{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:58:21Z","timestamp":1784383101542,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.phymed.2020.153224","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T18:49:23Z","timestamp":1588013363000},"page":"153224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Comparative study of raw and processed Vladimiriae Radix on pharmacokinetic and anti-acute gastritis effect through anti-oxidation and anti-inflammation"],"prefix":"10.1016","volume":"70","author":[{"given":"Wenjun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2020.153224_bib0001","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s10620-006-9301-3","article-title":"The role of zinc sulfate and metallothionein in protection against ethanol-induced gastric damage in rats","volume":"51","author":"Arda-Pirincci","year":"2006","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.phymed.2020.153224_bib0002","article-title":"Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal","volume":"31","author":"Ayala","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2020.153224_bib0003","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.phymed.2003.09.006","article-title":"Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip","volume":"12","author":"Bighetti","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2020.153224_bib0004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2014.02.031","article-title":"Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice","volume":"730","author":"Butturini","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.phymed.2020.153224_bib0005","series-title":"Pharmacopoeia of the People's Republic of China","year":"2015"},{"key":"10.1016\/j.phymed.2020.153224_bib0006","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/10286020.2018.1489379","article-title":"Pharmacokinetics of costunolide and dehydrocostuslactone after oral administration of Radix aucklandiae extract in normal and gastric ulcer rats","volume":"20","author":"Dong","year":"2018","journal-title":"J Asian Nat Prod Res"},{"key":"10.1016\/j.phymed.2020.153224_bib0007","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cbi.2015.10.018","article-title":"Apocynin protects against ethanol-induced gastric ulcer in rats by attenuating the upregulation of NADPH oxidases 1 and 4","volume":"242","author":"El-Naga","year":"2015","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.phymed.2020.153224_bib0008","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2020.153224_bib0009","first-page":"2872","article-title":"Comparative study on absorption of effective components from roasting-processed and crude Vladimiriae Radix in stomach, small intestine, and colon of rats","volume":"44","author":"Gao","year":"2013","journal-title":"Zhong Cao Yao"},{"key":"10.1016\/j.phymed.2020.153224_bib0010","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.jlumin.2011.04.041","article-title":"Binding studies of costunolide and dehydrocostuslactone with HSA by spectroscopy and atomic force microscopy","volume":"131","author":"Gao","year":"2011","journal-title":"J Lumin"},{"key":"10.1016\/j.phymed.2020.153224_bib0011","series-title":"Science of Processing Chinese Materia Medica","author":"Gong","year":"2003"},{"key":"10.1016\/j.phymed.2020.153224_bib0012","article-title":"Identification and quantification of the quality markers and anti-migraine active components in Chuanxiong Rhizoma and Cyperi Rhizoma herbal pair based on chemometric analysis between chemical constituents and pharmacological effects","author":"Guo","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.phymed.2020.153224_bib0013","first-page":"37","article-title":"Study on chemical components of the volatile oil in Radix Vladimiria souliei (Franch.) Ling before and after paper - roast","volume":"25","author":"Hu","year":"2010","journal-title":"Huaxi Yaoxue Zazhi"},{"key":"10.1016\/j.phymed.2020.153224_bib0014","first-page":"495","article-title":"Optimization of paper-roast process of Radix Vladimiriae by orthogonal design","volume":"32","author":"Hu","year":"2009","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.phymed.2020.153224_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.201900506","article-title":"A simple LC-MS\/MS approach for the simultaneous quantification of thirteen compounds in rats following oral administration of raw and processed Fructus Xanthii: Application in a comparative pharmacokinetic study","author":"Jiang","year":"2019","journal-title":"J Sep Sci."},{"key":"10.1016\/j.phymed.2020.153224_bib0016","article-title":"Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential","volume":"20","author":"Kim","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.phymed.2020.153224_bib0017","doi-asserted-by":"crossref","first-page":"e95530","DOI":"10.1371\/journal.pone.0095530","article-title":"Growth inhibitory, bactericidal, and morphostructural effects of dehydrocostus lactone from Magnolia sieboldii Leaves on antibiotic-susceptible and -resistant strains of Helicobacter pylori","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2020.153224_bib0018","first-page":"2708","article-title":"Stability of major pharmaceutical ingredients of Vladimiria souliei before and after being roasted in biological fluids in vitro","volume":"40","author":"Li","year":"2018","journal-title":"Zhong Cheng Yao"},{"key":"10.1016\/j.phymed.2020.153224_bib0019","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phymed.2020.153224_bib0020","series-title":"Annual Review Of Pharmacology And Toxicology","first-page":"401","article-title":"Role of Nrf2 in Oxidative Stress and Toxicity","volume":"53","author":"Ma","year":"2013"},{"key":"10.1016\/j.phymed.2020.153224_bib0021","first-page":"480","article-title":"Effect of Clopidogrel on plasma protein binding rates of ginsenoside Rg1","volume":"37","author":"Ma","year":"2017","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.phymed.2020.153224_bib0022","first-page":"4797","article-title":"Research progress on chemical constituents in Vladimiriae Radix and their pharmacological activities","volume":"48","author":"Mao","year":"2017","journal-title":"Zhong Cao Yao"},{"key":"10.1016\/j.phymed.2020.153224_bib0023","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/sj.bjp.0701104","article-title":"Suppressive effect of melatonin administration on ethanol-induced gastroduodenal injury in rats in vivo","volume":"121","author":"Melchiorri","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.phymed.2020.153224_bib0024","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/wsbm.1331","article-title":"Signaling via the NF kappa B system","volume":"8","author":"Mitchell","year":"2016","journal-title":"Wiley Interdiscip. Rev.-Syst. Biol"},{"key":"10.1016\/j.phymed.2020.153224_bib0025","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/ars.2012.5116","article-title":"The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice","volume":"20","author":"Mo","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2020.153224_bib0026","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00011-007-7015-4","article-title":"Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages","volume":"56","author":"Pae","year":"2007","journal-title":"Inflamm Res"},{"key":"10.1016\/j.phymed.2020.153224_bib0027","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.3748\/wjg.14.5857","article-title":"Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury","volume":"14","author":"Pan","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.phymed.2020.153224_bib0028","doi-asserted-by":"crossref","first-page":"41254","DOI":"10.1038\/srep41254","article-title":"Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc\/p53 and AKT\/14-3-3 pathway","volume":"7","author":"Peng","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.phymed.2020.153224_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40262-012-0018-5","article-title":"The clinical relevance of plasma protein binding changes","volume":"52","author":"Roberts","year":"2013","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.phymed.2020.153224_bib0030","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.foodchem.2012.02.028","article-title":"Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage","volume":"133","author":"Wang","year":"2012","journal-title":"Food Chemistry"},{"key":"10.1016\/j.phymed.2020.153224_bib0031","article-title":"Characterization of the cold and hot natures of raw and processed Rehmanniae Radix by integrated metabolomics and network pharmacology","author":"Xia","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2020.153224_bib0032","article-title":"Tiao He Yi Wei Granule, a Traditional Chinese Medicine, against Ethanol-Induced Gastric Ulcer in Mice","volume":"8","author":"Yao","year":"2015","journal-title":"Evid.-based Complement Altern. Med."},{"key":"10.1016\/j.phymed.2020.153224_bib0033","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0968-0896(00)00127-9","article-title":"Alcohol absorption inhibitors from bay leaf (Laurus nobilis): structure-requirements of sesquiterpenes for the activity","volume":"8","author":"Yoshikawa","year":"2000","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.phymed.2020.153224_bib0034","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jep.2013.10.024","article-title":"Pharmacokinetic study on costunolide and dehydrocostuslactone after oral administration of traditional medicine Aucklandia lappa Decne. by LC\/MS\/MS","volume":"151","author":"Zhang","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.phymed.2020.153224_bib0035","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cbi.2016.03.003","article-title":"Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation","volume":"250","author":"Zheng","year":"2016","journal-title":"Chem Biol Interact"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320300556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320300556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:23:25Z","timestamp":1760552605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711320300556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":35,"alternative-id":["S0944711320300556"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153224","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative study of raw and processed Vladimiriae Radix on pharmacokinetic and anti-acute gastritis effect through anti-oxidation and anti-inflammation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153224"}}