{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:36:23Z","timestamp":1781775383484,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006054","name":"Universidad de Guanajuato","doi-asserted-by":"publisher","award":["1025\/2016"],"award-info":[{"award-number":["1025\/2016"]}],"id":[{"id":"10.13039\/501100006054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006054","name":"Universidad de Guanajuato","doi-asserted-by":"publisher","award":["CIIC 95\/2018"],"award-info":[{"award-number":["CIIC 95\/2018"]}],"id":[{"id":"10.13039\/501100006054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007070","name":"Universidad Nacional de Mar del Plata","doi-asserted-by":"publisher","award":["EXA 824\/17"],"award-info":[{"award-number":["EXA 824\/17"]}],"id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PDCPN2014-247109"],"award-info":[{"award-number":["PDCPN2014-247109"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["FC 2015-02-834"],"award-info":[{"award-number":["FC 2015-02-834"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PUE 0076"],"award-info":[{"award-number":["PUE 0076"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.phymed.2019.152875","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T12:23:17Z","timestamp":1551270197000},"page":"152875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Effects of the binding of a Helianthus annuus lectin to Candida albicans cell wall on biofilm development and adhesion to host cells"],"prefix":"10.1016","volume":"58","author":[{"given":"Marianela","family":"Del Rio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de la Canal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Pinedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor M.","family":"Mora-Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Regente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2019.152875_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162465","article-title":"Anticandidal effect and mechanisms of monoterpenoid, perillyl alcohol against Candida albicans","volume":"11","author":"Ansari","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2019.152875_bib0002","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.diagmicrobio.2007.07.013","article-title":"Cellular surface hydrophobicity as an additional phenotypic criterion applied to differentiate strains of Candida albicans and Candida dubliniensis","volume":"60","author":"Blanco","year":"2008","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.phymed.2019.152875_bib0003","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1128\/EC.3.4.900-909.2004","article-title":"Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus","volume":"3","author":"Brand","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.phymed.2019.152875_bib0004","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fmed.2018.00028","article-title":"Candida biofilms: threats, challenges, and promising strategies","volume":"5","author":"Cavalheiro","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.phymed.2019.152875_bib0005","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phytochem.2015.05.020","article-title":"Toxic proteins in plants","volume":"117","author":"Dang","year":"2015","journal-title":"Phytochemestry"},{"key":"10.1016\/j.phymed.2019.152875_bib0006","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ijbiomac.2017.12.039","article-title":"PgTeL, the lectin found in Punica granatum juice, is an antifungal agent against Candida albicans and Candida krusei","volume":"108","author":"da Silva","year":"2018","journal-title":"Int. J. Bio. Macromol."},{"key":"10.1016\/j.phymed.2019.152875_bib0007","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jplph.2017.12.001","article-title":"Internalization of a sunflower mannose-binding lectin into phytopathogenic fungal cells induces cytotoxicity","volume":"221","author":"Del Rio","year":"2018","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0008","doi-asserted-by":"crossref","first-page":"e00986","DOI":"10.1128\/mBio.00986-15","article-title":"Cell wall remodeling enzymes modulate fungal cell wall elasticity and osmotic stress resistance","volume":"6","author":"Ene","year":"2015","journal-title":"MBio."},{"key":"10.1016\/j.phymed.2019.152875_bib0009","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-3-319-25304-6_2","article-title":"Cell surface interference with plasma membrane and transport processes in yeasts","volume":"892","author":"Francois","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2019.152875_bib0010","doi-asserted-by":"crossref","first-page":"306","DOI":"10.7164\/antibiotics.48.306","article-title":"A whole-cell Candida albicans assay for the detection of inhibitors towards fungal cell wall synthesis and assembly","volume":"48","author":"Frost","year":"1995","journal-title":"J. Antibiot."},{"key":"10.1016\/j.phymed.2019.152875_bib0011","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.mib.2011.06.001","article-title":"Mucosal biofilms of Candida albicans","volume":"14","author":"Ganguly","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0012","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.13005\/bbra\/2598","article-title":"Cell surface hydrophobicity as a virulence factor in Candida albicans","volume":"14","author":"Goswami","year":"2017","journal-title":"Biosci. Biotechnol. Res. Asia"},{"key":"10.1016\/j.phymed.2019.152875_bib0013","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/mmi.12426","article-title":"Mannosylation in Candida albicans: role in cell wall function and immune recognition","volume":"90","author":"Hall","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0014","doi-asserted-by":"crossref","first-page":"e39405","DOI":"10.1371\/journal.pone.0039405","article-title":"Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans","volume":"7","author":"Kingsbury","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2019.152875_bib0015","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1517\/14656566.9.6.927","article-title":"Fungicidal versus fungistatic: what's in a word?","volume":"9","author":"Lewis","year":"2008","journal-title":"Expert Opin. Pharmacothe."},{"key":"10.1016\/j.phymed.2019.152875_bib0016","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4236\/ojmm.2013.33028","article-title":"Effect of growth media, pH and temperature on yeast to hyphal transition in Candida albicans","volume":"3","author":"Nadeem","year":"2013","journal-title":"Open J. Med. Microbiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0017","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3389\/fmicb.2017.00980","article-title":"A Chitin-binding protein purified from Moringa oleifera seeds presents anticandidal activity by increasing cell membrane permeability and reactive oxygen species production","volume":"8","author":"Neto","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0018","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s10096-015-2323-z","article-title":"Biofilm-specific antibiotic tolerance and resistance","volume":"34","author":"Olsen","year":"2015","journal-title":"Eur. J. Clin. Micro-biol. Infect. Dis."},{"key":"10.1016\/j.phymed.2019.152875_bib0019","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.phymed.2019.152875_bib0020","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.phymed.2015.07.003","article-title":"Antifungal activity of a prenylated flavonoid from Dalea elegans against Candida albicans biofilms","volume":"22","author":"Peralta","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2019.152875_bib0021","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/092986612799363163","article-title":"Extracellular sunflower proteins: evidence on non-classical secretion of a jacalin-related lectin","volume":"19","author":"Pinedo","year":"2012","journal-title":"Prot. Pept. Lett."},{"key":"10.1016\/j.phymed.2019.152875_bib0022","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jplph.2015.06.004","article-title":"Molecular characterization of Helja, an extracellular jacalin-related protein from Helianthus annuus: insights into the relationship of this protein with unconventionally secreted lectins","volume":"183","author":"Pinedo","year":"2015","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0023","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ijbiomac.2017.02.019","article-title":"CasuL: a new lectin isolated from Calliandra surinamensis leaf pinnulae with cytotoxicity to cancer cells, antimicrobial activity and antibiofilm effect","volume":"98","author":"Proc\u00f3pio","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2019.152875_bib0024","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00284-014-0558-z","article-title":"A sunflower lectin with antifungal properties and putative medical mycology applications","volume":"69","author":"Regente","year":"2014","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0025","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1128\/AAC.00946-13","article-title":"Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence","volume":"58","author":"Rueda","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phymed.2019.152875_bib0026","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1099\/jmm.0.047852-0","article-title":"In vitro antifungal activity of the flavonoid baicalein against Candida species","volume":"61","author":"Serpa","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.phymed.2019.152875_bib0027","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1099\/mic.0.26656-0","article-title":"Differential surface localization and temperature dependent expression of the Candida albicans CSH1 protein","volume":"150","author":"Singleton","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.phymed.2019.152875_bib0029","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1007\/s00253-015-6654-6","article-title":"Plant antifungal proteins and their applications in agriculture","volume":"99","author":"Yan","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.phymed.2019.152875_bib0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1462-5822.2009.01412.x","article-title":"Interactions of Candida albicans with epithelial cells","volume":"12","author":"Zhu","year":"2010","journal-title":"Cell Microbiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:14:20Z","timestamp":1778559260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711319300467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":29,"alternative-id":["S0944711319300467"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152875","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the binding of a Helianthus annuus lectin to Candida albicans cell wall on biofilm development and adhesion to host cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152875"}}