{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:11:06Z","timestamp":1791285066634,"version":"4.1.0"},"reference-count":167,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.phymed.2021.153755","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T01:49:55Z","timestamp":1631843395000},"page":"153755","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"special_numbering":"C","title":["Targeting Nrf2\/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease"],"prefix":"10.1016","volume":"92","author":[{"given":"Ravichandran","family":"Jayasuriya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umapathy","family":"Dhamodharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunka Mohanram","family":"Ramkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2021.153755_bib0001","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/bph.12131","article-title":"Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers","volume":"169","author":"Aggarwal","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-46401-5_1","article-title":"Curcumin: the Indian solid gold","volume":"595","author":"Aggarwal","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2021.153755_bib0003","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3892\/mmr.2015.4579","article-title":"Systematic and comprehensive investigation of the toxicity of curcuminoidessential oil complex: a bioavailable turmeric formulation","volume":"13","author":"Aggarwal","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2021.153755_bib0004","series-title":"Polyphenols in Human Health and Disease","first-page":"xxiii","article-title":"List of contributors","author":"Aguiar Jr","year":"2014"},{"key":"10.1016\/j.phymed.2021.153755_bib0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2011.10.023","article-title":"Hesperidin alleviates acetaminophen-induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation","volume":"208","author":"Ahmad","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phymed.2021.153755_bib0006","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action","volume":"5","author":"Alam","year":"2014","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.phymed.2021.153755_bib0007","first-page":"933","article-title":"A review of flavonoid quercetin: metabolism, bioactivity and antioxidant properties","volume":"6","author":"Alrawaiq","year":"2014","journal-title":"Int. J. Pharmtech. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0008","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jcb.22800","article-title":"Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-kappaB and ERK","volume":"112","author":"Ang","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0009","first-page":"116","article-title":"Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury","volume":"20","author":"Ashrafizadeh","year":"2020","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0010","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ptr.1645","article-title":"Radical scavenging activity of alkanna tinctoria root extracts and their main constituents, hydroxynaphthoquinones","volume":"19","author":"Assimopoulou","year":"2005","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0011","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1271\/bbb.70545","article-title":"Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity","volume":"72","author":"Baek","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0012","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00204-011-0674-5","article-title":"The cytoprotective role of the Keap1-Nrf2 pathway","volume":"85","author":"Baird","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0013","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/bph.12577","article-title":"Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2","volume":"171","author":"Bhakkiyalakshmi","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0014","doi-asserted-by":"crossref","first-page":"44675","DOI":"10.1074\/jbc.M307633200","volume":"278","author":"Bloom","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/j.2040-4603.2013.tb00503.x","article-title":"Liver immunology","volume":"3","author":"Bogdanos","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phymed.2021.153755_bib0016","first-page":"318","article-title":"The antioxidant activity of coumarins and flavonoids","volume":"13","author":"Bubols","year":"2013","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0017","doi-asserted-by":"crossref","first-page":"e97735","DOI":"10.1172\/jci.insight.97735","article-title":"Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice","volume":"3","author":"Chartoumpekis","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.phymed.2021.153755_bib0018","series-title":"Diallyl disulfide (Registry No.: 2179-57-9)","year":"2021"},{"key":"10.1016\/j.phymed.2021.153755_bib0019","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2005.03.237","article-title":"Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells","volume":"331","author":"Chen","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2021.153755_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110781","article-title":"Protective effects of raspberry on the oxidative damage in HepG2 cells through Keap1\/Nrf2-dependent signaling pathway","volume":"133","author":"Chen","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0021","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1080\/10408398.2017.1345853","article-title":"Intracellular signaling pathways of inflammation modulated by dietary flavonoids: the most recent evidence","volume":"58","author":"Chen","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2021.153755_bib0022","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1021\/jf904549s","article-title":"Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells","volume":"58","author":"Chen","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0023","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1124\/dmd.113.056549","article-title":"Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of nuclear factor-E2-related factor 2-mediated upregulation of multidrug resistance-associated proteins","volume":"42","author":"Chen","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phymed.2021.153755_bib0024","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mam.2017.04.004","article-title":"The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"56","author":"Chow","year":"2017","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0025","doi-asserted-by":"crossref","first-page":"e98896","DOI":"10.1371\/journal.pone.0098896","article-title":"Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO","volume":"9","author":"Cleasby","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2021.153755_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110432","article-title":"Umbelliferone (7-hydroxycoumarin): a non-toxic antidiarrheal and antiulcerogenic coumarin","volume":"129","author":"Cruz","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2021.153755_bib0027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against d-galactosamine induced acute toxicity and oxidative\/nitrosative stress via Nrf2-NFkappaB pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0028","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.etap.2010.04.001","article-title":"Ameliorative effect of curcumin on hepatotoxicity induced by chloroquine phosphate","volume":"30","author":"Dattani","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0029","doi-asserted-by":"crossref","first-page":"729","DOI":"10.33549\/physiolres.931862","article-title":"Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of Wistar rats","volume":"59","author":"Djordjevic","year":"2010","journal-title":"Physiol. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0030","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/jn\/138.9.1615","article-title":"Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans","volume":"138","author":"Egert","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.phymed.2021.153755_bib0031","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.3748\/wjg.v16.i48.6046","article-title":"Regulation of hepatic blood flow: the hepatic arterial buffer response revisited","volume":"16","author":"Eipel","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2021.153755_bib0032","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/j.2042-7158.2012.01512.x","article-title":"Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart","volume":"64","author":"Elavarasan","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0033","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/1440-1681.12230","article-title":"Naringenin attenuates CCl4 -induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats","volume":"41","author":"Esmaeili","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.phymed.2021.153755_bib0034","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.intimp.2007.05.011","article-title":"Diammonium glycyrrhizinate, a component of traditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL-10- and IL-6-dependent manners","volume":"7","author":"Feng","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0035","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00436-010-1740-2","article-title":"Trypanocidal activity and acute toxicity assessment of triterpene acids","volume":"106","author":"Ferreira Dda","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0036","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1056\/NEJMoa1206328","article-title":"Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis","volume":"367","author":"Fox","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0037","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.taap.2010.06.005","article-title":"Sulforaphane protects microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response","volume":"247","author":"Gan","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0038","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1080\/10408398.2016.1244154","article-title":"A critical review on hepatoprotective effects of bioactive food components","volume":"58","author":"Ganesan","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2021.153755_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173606","article-title":"Vitexin restores pancreatic \u03b2-cell function and insulin signaling through Nrf2 and NF-\u03baB signaling pathways","volume":"888","author":"Ganesan","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/antiox6030068","article-title":"Solanum trilobatum L. ameliorate thioacetamide-induced oxidative stress and hepatic damage in Albino Rats","volume":"6","author":"Ganesan","year":"2017","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2021.153755_bib0041","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/nyas.13446","article-title":"Molecular targets of vitexin and isovitexin in cancer therapy: a critical review","volume":"1401","author":"Ganesan","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.phymed.2021.153755_bib0042","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.fct.2013.07.032","article-title":"Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion","volume":"59","author":"Gao","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0043","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00204-013-1078-5","article-title":"Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME","volume":"87","author":"Godoy","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0044","first-page":"503","article-title":"Protective effect of sulforaphane against oxidative stress: recent advances. Experimental and toxicologic pathology : official journal of the Gesellschaft fur","volume":"64","author":"Guerrero-Beltran","year":"2012","journal-title":"Toxikol. Pathol."},{"key":"10.1016\/j.phymed.2021.153755_bib0045","first-page":"10696","article-title":"A game-based approach to teaching and learning anatomy of the liver and portal venous system","volume":"14","author":"Hill","year":"2018","journal-title":"MedEdPORTAL J. Teach. Learn. Resour."},{"key":"10.1016\/j.phymed.2021.153755_bib0046","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/hr.2017.83","article-title":"Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury","volume":"41","author":"Hisamichi","year":"2018","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0047","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/tx0502138","article-title":"Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane","volume":"18","author":"Hong","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0048","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2012.02.011","article-title":"Ameliorative effects of diammonium glycyrrhizinate on inflammation in focal cerebral ischemic-reperfusion injury","volume":"1447","author":"Hou","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0049","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/nure.12060","article-title":"Sulforaphane: translational research from laboratory bench to clinic","volume":"71","author":"Houghton","year":"2013","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.phymed.2021.153755_bib0050","doi-asserted-by":"crossref","first-page":"42769","DOI":"10.1074\/jbc.M206911200","article-title":"Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription","volume":"277","author":"Huang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0051","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1021\/jf200579h","article-title":"Cinnamaldehyde enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression in HepG2 cells","volume":"59","author":"Huang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0052","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1475-2891-13-11","article-title":"Comparative absorption of curcumin formulations","volume":"13","author":"Jager","year":"2014","journal-title":"Nutr. J."},{"key":"10.1016\/j.phymed.2021.153755_bib0053","doi-asserted-by":"crossref","first-page":"12132","DOI":"10.1074\/jbc.M511198200","article-title":"Phosphorylation of tyrosine 568 controls nuclear export of Nrf2","volume":"281","author":"Jain","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0054","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2020.05.018","article-title":"Role of Nrf2 in MALAT1\/HIF-1alpha loop on the regulation of angiogenesis in diabetic foot ulcer","volume":"156","author":"Jayasuriya","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fct.2014.08.009","article-title":"Role of Nrf2 activation and NF-kappaB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice","volume":"73C","author":"Jin","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0056","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejphar.2008.12.055","article-title":"Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats","volume":"606","author":"Kalayarasan","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0057","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4062\/biomolther.2012.20.4.406","article-title":"Isorhamnetin-3-O-galactoside protects against CCl4-induced hepatic injury in mice","volume":"20","author":"Kim","year":"2012","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.phymed.2021.153755_bib0058","doi-asserted-by":"crossref","first-page":"e85984","DOI":"10.1371\/journal.pone.0085984","article-title":"Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 Activation","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2021.153755_bib0059","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/MCB.26.1.221-229.2006","article-title":"Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1","volume":"26","author":"Kobayashi","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2021.153755_bib0060","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/ars.2005.7.385","article-title":"Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation","volume":"7","author":"Kobayashi","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2021.153755_bib0061","doi-asserted-by":"crossref","first-page":"14130","DOI":"10.1038\/s41598-017-14520-8","article-title":"Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2\/ARE\/Prdx6 activity during aging and oxidative stress","volume":"7","author":"Kubo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2021.153755_bib0062","first-page":"351","article-title":"Antihepatotoxic effect of beta-carotene on paracetamol-induced hepatic damage in rats","volume":"43","author":"Kumar","year":"2005","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.phymed.2021.153755_bib0063","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02912891","article-title":"Biochemical activity of selenium and glutathione on country-made liquor (CML) induced hepatic damage in rats","volume":"22","author":"Kumar","year":"2007","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0064","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jep.2003.12.009","article-title":"Hepatoprotective activity of trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats","volume":"92","author":"Kumar","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/C3NP70065H","article-title":"Natural product-derived pharmacological modulators of Nrf2\/ARE pathway for chronic diseases","volume":"31","author":"Kumar","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phymed.2021.153755_bib0066","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s12272-011-0919-0","article-title":"Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents","volume":"34","author":"Kwon","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0067","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fct.2013.11.006","article-title":"The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats","volume":"63","author":"Lee","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0068","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/tox.21930","article-title":"Protective effects of diallyl disulfide on carbon tetrachloride-induced hepatotoxicity through activation of Nrf2","volume":"30","author":"Lee","year":"2013","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0069","first-page":"139","article-title":"An important role of Nrf2-ARE pathway in the cellular defense mechanism","volume":"37","author":"Lee","year":"2004","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2021.153755_bib0070","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3892\/ijmm.2016.2837","article-title":"Morin exerts cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2-dependent HO-1 expression and the activation of the ERK pathway","volume":"39","author":"Lee","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0071","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-3-642-38007-5_12","article-title":"Sulforaphane as a promising molecule for fighting cancer","volume":"159","author":"Lenzi","year":"2014","journal-title":"Cancer Treat. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0072","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.3390\/ijms20184445","article-title":"Emerging screening approaches in the development of Nrf2-Keap1 protein-protein interaction inhibitors","volume":"20","author":"Leung","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2021.153755_bib0073","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/molecules24010110","article-title":"Shikonin attenuates acetaminophen-induced hepatotoxicity by upregulation of Nrf2 through Akt\/GSK3beta signaling","volume":"24","author":"Li","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2021.153755_bib0074","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000324694","article-title":"Attenuation of glomerular injury in diabetic mice with tert-butylhydroquinone through nuclear factor erythroid 2-related factor 2-dependent antioxidant gene activation","volume":"33","author":"Li","year":"2011","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phymed.2021.153755_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110758","article-title":"Discovery of Keap1-Nrf2 small-molecule inhibitors from phytochemicals based on molecular docking","volume":"133","author":"Li","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0076","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopha.2018.01.030","article-title":"Corilagin, a promising medicinal herbal agent","volume":"99","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2021.153755_bib0077","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yrtph.2019.04.001","article-title":"Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats","volume":"105","author":"Li","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0078","doi-asserted-by":"crossref","first-page":"e35122","DOI":"10.1371\/journal.pone.0035122","article-title":"Mechanism of chemical activation of Nrf2","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2021.153755_bib0079","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1142\/S0192415X19500939","article-title":"Aged citrus peel (Chenpi) prevents acetaminophen-induced hepatotoxicity by epigenetically regulating Nrf2 pathway","volume":"47","author":"Lin","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-8741(95)90032-2","article-title":"Pharmacology of oleanolic acid and ursolic acid","volume":"49","author":"Liu","year":"1995","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0081","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0022-3565(25)12127-7","article-title":"Effect of oleanolic acid on hepatic toxicant-activating and detoxifying systems in mice","volume":"275","author":"Liu","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2021.153755_bib0082","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tiv.2011.10.013","article-title":"Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage","volume":"26","author":"Liu","year":"2012","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.phymed.2021.153755_bib0083","doi-asserted-by":"crossref","unstructured":"Liu, T., Xia, Y., Li, J., Li, S., Feng, J., Wu, L., Zhang, R., Xu, S., Cheng, K., Zhou, Y., Zhou, S., Dai, W., Chen, K., Wang, F., Lu, J., Zhou, Y., Guo, C., 2016. Shikonin attenuates concanavalin a-induced acute liver injury in mice via inhibition of the JNK pathway. Mediators of inflammation 2016, 2748367.","DOI":"10.1155\/2016\/2748367"},{"key":"10.1016\/j.phymed.2021.153755_bib0084","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuropharm.2013.11.026","article-title":"Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2\/ARE signaling pathway","volume":"79","author":"Lou","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2021.153755_bib0085","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.toxlet.2014.09.027","article-title":"Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2","volume":"232","author":"Lu","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phymed.2021.153755_bib0086","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12964-018-0314-2","article-title":"Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK\/GSK3beta-Nrf2 signaling pathway","volume":"17","author":"Lv","year":"2019","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.phymed.2021.153755_bib0087","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2017.02.016","article-title":"Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death","volume":"106","author":"Lv","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0088","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1082013211433073","article-title":"An overview of health-promoting compounds of broccoli (Brassica oleracea var. italica) and the effect of processing","volume":"18","author":"Mahn","year":"2012","journal-title":"Food Sci. Technol. Int."},{"key":"10.1016\/j.phymed.2021.153755_bib0089","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/nure.12152","article-title":"Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease","volume":"72","author":"Miles","year":"2014","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.phymed.2021.153755_bib0090","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1038\/s41598-019-43320-5","article-title":"Possible activation of NRF2 by vitamin E\/curcumin against altered thyroid hormone induced oxidative stress via NFkB\/AKT\/mTOR\/KEAP1 signalling in rat heart","volume":"9","author":"Mishra","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2021.153755_bib0091","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.etap.2014.08.004","article-title":"Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression","volume":"38","author":"Mohamed","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0092","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/PAF.0b013e31823d29ad","article-title":"Normal organ weights in men: part II-the brain, lungs, liver, spleen, and kidneys","volume":"33","author":"Molina","year":"2012","journal-title":"Am. J. Forensic Med. Pathol."},{"key":"10.1016\/j.phymed.2021.153755_bib0093","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s13346-011-0033-3","article-title":"Comparative oral bioavailability advantage from curcumin formulations","volume":"1","author":"Munjal","year":"2011","journal-title":"Drug Deliv. and Transl. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0094","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.freeradbiomed.2011.11.033","article-title":"Aldehyde dehydrogenases and cell proliferation","volume":"52","author":"Muzio","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0095","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1254\/jjp.75.363","article-title":"New curcuminoids isolated from Zingiber cassumunar protect cells suffering from oxidative stress: a flow-cytometric study using rat thymocytes and H2O2","volume":"75","author":"Nagano","year":"1997","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0096","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1439-0396.2007.00752.x","article-title":"Liver lipid metabolism","volume":"92","author":"Nguyen","year":"2008","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.phymed.2021.153755_bib0097","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0098","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ar.20681","article-title":"Lymph circulation in the liver","volume":"291","author":"Ohtani","year":"2008","journal-title":"Anat. Rec."},{"key":"10.1016\/j.phymed.2021.153755_bib0099","first-page":"322","article-title":"Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models","volume":"29","author":"Parhiz","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0100","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1742-7843.2006.pto_351.x","article-title":"Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver","volume":"98","author":"Pari","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0101","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1211\/0022357001774048","article-title":"Protective effect of curcumin in rat liver injury induced by carbon tetrachloride","volume":"52","author":"Park","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0102","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jep.2017.12.029","article-title":"In vitro and in vivo evaluation of systemic and genetic toxicity of citrus unshiu peel","volume":"215","author":"Park","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0103","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/0973-7847.65321","article-title":"Extracts from the history and medical properties of garlic","volume":"4","author":"Petrovska","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.phymed.2021.153755_bib0104","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phytochem.2011.12.022","article-title":"Oleanolic acid","volume":"77","author":"Pollier","year":"2012","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2021.153755_bib0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.56499\/jppres14.050_3.1.13","article-title":"Acute and 28-day subchronic toxicity studies of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark","volume":"3","author":"Prado","year":"2015","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0106","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.toxlet.2008.12.014","article-title":"Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice","volume":"185","author":"Prince","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phymed.2021.153755_bib0107","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.3389\/fphar.2018.01562","article-title":"Treatment with naringenin elevates the activity of transcription factor Nrf2 to protect pancreatic beta-cells from streptozotocin-induced diabetes in vitro and in vivo","volume":"9","author":"Rajappa","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0108","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/sj.onc.1210392","article-title":"Differential regulation and properties of MAPKs","volume":"26","author":"Raman","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2021.153755_bib0109","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.lfs.2006.01.005","article-title":"Antioxidant role of umbelliferone in STZ-diabetic rats","volume":"79","author":"Ramesh","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2021.153755_bib0110","doi-asserted-by":"crossref","first-page":"7542","DOI":"10.1021\/ac401569j","article-title":"Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals","volume":"85","author":"Ramkumar","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0111","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s13105-014-0318-3","article-title":"Naringenin confers protection against oxidative stress through upregulation of Nrf2 target genes in cardiomyoblast cells","volume":"70","author":"Ramprasath","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0112","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.phymed.2021.153755_bib0113","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.antiviral.2017.12.004","article-title":"A natural small molecule inhibitor corilagin blocks HCV replication and modulates oxidative stress to reduce liver damage","volume":"150","author":"Reddy","year":"2018","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0114","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bcp.2008.12.028","article-title":"Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes","volume":"77","author":"Reisman","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0115","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.1014275108","article-title":"Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism","volume":"108","author":"Ren","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2021.153755_bib0116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.07.029","article-title":"Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin\u2013a mini-review","volume":"113","author":"Roohbakhsh","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2021.153755_bib0117","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phymed.2021.153755_bib0118","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1016\/S0021-9258(18)99004-6","article-title":"The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity","volume":"266","author":"Rushmore","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0119","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1021\/tx0601105","article-title":"Ebselen, a seleno-organic antioxidant, as an electrophile","volume":"19","author":"Sakurai","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0120","doi-asserted-by":"crossref","first-page":"14841","DOI":"10.1074\/jbc.M513737200","article-title":"Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2","volume":"281","author":"Salazar","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0121","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/tox.21940","article-title":"Effects of nanoparticle-encapsulated curcumin on arsenic-induced liver toxicity in rats","volume":"30","author":"Sankar","year":"2013","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2021.153755_bib0122","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/aps.2010.142","article-title":"Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets","volume":"31","author":"Severi","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2021.153755_bib0123","first-page":"118","article-title":"Cytoprotective, antihyperglycemic and antioxidative effect of naringenin on liver and kidneys of swiss diabetic mice","volume":"6","author":"Sharma","year":"2016","journal-title":"Int. J. Health Sci. Res."},{"key":"10.1016\/j.phymed.2021.153755_bib0124","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s12291-009-0074-2","article-title":"Effect of ethanolic leaf extract of trianthema portulacastrum L. On aflatoxin induced hepatic damage in rats","volume":"24","author":"Sharmila Banu","year":"2009","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12291-009-0047-5","article-title":"Ethanolic leaves extract of trianthema portulacastrum L. ameliorates aflatoxin B(1) induced hepatic damage in rats","volume":"24","author":"Sharmila Banu","year":"2009","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0126","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1158\/1535-7163.MCT-05-0293","article-title":"Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin","volume":"5","author":"Shen","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phymed.2021.153755_bib0127","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biopha.2017.09.039","article-title":"The synergy of diammonium glycyrrhizinate remarkably reduces the toxicity of oxymatrine in ICR mice","volume":"97","author":"Shi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2021.153755_bib0128","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jnutbio.2017.02.015","article-title":"Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade","volume":"44","author":"Sireesh","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0129","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1248\/bpb.30.74","article-title":"Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives","volume":"30","author":"Somparn","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2021.153755_bib0130","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s12017-008-8037-y","article-title":"Hormetic dietary phytochemicals","volume":"10","author":"Son","year":"2008","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.phymed.2021.153755_bib0131","first-page":"412","article-title":"Long-term systemic toxicity of shikonin derivatives in Wistar rats","volume":"57","author":"Su","year":"2013","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2021.153755_bib0132","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0944-7113(98)80044-5","article-title":"In vitro scavenger and antioxidant properties of hesperidin and neohesperidin dihydrochalcone","volume":"5","author":"Suarez","year":"1998","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2021.153755_bib0133","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cpr.12102","article-title":"Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells","volume":"47","author":"Suganya","year":"2014","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2021.153755_bib0134","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/antiox7070078","article-title":"Protective effect of aqueous extract from the leaves of justicia tranquebariesis against thioacetamide-induced oxidative stress and hepatic fibrosis in rats","volume":"7","author":"Sukalingam","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2021.153755_bib0135","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3390\/molecules25051053","article-title":"Quercetin protects against lipopolysaccharide-induced intestinal oxidative stress in broiler chickens through activation of Nrf2 pathway","volume":"25","author":"Sun","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2021.153755_bib0136","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.taap.2011.05.011","article-title":"Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB\/c mice","volume":"255","author":"Sun","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0137","doi-asserted-by":"crossref","first-page":"e6588","DOI":"10.1371\/journal.pone.0006588","article-title":"Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response","volume":"4","author":"Sun","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2021.153755_bib0138","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bionut.2014.01.005","article-title":"Hesperidin safeguards hepatocytes from valproate-induced liver dysfunction in Sprague-Dawley rats","volume":"4","author":"Suresh","year":"2014","journal-title":"Biomed. Prev. Nutr."},{"key":"10.1016\/j.phymed.2021.153755_bib0139","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/415078","article-title":"Sulforaphane as a potential protective phytochemical against neurodegenerative diseases","volume":"2013","author":"Tarozzi","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2021.153755_bib0140","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1517\/13543776.2013.836182","article-title":"Therapeutic and cosmetic applications of mangiferin: a patent review","volume":"23","author":"Telang","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.phymed.2021.153755_bib0141","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1124\/jpet.119.261792","article-title":"Therapeutic effects of Nrf2 activation by bardoxolone methyl in chronic heart failure","volume":"371","author":"Tian","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2021.153755_bib0142","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/MCB.00225-13","article-title":"The Keap1-Nrf2 system prevents onset of diabetes mellitus","volume":"33","author":"Uruno","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2021.153755_bib0143","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jmf.2018.0024","article-title":"Isothiocyanate from broccoli, sulforaphane, and its properties","volume":"22","author":"Vanduchova","year":"2019","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2021.153755_bib0144","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2017.02.026","article-title":"Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells","volume":"801","author":"Vanitha","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0145","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/ars.2010.3211","article-title":"Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases","volume":"13","author":"Villeneuve","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2021.153755_bib0146","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jnutbio.2012.03.005","article-title":"The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism","volume":"23","author":"Vomhof-Dekrey","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0147","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/138955712800493870","article-title":"Perspectives on medicinal properties of mangiferin","volume":"12","author":"Vyas","year":"2012","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0148","article-title":"Resveratrol prevents diabetic cardiomyopathy by increasing Nrf2 expression and transcriptional activity","volume":"2018","author":"Wang","year":"2018","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.phymed.2021.153755_bib0149","doi-asserted-by":"crossref","first-page":"788","DOI":"10.7150\/ijbs.30677","article-title":"Farrerol ameliorates APAP-induced hepatotoxicity via activation of Nrf2 and autophagy","volume":"15","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2021.153755_bib0150","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jnutbio.2011.08.004","article-title":"Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes","volume":"23","author":"Wang","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2021.153755_bib0151","doi-asserted-by":"crossref","first-page":"921","DOI":"10.7150\/ijbs.42300","article-title":"Aldehyde dehydrogenase, liver disease and cancer","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2021.153755_bib0152","doi-asserted-by":"crossref","first-page":"e44686","DOI":"10.1371\/journal.pone.0044686","article-title":"Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2021.153755_bib0153","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.2174\/092986709789578187","article-title":"The structure and pharmacological functions of coumarins and their derivatives","volume":"16","author":"Wu","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2021.153755_bib0154","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.taap.2014.08.003","article-title":"Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin","volume":"280","author":"Xu","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbi.2012.05.011","article-title":"Curcumin encapsulated in chitosan nanoparticles: a novel strategy for the treatment of arsenic toxicity","volume":"199","author":"Yadav","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2021.153755_bib0156","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.celrep.2017.01.064","article-title":"Nrf2 improves leptin and insulin resistance provoked by hypothalamic oxidative stress","volume":"18","author":"Yagishita","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2021.153755_bib0157","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5967434","article-title":"Farrerol directly targets GSK-3beta to activate Nrf2-ARE pathway and protect EA.hy926 cells against oxidative stress-induced injuries","volume":"2020","author":"Yan","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2021.153755_bib0158","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180444","article-title":"Umbelliferone alleviates hepatic injury in diabetic db\/db mice via inhibiting inflammatory response and activating Nrf2-mediated antioxidant","volume":"38","author":"Yin","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phymed.2021.153755_bib0159","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1021\/np300465f","article-title":"Dehydrozingerone, a structural analogue of curcumin, induces cell-cycle arrest at the G2\/M phase and accumulates intracellular ROS in HT-29 human colon cancer cells","volume":"75","author":"Yogosawa","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2021.153755_bib0160","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.3390\/nu12103026","article-title":"Discovery of sulforaphane as a potent BACE1 inhibitor based on kinetics and computational studies","volume":"12","author":"Youn","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2021.153755_bib0161","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2021.153755_bib0162","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.3748\/wjg.v12.i28.4578","article-title":"Anti-inflammatory effect of diammonium glycyrrhizinate in a rat model of ulcerative colitis","volume":"12","author":"Yuan","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2021.153755_bib0163","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/aps.2013.165","article-title":"Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro","volume":"35","author":"Zhang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2021.153755_bib0164","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","article-title":"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress","volume":"23","author":"Zhang","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2021.153755_bib0165","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3389\/fphar.2018.01257","article-title":"Black truffle aqueous extract attenuates oxidative stress and inflammation in STZ-induced hyperglycemic rats via Nrf2 and NF-\u03baB pathways","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0166","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fphar.2019.00497","article-title":"Pterostilbene activates the Nrf2-dependent antioxidant response to ameliorate arsenic-induced intracellular damage and apoptosis in human keratinocytes","volume":"10","author":"Zhou","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153755_bib0167","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1089\/ars.2013.5538","article-title":"Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin","volume":"21","author":"Zou","year":"2014","journal-title":"Antioxid. Redox Signal."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711321002981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711321002981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:31:41Z","timestamp":1760553101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711321002981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":167,"alternative-id":["S0944711321002981"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153755","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Nrf2\/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153755","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153755"}}