{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:13:29Z","timestamp":1780989209553,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873576"],"award-info":[{"award-number":["81873576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774109"],"award-info":[{"award-number":["81774109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Health Science and Technology Project of Zhejiang Provincial Health Commission","award":["2020RC081"],"award-info":[{"award-number":["2020RC081"]}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and technology Bureau","doi-asserted-by":"publisher","award":["Y20190076"],"award-info":[{"award-number":["Y20190076"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.phymed.2019.153108","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T11:13:27Z","timestamp":1570187607000},"page":"153108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b\/PTEN axis"],"prefix":"10.1016","volume":"66","author":[{"given":"Wujun","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinuo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-2229","authenticated-orcid":false,"given":"Jianjian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2019.153108_bib0001","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2012.06.022","article-title":"DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats","volume":"264","author":"Bian","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2019.153108_bib0002","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1158\/0008-5472.CAN-18-4110","article-title":"Loss of PTEN accelerates NKX3.1 degradation to promote prostate cancer progression","volume":"79","author":"Bowen","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2019.153108_bib0003","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/abbs\/gmt143","article-title":"Isolation and culture of hepatic stellate cells from mouse liver","volume":"46","author":"Chang","year":"2014","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.phymed.2019.153108_bib0004","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/iub.1030","article-title":"MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas","volume":"64","author":"Chen","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.phymed.2019.153108_bib0005","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1038\/srep11549","article-title":"Integrative miRNA and gene expression profiling analysis of human quiescent hepatic stellate cells","volume":"5","author":"Coll","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2019.153108_bib0006","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.phymed.2019.153108_bib0007","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2019.153108_bib0008","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/hep.29270","article-title":"Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression","volume":"66","author":"Han","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2019.153108_bib0009","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tox.2004.01.010","article-title":"Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage)","volume":"197","author":"Kim","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2019.153108_bib0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/bjp.2008.79","article-title":"Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production","volume":"154","author":"Kim","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2019.153108_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5030038","article-title":"Hepatic stellate cells and microRNAs in pathogenesis of liver fibrosis","volume":"5","author":"Kitano","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.phymed.2019.153108_bib0012","article-title":"Liquiritigenin inhibits hepatic fibrogenesis and TGF-beta1\/Smad with Hippo\/YAP signal","volume":"62","author":"Lee","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2019.153108_bib0013","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.intimp.2009.02.007","article-title":"Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not","volume":"9","author":"Lee","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2019.153108_bib0014","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/labinvest.2008.20","article-title":"Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells","volume":"88","author":"Lin","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1016\/j.phymed.2019.153108_bib0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3892\/br.2013.199","article-title":"miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (Review)","volume":"2","author":"Liu","year":"2014","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.phymed.2019.153108_bib0016","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12943-019-1040-0","article-title":"Circular RNA circSLC8A1 acts as a sponge of miR-130b\/miR-494 in suppressing bladder cancer progression via regulating PTEN","volume":"18","author":"Lu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2019.153108_bib0017","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1248\/bpb.b14-00430","article-title":"Tacrine, an oral acetylcholinesterase inhibitor, induced hepatic oxidative damage, which was blocked by liquiritigenin through GSK3-beta inhibition","volume":"38","author":"Park","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2019.153108_bib0018","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1111\/j.1440-1746.2006.04659.x","article-title":"Molecular mechanisms of hepatic fibrogenesis","volume":"22 Suppl 1","author":"Parsons","year":"2007","journal-title":"J. Gastroenterol. Hepatol"},{"key":"10.1016\/j.phymed.2019.153108_bib0019","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2019.153108_bib0020","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00535-009-0073-3","article-title":"The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation","volume":"44","author":"Takashima","year":"2009","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.phymed.2019.153108_bib0021","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2019.153108_bib0022","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2019.153108_bib0023","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/onc.2009.468","article-title":"TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3","volume":"29","author":"Wang","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2019.153108_bib0024","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbrc.2012.03.025","article-title":"miR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients","volume":"421","author":"Wang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2019.153108_bib0025","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/jphp.12170","article-title":"Liquiritigenin exhibits antitumour action in pituitary adenoma cells via Ras\/ERKs and ROS-dependent mitochondrial signalling pathways","volume":"66","author":"Wang","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2019.153108_bib0026","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/jcb.27477","article-title":"Interleukin-1beta\/nuclear factor-kappaB signaling promotes osteosarcoma cell growth through the microRNA-181b\/phosphatase and tensin homolog axis","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.phymed.2019.153108_bib0027","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.3748\/wjg.v23.i32.5904","article-title":"Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis","volume":"23","author":"Xie","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2019.153108_bib0028","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.biopha.2016.12.066","article-title":"Liquiritigenin attenuates cardiac injury induced by high fructose-feeding through fibrosis and inflammation suppression","volume":"86","author":"Xie","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2019.153108_bib0029","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ymthe.2016.10.015","article-title":"HOTAIR epigenetically modulates PTEN expression via MicroRNA-29b: a novel mechanism in regulation of liver fibrosis","volume":"25","author":"Yu","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.phymed.2019.153108_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9856538","article-title":"Identification of a novel lincRNA-p21-miR-181b-PTEN signaling cascade in liver fibrosis","volume":"2016","author":"Yu","year":"2016","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2019.153108_bib0031","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1111\/jcmm.12655","article-title":"Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation","volume":"19","author":"Yu","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2019.153108_bib0032","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/febs.12574","article-title":"Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation\u2013a novel mechanism suppressing liver fibrosis","volume":"281","author":"Zheng","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.phymed.2019.153108_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-014-2199-8","article-title":"Hepatic stellate cell is activated by microRNA-181b via PTEN\/Akt pathway","volume":"398","author":"Zheng","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phymed.2019.153108_bib0034","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.biopha.2018.07.045","article-title":"Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-kappaB and NLRP3 inflammasome pathways","volume":"106","author":"Zhu","year":"2018","journal-title":"Biomed. Pharmacother."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319303502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711319303502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T16:58:45Z","timestamp":1575478725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711319303502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":34,"alternative-id":["S0944711319303502"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2019.153108","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b\/PTEN axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2019.153108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153108"}}