{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:07:45Z","timestamp":1782158865286,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973860"],"award-info":[{"award-number":["81973860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874470"],"award-info":[{"award-number":["81874470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19ZR1458700"],"award-info":[{"award-number":["19ZR1458700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004492","name":"National Youth Foundation of China","doi-asserted-by":"publisher","award":["81904214"],"award-info":[{"award-number":["81904214"]}],"id":[{"id":"10.13039\/501100004492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1705305"],"award-info":[{"award-number":["2018YFC1705305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.phymed.2020.153299","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T02:33:17Z","timestamp":1597285997000},"page":"153299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Role of keratinocytes and immune cells in the anti-inflammatory effects of Tripterygium wilfordii Hook. f. in a murine model of psoriasis"],"prefix":"10.1016","volume":"77","author":[{"given":"Yi","family":"Ru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Kuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokgyeong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-9679","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2020.153299_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2017.02.018","article-title":"Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase","volume":"46","author":"Al-Harbi","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2020.153299_bib0002","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.imbio.2016.10.013","article-title":"Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A\/IL-17 receptor signaling in a murine model","volume":"222","author":"Al-Harbi","year":"2017","journal-title":"Immunobiol"},{"key":"10.1016\/j.phymed.2020.153299_bib0003","first-page":"273","article-title":"Dermatology branch psoriasis Chinese medicine treatment expert consensus (2017 edition)","volume":"17","year":"2018","journal-title":"Chin. J. Dermatovenereol. Integr. Tradit. West. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173276","article-title":"Effectiveness and safety of traditional Chinese medical bath therapy combined with ultraviolet irradiation in the treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Guan","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2020.153299_bib0006","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.3390\/ijms20102558","article-title":"Apoptotic or antiproliferative activity of natural products against keratinocytes for the treatment of psoriasis","volume":"20","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2020.153299_bib0007","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jep.2013.10.045","article-title":"Total alkaloids of tripterygium hypoglaucum (levl.) hutch inhibits tumor growth both in vitro and in vivo","volume":"151","author":"Jiang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2020.153299_bib0008","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12016-012-8305-3","article-title":"Clinical and histologic diagnostic guidelines for psoriasis: a critical review","volume":"44","author":"Johnson","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.phymed.2020.153299_bib0009","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2015.03.010","article-title":"Therapeutic and immunomodulatory effects of glucosamine in combination with low-dose cyclosporine A in a murine model of imiquimod-induced psoriasis","volume":"756","author":"Kim","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2020.153299_bib0010","first-page":"342","article-title":"A study of helper T cell Th1\/Th2 immune response pattern of \u03b3\u03b4T cells in asthma","volume":"43","author":"Li","year":"2004","journal-title":"Chin. J. Int. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0011","first-page":"328","article-title":"The expression of Caspase-3 and bcl-2 in psoriasis lesions before and after calcipotriol treatment","volume":"6","author":"Liu","year":"2013","journal-title":"J. Pract. Dermatol."},{"key":"10.1016\/j.phymed.2020.153299_bib0012","doi-asserted-by":"crossref","first-page":"e941","DOI":"10.1038\/cddis.2013.469","article-title":"Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation","volume":"4","author":"Liu","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2020.153299_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152914","article-title":"Tripterygium agents for the treatment of atopic eczema: a bayesian analysis of randomized controlled trials","volume":"59","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2020.153299_bib0014","article-title":"Efficacy and safety of Jueyin granules for patients with mild-to-moderate psoriasis vulgaris: protocol for a multicenter randomized placebo-controlled trial","volume":"2020","author":"Li","year":"2020","journal-title":"Evid Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0015","first-page":"213","article-title":"Effects of triperygium wiIfordii ointment on expression of Intercelluar adhesion molecule-1 and matrix metallo-proteinase-9 in psoriatic lesion","volume":"6","author":"Liu","year":"2007","journal-title":"Chin. J. Dermatovenereol. Integr. Tradit. West. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0016","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.phymed.2020.153299_bib0017","doi-asserted-by":"crossref","first-page":"694","DOI":"10.21037\/atm.2019.10.46","article-title":"Characteristics of psoriasis vulgaris in China: a prospective cohort study protocol","volume":"7","author":"Luo","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0018","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6419509","article-title":"Establishment of mouse models of psoriasis with blood stasis syndrome complicated with glucose and lipid metabolism disorders","volume":"2019","author":"Luo","year":"2019","journal-title":"Evid-Based Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2623085","article-title":"Efficacy and safety of tripterygium wilfordii hook f on psoriasis vulgaris: a systematic review and meta-analysis of randomized controlled trials","volume":"2018","author":"Lv","year":"2018","journal-title":"Evid-Based Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0020","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/labinvest.2012.69","article-title":"Pathological crosstalk in vitro between T lymphocytes and lesional keratinocytes in psoriasis: necessity of direct cell-to-cell contact","volume":"92","author":"Martin","year":"2012","journal-title":"Lab. Invest."},{"key":"10.1016\/j.phymed.2020.153299_bib0021","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/B978-0-12-394387-3.00005-7","article-title":"Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity","volume":"116","author":"Matthews","year":"2012","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.phymed.2020.153299_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110352","article-title":"Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity","volume":"182","author":"Meng","year":"2019","journal-title":"Colloids. Surf. B. Biointerfaces"},{"key":"10.1016\/j.phymed.2020.153299_bib0023","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaad.2013.11.013","article-title":"Psoriasis prevalence among adults in the United States","volume":"70","author":"Rachakonda","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phymed.2020.153299_bib0024","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.coi.2008.03.006","article-title":"\u03b3\u03b4 T cells: an important source of IL-17","volume":"20","author":"Roark","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.phymed.2020.153299_bib0025","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3389\/fphar.2019.01250","article-title":"Adverse events associated with treatment of tripterygium wilfordii hook f: a quantitative evidence synthesis","volume":"10","author":"Ru","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2020.153299_bib0026","doi-asserted-by":"crossref","first-page":"488","DOI":"10.21037\/atm.2019.09.05","article-title":"Oral Taodan granules for mild-to-moderate psoriasis vulgaris: protocol for a randomized, double-blind, multicenter clinical trial","volume":"7","author":"Ru","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0027","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"Van-der","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2020.153299_bib0029","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s12906-016-1453-x","article-title":"Comparative analysis of four terpenoids in root and cortex of Tripterygium wilfordii Radix by different drying methods","volume":"16","author":"Wang","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0030","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-3083.2008.02147.x","article-title":"Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis","volume":"68","author":"Wang","year":"2008","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.phymed.2020.153299_bib0031","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4103\/0366-6999.151069","article-title":"Efficacy and safety of tripterygium wilfordii hook f versus acitretin in moderate to severe psoriasis vulgaris: a randomized clinical trial","volume":"128","author":"Wu","year":"2015","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.phymed.2020.153299_bib0032","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/sji.12629","article-title":"IL-23 Activated \u03b3\u03b4T cells affect Th17 cells and regulatory T cells by secreting IL-21 in children with primary nephrotic syndrome","volume":"87","author":"Zhang","year":"2018","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.phymed.2020.153299_bib0033","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3892\/ijmm.2016.2670","article-title":"Multi-glycoside of tripterygium wilfordii hook. f. ameliorates imiquimod-induced skin lesions through a STAT3-dependent mechanism involving the inhibition of Th17-mediated inflammatory responses","volume":"38","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2020.153299_bib0034","doi-asserted-by":"crossref","first-page":"e3133","DOI":"10.1038\/cddis.2017.529","article-title":"Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells","volume":"8","author":"Zhao","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2020.153299_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152940","article-title":"Total glucosides of paeony for the treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials","volume":"62","author":"Zheng","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2020.153299_bib0036","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ejphar.2011.09.014","article-title":"Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-\u03baB activity","volume":"670","author":"Zhou","year":"2011","journal-title":"Eur. J. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320301318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320301318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:14:21Z","timestamp":1778559261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711320301318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":34,"alternative-id":["S0944711320301318"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153299","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of keratinocytes and immune cells in the anti-inflammatory effects of Tripterygium wilfordii Hook. f. in a murine model of psoriasis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153299"}}