{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:15:37Z","timestamp":1793744137158,"version":"4.6.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.phymed.2020.153395","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T23:13:00Z","timestamp":1603408380000},"page":"153395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"special_numbering":"C","title":["Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-0185","authenticated-orcid":false,"given":"Javad","family":"Heshmati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Moini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Sepidarkish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Morvaridzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriko","family":"Palmowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Farid","family":"Mojtahedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-9253","authenticated-orcid":false,"given":"Farzad","family":"Shidfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.phymed.2020.153395_bib0001","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/13.3.651","article-title":"Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries","volume":"13","author":"Agrawal","year":"1998","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.phymed.2020.153395_bib0002","first-page":"1","article-title":"Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials","author":"Akbari","year":"2020","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2020.153395_bib0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2017.09.016","article-title":"Polycystic ovarian syndrome (PCOS): long-term metabolic consequences","volume":"86","author":"Anagnostis","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2020.153395_bib0004","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ctim.2019.02.014","article-title":"Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled clinical trial","volume":"43","author":"Asadi","year":"2019","journal-title":"Complement. Ther. Med."},{"issue":"1","key":"10.1016\/j.phymed.2020.153395_bib0005","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jtcme.2017.04.008","article-title":"Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome","volume":"8","author":"Borzoei","year":"2018","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.phymed.2020.153395_bib0006","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.2147\/DDDT.S117432","article-title":"The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis","volume":"10","author":"Chin","year":"2016","journal-title":"Drug Des. Devel. Ther"},{"issue":"4","key":"10.1016\/j.phymed.2020.153395_bib0007","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/pcan.2010.26","article-title":"Curcumin interrupts the interaction between the androgen receptor and Wnt\/\u03b2-catenin signaling pathway in LNCaP prostate cancer cells","volume":"13","author":"Choi","year":"2010","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0008","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jnutbio.2013.09.013","article-title":"Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial","volume":"25","author":"Chuengsamarn","year":"2014","journal-title":"J. Nutr. Biochem."},{"issue":"11","key":"10.1016\/j.phymed.2020.153395_bib0009","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.phymed.2015.11.009","article-title":"Role of phytochemicals in the management of metabolic syndrome","volume":"23","author":"Cicero","year":"2016","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0010","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","article-title":"Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.phymed.2020.153395_bib0011","first-page":"1","article-title":"Relationship among obesity, insulin resistance, and hyperinsulinemia in the polycystic ovary syndrome","author":"Dahan","year":"2019","journal-title":"Endocrine"},{"key":"10.1016\/j.phymed.2020.153395_bib0012","first-page":"1","article-title":"Multifunctional MIL-Cur@ FC as a theranostic agent for magnetic resonance imaging and targeting drug delivery: in vitro and in vivo study","author":"Dehghani","year":"2020","journal-title":"J. Drug. Target."},{"key":"10.1016\/j.phymed.2020.153395_bib0013","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.phrs.2016.07.004","article-title":"Effect of curcumin on circulating interleukin-6 concentrations: a systematic review and meta-analysis of randomized controlled trials","volume":"111","author":"Derosa","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"21","key":"10.1016\/j.phymed.2020.153395_bib0014","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1128\/MCB.00289-06","article-title":"Hormonal control of androgen receptor function through SIRT1","volume":"26","author":"Fu","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.diabres.2007.12.004","article-title":"Curcumin inhibits glucose production in isolated mice hepatocytes","volume":"80","author":"Fujiwara","year":"2008","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phymed.2020.153395_bib0016","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3389\/fendo.2019.00699","article-title":"Comparative evaluation of biomarkers of inflammation among Indian women with Polycystic ovary syndrome (PCOS) consuming vegetarian versus non-vegetarian diet","volume":"10","author":"Ganie","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0017","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.phymed.2013.08.014","article-title":"Curcumin is a direct inhibitor of glucose transport in adipocytes","volume":"21","author":"Green","year":"2014","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.phymed.2020.153395_bib0018","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4239\/wjd.v3.i5.94","article-title":"Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice","volume":"3","author":"He","year":"2012","journal-title":"World J. Diabetes"},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0019","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.dsx.2020.01.002","article-title":"The effects of curcumin supplementation on oxidative stress, sirtuin-1 and peroxisome proliferator activated receptor \u03b3 coactivator 1\u03b1 gene expression in polycystic ovarian syndrome (PCOS) patients: a randomized placebo-controlled clinical trial","volume":"14","author":"Heshmati","year":"2020","journal-title":"Diabetes Metab. Syndr.: Clin. Res. Rev."},{"key":"10.1016\/j.phymed.2020.153395_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnesp.2020.01.005","article-title":"Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial","author":"Jamilian","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0021","article-title":"Anti-inflammatory properties of curcumin, a major constituent","volume":"14","author":"Julie","year":"2009","journal-title":"Altern. Med. Rev."},{"issue":"8\u20139","key":"10.1016\/j.phymed.2020.153395_bib0022","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.fct.2010.05.073","article-title":"Synergistic effect of curcumin and insulin on muscle cell glucose metabolism","volume":"48","author":"Kang","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.phymed.2020.153395_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600471","article-title":"Curcumin improves glucose tolerance via stimulation of glucagon\u2010like peptide\u20101 secretion","volume":"61","author":"Kato","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"10.1016\/j.phymed.2020.153395_bib0024","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jcp.22093","article-title":"Curcumin stimulates glucose uptake through AMPK\u2010p38 MAPK pathways in L6 myotube cells","volume":"223","author":"Kim","year":"2010","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.phymed.2020.153395_bib0025","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2020.153395_bib0026","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.phymed.2020.153395_bib0027","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.numecd.2009.11.009","article-title":"Curcumin improves insulin resistance in skeletal muscle of rats","volume":"21","author":"Na","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.phymed.2020.153395_bib0028","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jep.2018.03.001","article-title":"The effects of Nigella sativa L. on obesity: a systematic review and meta-analysis","volume":"219","author":"Namazi","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0029","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/13813450802033958","article-title":"Role of curcumin in health and disease","volume":"114","author":"Pari","year":"2008","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.phymed.2020.153395_bib0030","unstructured":"Priyanka, R.H., Hemanth, K., Apurva, M., Bakshi, V., & Kumar, B.H. (2018). Observational study on risk factors, complications and management of polycystic ovarian syndrome."},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0031","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.apjr.2016.01.006","article-title":"Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome","volume":"5","author":"Reddy","year":"2016","journal-title":"Asian Pacif. J. Reprod."},{"issue":"5","key":"10.1016\/j.phymed.2020.153395_bib0032","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.phymed.2020.153395_bib0033","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam","year":"2004","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.phymed.2020.153395_bib0034","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.dsx.2016.06.025","article-title":"Effect of omega-3 fatty acids supplementation on insulin resistance in women with polycystic ovary syndrome: meta-analysis of randomized controlled trials","volume":"11","author":"Sadeghi","year":"2017","journal-title":"Diabetes Metab. Syndr.: Clin. Res. Rev."},{"key":"10.1016\/j.phymed.2020.153395_bib0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.phrs.2016.03.026","article-title":"Curcumin downregulates human tumor necrosis factor-\u03b1 levels: a systematic review and meta-analysis ofrandomized controlled trials","volume":"107","author":"Sahebkar","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2020.153395_bib0036","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jff.2015.01.005","article-title":"Effect of curcuminoids on oxidative stress: a systematic review and meta-analysis of randomized controlled trials","volume":"18","author":"Sahebkar","year":"2015","journal-title":"J. Funct. Foods"},{"issue":"9","key":"10.1016\/j.phymed.2020.153395_bib0037","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/mnfr.200700184","article-title":"Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db\/db mice","volume":"52","author":"Seo","year":"2008","journal-title":"Mol. Nutr. Food. Res."},{"issue":"8","key":"10.1016\/j.phymed.2020.153395_bib0038","first-page":"904","article-title":"Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity","volume":"9","author":"Shi","year":"2009","journal-title":"Anti-Cancer Agents Med. Chem. (Formerly Curr. Med. Chem.-Anti-Cancer Agents)"},{"issue":"8","key":"10.1016\/j.phymed.2020.153395_bib0039","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/oby.20213","article-title":"Longitudinal weight gain in women identified with polycystic ovary syndrome: results of an observational study in young women","volume":"21","author":"Teede","year":"2013","journal-title":"Obesity"},{"issue":"9","key":"10.1016\/j.phymed.2020.153395_bib0040","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.phymed.2020.153395_bib0041","doi-asserted-by":"crossref","first-page":"13679","DOI":"10.1038\/s41598-018-32032-x","article-title":"Curcumin alleviates postprandial glycaemic response in healthy subjects: a cross-over, randomized controlled study","volume":"8","author":"Thota","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.phymed.2020.153395_bib0042","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/1933719109332822","article-title":"Modulation of ovarian structure and abdominal obesity in curcumin-and flutamide-treated aging FSH-R haploinsufficient mice","volume":"16","author":"Tiwari-Pandey","year":"2009","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2020.153395_bib0043","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1475-2891-9-43","article-title":"Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects","volume":"9","author":"Wickenberg","year":"2010","journal-title":"Nutr. J."},{"issue":"3","key":"10.1016\/j.phymed.2020.153395_bib0044","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/JME-17-0214","article-title":"Curcumin exerts a protective effect against premature ovarian failure in mice","volume":"60","author":"Yan","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.phymed.2020.153395_bib0045","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.freeradbiomed.2013.07.007","article-title":"SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury","volume":"65","author":"Yang","year":"2013","journal-title":"Free Rad. Biol. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320302269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711320302269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:26:46Z","timestamp":1760552806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711320302269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":45,"alternative-id":["S0944711320302269"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153395","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2020.153395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153395"}}