{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T06:05:43Z","timestamp":1782626743651,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.phymed.2019.152860","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T12:03:51Z","timestamp":1549281831000},"page":"152860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis"],"prefix":"10.1016","volume":"61","author":[{"given":"Hui-juan","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reihane","family":"Ziadlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Grad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xiao","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-4873","authenticated-orcid":false,"given":"Xin-sheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Alini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-luan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2019.152860_bib0001","doi-asserted-by":"crossref","first-page":"36168","DOI":"10.1074\/jbc.M112.344747","article-title":"A phytoestrogen diarylheptanoid mediates estrogen receptor\/akt\/glycogen synthase kinase 3 beta protein-dependent activation of the wnt\/beta-catenin signaling pathway","volume":"287","author":"Bhukhai","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2019.152860_bib0002","first-page":"1382","article-title":"Novel regimen of hormone replacement therapy: efficacy and safety of transdermal estrogen plus intermittent progesterone","volume":"22","author":"Gomaa","year":"2015","journal-title":"Menopause"},{"key":"10.1016\/j.phymed.2019.152860_bib0003","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.cyto.2011.09.005","article-title":"Primary human bone marrow adipocytes support TNF-alpha-induced osteoclast differentiation and function through RANKL expression","volume":"56","author":"Goto","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.phymed.2019.152860_bib0004","doi-asserted-by":"crossref","DOI":"10.1007\/s11657-016-0301-4","article-title":"New insights into the tonifying kidney-yin herbs and formulas for the treatment of osteoporosis","volume":"12","author":"He","year":"2017","journal-title":"Arch. Osteoporos."},{"key":"10.1016\/j.phymed.2019.152860_bib0005","doi-asserted-by":"crossref","first-page":"11404","DOI":"10.1074\/jbc.275.15.11404","article-title":"Estrogen suppresses transcription of lipoprotein lipase gene - Existence of a unique estrogen response element on the lipoprotein lipase promoter","volume":"275","author":"Homma","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2019.152860_bib0006","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm1096-1132","article-title":"Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta","volume":"2","author":"Hughes","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2019.152860_bib0007","doi-asserted-by":"crossref","first-page":"83","DOI":"10.11005\/jbm.2013.20.2.83","article-title":"Bone morphogenetic protein-2 desensitizes MC3T3-E1 osteoblastic cells to estrogen through transcriptional downregulation of estrogen receptor 1","volume":"20","author":"Ishibashi","year":"2013","journal-title":"J. Bone. Metab."},{"key":"10.1016\/j.phymed.2019.152860_bib0008","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jim.2010.01.014","article-title":"Dimethyl sulfoxide (DMSO) exposure to human peripheral blood mononuclear cells (PBMCs) abolish T cell responses only in high concentrations and following coincubation for more than two hours","volume":"356","author":"Kloverpris","year":"2010","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.phymed.2019.152860_bib0009","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00441-009-0832-8","article-title":"Regulation of bone development and extracellular matrix protein genes by RUNX2","volume":"339","author":"Komori","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.phymed.2019.152860_bib0010","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.01428-09","article-title":"Osteocyte wnt\/beta-catenin signaling is required for normal bone homeostasis","volume":"30","author":"Kramer","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2019.152860_bib0011","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1210\/endo.138.3.4979","article-title":"Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta","volume":"138","author":"Kuiper","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.phymed.2019.152860_bib0012","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/jbmr.2557","article-title":"Short-term effect of estrogen on human bone marrow fat","volume":"30","author":"Limonard","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2019.152860_bib0013","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.bmcl.2014.01.029","article-title":"Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia","volume":"24","author":"Liu","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2019.152860_bib0014","first-page":"134","article-title":"Cellular and molecular mechanisms of postmenopausal osteoporosis","author":"Manolagas","year":"2000","journal-title":"Serono. Symp."},{"key":"10.1016\/j.phymed.2019.152860_bib0015","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/dvdy.21187","article-title":"Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency","volume":"236","author":"Maruyama","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.phymed.2019.152860_bib0016","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.steroids.2013.02.011","article-title":"Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling","volume":"78","author":"Matsumoto","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.phymed.2019.152860_bib0017","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00018-008-8429-z","article-title":"Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program","volume":"66","author":"Muruganandan","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2019.152860_bib0018","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.biomaterials.2015.02.061","article-title":"The utilization of decellularized tendon slices to provide an inductive microenvironment for the proliferation and tenogenic differentiation of stem cells","volume":"52","author":"Ning","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.phymed.2019.152860_bib0019","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1210\/jc.2015-2338","article-title":"The role of bone marrow fat in skeletal health: usefulness and perspectives for clinicians","volume":"100","author":"Paccou","year":"2015","journal-title":"J. Clin. Endocr. Metab."},{"key":"10.1016\/j.phymed.2019.152860_bib0020","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ceb.2007.09.014","article-title":"Wnt\/beta-catenin signaling in adipogenesis and metabolism","volume":"19","author":"Prestwich","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.phymed.2019.152860_bib0021","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.physiol.70.113006.100518","article-title":"Estrogen signaling through the transmembrane G protein-coupled receptor GrPR30","volume":"70","author":"Prossnitz","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.phymed.2019.152860_bib0022","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/1097-4644(20001215)79:4<557::AID-JCB40>3.0.CO;2-H","article-title":"Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation","volume":"79","author":"Rodriguez","year":"2000","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2019.152860_bib0023","first-page":"565","article-title":"Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells","volume":"18","author":"Rucinski","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2019.152860_bib0024","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/ageing\/afv069","article-title":"Oestrogen replacement in postmenopausal women","volume":"44","author":"Sassarini","year":"2015","journal-title":"Age Ageing"},{"key":"10.1016\/j.phymed.2019.152860_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2015.00040","article-title":"Marrow fat and bone: review of clinical findings","volume":"6","author":"Schwartz","year":"2015","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2019.152860_bib0026","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1078\/0944-7113-00148","article-title":"Daidzein, coumestrol and zearalenone affect lipogenesis and lipolysis in rat adipocytes","volume":"9","author":"Szkudelska","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2019.152860_bib0027","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1517\/14728220902915310","article-title":"Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies","volume":"13","author":"Takada","year":"2009","journal-title":"Expert Opin Ther Tar"},{"key":"10.1016\/j.phymed.2019.152860_bib0028","doi-asserted-by":"crossref","first-page":"16302","DOI":"10.1074\/jbc.M001364200","article-title":"Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1","volume":"275","author":"Tcherepanova","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2019.152860_bib0029","article-title":"Puerarin promotes osteogenesis and inhibits adipogenesis in vitro","volume":"8","author":"Wang","year":"2013","journal-title":"Chin. Med.-UK"},{"key":"10.1016\/j.phymed.2019.152860_bib0030","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1210\/endo.138.9.5359","article-title":"The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage","volume":"138","author":"Weinstein","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.phymed.2019.152860_bib0031","first-page":"13","article-title":"Smad signal pathway in BMP-2-induced osteogenesis - a mini review","volume":"3","author":"Wu","year":"2008","journal-title":"J. Dent. Sci."},{"key":"10.1016\/j.phymed.2019.152860_bib0032","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jbm.b.31326","article-title":"Coumestrol promotes proliferation and osteoblastic differentiation in rat bone marrow stromal cells","volume":"90B","author":"Wu","year":"2009","journal-title":"J. Biomed. Mater. Res. B."},{"key":"10.1016\/j.phymed.2019.152860_bib0033","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejphar.2017.03.001","article-title":"Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts","volume":"801","author":"Zhai","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2019.152860_bib0034","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.biopha.2018.03.166","article-title":"The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K\/Akt axis","volume":"102","author":"Zhai","year":"2018","journal-title":"Biomed. Pharmacother."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T16:21:51Z","timestamp":1568391711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711319300315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":34,"alternative-id":["S0944711319300315"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152860","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152860","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152860"}}