{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:56:35Z","timestamp":1793642195664,"version":"4.5.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006469","name":"Fund for the Development of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.phymed.2021.153551","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T01:36:24Z","timestamp":1616117784000},"page":"153551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells"],"prefix":"10.1016","volume":"85","author":[{"given":"Jingjing","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2021.153551_bib0001","first-page":"92","article-title":"Shuganning injections caused 31 cases of adverse reactions literature analysis","volume":"36","author":"An","year":"2017","journal-title":"Nei Mongol J. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2021.153551_bib0002","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2021.153551_bib0003","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.chembiol.2020.03.014","article-title":"Achieving life through death: redox biology of lipid peroxidation in ferroptosis","volume":"27","author":"Bayir","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phymed.2021.153551_bib0004","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/cancers12010164","article-title":"Ferroptosis in Cancer Cell Biology","volume":"12","author":"Bebber","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.phymed.2021.153551_bib0022","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2021.153551_bib0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2017.12.025","article-title":"Heme oxygenase-1 mediates BAY 11\u20137085 induced ferroptosis","volume":"416","author":"Chang","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2021.153551_bib0006","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1038\/onc.2017.146","article-title":"ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner","volume":"36","author":"Chen","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2021.153551_bib0007","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/ijms20010039","article-title":"A dual role of heme oxygenase-1 in cancer cells","volume":"20","author":"Chiang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2021.153551_bib0008","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2021.153551_bib0009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phymed.2021.153551_bib0010","first-page":"1349","article-title":"Effects of Shuganning injection combined with reduced glutathione on liver function and serum T lymphocyte levels in patients with primary liver cancer after transcatheter arterial chemoembolization","volume":"13","author":"Dou","year":"2018","journal-title":"China Med."},{"key":"10.1016\/j.phymed.2021.153551_bib0011","doi-asserted-by":"crossref","first-page":"eaav0936","DOI":"10.1126\/scitranslmed.aav0936","article-title":"Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state","volume":"11","author":"Echeverria","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.phymed.2021.153551_bib0012","first-page":"353","article-title":"Expert consensus on treatment of acute and chronic liver diseases with Shuganning Zhusheye (2020 edition)","volume":"14","year":"2020","journal-title":"Chin. J. Exp. Clin. Infect. Dis."},{"key":"10.1016\/j.phymed.2021.153551_bib0013","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1056\/NEJMra1001389","article-title":"Triple-negative breast cancer","volume":"363","author":"Foulkes","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2021.153551_bib0014","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1002\/jcp.29221","article-title":"Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2\/heme oxygenase-1 signaling pathway in non-small-cell lung cancer","volume":"235","author":"Gai","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phymed.2021.153551_bib0015","first-page":"1487","article-title":"Clinical observation of compound glycyrrhizin combined with Shuganning on hepatoprotective effect of hepatic arterial infusion chemoembolization for primary liver cancer","volume":"13","author":"Gao","year":"2013","journal-title":"Chin. Rem. Clin."},{"key":"10.1016\/j.phymed.2021.153551_bib0016","first-page":"1291","article-title":"Progress in clinical application of Shuganning injection","volume":"27","author":"Guan","year":"2014","journal-title":"J. Med. Theory Pract."},{"key":"10.1016\/j.phymed.2021.153551_bib0017","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-5793(86)80626-3","article-title":"Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides","volume":"201","author":"Gutteridge","year":"1986","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2021.153551_bib0018","first-page":"1188","volume":"181","author":"Hadian","year":"2020","journal-title":"SnapShot"},{"key":"10.1016\/j.phymed.2021.153551_bib0019","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting ferroptosis to iron out cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2021.153551_bib0020","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1172\/JCI99032","article-title":"Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma","volume":"128","author":"Hassannia","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2021.153551_bib0021","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1172\/JCI99032","article-title":"Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma","volume":"128","author":"Hassannia","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2021.153551_bib0023","doi-asserted-by":"crossref","first-page":"24393","DOI":"10.18632\/oncotarget.5162","article-title":"Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death","volume":"6","author":"Kwon","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2021.153551_bib0024","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ctrv.2017.11.003","article-title":"Triple negative breast cancer: emerging therapeutic modalities and novel combination therapies","volume":"62","author":"Lee","year":"2018","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.phymed.2021.153551_bib0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.fitote.2018.07.009","article-title":"Traditional Chinese herbal injection: current status and future perspectives","volume":"129","author":"Li","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2021.153551_bib0026","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11882-019-0872-4","article-title":"Drug safety evaluation in China","volume":"19","author":"Li","year":"2019","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.phymed.2021.153551_bib0027","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrc2129","article-title":"Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer","volume":"7","author":"Liby","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2021.153551_bib0028","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.phrs.2016.07.044","article-title":"Neo-tanshinlactone selectively inhibits the proliferation of estrogen receptor positive breast cancer cells through transcriptional down-regulation of estrogen receptor alpha","volume":"111","author":"Lin","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2021.153551_bib0029","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1038\/s41598-017-02222-0","article-title":"Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2021.153551_bib0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.phymed.2021.153551_bib0031","series-title":"Pharmacopoeia of the People's Republic of China","author":"Pharmacopoeia","year":"2005"},{"key":"10.1016\/j.phymed.2021.153551_bib0032","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/cyto.a.20491","article-title":"Flow cytometry measurement of the labile iron pool in human hematopoietic cells","volume":"73","author":"Prus","year":"2008","journal-title":"Cytometry A"},{"key":"10.1016\/j.phymed.2021.153551_bib0033","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2021.153551_bib0034","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccr.2013.08.020","article-title":"Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target","volume":"24","author":"Timmerman","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2021.153551_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9561281","article-title":"Lysosomal destabilizing drug siramesine and the dual tyrosine kinase inhibitor lapatinib induce a synergistic ferroptosis through reduced heme oxygenase-1 (HO-1) levels","volume":"2019","author":"Villalpando-Rodriguez","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2021.153551_bib0036","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jama.2018.19323","article-title":"Breast cancer treatment a review","volume":"321","author":"Waks","year":"2019","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"10.1016\/j.phymed.2021.153551_bib0037","first-page":"543","article-title":"Research progress in clinical application of Shuganning injection","volume":"17","author":"Wang","year":"2020","journal-title":"Chin. Pharmacovigil."},{"key":"10.1016\/j.phymed.2021.153551_bib0038","first-page":"824","article-title":"Fingerprint chromatography of Shuganning injection by HPLC","volume":"32","author":"Zhang","year":"2015","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"10.1016\/j.phymed.2021.153551_bib0039","first-page":"1622","article-title":"Study on the compatibility stability of Shuganning injection","volume":"35","author":"Zhi","year":"2018","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"10.1016\/j.phymed.2021.153551_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711321000933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711321000933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:27:49Z","timestamp":1760552869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711321000933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":40,"alternative-id":["S0944711321000933"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153551","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153551","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153551"}}