{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:58:07Z","timestamp":1768075087027,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873126"],"award-info":[{"award-number":["81873126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.phymed.2021.153675","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T09:46:06Z","timestamp":1626601566000},"page":"153675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice"],"prefix":"10.1016","volume":"91","author":[{"given":"Xin-xin","family":"Ling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei-bei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-shao","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Pana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-rui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-tang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-qin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2021.153675_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101295","article-title":"Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system","volume":"26","author":"Cui","year":"2019","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2021.153675_bib0002","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1161\/HYPERTENSIONAHA.114.04468","article-title":"Null mutation of the nicotinamide adenine dinucleotide phosphate-oxidase subunit p67phox protects the Dahl-S rat from salt-induced reductions in medullary blood flow and glomerular filtration rate","volume":"65","author":"Evans","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2021.153675_bib0003","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/aps.2010.116","article-title":"Emerging role of junctophilin-2 as a regulator of calcium handling in the heart","volume":"31","author":"Garbino","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"10184","key":"10.1016\/j.phymed.2021.153675_bib0004","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/S0140-6736(19)30041-8","article-title":"Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"393","year":"2019","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.phymed.2021.153675_bib0005","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.00029.2002","article-title":"The calpain system","volume":"83","author":"Goll","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2021.153675_bib0006","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.jacc.2019.02.015","article-title":"Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction","volume":"73","author":"Greene","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2021.153675_bib0007","doi-asserted-by":"crossref","first-page":"17946","DOI":"10.1074\/jbc.M115.652396","article-title":"Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes","volume":"290","author":"Guo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2021.153675_bib0008","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan3303","article-title":"E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator","volume":"362","author":"Guo","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.phymed.2021.153675_bib0009","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fphar.2019.00049","article-title":"Prediction of Drug Positioning for Quan-Du-Zhong Capsules Against Hypertensive Nephropathy Based on the Robustness of Disease Network","volume":"10","author":"Guo","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.phymed.2021.153675_bib0010","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.jep.2014.07.006","article-title":"Effects of Xin-Ji-Er-Kang formula on 2K1C-induced hypertension and cardiovascular remodeling in rats","volume":"155","author":"Guo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2021.153675_bib0011","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jconrel.2006.12.029","article-title":"Ultrasonically targeted delivery into endothelial and smooth muscle cells in ex vivo arteries","volume":"118","author":"Hallow","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.phymed.2021.153675_bib0012","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11427-013-4490-4","article-title":"Morphogenesis of T-tubules in heart cells: the role of junctophilin-2","volume":"56","author":"Han","year":"2013","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.phymed.2021.153675_bib0013","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1016\/j.jacc.2017.04.041","article-title":"Traditional Chinese Medicine for Cardiovascular Disease: Evidence and Potential Mechanisms","volume":"69","author":"Hao","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2021.153675_bib0014","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/CIRCRESAHA.110.232470","article-title":"A major role for HERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer","volume":"107","author":"Hou","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2021.153675_bib0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.phymed.2018.03.036","article-title":"Effects of Xin-Ji-Er-Kang on heart failure induced by myocardial infarction: Role of inflammation, oxidative stress and endothelial dysfunction","volume":"42","author":"Hu","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2021.153675_bib0016","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrcardio.2012.145","article-title":"Altered sarcoplasmic reticulum calcium cycling\u2013targets for heart failure therapy","volume":"9","author":"Kho","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2021.153675_bib0017","doi-asserted-by":"crossref","first-page":"9354","DOI":"10.1073\/pnas.94.17.9354","article-title":"Calpain is a mediator of preservation-reperfusion injury in rat liver transplantation","volume":"94","author":"Kohli","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2021.153675_bib0018","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.2337\/dc11-1959","article-title":"Prospective associations of B-type natriuretic peptide with markers of left ventricular function in individuals with and without type 2 diabetes: an 8-year follow-up of the Hoorn Study","volume":"35","author":"Kroon","year":"2012","journal-title":"Diabetes Care."},{"key":"10.1016\/j.phymed.2021.153675_bib0019","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCRESAHA.107.160077","article-title":"Targeting the calpain\/calpastatin system as a new strategy to prevent cardiovascular remodeling in angiotensin II-induced hypertension","volume":"102","author":"Letavernier","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2021.153675_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109124","article-title":"Xin-Ji-Er-Kang ameliorates kidney injury following myocardial infarction by inhibiting oxidative stress via Nrf2\/HO-1 pathway in rats","volume":"117","author":"Lian","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2021.153675_bib0021","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ijbiomac.2018.01.048","article-title":"Cardioprotection activity and mechanism of Astragalus polysaccharide in vivo and in vitro","volume":"111","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2021.153675_bib0022","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/HYPERTENSIONAHA.115.05578","article-title":"Elevated Endothelial Hypoxia-Inducible Factor-1\u03b1 Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease","volume":"66","author":"Luo","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2021.153675_bib0023","first-page":"19","article-title":"A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin","volume":"2","author":"Mavani","year":"2015","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.phymed.2021.153675_bib0024","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCHEARTFAILURE.111.965392","article-title":"Chronic administration of oral vasopressin type 2 receptor antagonist tolvaptan exerts both myocardial and renal protective effects in rats with hypertensive heart failure","volume":"5","author":"Morooka","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.phymed.2021.153675_bib0025","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1080\/13880209.2017.1280513","article-title":"Appraisal of anti-arthritic and nephroprotective potential of Cuscuta reflexa","volume":"55","author":"Niazi","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2021.153675_bib0026","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/jama.2015.7515","article-title":"Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events","volume":"314","author":"Pursnani","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2021.153675_bib0027","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1289\/ehp.1003012","article-title":"Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose-response function for regulatory benefits analysis","volume":"119","author":"Roman","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.phymed.2021.153675_bib0028","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s11427-016-5007-8","article-title":"Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives","volume":"59","author":"Sun","year":"2016","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.phymed.2021.153675_bib0029","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.kint.2016.10.018","article-title":"Dietary salt restriction is beneficial to the management of autosomal dominant polycystic kidney disease","volume":"91","author":"Torres","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2021.153675_bib0030","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrc3081","article-title":"Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells","volume":"11","author":"Tyson","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2021.153675_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2019.110644","article-title":"Eicosapentaenoic acid prevents salt sensitivity in diabetic rats and decreases oxidative stress","volume":"72","author":"Vara-Messler","year":"2020","journal-title":"Nutrition"},{"key":"10.1016\/j.phymed.2021.153675_bib0032","doi-asserted-by":"crossref","first-page":"802","DOI":"10.15252\/emmm.201607300","article-title":"A clinical and mechanistic study of topical borneol-induced analgesia","volume":"9","author":"Wang","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phymed.2021.153675_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108937","article-title":"Protective effect of Xin-Ji-Er-Kang on cardiovascular remodeling in high-salt induced hypertensive mice: Role ofoxidative stress and endothelial dysfunction","volume":"115","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2021.153675_bib0034","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1161\/CIRCULATIONAHA.118.038529","article-title":"Cardiac Troponin T and Troponin I in the General Population","volume":"139","author":"Welsh","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2021.153675_bib0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12968-015-0121-5","article-title":"The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"17","author":"Yi","year":"2015","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.phymed.2021.153675_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/md17010002","article-title":"Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress","volume":"17","author":"Yoon","year":"2018","journal-title":"Mar Drugs"},{"key":"10.1016\/j.phymed.2021.153675_bib0037","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/CIRCULATIONAHA.113.008452","article-title":"Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure","volume":"129","author":"Zhang","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2021.153675_bib0038","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/HYPERTENSIONAHA.118.12084","article-title":"GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)","volume":"73","author":"Zhang","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2021.153675_bib0039","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijbiomac.2015.09.069","article-title":"Cardiovascular protective effect of polysaccharide from Ophiopogon japonicus in diabetic rats","volume":"82","author":"Zhang","year":"2016","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132100218X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132100218X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:28:15Z","timestamp":1760552895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132100218X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":39,"alternative-id":["S094471132100218X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153675","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153675"}}