{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:55:19Z","timestamp":1790873719379,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["106-2811-B-039 -014 -"],"award-info":[{"award-number":["106-2811-B-039 -014 -"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2811-B-039 -026 \\u2013"],"award-info":[{"award-number":["105-2811-B-039 -026 \\u2013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.phymed.2021.153576","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T19:12:24Z","timestamp":1618773144000},"page":"153576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation"],"prefix":"10.1016","volume":"87","author":[{"given":"Wei-Hsiang","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Kuei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ji","family":"Shiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Kuang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Ming","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsin","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Lian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2021.153576_bib0001","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10522-019-09837-y","article-title":"D-Galactose-induced accelerated aging model: an overview","volume":"20","author":"Azman","year":"2019","journal-title":"Biogerontology"},{"key":"10.1016\/j.phymed.2021.153576_bib0002","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2021.153576_bib0003","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jalz.2018.07.215","article-title":"Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer\u2019s disease","volume":"15","author":"Bell","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.phymed.2021.153576_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-76715-4_1","article-title":"Molecular mechanisms of axonal growth","volume":"621","author":"Bouquet","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.phymed.2021.153576_bib0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.exger.2014.05.017","article-title":"Oxidation scrutiny in persuaded aging and chronological aging at systemic redox homeostasis level","volume":"57","author":"Cebe","year":"2014","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.phymed.2021.153576_bib0006","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S2225-4110(16)30054-2","article-title":"Gastrodiae Rhizoma (tian ma): a review of biological activity and antidepressant mechanisms","volume":"1","author":"Chen","year":"2011","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.phymed.2021.153576_bib0007","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2016.02.001","article-title":"Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling","volume":"182","author":"Chen","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.phymed.2021.153576_bib0008","doi-asserted-by":"crossref","first-page":"e9011","DOI":"10.1371\/journal.pone.0009011","article-title":"Timing-dependent actions of NGF required for cell differentiation","volume":"5","author":"Chung","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2021.153576_bib0009","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1124\/jpet.106.118018","article-title":"Beryllium induces premature senescence in human fibroblasts","volume":"322","author":"Coates","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.phymed.2021.153576_bib0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/7854_2012_232","article-title":"Hippocampal neurogenesis and ageing","volume":"15","author":"Couillard-Despres","year":"2013","journal-title":"Curr Top Behav Neurosci"},{"key":"10.1016\/j.phymed.2021.153576_bib0011","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1017\/S1041610215000563","article-title":"Discriminative power of the advanced activities of daily living (a-ADL) tool in the diagnosis of mild cognitive impairment in an older population","volume":"27","author":"De Vriendt","year":"2015","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.phymed.2021.153576_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2017.10.013","article-title":"The adenosine A2A receptor agonist T1-11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease","volume":"110","author":"Ferrante","year":"2018","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.phymed.2021.153576_bib0013","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0197-4580(02)00019-2","article-title":"Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases","volume":"23","author":"Floyd","year":"2002","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.phymed.2021.153576_bib0014","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1083\/jcb.149.7.1443","article-title":"Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity","volume":"149","author":"Frey","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.phymed.2021.153576_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900629","article-title":"Conjugated physiological resveratrol metabolites induce senescence in breast cancer cells: role of p53\/p21 and p16\/Rb pathways, and ABC transporters","volume":"63","author":"Gimenez-Bastida","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.phymed.2021.153576_bib0016","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bbr.2011.05.013","article-title":"Adult neurogenesis: optimizing hippocampal function to suit the environment","volume":"227","author":"Glasper","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.phymed.2021.153576_bib0017","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2021.153576_bib0018","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ncomms1001","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"1","author":"Herranz","year":"2010","journal-title":"Nat Commun"},{"key":"10.1016\/j.phymed.2021.153576_bib0019","doi-asserted-by":"crossref","first-page":"315","DOI":"10.18632\/aging.100156","article-title":"Impact of Sirt1 on mammalian aging","volume":"2","author":"Herranz","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.phymed.2021.153576_bib0020","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.phymed.2021.153576_bib0021","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuron.2014.01.028","article-title":"SIRT1 in neurodevelopment and brain senescence","volume":"81","author":"Herskovits","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2021.153576_bib0022","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.arr.2009.10.001","article-title":"Anti-aging herbal medicine\u2013how and why can they be used in aging-associated neurodegenerative diseases?","volume":"9","author":"Ho","year":"2010","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.phymed.2021.153576_bib0023","first-page":"137","article-title":"GAP-43 in synaptic plasticity: molecular perspectives","volume":"5","author":"Holahan","year":"2015","journal-title":"Res Rep Biochem"},{"key":"10.1016\/j.phymed.2021.153576_bib0024","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(96)01501-2","article-title":"Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats","volume":"56","author":"Hsieh","year":"1997","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.phymed.2021.153576_bib0025","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.18632\/aging.103279","article-title":"T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice","volume":"12","author":"Hsu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.phymed.2021.153576_bib0026","doi-asserted-by":"crossref","first-page":"713","DOI":"10.5966\/sctm.2013-0111","article-title":"Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons","volume":"3","author":"Hsu","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.phymed.2021.153576_bib0027","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.phymed.2021.153576_bib0028","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/np0605182","article-title":"Neuroprotective principles from Gastrodia elata","volume":"70","author":"Huang","year":"2007","journal-title":"J Nat Prod"},{"key":"10.1016\/j.phymed.2021.153576_bib0029","doi-asserted-by":"crossref","first-page":"e20934","DOI":"10.1371\/journal.pone.0020934","article-title":"A new drug design targeting the adenosinergic system for Huntington's disease","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2021.153576_bib0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.expneurol.2013.01.006","article-title":"Loss of hippocampal neurogenesis, increased novelty-induced activity, decreased home cage activity, and impaired reversal learning one year after irradiation of the young mouse brain","volume":"247","author":"Kalm","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.phymed.2021.153576_bib0031","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nbt1051","article-title":"Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy","volume":"23","author":"Kim","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.phymed.2021.153576_bib0032","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1089\/rej.2014.1573","article-title":"Markers of oxidative stress in senescent erythrocytes obtained from young and old age rats","volume":"17","author":"Kumar","year":"2014","journal-title":"Rejuvenation Res"},{"key":"10.1016\/j.phymed.2021.153576_bib0033","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5483\/BMBRep.2019.52.1.290","article-title":"Sirtuin signaling in cellular senescence and aging","volume":"52","author":"Lee","year":"2019","journal-title":"BMB Rep"},{"key":"10.1016\/j.phymed.2021.153576_bib0034","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0031-9422(95)00955-8","article-title":"Parishins B and C from rhizomes of Gastrodia elata","volume":"42","author":"Lin","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2021.153576_bib0035","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.phymed.2012.12.008","article-title":"beta-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression","volume":"20","author":"Liu","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2021.153576_bib0036","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuint.2012.12.010","article-title":"Hydrogen sulfide protects SH-SY5Y neuronal cells against d-galactose induced cell injury by suppression of advanced glycation end products formation and oxidative stress","volume":"62","author":"Liu","year":"2013","journal-title":"Neurochem Int"},{"key":"10.1016\/j.phymed.2021.153576_bib0037","doi-asserted-by":"crossref","DOI":"10.3390\/biom10030420","article-title":"Role of p53 in the Regulation of Cellular Senescence","volume":"10","author":"Mijit","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2021.153576_bib0038","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.3390\/molecules17066728","article-title":"The role of bioactive compounds on the promotion of neurite outgrowth","volume":"17","author":"More","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2021.153576_bib0039","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1159\/000491113","article-title":"Gintonin attenuates D-galactose-induced hippocampal senescence by improving long-term hippocampal potentiation, neurogenesis, and cognitive functions","volume":"64","author":"Nam","year":"2018","journal-title":"Gerontology"},{"key":"10.1016\/j.phymed.2021.153576_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2018.06.008","article-title":"Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence","volume":"46","author":"Nanni","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2021.153576_bib0041","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/35059131","article-title":"Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence","volume":"409","author":"Ohtani","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2021.153576_bib0042","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.arr.2018.02.004","article-title":"Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming","volume":"43","author":"Ong","year":"2018","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.phymed.2021.153576_bib0043","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1038\/npp.2013.158","article-title":"Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus","volume":"38","author":"Parihar","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phymed.2021.153576_bib0044","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1016\/j.neurobiolaging.2013.05.010","article-title":"Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory","volume":"34","author":"Pristera","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.phymed.2021.153576_bib0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2014.02.044","article-title":"Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neurons","volume":"731","author":"Qiu","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.phymed.2021.153576_bib0046","first-page":"497","article-title":"Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA","volume":"14","author":"Raja","year":"2019","journal-title":"Asian J Pharm Sci"},{"key":"10.1016\/j.phymed.2021.153576_bib0047","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1254\/jphs.12R06CP","article-title":"Neural regeneration: role of traditional Chinese medicine in neurological diseases treatment","volume":"120","author":"Ren","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.phymed.2021.153576_bib0048","article-title":"D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices","volume":"12","author":"Sadigh-Eteghad","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2021.153576_bib0049","first-page":"305","article-title":"Neuronal differentiation of PC12 and embryonic stem cells in two- and three-dimensional in vitro culture","volume":"52","author":"Sadri","year":"2014","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.phymed.2021.153576_bib0050","doi-asserted-by":"crossref","first-page":"e79619","DOI":"10.1371\/journal.pone.0079619","article-title":"New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth","volume":"8","author":"Shih","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2021.153576_bib0051","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exger.2017.10.029","article-title":"Role of D-galactose-induced brain aging and its potential used for therapeutic interventions","volume":"101","author":"Shwe","year":"2018","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.phymed.2021.153576_bib0052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2009.10.003","article-title":"Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects","volume":"492","author":"Spencer","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.phymed.2021.153576_bib0053","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020272","article-title":"Neurogenic traditional Chinese medicine as a promising strategy for the treatment of Alzheimer\u2019s disease","volume":"18","author":"Sreenivasmurthy","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.phymed.2021.153576_bib0054","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.febslet.2010.04.063","article-title":"Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells","volume":"584","author":"Sugino","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.phymed.2021.153576_bib0055","first-page":"2519","article-title":"Triptolide promotes senescence of prostate cancer cells through histone methylation and heterochromatin formation","volume":"18","author":"Tamgue","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.phymed.2021.153576_bib0056","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fncel.2013.00059","article-title":"Genetic control of adult neurogenesis: interplay of differentiation, proliferation and survival modulates new neurons function, and memory circuits","volume":"7","author":"Tirone","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.phymed.2021.153576_bib0057","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/acschemneuro.5b00069","article-title":"A small linear peptide encompassing the NGF N-terminus partly mimics the biological activities of the entire neurotrophin in PC12 cells","volume":"6","author":"Travaglia","year":"2015","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.phymed.2021.153576_bib0058","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12929-016-0266-z","article-title":"Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer\u2019s disease-related pathologies in APPswe\/PS1dE9 transgenic mice","volume":"23","author":"Tsai-Teng","year":"2016","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.phymed.2021.153576_bib0059","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020598","article-title":"The cyanthin diterpenoid and sesterterpene constituents of Hericium erinaceus mycelium ameliorate Alzheimer\u2019s disease-related pathologies in APP\/PS1 transgenic mice","volume":"19","author":"Tzeng","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.phymed.2021.153576_bib0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnins.2016.00026","article-title":"Regulation of neurogenesis by neurotrophins during adulthood: expected and unexpected roles","volume":"10","author":"Vilar","year":"2016","journal-title":"Front Neurosci"},{"key":"10.1016\/j.phymed.2021.153576_bib0061","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1073\/pnas.1524259113","article-title":"Neurodevelopmental origins of lifespan changes in brain and cognition","volume":"113","author":"Walhovd","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phymed.2021.153576_bib0062","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1021\/acs.jmedchem.8b01742","article-title":"In vitro and in vivo antitumor effects of plant-derived miliusanes and their induction of cellular senescence","volume":"62","author":"Xu","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.phymed.2021.153576_bib0063","doi-asserted-by":"crossref","first-page":"24200","DOI":"10.3390\/ijms141224200","article-title":"Neuritogenic monoglyceride derived from the constituent of a marine fish for activating the PI3K\/ERK\/CREB signalling pathways in PC12 cells","volume":"14","author":"Yang","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.phymed.2021.153576_bib0064","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1096\/fj.05-5206com","article-title":"Tau associates with actin in differentiating PC12 cells","volume":"20","author":"Yu","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.phymed.2021.153576_bib0065","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2016.06.057","article-title":"The rhizome of Gastrodia elata Blume-An ethnopharmacological review","volume":"189","author":"Zhan","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.phymed.2021.153576_bib0066","doi-asserted-by":"crossref","first-page":"688","DOI":"10.14336\/AD.2017.1002","article-title":"Traditional Chinese medicine and aging intervention","volume":"8","author":"Zhao","year":"2017","journal-title":"Aging Dis"},{"key":"10.1016\/j.phymed.2021.153576_bib0067","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/cns.12334","article-title":"Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1\/2 and PI3K\/Akt signaling pathways in the neurite extension process","volume":"21","author":"Zhao","year":"2015","journal-title":"CNS Neurosci Ther"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711321001185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711321001185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:30:17Z","timestamp":1778776217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711321001185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":67,"alternative-id":["S0944711321001185"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153576","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153576"}}