{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:10:46Z","timestamp":1792293046953,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.phymed.2022.153941","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T15:12:51Z","timestamp":1642605171000},"page":"153941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Natural Citrus flavanone 5-demethylnobiletin stimulates melanogenesis through the activation of cAMP\/CREB pathway in B16F10 cells"],"prefix":"10.1016","volume":"98","author":[{"given":"Hui Miao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Qun","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome P.L.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Lin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Kam Wai","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Lai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty Yuen Kwan","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.153941_bib0001","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1600-0854.2011.01172.x","article-title":"The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking","volume":"12","author":"Beaumont","year":"2011","journal-title":"Traffic"},{"key":"10.1016\/j.phymed.2022.153941_bib0002","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The protective role of melanin against UV damage in human skin","volume":"84","author":"Brenner","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.phymed.2022.153941_bib0003","doi-asserted-by":"crossref","first-page":"12635","DOI":"10.1074\/jbc.M800130200","article-title":"Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport","volume":"283","author":"Chiaverini","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2022.153941_bib0004","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1021\/jf4024678","article-title":"Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells","volume":"61","author":"Chiu","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2022.153941_bib0005","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3390\/ijms17071144","article-title":"Signaling pathways in melanogenesis","volume":"17","author":"D'Mello","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.153941_bib0006","first-page":"1265","article-title":"Lysosome-related organelles","volume":"14","author":"Dell'Angelica","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2022.153941_bib0007","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.lfs.2015.10.009","article-title":"Isosakuranetin, a 4\u2032-O-methylated flavonoid, stimulates melanogenesis in B16BL6 murine melanoma cells","volume":"143","author":"Drira","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.153941_bib0008","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/pcmr.12535","article-title":"Fluorescent quantification of melanin","volume":"29","author":"Fernandes","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.phymed.2022.153941_bib0009","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1042\/BST0391191","article-title":"Melanosomes on the move: a model to understand organelle dynamics","volume":"39","author":"Hume","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.phymed.2022.153941_bib0010","first-page":"e58185","article-title":"Quantification of hypopigmentation activity in vitro","author":"Kim","year":"2019","journal-title":"JoVE (J. Visualiz. Exp.)"},{"key":"10.1016\/j.phymed.2022.153941_bib0011","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lfs.2016.08.015","article-title":"The activation of melanogenesis by p-CREB and MITF signaling with extremely low-frequency electromagnetic fields on B16F10 melanoma","volume":"162","author":"Kim","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.153941_bib0012","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.abd.2019.09.023","article-title":"Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors","volume":"94","author":"Mar\u00e7on","year":"2019","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.phymed.2022.153941_bib0013","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/35096009","article-title":"The melanosome: membrane dynamics in black and white","volume":"2","author":"Marks","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2022.153941_bib0014","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.3390\/molecules22081303","article-title":"Upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo","volume":"22","author":"Niu","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2022.153941_bib0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jb\/mvs009","article-title":"Role of Rab family GTPases and their effectors in melanosomal logistics","volume":"151","author":"Ohbayashi","year":"2012","journal-title":"J. Biochem."},{"key":"10.1016\/j.phymed.2022.153941_bib0016","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00018-009-8703-8","article-title":"Cellular mechanisms regulating human melanogenesis","volume":"66","author":"Park","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phymed.2022.153941_bib0017","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cellsig.2017.09.004","article-title":"Recent development of signaling pathways inhibitors of melanogenesis","volume":"40","author":"Pillaiyar","year":"2017","journal-title":"Cell Signal"},{"key":"10.1016\/j.phymed.2022.153941_bib0018","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3390\/ijms20030536","article-title":"Leathesia difformis extract inhibits \u03b1-MSH-induced melanogenesis in B16F10 cells via down-regulation of CREB signaling pathway","volume":"20","author":"Seo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.153941_bib0019","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3390\/ijms19092667","article-title":"MC1R: front and center in the bright side of dark eumelanin and DNA repair","volume":"19","author":"Swope","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.153941_bib0020","first-page":"41","article-title":"Melanogenic factors: regulation of gene expression","volume":"97","author":"Vachtenheim","year":"1996","journal-title":"Sb. Lek."},{"key":"10.1016\/j.phymed.2022.153941_bib0021","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1590\/S0365-05962013000100009","article-title":"Mechanisms regulating melanogenesis","volume":"88","author":"Videira","year":"2013","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.phymed.2022.153941_bib0022","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1242\/jcs.040667","article-title":"Melanosomes at a glance","volume":"121","author":"Wasmeier","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phymed.2022.153941_bib0023","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/mnfr.201300211","article-title":"Identification of novel bioactive metabolites of 5-demethylnobiletin in mice","volume":"57","author":"Zheng","year":"2013","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322000198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322000198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:34:48Z","timestamp":1760553288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322000198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":23,"alternative-id":["S0944711322000198"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.153941","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural Citrus flavanone 5-demethylnobiletin stimulates melanogenesis through the activation of cAMP\/CREB pathway in B16F10 cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.153941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153941"}}