morphological, pasting and thermal characteristics of elephant foot yam (Amorphophallus paeoniifolius) starch","volume":"55","author":"Sukhija","year":"2016","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.phymed.2019.152857_bib0022","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s40265-018-0884-8","article-title":"BRAF and MEK inhibitors: use and resistance in BRAF-mutated cancers","volume":"78","author":"Sanchez","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.phymed.2019.152857_bib0023","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jep.2010.05.038","article-title":"Carthamus tinctorius L. prevents LPS-induced TNFalpha signaling activation and cell apoptosis through JNK1\/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells","volume":"130","author":"Tien","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2019.152857_bib0024","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jep.2016.05.062","article-title":"The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: a (preliminary) meta-analysis","volume":"191","author":"Tian","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2019.152857_bib0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/SHK.0000000000000670","article-title":"The role and use of estrogens following trauma","volume":"46","author":"Weniger","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2019.152857_bib0026","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7834381","article-title":"Royal jelly attenuates LPS-induced inflammation in BV-2 microglial cells through modulating NF- \u03baB and p38\/JNK signaling pathways","author":"You","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2019.152857_bib0027","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.carbpol.2014.09.082","article-title":"Purification and structural characterization of Chinese yam polysaccharide and its activities","volume":"117","author":"Yang","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2019.152857_bib0028","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/molecules23020011","article-title":"Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo","volume":"23","author":"Zeng","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2019.152857_bib0029","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/SHK.0b013e31818ec609","article-title":"Cardiac-specific overexpression of insulin-like growth Factor I (Igf-1) rescues lipopolysaccharide-induced cardiac dysfunction and activation of stress signaling in murine cardiomyocytes","volume":"32","author":"Zhao","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2019.152857_bib0030","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2014.04.020","article-title":"Ablation of Akt2 protects against lipopolysaccharide-induced cardiac dysfunction: role of Akt ubiquitination E3 ligase TRAF6","volume":"74","author":"Zhang","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phymed.2019.152857_bib0031","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jss.2013.01.068","article-title":"Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes","volume":"183","author":"Zou","year":"2013","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.phymed.2019.152857_bib0032","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0043-100221","article-title":"Estrogen maintains skeletal muscle in septic rats associated with altering hypothalamic inflammation and neuropeptides","volume":"49","author":"Zhao","year":"2017","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.phymed.2019.152857_bib0033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15384101.2017.1407891","article-title":"VEGFC\/VEGFR3 signaling regulates mouse spermatogonial cell proliferation via the activation of AKT\/MAPK and cCyclin D1 pathway and mediates the apoptosis by affecting caspase 3\/9 and Bcl-2","volume":"17","author":"Zhao","year":"2018","journal-title":"Cell Cycle"}],"updated-by":[{"DOI":"10.1016\/j.phymed.2025.157102","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000}},{"DOI":"10.1016\/j.phymed.2020.153283","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000}}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:17:00Z","timestamp":1760552220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711319300285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":31,"alternative-id":["S0944711319300285"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152857","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.phymed.2025.157102","asserted-by":"object"},{"id-type":"doi","id":"10.1016\/j.phymed.2020.153283","asserted-by":"object"}]},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chinese yam extract and adenosine attenuated LPS-induced cardiac dysfunction by inhibiting RAS and apoptosis via the ER-mediated activation of SHC\/Ras\/Raf1 pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"152857"}}