{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:16:34Z","timestamp":1791771394957,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011501","name":"QingHai Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.phymed.2020.153186","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T23:47:15Z","timestamp":1581724035000},"page":"153186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway"],"prefix":"10.1016","volume":"68","author":[{"given":"Zhanjun","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4375-8316","authenticated-orcid":false,"given":"Yubao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouning","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2020.153186_bib0001","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.12688\/f1000research.9465.1","article-title":"Advances in the management of osteosarcoma","volume":"5","author":"Bielack","year":"2016","journal-title":"F1000Res."},{"issue":"3","key":"10.1016\/j.phymed.2020.153186_bib0002","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bcp.2014.11.012","article-title":"DJ-1 as a human oncogene and potential therapeutic target","volume":"93","author":"Cao","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2020.153186_bib0003","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ccr.2014.03.015","article-title":"Endoplasmic reticulum stress in malignancy","volume":"25","author":"Clarke","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2020.153186_bib0004","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-981-10-6583-5_13","article-title":"DJ-1 as a therapeutic target against cancer","volume":"1037","author":"Cao","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2020.153186_bib0005","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.biopha.2018.08.127","article-title":"Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN","volume":"107","author":"Deng","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.phymed.2020.153186_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181729","article-title":"Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of acute myeloid leukemic cells","volume":"12","author":"Fatehchand","year":"2017","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.phymed.2020.153186_bib0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/iep.12221","article-title":"Identification of DJ-1 as a contributor to multidrug resistance in human small-cell lung cancer using proteomic analysis","volume":"98","author":"Gao","year":"2017","journal-title":"Int. J. Exp. Pathol."},{"issue":"4","key":"10.1016\/j.phymed.2020.153186_bib0008","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.devcel.2010.02.013","article-title":"Progressive activation of Cyclinb1-Cdk1 coordinates entry to mitosis","volume":"18","author":"Gavet","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.phymed.2020.153186_bib0009","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fphar.2018.00068","article-title":"Rosmarinic acid activates AMPK to inhibit metastasis of colorectal cancer","volume":"9","author":"Han","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2020.153186_bib0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/carcin\/bgs002","article-title":"DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC\/ERK\/UPA","volume":"33","author":"He","year":"2012","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.phymed.2020.153186_bib0011","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1023\/B:NERE.0000014823.74782.b7","article-title":"Mitochondrial function in apoptotic neuronal cell death","volume":"29","author":"Haeberlein","year":"2004","journal-title":"Neurochem Res."},{"issue":"5","key":"10.1016\/j.phymed.2020.153186_bib0040","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/bjc.2014.40","article-title":"DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression","volume":"110","author":"Ismail","year":"2014","journal-title":"Br. J. Cancer."},{"issue":"12","key":"10.1016\/j.phymed.2020.153186_bib0012","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1007\/s10529-014-1640-0","article-title":"New trends in biotechnological production of rosmarinic acid","volume":"36","author":"Khojasteh","year":"2014","journal-title":"Biotechnol. Lett."},{"issue":"3","key":"10.1016\/j.phymed.2020.153186_bib0013","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ccr.2005.02.010","article-title":"DJ-1, a novel regulator of the tumor suppressor PTEN","volume":"7","author":"Kim","year":"2005","journal-title":"Cancer Cell"},{"issue":"12","key":"10.1016\/j.phymed.2020.153186_bib0014","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1111\/j.1582-4934.2010.01178.x","article-title":"Proteomics and syndrome of Chinese medicine","volume":"14","author":"Lu","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.phymed.2020.153186_bib0015","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1038\/ncomms8769","article-title":"PI3K\/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis","volume":"6","author":"Lee","year":"2015","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.phymed.2020.153186_bib0016","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/cam4.1325","article-title":"High expression of DJ-1 promotes growth and invasion via the PTEN-AKT pathway and predicts a poor prognosis in colorectal cancer","volume":"7","author":"Lin","year":"2018","journal-title":"Cancer Med."},{"issue":"4","key":"10.1016\/j.phymed.2020.153186_bib0017","doi-asserted-by":"crossref","first-page":"418","DOI":"10.7150\/ijbs.23602","article-title":"Glaucocalyxin A induces G2\/M cell cycle arrest and apoptosis through the PI3K\/Akt pathway in human bladder cancer cells","volume":"14","author":"Lin","year":"2018","journal-title":"Int. J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.phymed.2020.153186_bib0018","first-page":"6377","article-title":"Diallyl disulfide effect on the invasion and migration ability of HL-60 cells with a high expression of DJ-1 in the nucleus through the suppression of the SRC signaling pathway","volume":"15","author":"Liu","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.phymed.2020.153186_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.12.027","article-title":"Lariciresinol induces apoptosis in HEPG2 cells via mitochondrial- mediated apoptosis pathway","volume":"821","author":"Ma","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2020.153186_bib0020","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.biopha.2018.05.129","article-title":"Proteomics analysis demonstrating rosmarinic acid suppresses cell growth by blocking the glycolytic pathway in human HEPG2 cells","volume":"105","author":"Ma","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.phymed.2020.153186_bib0021","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00204-008-0304-z","article-title":"Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis","volume":"82","author":"Mat\u00e9s","year":"2008","journal-title":"Arch. Toxicol."},{"issue":"11","key":"10.1016\/j.phymed.2020.153186_bib0022","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1371\/journal.pbio.0020327","article-title":"Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES-derived cell model of primary Parkinsonism","volume":"2","author":"Martinat","year":"2004","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.phymed.2020.153186_bib0023","first-page":"63","article-title":"The proteome profile of the human osteosarcoma U2OS cell line","volume":"5","author":"Niforou","year":"2008","journal-title":"Cancer Genom. Proteom."},{"issue":"3","key":"10.1016\/j.phymed.2020.153186_bib0024","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00441-016-2364-3","article-title":"Induction of apoptosis, stimulation of cell-cycle arrest and inhibition of angiogenesis make human amnion-derived cells promising sources for cell therapy of cancer","volume":"363","author":"Niknejad","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.phymed.2020.153186_bib0025","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/B978-0-12-407695-2.00007-X","article-title":"Role of cyclin B1 levels in DNA damage and DNA damage-induced senescence","volume":"305","author":"Nakayama","year":"2013","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.phymed.2020.153186_bib0026","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.biopha.2018.07.123","article-title":"Rosmarinic acid influences collagen, MMPs, TIMPs, glycosylation and MUC1 in CRL-1739 gastric cancer cell line","volume":"107","author":"Radziejewska","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.phymed.2020.153186_bib0027","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.3892\/or.2013.2684","article-title":"Enhancement of baicalin by hexamethylene bisacetamide on the induction of apoptosis contributes to simultaneous activation of the intrinsic and extrinsic apoptotic pathways in human leukemia cells","volume":"30","author":"Ren","year":"2013","journal-title":"Oncol. Rep."},{"issue":"18","key":"10.1016\/j.phymed.2020.153186_bib0028","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1007\/s00253-018-9223-y","article-title":"Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics","volume":"102","author":"Swamy","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"Suppl 1","key":"10.1016\/j.phymed.2020.153186_bib0029","first-page":"421","article-title":"Herbal medicine as inducers of apoptosis in cancer treatment","volume":"4","author":"Safarzadeh","year":"2014","journal-title":"Adv. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.phymed.2020.153186_bib0030","first-page":"176","article-title":"c-FLIP, a master anti-apoptotic regulator","volume":"4","author":"Safa","year":"2012","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.phymed.2020.153186_bib0031","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1471-2407-8-241","article-title":"Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients","volume":"8","author":"Tian","year":"2008","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.phymed.2020.153186_bib0032","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.18632\/oncotarget.6451","article-title":"Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down- regulating FUT4","volume":"7","author":"Tian","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2020.153186_bib0033","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.12659\/MSM.896861","article-title":"DJ-1 expression in cervical carcinoma and its effects on cell viability and apoptosis","volume":"22","author":"Wang","year":"2016","journal-title":"Med. Sci. Monit."},{"issue":"8","key":"10.1016\/j.phymed.2020.153186_bib0034","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.7150\/jca.14539","article-title":"DJ-1 is upregulated in oral squamous cell carcinoma and promotes oral cancer cell proliferation and invasion","volume":"7","author":"Xu","year":"2016","journal-title":"J. Cancer"},{"issue":"2","key":"10.1016\/j.phymed.2020.153186_bib0035","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/ijc.23049","article-title":"Phosphoinositide 3-kinase\/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death","volume":"122","author":"Yu","year":"2008","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.phymed.2020.153186_bib0036","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41419-018-0684-9","article-title":"Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K\/Akt pathway","volume":"9","author":"Zhu","year":"2018","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.phymed.2020.153186_bib0037","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41419-018-0724-5","article-title":"Linc00462 promotes pancreatic cancer invasiveness through the miR-665\/TGFBR1-TGFBR2\/ SMAD2\/3 pathway","volume":"9","author":"Zhou","year":"2018","journal-title":"Cell Death Dis."},{"issue":"7579","key":"10.1016\/j.phymed.2020.153186_bib0038","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature16064","article-title":"Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer","volume":"527","author":"Zheng","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2020.153186_bib0039","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1756-9966-31-94","article-title":"Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma","volume":"31","author":"Zhu","year":"2012","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320300192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320300192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:23:43Z","timestamp":1760552623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711320300192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":40,"alternative-id":["S0944711320300192"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153186","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153186"}}