{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:30:03Z","timestamp":1781893803180,"version":"3.54.5"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.phymed.2020.153317","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T08:47:12Z","timestamp":1599122832000},"page":"153317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"special_numbering":"C","title":["Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2637-3927","authenticated-orcid":false,"given":"Suresh","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-2007","authenticated-orcid":false,"given":"Shivani","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-7888","authenticated-orcid":false,"given":"Anil","family":"Panwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2020.153317_bib0001","doi-asserted-by":"crossref","first-page":"27","DOI":"10.17525\/vrrjournal.v10i1.236","article-title":"Natural piperine as a new alternative against influenza viruses","volume":"10","author":"Couceiro","year":"2005","journal-title":"Virus Rev. Res."},{"key":"10.1016\/j.phymed.2020.153317_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2020.1763201","article-title":"An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study","author":"Das","year":"2020","journal-title":"J. Biomol. Struct. Dynam."},{"key":"10.1016\/j.phymed.2020.153317_bib0003","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.virol.2017.12.024","article-title":"An \u201cOld\u201d protein with a new story: coronavirus endoribonuclease is important for evading host antiviral defenses","volume":"517","author":"Deng","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.phymed.2020.153317_bib0004","series-title":"Proceedings of the National Academy of Sciences","first-page":"E4251","article-title":"Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages","volume":"114","author":"Deng","year":"2017"},{"key":"10.1016\/j.phymed.2020.153317_bib0005","first-page":"4773","article-title":"A SARS-CoV-2-human protein-protein interaction map reveals drug","volume":"295","author":"Gordon","year":"2020","journal-title":"Targets Potential Drug-Repurpos."},{"key":"10.1016\/j.phymed.2020.153317_bib0006","doi-asserted-by":"crossref","first-page":"W270","DOI":"10.1093\/nar\/gkr366","article-title":"SwissDock, a protein-small molecule docking web service based on EADock DSS","volume":"39","author":"Grosdidier","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2020.153317_bib0007","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nmeth.4067","article-title":"CHARMM36m: an improved force field for folded and intrinsically disordered proteins","volume":"14","author":"Huang","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2020.153317_bib0008","series-title":"Crystal Structure of Nsp15 Endoribonuclease NendoU from SARS-CoV-2","author":"Kim","year":"2020"},{"key":"10.1016\/j.phymed.2020.153317_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006195","article-title":"Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication","volume":"13","author":"Kindler","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.phymed.2020.153317_bib0010","article-title":"COVID-19 Docking Server: an interactive server for docking small molecules, peptides and antibodies against potential targets of COVID-19","author":"Kong","year":"2020","journal-title":"arXiv Preprint"},{"key":"10.1016\/j.phymed.2020.153317_bib0011","series-title":"Antiviral Properties of phytochemicals. In Dietary Phytochemicals and Microbes","first-page":"93","author":"Liu","year":"2012"},{"key":"10.1016\/j.phymed.2020.153317_bib0012","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2020.153317_bib0013","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2017.03.014","article-title":"Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding","volume":"142","author":"Mounce","year":"2017","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phymed.2020.153317_bib0014","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/138955708785909943","article-title":"Antiviral activity of phytochemicals: a comprehensive review","volume":"8","author":"Naithani","year":"2008","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.phymed.2020.153317_bib0015","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014A visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2020.153317_bib0016","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1107\/S0907444904011679","article-title":"PRODRG: a tool for high-throughput crystallography of protein-ligand complexes","volume":"60","author":"Sch\u00fcttelkopf","year":"2004","journal-title":"Acta Crystallograph. Sec. D: Biol. Crystallogr."},{"key":"10.1016\/j.phymed.2020.153317_bib0017","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ijantimicag.2019.07.015","article-title":"Ursonic acid: a novel antiviral compound inhibiting rotavirus infection in vitro","volume":"54","author":"Tohm\u00e9","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.phymed.2020.153317_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-63397-7","article-title":"tomatidine, a natural steroidal alkaloid shows antiviral activity towards the chikungunya virus in vitro","volume":"10","author":"Troost","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2020.153317_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2020.1763202","article-title":"Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target","author":"Umesh, Kundu","year":"2020","journal-title":"J. Biomol. Struct. Dynam."},{"key":"10.1016\/j.phymed.2020.153317_bib0020","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1128\/MMBR.69.4.635-664.2005","article-title":"Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus","volume":"69","author":"Weiss","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.phymed.2020.153317_bib0021","article-title":"Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods","author":"Wu","year":"2020","journal-title":"Acta Pharm. Sin. B."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320301495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320301495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:30:48Z","timestamp":1760553048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711320301495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":21,"alternative-id":["S0944711320301495"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153317","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153317"}}