{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:25:46Z","timestamp":1788305146767,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070389"],"award-info":[{"award-number":["32070389"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573550"],"award-info":[{"award-number":["81573550"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1707105"],"award-info":[{"award-number":["2018YFC1707105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.phymed.2022.153952","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T22:56:13Z","timestamp":1642632973000},"page":"153952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The anti-inflammatory activity by suppressing the TRAF6\/MAPKs pathway of trishizukaol a from Sarcandra glabra"],"prefix":"10.1016","volume":"98","author":[{"given":"Rong","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.phymed.2022.153952_bib0001","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20102049","article-title":"Mitochondrial reactive oxygen species promote production of pro-inflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)","volume":"208","author":"Bulua","year":"2011","journal-title":"J. Exp. Med."},{"issue":"34","key":"10.1016\/j.phymed.2022.153952_bib0002","doi-asserted-by":"crossref","first-page":"13191","DOI":"10.1074\/jbc.RA118.002649","article-title":"Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity","volume":"293","author":"Brenke","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2022.153952_bib0003","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.intimp.2015.12.029","article-title":"Anti-inflammatory effect of corymbocoumarin from Seseli gummiferum subsp. corymbosum through suppression of NF-\u03baB signaling pathway and induction of HO-1 expression in LPS-stimulated RAW 264.7 cells","volume":"31","author":"Chun","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2022.153952_bib0004","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1073\/pnas.1721788115","article-title":"Mechanism of ubiquitin transfer promoted by TRAF6","volume":"115","author":"Fu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"38","key":"10.1016\/j.phymed.2022.153952_bib0005","doi-asserted-by":"crossref","first-page":"10646","DOI":"10.1021\/acs.jafc.9b04053","article-title":"Sesquiterpenes with phytopathogenic fungi inhibitory activities from fungus trichoderma virens from litchi chinensis sonn","volume":"67","author":"Hu","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"14","key":"10.1016\/j.phymed.2022.153952_bib0006","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1111\/jcmm.15409","article-title":"Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT\/mTOR pathway","volume":"24","author":"Huang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"9","key":"10.1016\/j.phymed.2022.153952_bib0007","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.phymed.2022.153952_bib0008","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jnutbio.2012.04.017","article-title":"TRAF6 is functional in inhibition of TLR4-mediated NF-\u03baB activation by resveratrol","volume":"24","author":"Jakus","year":"2013","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.phymed.2022.153952_bib0009","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0031-9422(97)00419-6","article-title":"Sesquiterpenoid dimer and trimer from Chloranthus japonicus","volume":"47","author":"Kawabata","year":"1998","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.phymed.2022.153952_bib0010","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2022.153952_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2021.113636","article-title":"Improving sesquiterpenoids production of Sarcandra glabra callus culture","volume":"169","author":"Li","year":"2021","journal-title":"Ind. Crops Prod."},{"issue":"8","key":"10.1016\/j.phymed.2022.153952_bib0012","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1080\/15548627.2018.1474995","article-title":"Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NF-\u03baB activation and autophagy activation","volume":"14","author":"Min","year":"2018","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.phymed.2022.153952_bib0013","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.18632\/aging.101089","article-title":"Decreased mTOR signaling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria","volume":"8","author":"Miwa","year":"2016","journal-title":"Aging"},{"issue":"8","key":"10.1016\/j.phymed.2022.153952_bib0014","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"Netea","year":"2017","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2022.153952_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13046-017-0502-8","article-title":"Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6","volume":"36","author":"Qi","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.phymed.2022.153952_bib0016","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11596-015-1459-5","article-title":"Regulatory effects of AT\u2081R-TRAF6-MAPKs signaling on proliferation of intermittent hypoxia-induced human umbilical vein endothelial cells","volume":"35","author":"Shang","year":"2015","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"10.1016\/j.phymed.2022.153952_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153472","article-title":"Shizukaol a exerts anti-inflammatory effect by regulating HMGB1\/Nrf2\/HO-1 pathway","volume":"82","author":"Tang","year":"2021","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.phymed.2022.153952_bib0018","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1021\/jm3013344","article-title":"A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK\/Nrf2 pathway","volume":"56","author":"Vrba","year":"2013","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.phymed.2022.153952_bib0019","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1038\/s41598-018-38466-7","article-title":"Alfalfa polysaccharide prevents H2O2-induced oxidative damage in MEFs by activating MAPK\/Nrf2 signaling pathways and suppressing NF-\u03baB signaling pathways","volume":"9","author":"Wang","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.phymed.2022.153952_bib0020","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1021\/acs.orglett.6b00112","article-title":"Sarglaperoxides A and B, sesquiterpenoid-Normonoterpene conjugates with a peroxide bridge from the seeds of Sarcandra glabra","volume":"18","author":"Wang","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.phymed.2022.153952_bib0021","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cjoc.202000456","article-title":"Sarcaglarols A\u2013D, lindenane\u2212monoterpene heterodimers from Sarcandra glabra based on molecular networks","volume":"39","author":"Wang","year":"2021","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.phymed.2022.153952_bib0022","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.indcrop.2019.05.041","article-title":"Anti-inflammatory lindenane sesquiterpenoids and dimers from Sarcandra glabra and its upregulating AKT\/Nrf2\/HO-1 signaling mechanism","volume":"137","author":"Wei","year":"2019","journal-title":"Ind. Crops. Prod."},{"issue":"1","key":"10.1016\/j.phymed.2022.153952_bib0023","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12974-016-0723-3","article-title":"Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK","volume":"13","author":"Wong","year":"2016","journal-title":"J Neuroinflammation"},{"issue":"47","key":"10.1016\/j.phymed.2022.153952_bib0024","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1016\/j.tet.2018.10.005","article-title":"Synthetic studies toward lindenane-type dimers via diels-alder reaction","volume":"74","author":"Wu","year":"2018","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phymed.2022.153952_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9990910","article-title":"Transcriptome characterization and identification of molecular markers (SNP, SSR, and Indels) in the medicinal plant Sarcandra glabra spp","volume":"2021","author":"Xu","year":"2021","journal-title":"BioMed Res. Int."},{"issue":"6","key":"10.1016\/j.phymed.2022.153952_bib0026","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.molcel.2008.09.002","article-title":"TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta","volume":"31","author":"Yamashita","year":"2008","journal-title":"Mol. Cell."},{"key":"10.1016\/j.phymed.2022.153952_bib0027","doi-asserted-by":"crossref","DOI":"10.1039\/D0QO00093K","article-title":"Tricarabrols A\u2013C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi","volume":"7","author":"Yuan","year":"2020","journal-title":"Org. Chem. Front."},{"key":"10.1016\/j.phymed.2022.153952_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111915","article-title":"Anti-inflammatory and antioxidant effects of Chaetoglobosin Vb in LPS-induced RAW264.7 cells: achieved via the MAPK and NF-\u03baB signaling pathways","volume":"147","author":"Zhang","year":"2021","journal-title":"Food Chem. Toxicol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322000307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322000307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:35:29Z","timestamp":1760553329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322000307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":28,"alternative-id":["S0944711322000307"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.153952","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anti-inflammatory activity by suppressing the TRAF6\/MAPKs pathway of trishizukaol a from Sarcandra glabra","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.153952","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"153952"}}