{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:22:38Z","timestamp":1792092158533,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874020"],"award-info":[{"award-number":["81874020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772440"],"award-info":[{"award-number":["81772440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.phymed.2020.153387","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T12:46:36Z","timestamp":1602679596000},"page":"153387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"special_numbering":"C","title":["Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study"],"prefix":"10.1016","volume":"80","author":[{"given":"Kai","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8022-5987","authenticated-orcid":false,"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2020.153387_bib0001","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41419-017-0217-y","article-title":"Glucagon-like peptide-1 receptor regulates endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and the progression of osteoarthritis in rat","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2020.153387_bib0002","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joca.2012.08.027","article-title":"Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review","volume":"20","author":"de Lange-Brokaar","year":"2012","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.phymed.2020.153387_bib0003","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.intimp.2017.06.004","article-title":"Hyperoside inhibits lipopolysaccharide-induced inflammatory responses in microglial cells via p38 and NF\u03baB pathways","volume":"50","author":"Fan","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2020.153387_bib0004","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1172\/JCI119056","article-title":"Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes","volume":"98","author":"Geng","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2020.153387_bib0005","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.phymed.2020.153387_bib0006","first-page":"376","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Osteoarthritis. The Lancet"},{"key":"10.1016\/j.phymed.2020.153387_bib0007","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/jpi.12362","article-title":"Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin","volume":"61","author":"Hosseinzadeh","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.phymed.2020.153387_bib0008","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.apjtm.2015.12.001","article-title":"Protective effect of hyperoside on cardiac ischemia reperfusion injury through inhibition of ER stress and activation of Nrf2 signaling","volume":"9","author":"Hou","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.phymed.2020.153387_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172481","article-title":"Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K\/AKT\/NF-\u03baB pathways","volume":"859","author":"Huang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2020.153387_bib0010","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2020.153387_bib0011","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/aps.2016.7","article-title":"Hyperoside exerts anti-inflammatory and anti-arthritic effects in LPS-stimulated human fibroblast-like synoviocytes in vitro and in mice with collagen-induced arthritis","volume":"37","author":"Jin","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2020.153387_bib0012","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.freeradbiomed.2018.01.013","article-title":"Nrf2\/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1\/2\/ELK1-P70S6K-P90RSK signaling axis","volume":"116","author":"Khan","year":"2018","journal-title":"Free Radic. Bio. Med."},{"key":"10.1016\/j.phymed.2020.153387_bib0013","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2017.02.041","article-title":"Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS\/ERK\/Nrf2 signaling pathways in human Osteoarthritis chondrocytes","volume":"106","author":"Khan","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2020.153387_bib0014","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/rheumatology\/ker525","article-title":"Phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix degradation","volume":"51","author":"Kim","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.phymed.2020.153387_bib0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","article-title":"Redox and NF-\u03baB signaling in osteoarthritis","volume":"132","author":"Lepetsos","year":"2019","journal-title":"Free Radical. Bio. Med."},{"key":"10.1016\/j.phymed.2020.153387_bib0016","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.joca.2005.10.009","article-title":"NF-\u03baBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1\u03b2-induced and TNF-\u03b1-induced chondrocytes","volume":"14","author":"Lianxu","year":"2006","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.phymed.2020.153387_bib0017","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1002\/jcp.26460","article-title":"Blocking PI3K\/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis","volume":"233","author":"Lin","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phymed.2020.153387_bib0018","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.phymed.2020.153387_bib0019","article-title":"Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats","volume":"2013","author":"Mannelli","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2020.153387_bib0020","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/nyas.13407","article-title":"Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?","volume":"1401","author":"Marchev","year":"2017","journal-title":"Ann N.Y. Acad. Sci."},{"key":"10.1016\/j.phymed.2020.153387_bib0021","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","article-title":"The role of metabolism in the pathogenesis of osteoarthritis","volume":"13","author":"Mobasheri","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2020.153387_bib0022","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.3390\/ijms19082308","article-title":"Sargassumserratifolium extract attenuates interleukin-1\u03b2-induced oxidative stress and inflammatory response in chondrocytes by suppressing the activation of NF-\u03baB, p38 MAPK, and PI3K\/Akt","volume":"19","author":"Park","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2020.153387_bib0023","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.joca.2015.02.167","article-title":"IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes","volume":"23","author":"Rousset","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.phymed.2020.153387_bib0024","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1016\/j.joca.2010.05.026","article-title":"Basic methods in histopathology of joint tissues","volume":"18","author":"Schmitz","year":"2010","journal-title":"Osteoarthr. Cartilage"},{"key":"10.1016\/j.phymed.2020.153387_bib0025","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2020.153387_bib0026","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. T."},{"key":"10.1016\/j.phymed.2020.153387_bib0027","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fphar.2019.00163","article-title":"Icariin protects bone marrow mesenchymal stem cells against iron overload induced dysfunction through mitochondrial fusion and fission, PI3K\/AKT\/mTOR and MAPK pathways","volume":"10","author":"Yao","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2020.153387_bib0029","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.intimp.2017.01.003","article-title":"Hyperoside attenuates OVA-induced allergic airway inflammation by activating Nrf2","volume":"44","author":"Ye","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2020.153387_bib0030","first-page":"10","article-title":"Hyperoside decreases the apoptosis and autophagy rates of osteoblast MC3T3-E1 cells by regulating TNF-like weak inducer of apoptosis and the p38mitogen activated protein kinase pathway","volume":"19","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2020.153387_bib0031","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00441-014-2010-x","article-title":"A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration","volume":"358","author":"Zhang","year":"2014","journal-title":"Cell Tissue Res."}],"updated-by":[{"DOI":"10.1016\/j.phymed.2026.158447","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320302178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320302178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:48:19Z","timestamp":1782852499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711320302178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":30,"alternative-id":["S0944711320302178"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153387","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153387"}}