{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:14:33Z","timestamp":1790792073919,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.phymed.2020.153391","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T02:17:24Z","timestamp":1602901044000},"page":"153391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["\u03b1-Linolenic acid attenuates pseudo-allergic reactions by inhibiting Lyn kinase activity"],"prefix":"10.1016","volume":"80","author":[{"given":"Yuanyuan","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaomei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4900-5753","authenticated-orcid":false,"given":"Hongli","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2020.153391_bib0001","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4103\/0019-5154.139872","article-title":"Topical steroid-damaged skin","volume":"59","author":"Abraham","year":"2014","journal-title":"Indian J. Dermatol."},{"key":"10.1016\/j.phymed.2020.153391_bib0002","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1034\/j.1398-9995.1999.00726.x","article-title":"Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: the effect of cetirizine and dimethindene","volume":"54","author":"Borici-Mazi","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.phymed.2020.153391_bib0003","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2020.153391_bib0004","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1034\/j.1398-9995.2003.00091.x","article-title":"Quality of life and patients\u2019 satisfaction in chronic urticaria and respiratory allergy","volume":"58","author":"Baiardini","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.phymed.2020.153391_bib0005","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3389\/fimmu.2014.00453","article-title":"Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells","volume":"5","author":"Blank","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0006","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.jaci.2015.10.042","article-title":"v-3 Fatty acids contribute to the asthma-protective effect of unprocessed cow's milk","volume":"137","author":"Brick","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0007","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s11745-008-3171-8","article-title":"Dietary perilla oil inhibits proinflammatory cytokine production in the bronchoalveolar lavage fluid of ovalbumin-challenged mice","volume":"43","author":"Chang","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.phymed.2020.153391_bib0008","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4103\/2229-5178.142483","article-title":"Side-effects of topical steroids: a long overdue revisit","volume":"5","author":"Coondoo","year":"2014","journal-title":"Indian Dermatol. Online"},{"key":"10.1016\/j.phymed.2020.153391_bib0009","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1017\/S0007114508020321","article-title":"Intervention with flaxseed and borage oil supplements modulates skin condition in women","volume":"101","author":"De Spirt","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phymed.2020.153391_bib0010","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.4049\/jimmunol.0904064","volume":"184","author":"Damiana","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0011","article-title":"Regulation and function of syk tyrosine kinase in mast cell signaling and beyond","volume":"2011","author":"De Castro","year":"2011","journal-title":"J. Signal Transduct."},{"key":"10.1016\/j.phymed.2020.153391_bib0013","first-page":"123","article-title":"Adverse effects of topical corticosteroid use","volume":"162","author":"Fisher","year":"1995","journal-title":"West J. Med."},{"key":"10.1016\/j.phymed.2020.153391_bib0014","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jaci.2014.05.004","article-title":"Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria","volume":"134","author":"Fujisawa","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0015","doi-asserted-by":"crossref","first-page":"1153e1165","DOI":"10.1111\/bjd.14768","article-title":"Updosing nonsedating antihistamines in patients with chronic spontaneous urticaria: a systematic review and meta-analysis","volume":"175","author":"Guillen-Aguinaga","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.phymed.2020.153391_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2005.01.010","article-title":"Adverse effects of topical glucocorticosteroids","volume":"54","author":"Hengge","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phymed.2020.153391_bib0018","first-page":"2797","article-title":"Investigation and analysis on the adverse reactions caused by 12 kinds of commonly used traditional Chinese medicine injections","volume":"6","author":"Hou","year":"2012","journal-title":"Afri. Micro. Res."},{"key":"10.1016\/j.phymed.2020.153391_bib0019","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaci.2016.02.042","article-title":"Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring","volume":"139","author":"Hansen","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2020.153391_bib0020","doi-asserted-by":"crossref","first-page":"13714","DOI":"10.1038\/s41598-017-14224-z","article-title":"Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs","volume":"7","author":"Han","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2020.153391_bib0021","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.foodchem.2013.03.001","article-title":"Dietary flaxseed oil and fish oil modulates expression of antioxidant and inflammatory genes with alleviation of protein glycation status and inflammation in liver of streptozotocin-nicotinamide induced diabetic rats","volume":"141","author":"Jangale","year":"2013","journal-title":"Food. Chem."},{"key":"10.1016\/j.phymed.2020.153391_bib0022","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.4049\/jimmunol.165.3.1210","article-title":"Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation","volume":"165","author":"Kawakami","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0023","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.1038\/srep09750","article-title":"Dietary v3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut","volume":"5","author":"Kunisawa","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2020.153391_bib0024","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1365-2222.2011.03779.x","article-title":"Anaphylaxis: mechanisms and management","volume":"41","author":"Lee","year":"2011","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.phymed.2020.153391_bib0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11882-016-0598-5","article-title":"Mast cells and anaphylaxis","volume":"16","author":"Lieberman","year":"2016","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.phymed.2020.153391_bib0026","doi-asserted-by":"crossref","first-page":"31863","DOI":"10.1074\/jbc.274.45.31863","article-title":"Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor activation of c-Jun amino-terminal kinase\/stress-activated protein kinase and Lyn kinase is mediated by related adhesion focal tyrosine kinase\/proline-rich tyrosine kinase 2","volume":"274","author":"Munshi","year":"1999","journal-title":"J. Bio. Chem."},{"key":"10.1016\/j.phymed.2020.153391_bib0027","doi-asserted-by":"crossref","first-page":"6557\u20106560","DOI":"10.1016\/j.bmcl.2009.10.038","article-title":"Structural basis for the inhibitor recognition of human Lyn kinase domain","volume":"19","author":"Miyano","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2020.153391_bib0028","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1398-9995.2008.01853.x","article-title":"Chronic urticaria: a patient survey on quality-of-life, treatment usage and doctor-patient relation","volume":"64","author":"Maurer","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.phymed.2020.153391_bib0029","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1038\/jid.2014.226","article-title":"Substance P is upregulated in the serum of patients with chronic spontaneous urticaria","volume":"134","author":"Metz","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2020.153391_bib0030","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jaci.2015.05.030","article-title":"Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis","volume":"136","author":"Magnusson","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0031","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2020.153391_bib0032","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1365-2133.1997.d01-1168.x","article-title":"The impact of chronic urticaria on the quality of life","volume":"136","author":"O'Donnell","year":"1997","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.phymed.2020.153391_bib0033","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1084\/jem.20040382","article-title":"Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase","volume":"199","author":"Odom","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2020.153391_bib0034","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ni817","article-title":"Fyn kinase initiates complementary signals required for IgE dependent mast cell degranulation","volume":"3","author":"Parravicini","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/1523-1747.ep12392604","article-title":"Dietary fish-oil supplementation in humans reduces UVB-erythemal sensitivity but increases epidermal lipid peroxidation","volume":"103","author":"Rhodes","year":"1994","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2020.153391_bib0036","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jada.2008.12.022","article-title":"A systemic review of the roles of n-3 fatty acids in health and disease [J]","volume":"109","author":"Riediger","year":"2009","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.phymed.2020.153391_bib0037","first-page":"3399","article-title":"Alternatively spliced murine Lyn mRNAs encode distinct proteins","volume":"11","author":"Stanley","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2020.153391_bib0038","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0140-6736(92)91000-X","article-title":"Cutaneous responses to vasoactive intestinal polypeptide in chronic idiopathic urticaria","volume":"339","author":"Smith","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2020.153391_bib0039","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0161-5890(02)00068-8","article-title":"Protein tyrosine kinase Syk in mast cell signaling","volume":"38","author":"Siraganian","year":"2002","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbapap.2004.11.001","article-title":"Involvement of neutral endopeptidase in neoplastic progression","volume":"1751","author":"Sumitomoa","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2020.153391_bib0041","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jaci.2016.04.051","article-title":"Roles of Mas-related G proteincoupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases","volume":"138","author":"Subramanian","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2020.153391_bib0042","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.cellbio.13.1.513","article-title":"Cellular functions regulated by Src family kinases","volume":"13","author":"Thomas","year":"1997","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2020.153391_bib0043","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbrc.2006.08.177","article-title":"Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors","volume":"349","author":"Tatemoto","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2020.153391_bib0044","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cyto.2011.04.009","article-title":"Non-Fc epsilon R bearing mast cells secrete sufficient interleukin-4 to control Francisella tularensis replication within macrophages","volume":"55","author":"Thathiah","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.phymed.2020.153391_bib0045","first-page":"676","article-title":"Sinomenine potentiates P815 cell degranulation via upregulation of Ca2+ mobilization through the Lyn\/PLC\u03b3\/IP3R pathway","volume":"29","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2020.153391_bib0046","doi-asserted-by":"crossref","first-page":"147\u2010154","DOI":"10.1016\/j.bcp.2017.12.017","article-title":"Saikosaponin A inhibits compound 48\/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo","volume":"148","author":"Wang","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2020.153391_bib0047","first-page":"2391","article-title":"Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus","volume":"11","author":"Yi","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2020.153391_bib0048","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0006-291X(03)01042-8","article-title":"Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2\/BSK in rat basophilic leukemia RBL-2H3 cells","volume":"306","author":"Yamamoto","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2020.153391_bib0049","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrc1366","article-title":"A renaissance for SRC","volume":"4","author":"Yeatman","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2020.153391_bib0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/all.12338","article-title":"Chronic urticaria in Chinese population: a hospital\u2010 based multicenter epidemiological study","volume":"69","author":"Zhong","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.phymed.2020.153391_bib0051","doi-asserted-by":"crossref","first-page":"1393e1414","DOI":"10.1111\/all.13397","article-title":"The EAACI\/GA(2)LEN\/EDF\/WAO guideline for the definition, classification, diagnosis and management of urticaria","volume":"73","author":"Zuberbier","year":"2018","journal-title":"Allergy"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320302221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320302221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:25:22Z","timestamp":1760552722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711320302221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":49,"alternative-id":["S0944711320302221"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153391","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b1-Linolenic acid attenuates pseudo-allergic reactions by inhibiting Lyn kinase activity","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153391","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153391"}}