{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:40:38Z","timestamp":1786995638543,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"CONACyT 219765","award":["OP2-144645"],"award-info":[{"award-number":["OP2-144645"]}]},{"name":"DGAPA IN217516"},{"name":"DGAPA IN213418"},{"name":"Canadian Institutes of"},{"DOI":"10.13039\/100005622","name":"Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005622","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pathways Intervention Research Team"},{"name":"CONACyT-Infraestructura 280275"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.phymed.2019.152891","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T22:43:24Z","timestamp":1552430604000},"page":"152891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-722X","authenticated-orcid":false,"given":"Berenice","family":"Ovalle-Magallanes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-8710","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Navarrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8782-5165","authenticated-orcid":false,"given":"Pierre S.","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando R.","family":"Tovar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia G.","family":"Noriega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tovar-Palacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2019.152891_bib0001","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jep.2005.04.019","article-title":"Mexican plants with hypoglycaemic effect used in the treatment of diabetes","volume":"99","author":"Andrade-Cetto","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2019.152891_bib0002","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0031-6997(25)00026-2","article-title":"What is synergy?","volume":"1989","author":"Berenbaum","year":"1989","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2019.152891_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/192503","article-title":"Is there a link between mitochondrial reserve respiratory capacity and aging?","volume":"2012","author":"Desler","year":"2012","journal-title":"J. Aging Res."},{"key":"10.1016\/j.phymed.2019.152891_bib0004","first-page":"L 276\/33","article-title":"Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes","year":"2010","journal-title":"Official J. Eur. Union"},{"key":"10.1016\/j.phymed.2019.152891_bib0005","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/01.psy.0000174994.91245.34","article-title":"Antagonism of the serotonin (5-HT)-2 receptor and insulin sensitivity: implications for atypical antipsychotics","volume":"67","author":"Gilles","year":"2005","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.phymed.2019.152891_bib0006","doi-asserted-by":"crossref","first-page":"13563","DOI":"10.1074\/jbc.274.19.13563","article-title":"Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle","volume":"274","author":"Hajduch","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2019.152891_bib0007","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1080\/13880209.2017.1280687","article-title":"The fatty acid-rich fraction of Eruca sativa (rocket salad) leaf extract exerts antidiabetic effects in cultured skeletal muscle, adipocytes and liver cells","volume":"55","author":"Hetta","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2019.152891_bib0008","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1100\/tsw.2010.180","article-title":"Therapeutic potential of 5-HT2C receptor ligands","volume":"10","author":"Jensen","year":"2010","journal-title":"Sci. World J."},{"key":"10.1016\/j.phymed.2019.152891_bib0009","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/cbin.10915","article-title":"Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism","volume":"42","author":"Ke","year":"2018","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.phymed.2019.152891_bib0010","doi-asserted-by":"crossref","first-page":"22301","DOI":"10.3390\/molecules201219847","article-title":"Potent PPAR\u03b3 ligands from Swietenia macrophylla are capable of stimulating glucose uptake in muscle cells","volume":"20","author":"Lau","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2019.152891_bib0011","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jep.2009.10.026","article-title":"Enhancement of muscle cell glucose uptake by medicinal plant species of Canada's native populations is mediated by a common, metformin-like mechanism","volume":"127","author":"Martineau","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2019.152891_bib0012","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/189819","article-title":"The action of antidiabetic plants of the Canadian James Bay Cree traditional pharmacopeia on key enzymes of hepatic glucose homeostasis","volume":"2013","author":"Nachar","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2019.152891_bib0013","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.biopha.2017.05.073","article-title":"Antihyperalgesic activity of a mexicanolide isolated from Swietenia humilis extract in nicotinamide-streptozotocin hyperglycemic mice","volume":"92","author":"Ovalle-Magallanes","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2019.152891_bib0014","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.phytochem.2014.11.004","article-title":"Hypoglycemic and antihyperglycemic effects of phytopreparations and limonoids from Swietenia humilis","volume":"110","author":"Ovalle-Magallanes","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2019.152891_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000229","article-title":"Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation","volume":"7","author":"Paulmann","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phymed.2019.152891_bib0016","first-page":"380","article-title":"Use of medicinal plants among patients with diabetes mellitus type 2 in Morelos, Mexico","volume":"8","author":"Romero-Cerecero","year":"2009","journal-title":"BLACPMA"},{"key":"10.1016\/j.phymed.2019.152891_bib0017","author":"Secretar\u00eda de"},{"key":"10.1016\/j.phymed.2019.152891_bib0018","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-4419-6306-2_17","article-title":"Combination analysis","volume":"678","author":"Tallarida","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2019.152891_bib0019","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2337\/db11-0870","article-title":"A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5","volume":"61","author":"Tudhope","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2019.152891_bib0020","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fitote.2010.11.016","article-title":"Synergy research: approaching a new generation of phytopharmaceuticals","volume":"82","author":"Wagner","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2019.152891_bib0021","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1517\/13543776.11.9.1429","article-title":"Glucose-6-phosphatase inhibitors for the treatment of type 2 diabetes","volume":"11","author":"Westergaard","year":"2001","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.phymed.2019.152891_bib0022","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijpharm.2004.09.018","article-title":"A practical note on the use of cytotoxicity assays","volume":"288","author":"Weyermann","year":"2005","journal-title":"Int. J. Pharm."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319300613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:17:31Z","timestamp":1760552251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711319300613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":22,"alternative-id":["S0944711319300613"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152891","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2019.152891","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152891"}}