{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:58:54Z","timestamp":1789790334072,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.phymed.2021.153795","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T01:39:47Z","timestamp":1633743587000},"page":"153795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Baoyuan Capsule promotes neurogenesis and neurological functional recovery through improving mitochondrial function and modulating PI3K\/Akt signaling pathway"],"prefix":"10.1016","volume":"93","author":[{"given":"Qiaohui","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixia","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bun","family":"Tsoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2021.153795_bib0001","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nn1707","article-title":"Potential role for adult neurogenesis in the encoding of time in new memories","volume":"9","author":"Aimone","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phymed.2021.153795_bib0002","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.neuron.2016.12.017","article-title":"Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis","volume":"93","author":"Beckervordersandforth","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2021.153795_bib0003","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0140-6736(15)60690-0","article-title":"Efficacy and safety of very early mobilisation within 24h of stroke onset (AVERT): a randomised controlled trial","volume":"386","author":"Bernhardt","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2021.153795_bib0004","first-page":"1","article-title":"Mitochondrial transfer as a therapeutic strategy against ischemic stroke","author":"Chen","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.phymed.2021.153795_bib0005","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1007\/s12035-020-02016-y","article-title":"Proteomics-guided study on Buyang Huanwu decoction for its neuroprotective and neurogenic mechanisms for transient ischemic stroke: involvements of EGFR\/PI3K\/Akt\/Bad\/14-3-3 and Jak2\/Stat3\/Cyclin D1 signaling cascades","volume":"57","author":"Chen","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2021.153795_bib0006","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1007\/s12035-018-1294-3","article-title":"Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR\/MAPK signaling cascades","volume":"56","author":"Chen","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2021.153795_bib0007","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.devcel.2007.04.001","article-title":"Functional redundancy of GSK-3alpha and GSK-3beta in Wnt\/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines","volume":"12","author":"Doble","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.phymed.2021.153795_bib0008","first-page":"275","article-title":"Measurement of mitochondrial mass by flow cytometry during oxidative stress","volume":"4","author":"Doherty","year":"2017","journal-title":"Reactive Oxygen Species (Apex, NC)"},{"key":"10.1016\/j.phymed.2021.153795_bib0009","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.biopsych.2006.03.082","article-title":"Hippocampal neurogenesis: regulation by stress and antidepressants","volume":"59","author":"Dranovsky","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2021.153795_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113495","article-title":"Combination of matrix solid phase dispersion and response surface evaluation for simultaneous detections of multiple bioactive constituents of traditional Chinese medicine formula: using Baoyuan Capsule as an example","volume":"190","author":"Du","year":"2020","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.phymed.2021.153795_bib0011","doi-asserted-by":"crossref","first-page":"9029","DOI":"10.1007\/s12035-018-1027-7","article-title":"Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation","volume":"55","author":"Feng","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2021.153795_bib0012","doi-asserted-by":"crossref","first-page":"9334","DOI":"10.1007\/s12035-018-1042-8","article-title":"Baicalin modulates APPL2\/glucocorticoid receptor signaling cascade, promotes neurogenesis, and attenuates emotional and olfactory dysfunctions in chronic corticosterone-induced depression","volume":"55","author":"Gao","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2021.153795_bib0013","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jep.2010.07.033","article-title":"Ginsenoside Rb1 regulates the expressions of brain-derived neurotrophic factor and caspase-3 and induces neurogenesis in rats with experimental cerebral ischemia","volume":"132","author":"Gao","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2021.153795_bib0014","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.3389\/fcell.2020.577790","article-title":"Alpinia oxyphylla Miq. and its active compound P-coumaric acid promote brain-derived neurotrophic factor signaling for inducing hippocampal neurogenesis and improving post-cerebral ischemic spatial cognitive functions","volume":"8","author":"He","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2021.153795_bib0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12035-011-8186-0","article-title":"The role of Notch signaling in adult neurogenesis","volume":"44","author":"Imayoshi","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2021.153795_bib0016","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1242\/dev.137075","article-title":"Proliferation, survival and metabolism: the role of PI3K\/AKT\/mTOR signalling in pluripotency and cell fate determination","volume":"143","author":"Jason","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.phymed.2021.153795_bib0017","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.0403678101","article-title":"Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw, Ind) mice","volume":"101","author":"Jin","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phymed.2021.153795_bib0018","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.stem.2016.04.015","article-title":"Mitochondrial dynamics impacts stem cell identity and fate decisions by regulating a nuclear transcriptional program","volume":"19","author":"Khacho","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.phymed.2021.153795_bib0019","doi-asserted-by":"crossref","unstructured":"Le Belle, J.E., Orozco, N.M., Paucar, A.A., Saxe, J.P., Mottahedeh, J., Pyle, A.D., Wu, H., Kornblum, H.I.J.C.s.c., 2011. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner. 8, 59\u201371.","DOI":"10.1016\/j.stem.2010.11.028"},{"key":"10.1016\/j.phymed.2021.153795_bib0020","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.freeradbiomed.2008.08.022","article-title":"4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt\/NF-\u03baB signaling pathways","volume":"45","author":"Lee","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2021.153795_bib0021","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fphar.2020.00352","article-title":"Mitochondrial MPTP: a novel target of ethnomedicine for stroke treatment by apoptosis inhibition","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153795_bib0022","doi-asserted-by":"crossref","first-page":"13621","DOI":"10.1073\/pnas.1811825116","article-title":"Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke","volume":"116","author":"Liang","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phymed.2021.153795_bib0023","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/096382899297198","article-title":"Characterization of elderly patients in rehabilitation: stroke versus hip fracture","volume":"21","author":"Lieberman","year":"1999","journal-title":"Disabil. Rehabil."},{"key":"10.1016\/j.phymed.2021.153795_bib0024","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0896-6273(00)00148-3","article-title":"Noggin antagonizes BMP signaling to create a niche for adult neurogenesis","volume":"28","author":"Lim","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2021.153795_bib0025","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jep.2012.05.057","article-title":"Promotive effect of ginsenoside Rd on proliferation of neural stem cells in vivo and in vitro","volume":"142","author":"Lin","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2021.153795_bib0026","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3390\/biom10030484","article-title":"Ginsenoside compound K induces adult hippocampal proliferation and survival of newly generated cells in young and elderly mice","volume":"10","author":"Oh","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2021.153795_bib0027","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0167-4889(98)00088-3","article-title":"Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells","volume":"1404","author":"Rottenberg","year":"1998","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.phymed.2021.153795_bib0028","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/bc.bc_14_18","article-title":"Mitochondrial targeting as a novel therapy for stroke","volume":"4","author":"Russo","year":"2018","journal-title":"Brain Circulation"},{"key":"10.1016\/j.phymed.2021.153795_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(03)00318-5","article-title":"Ginsenoside Rg1 increases ischemia-induced cell proliferation and survival in the dentate gyrus of adult gerbils","volume":"344","author":"Shen","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2021.153795_bib0030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fphar.2020.00285","article-title":"Ginsenoside-Rb1 for ischemic stroke: a systematic review and meta-analysis of preclinical evidence and possible mechanisms","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2021.153795_bib0031","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.cellbio.042308.113256","article-title":"Signaling in adult neurogenesis","volume":"25","author":"Suh","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2021.153795_bib0032","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.talanta.2018.06.022","article-title":"Identification of non volatile migrant compounds and NIAS in polypropylene films used as food packaging characterized by UPLC-MS\/QTOF","volume":"188","author":"Vera","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.phymed.2021.153795_bib0033","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-3223(02)01424-5","article-title":"Post stroke depression: epidemiology, pathophysiology, and biological treatment","volume":"52","author":"Whyte","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2021.153795_bib0034","doi-asserted-by":"crossref","DOI":"10.14336\/AD.2021.0729","article-title":"Mammalian AKT, the emerging roles on mitochondrial function in diseases","author":"Xie","year":"2022","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2021.153795_bib0035","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.neuropharm.2011.05.029","article-title":"Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice","volume":"61","author":"Ye","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2021.153795_bib0036","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature06968","article-title":"The ground state of embryonic stem cell self-renewal","volume":"453","author":"Ying","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2021.153795_bib0037","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.phrs.2019.04.021","article-title":"Ginsenoside F1 promotes angiogenesis by activating the IGF-1\/IGF1R pathway","volume":"144","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2021.153795_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2010.7483.x","article-title":"The Wnt\/\u03b2-catenin signaling pathway in the adult neurogenesis","volume":"33","author":"Zhang","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phymed.2021.153795_bib0039","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jep.2010.01.064","article-title":"Ginseng total saponins enhance neurogenesis after focal cerebral ischemia","volume":"133","author":"Zheng","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2021.153795_bib0040","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1002\/jssc.201701370","article-title":"Screening and analysis of potentially active components in Shenxiong glucose injection using UHPLC coupled with photodiode array detection and MS\/MS","volume":"41","author":"Zhou","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.phymed.2021.153795_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462405","article-title":"A five-dimensional data collection strategy for multicomponent discovery and characterization in Traditional Chinese Medicine: Gastrodia Rhizoma as a case study","volume":"1653","author":"Zhu","year":"2021","journal-title":"J. Chromatogr. A"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132100338X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132100338X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:35:46Z","timestamp":1760553346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132100338X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":41,"alternative-id":["S094471132100338X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153795","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baoyuan Capsule promotes neurogenesis and neurological functional recovery through improving mitochondrial function and modulating PI3K\/Akt signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2021.153795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153795"}}